Details for: IGKV1D 13

Gene ID: 28902

Symbol: IGKV1D 13

Ensembl ID: ENSG00000276566

Description: immunoglobulin kappa variable 1D-13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4559
    Cell Significance Index: 6.6500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1798
    Cell Significance Index: 2.0100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0132
    Cell Significance Index: -0.1800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0200
    Cell Significance Index: -0.3400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0225
    Cell Significance Index: -0.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0248
    Cell Significance Index: -1.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0285
    Cell Significance Index: -0.6900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0300
    Cell Significance Index: -0.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0366
    Cell Significance Index: -0.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0380
    Cell Significance Index: -1.7700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0394
    Cell Significance Index: -0.4400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0406
    Cell Significance Index: -0.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0411
    Cell Significance Index: -1.5100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0550
    Cell Significance Index: -0.6500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0581
    Cell Significance Index: -1.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0624
    Cell Significance Index: -1.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0658
    Cell Significance Index: -1.7900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0663
    Cell Significance Index: -0.8200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0667
    Cell Significance Index: -1.0800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0685
    Cell Significance Index: -0.8800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0704
    Cell Significance Index: -0.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0710
    Cell Significance Index: -1.6400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0762
    Cell Significance Index: -1.4900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0787
    Cell Significance Index: -0.9300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0804
    Cell Significance Index: -1.0400
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0840
    Cell Significance Index: -0.7600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0855
    Cell Significance Index: -1.2200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0895
    Cell Significance Index: -1.5300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0909
    Cell Significance Index: -1.0900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0910
    Cell Significance Index: -1.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0914
    Cell Significance Index: -1.6900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0959
    Cell Significance Index: -0.9800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0961
    Cell Significance Index: -1.3200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0996
    Cell Significance Index: -1.0600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1033
    Cell Significance Index: -1.2200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1043
    Cell Significance Index: -1.2000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1051
    Cell Significance Index: -1.1300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1073
    Cell Significance Index: -1.1300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1073
    Cell Significance Index: -1.3100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1083
    Cell Significance Index: -1.4300
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1104
    Cell Significance Index: -1.0100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1107
    Cell Significance Index: -1.4500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1120
    Cell Significance Index: -1.2200
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1121
    Cell Significance Index: -0.7300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1149
    Cell Significance Index: -1.2200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1172
    Cell Significance Index: -1.2000
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.1177
    Cell Significance Index: -1.3500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1188
    Cell Significance Index: -1.3500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1196
    Cell Significance Index: -1.6400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1219
    Cell Significance Index: -1.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1231
    Cell Significance Index: -1.8200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1232
    Cell Significance Index: -1.3700
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1233
    Cell Significance Index: -1.3700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1237
    Cell Significance Index: -1.3700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1247
    Cell Significance Index: -1.3500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1249
    Cell Significance Index: -1.6600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1267
    Cell Significance Index: -1.2500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1270
    Cell Significance Index: -1.6400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1292
    Cell Significance Index: -1.4200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1293
    Cell Significance Index: -1.2000
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.1295
    Cell Significance Index: -1.3700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1308
    Cell Significance Index: -1.5200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1311
    Cell Significance Index: -1.3600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1323
    Cell Significance Index: -1.3700
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1343
    Cell Significance Index: -1.1900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1374
    Cell Significance Index: -1.4600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1379
    Cell Significance Index: -1.6300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1383
    Cell Significance Index: -1.7000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1400
    Cell Significance Index: -1.3700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1404
    Cell Significance Index: -1.2900
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1418
    Cell Significance Index: -1.2700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1428
    Cell Significance Index: -1.3300
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1431
    Cell Significance Index: -1.5000
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.1441
    Cell Significance Index: -1.5400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1451
    Cell Significance Index: -1.6700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1454
    Cell Significance Index: -1.6100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1454
    Cell Significance Index: -1.5900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1457
    Cell Significance Index: -1.6900
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1457
    Cell Significance Index: -1.2700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1464
    Cell Significance Index: -1.2900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1464
    Cell Significance Index: -1.1700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1471
    Cell Significance Index: -1.6000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1513
    Cell Significance Index: -1.7100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1525
    Cell Significance Index: -1.3000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1538
    Cell Significance Index: -1.5600
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1546
    Cell Significance Index: -1.6800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1548
    Cell Significance Index: -1.5800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1556
    Cell Significance Index: -1.3600
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.1556
    Cell Significance Index: -1.6500
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1559
    Cell Significance Index: -1.4800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1575
    Cell Significance Index: -1.5600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1577
    Cell Significance Index: -1.7000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1583
    Cell Significance Index: -1.5200
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.1592
    Cell Significance Index: -1.5700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1596
    Cell Significance Index: -1.3200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1612
    Cell Significance Index: -1.7000
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1627
    Cell Significance Index: -1.1500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1632
    Cell Significance Index: -1.7300
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1634
    Cell Significance Index: -1.6900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1636
    Cell Significance Index: -1.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Genomic Location:** The IGKV1D 13 gene is located on chromosome 2p12.1, which is a region rich in immunoglobulin genes, indicating its involvement in the adaptive immune system. 2. **Gene Structure:** The IGKV1D 13 gene consists of a single coding exon and a 5' untranslated region (UTR) that contains a regulatory element essential for gene expression. 3. **Protein Function:** The IGKV1D 13 gene encodes for a kappa light chain variable region, which is a critical component of immunoglobulins. This region determines the specificity and affinity of antibodies for antigens. 4. **Cellular Expression:** The IGKV1D 13 gene is significantly expressed in various cell types, including T cells, granulocyte-monocyte progenitor cells, goblet cells, hematopoietic cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, abnormal cells, early T lineage precursors, and neoplastic cells. **Pathways and Functions:** 1. **Adaptive Immune Response:** The IGKV1D 13 gene plays a crucial role in the adaptive immune response, where it contributes to the production of immunoglobulins that recognize and neutralize pathogens. 2. **Immunoglobulin Production:** The IGKV1D 13 gene is essential for the production of immunoglobulins, which are composed of heavy and light chains. The kappa light chain variable region, encoded by this gene, determines the specificity and affinity of antibodies for antigens. 3. **Immunoglobulin Complex Organization:** The IGKV1D 13 gene contributes to the organization of immunoglobulin complexes on the plasma membrane, which is essential for the efficient recognition and neutralization of pathogens. 4. **Cell Signaling:** The IGKV1D 13 gene is involved in cell signaling pathways that regulate immune cell function, including T cell activation and cytokine production. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations in the IGKV1D 13 gene can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia, where patients are unable to produce immunoglobulins, making them susceptible to recurrent infections. 2. **Cancer:** Aberrant expression of the IGKV1D 13 gene has been observed in various types of cancer, including lymphoma and leukemia, where it may contribute to tumorigenesis and immune evasion. 3. **Autoimmune Diseases:** Dysregulation of the IGKV1D 13 gene has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it may contribute to the production of autoantibodies and tissue damage. 4. **Vaccine Development:** Understanding the IGKV1D 13 gene's role in immunoglobulin production and immune response may lead to the development of more effective vaccines that can induce long-term immune memory and protection against pathogens. In conclusion, the IGKV1D 13 gene plays a critical role in the adaptive immune system, and its dysregulation can lead to various immunodeficiency disorders, autoimmune diseases, and cancer. Further research is necessary to fully understand the complexities of this gene and its implications in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.