Details for: TRAV26 2

Gene ID: 28656

Symbol: TRAV26 2

Ensembl ID: ENSG00000211812

Description: T cell receptor alpha variable 26-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.4090
    Cell Significance Index: 2.2300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0014
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0114
    Cell Significance Index: -2.3000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0119
    Cell Significance Index: -0.1500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0138
    Cell Significance Index: -0.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0156
    Cell Significance Index: -0.3900
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0193
    Cell Significance Index: -0.1600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0306
    Cell Significance Index: -0.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0339
    Cell Significance Index: -1.5800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0356
    Cell Significance Index: -0.4200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0360
    Cell Significance Index: -0.4900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0369
    Cell Significance Index: -0.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0397
    Cell Significance Index: -0.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0438
    Cell Significance Index: -2.0600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0443
    Cell Significance Index: -0.5000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0481
    Cell Significance Index: -0.8300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0487
    Cell Significance Index: -0.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0520
    Cell Significance Index: -1.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0553
    Cell Significance Index: -1.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0634
    Cell Significance Index: -1.6200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0647
    Cell Significance Index: -0.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0660
    Cell Significance Index: -2.1600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0671
    Cell Significance Index: -1.7100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0683
    Cell Significance Index: -0.6900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0702
    Cell Significance Index: -1.1800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0763
    Cell Significance Index: -0.6500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0812
    Cell Significance Index: -0.7700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0818
    Cell Significance Index: -1.3300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0845
    Cell Significance Index: -0.7900
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0850
    Cell Significance Index: -0.9800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0868
    Cell Significance Index: -0.9000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0922
    Cell Significance Index: -2.3000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0926
    Cell Significance Index: -1.2700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0939
    Cell Significance Index: -1.1100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0943
    Cell Significance Index: -1.2200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0959
    Cell Significance Index: -1.8800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0965
    Cell Significance Index: -0.8300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0989
    Cell Significance Index: -1.5900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1013
    Cell Significance Index: -1.0500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1021
    Cell Significance Index: -1.5500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1029
    Cell Significance Index: -1.3200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1030
    Cell Significance Index: -1.0500
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1065
    Cell Significance Index: -0.8900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1087
    Cell Significance Index: -1.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1090
    Cell Significance Index: -2.0200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1095
    Cell Significance Index: -1.4300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1113
    Cell Significance Index: -1.3800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1118
    Cell Significance Index: -1.0900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1122
    Cell Significance Index: -1.4700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1125
    Cell Significance Index: -1.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1144
    Cell Significance Index: -1.1000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1144
    Cell Significance Index: -1.4700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1160
    Cell Significance Index: -1.2300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1164
    Cell Significance Index: -1.3500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1166
    Cell Significance Index: -1.5300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1168
    Cell Significance Index: -1.4500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1182
    Cell Significance Index: -1.0200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1185
    Cell Significance Index: -1.0000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1189
    Cell Significance Index: -1.1500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1204
    Cell Significance Index: -1.4800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1216
    Cell Significance Index: -1.6000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1217
    Cell Significance Index: -1.5200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1219
    Cell Significance Index: -1.6200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1219
    Cell Significance Index: -1.4500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1237
    Cell Significance Index: -1.4600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1242
    Cell Significance Index: -1.6000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1243
    Cell Significance Index: -0.8600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1243
    Cell Significance Index: -1.4900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1251
    Cell Significance Index: -1.4100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1254
    Cell Significance Index: -1.4400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1270
    Cell Significance Index: -1.2800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1273
    Cell Significance Index: -1.3800
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1301
    Cell Significance Index: -1.3900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1340
    Cell Significance Index: -1.6300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1340
    Cell Significance Index: -1.2700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1366
    Cell Significance Index: -1.5300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1382
    Cell Significance Index: -1.5900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1384
    Cell Significance Index: -1.4600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1390
    Cell Significance Index: -1.5200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1391
    Cell Significance Index: -1.4100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1395
    Cell Significance Index: -1.1300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1404
    Cell Significance Index: -1.5200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1430
    Cell Significance Index: -1.7000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1432
    Cell Significance Index: -1.6500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1433
    Cell Significance Index: -1.1200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1439
    Cell Significance Index: -1.7000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1442
    Cell Significance Index: -1.5800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1459
    Cell Significance Index: -1.4900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1460
    Cell Significance Index: -1.5300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1468
    Cell Significance Index: -1.6400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1481
    Cell Significance Index: -1.7500
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1497
    Cell Significance Index: -1.3600
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1501
    Cell Significance Index: -1.4700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1514
    Cell Significance Index: -1.4000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1529
    Cell Significance Index: -1.5600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1534
    Cell Significance Index: -1.4400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1544
    Cell Significance Index: -1.7100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1563
    Cell Significance Index: -1.5600
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1563
    Cell Significance Index: -1.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRAV26.2 is expressed in a wide range of cell types, including effector CD8-positive, alpha-beta T cells, central memory CD4-positive, alpha-beta T cells, and early T lineage precursors. Its expression is also observed in precursor B cells, neutrophils, and megakaryocyte-erythroid progenitor cells. 2. **Variable Region:** TRAV26.2 is a variable region of the alpha-beta TCR, which is responsible for recognizing and binding to specific antigens. 3. **Diversity:** The TRAV26.2 gene contributes to the immense diversity of the TCR repertoire, enabling alpha-beta T cells to recognize a vast array of antigens. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV26.2 plays a crucial role in the adaptive immune response, enabling alpha-beta T cells to recognize and respond to specific antigens. 2. **Response to Bacterium:** The expression of TRAV26.2 is upregulated in response to bacterial infections, highlighting its importance in the host's defense against bacterial pathogens. 3. **T Cell Receptor Complex:** TRAV26.2 is a component of the TCR complex, which forms a heterodimer with the TRAV gene product to create a functional TCR. **Clinical Significance:** 1. **Autoimmune Diseases:** Abnormalities in the TRAV26.2 gene have been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes, highlighting the importance of this gene in maintaining immune homeostasis. 2. **Cancer Immunotherapy:** The expression of TRAV26.2 has been linked to cancer immunotherapy responses, suggesting that targeting this gene may be a viable strategy for enhancing anti-tumor immunity. 3. **Infectious Diseases:** The role of TRAV26.2 in responding to bacterial infections underscores its importance in the host's defense against bacterial pathogens. In conclusion, the TRAV26.2 gene plays a critical role in the adaptive immune response, and its dysregulation has been implicated in various immune-related disorders. Further research into the functions and clinical significance of TRAV26.2 is necessary to fully appreciate its importance in maintaining immune homeostasis and responding to pathogens.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.