Details for: TRAV9 2

Gene ID: 28677

Symbol: TRAV9 2

Ensembl ID: ENSG00000211793

Description: T cell receptor alpha variable 9-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.5282
    Cell Significance Index: 2.8800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.5216
    Cell Significance Index: 5.8300
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.2412
    Cell Significance Index: 0.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0044
    Cell Significance Index: -3.3000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0324
    Cell Significance Index: -0.5500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0352
    Cell Significance Index: -0.3700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0542
    Cell Significance Index: -0.6400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0595
    Cell Significance Index: -0.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0718
    Cell Significance Index: -1.9200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0813
    Cell Significance Index: -1.0200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0882
    Cell Significance Index: -1.2900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0974
    Cell Significance Index: -1.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1004
    Cell Significance Index: -4.7200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1049
    Cell Significance Index: -1.0600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1057
    Cell Significance Index: -0.9000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1273
    Cell Significance Index: -1.8800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1278
    Cell Significance Index: -1.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1307
    Cell Significance Index: -3.3300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1326
    Cell Significance Index: -1.1400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1400
    Cell Significance Index: -1.3100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1411
    Cell Significance Index: -1.7500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1414
    Cell Significance Index: -1.8300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1424
    Cell Significance Index: -1.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1462
    Cell Significance Index: -1.4100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1490
    Cell Significance Index: -1.5800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1556
    Cell Significance Index: -3.7700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1570
    Cell Significance Index: -1.5300
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1585
    Cell Significance Index: -1.0900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1595
    Cell Significance Index: -2.7500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1655
    Cell Significance Index: -2.5600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1723
    Cell Significance Index: -1.7800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1816
    Cell Significance Index: -2.3900
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.1850
    Cell Significance Index: -1.9600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1872
    Cell Significance Index: -3.6600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1885
    Cell Significance Index: -1.8900
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1891
    Cell Significance Index: -1.9900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1895
    Cell Significance Index: -1.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1942
    Cell Significance Index: -3.5900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1945
    Cell Significance Index: -3.1500
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2036
    Cell Significance Index: -1.8600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2048
    Cell Significance Index: -3.5000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2059
    Cell Significance Index: -2.1400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2189
    Cell Significance Index: -2.2700
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2198
    Cell Significance Index: -2.3000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2223
    Cell Significance Index: -2.3900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2224
    Cell Significance Index: -2.5800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2240
    Cell Significance Index: -2.4500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2264
    Cell Significance Index: -2.8600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2267
    Cell Significance Index: -1.7900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2299
    Cell Significance Index: -2.1800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2304
    Cell Significance Index: -3.1600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2323
    Cell Significance Index: -2.3600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2333
    Cell Significance Index: -3.4000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2365
    Cell Significance Index: -3.3600
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2377
    Cell Significance Index: -1.9700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2390
    Cell Significance Index: -2.0900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2392
    Cell Significance Index: -2.5900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2393
    Cell Significance Index: -3.1300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2403
    Cell Significance Index: -2.8600
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2410
    Cell Significance Index: -2.3600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2443
    Cell Significance Index: -2.2600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2449
    Cell Significance Index: -3.0100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2468
    Cell Significance Index: -3.2800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2487
    Cell Significance Index: -3.2000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2521
    Cell Significance Index: -2.5400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2560
    Cell Significance Index: -2.7600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2583
    Cell Significance Index: -3.1400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2585
    Cell Significance Index: -3.1200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2603
    Cell Significance Index: -3.5100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2614
    Cell Significance Index: -3.4300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2618
    Cell Significance Index: -2.9500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2619
    Cell Significance Index: -3.1400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2659
    Cell Significance Index: -3.0600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2668
    Cell Significance Index: -3.0700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2691
    Cell Significance Index: -3.1800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2694
    Cell Significance Index: -3.1300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2696
    Cell Significance Index: -3.5200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2795
    Cell Significance Index: -3.1800
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.2813
    Cell Significance Index: -2.6100
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2824
    Cell Significance Index: -2.3600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2828
    Cell Significance Index: -3.4400
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.2840
    Cell Significance Index: -2.5800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2847
    Cell Significance Index: -3.1300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2853
    Cell Significance Index: -2.7600
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.2864
    Cell Significance Index: -3.1000
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2868
    Cell Significance Index: -2.5800
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.2880
    Cell Significance Index: -2.1700
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2893
    Cell Significance Index: -3.1700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2896
    Cell Significance Index: -3.1400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2898
    Cell Significance Index: -3.4400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2902
    Cell Significance Index: -2.3500
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.2911
    Cell Significance Index: -2.5800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2927
    Cell Significance Index: -3.5600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2936
    Cell Significance Index: -3.0000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2942
    Cell Significance Index: -3.2100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2945
    Cell Significance Index: -3.5000
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.2945
    Cell Significance Index: -2.9900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2970
    Cell Significance Index: -3.5100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.2974
    Cell Significance Index: -2.4600
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.2980
    Cell Significance Index: -3.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRAV9.2 is significantly expressed in hematopoietic cells, leukocytes, granulocyte-monocyte progenitor cells, goblet cells, and intestinal epithelial cells, suggesting its role in the development and function of these cell types. 2. **Gene Ontology:** TRAV9.2 is classified under the gene ontology categories of adaptive immune response and T cell receptor complex, emphasizing its involvement in the immune system. 3. **Ensembl ID:** The Ensembl ID (ENSG00000211793) assigned to TRAV9.2 provides a unique identifier for this gene, facilitating its tracking and analysis. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV9.2 is integral to the adaptive immune response, enabling T cells to recognize and respond to specific antigens. The variable region of the T cell receptor alpha chain, encoded by TRAV9.2, interacts with major histocompatibility complex (MHC) molecules to facilitate antigen recognition. 2. **T Cell Receptor Complex:** TRAV9.2 is part of the T cell receptor complex, which consists of the T cell receptor alpha, beta, gamma, and delta chains. The interactions between these chains and MHC molecules are crucial for the activation and function of T cells. 3. **Immune Cell Development:** TRAV9.2 is expressed in early T lineage precursors, suggesting its role in the development and maturation of T cells. **Clinical Significance:** 1. **Cancer Immunotherapy:** Understanding the role of TRAV9.2 in T cell function and antigen recognition can inform the development of cancer immunotherapies, which harness the immune system to target and eliminate cancer cells. 2. **Autoimmune Diseases:** TRAV9.2 may also play a role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where T cell dysfunction and inappropriate antigen recognition contribute to disease pathology. 3. **Infectious Diseases:** The expression of TRAV9.2 in intestinal epithelial cells suggests its potential role in mucosal immunity, which is critical for preventing infections and maintaining gut homeostasis. 4. **Regulatory T Cells:** TRAV9.2 may also be involved in the function and regulation of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmunity. In conclusion, TRAV9.2 is a critical gene that encodes for a variable region of the T cell receptor alpha chain, playing a pivotal role in the adaptive immune response and T cell function. Its widespread expression across various cell types and its involvement in immune cell development and function highlight its importance in human health. Further research into the functions and clinical implications of TRAV9.2 is necessary to fully elucidate its significance in the immune system and to develop novel therapeutic strategies for immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.