IGKV1 27 | ENSG00000244575 | NCBI 28935

Details for: IGKV1 27

Gene ID: 28935

Symbol: IGKV1 27

Ensembl ID: ENSG00000244575

Description: immunoglobulin kappa variable 1-27

Associated with

Adaptive immune response
(GO:0002250)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0032
Cell Significance Index: -0.0500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0106
Cell Significance Index: -8.0300
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0394
Cell Significance Index: -0.5600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0851
Cell Significance Index: -14.5300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1094
Cell Significance Index: -14.1400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1580
Cell Significance Index: -4.3000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1685
Cell Significance Index: -4.2100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1703
Cell Significance Index: -8.8500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1862
Cell Significance Index: -8.6800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1895
Cell Significance Index: -14.1200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2109
Cell Significance Index: -13.2900
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2587
Cell Significance Index: -6.5900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2695
Cell Significance Index: -7.2100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2706
Cell Significance Index: -6.5600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2749
Cell Significance Index: -10.0900
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3484
Cell Significance Index: -8.9000
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.3520
Cell Significance Index: -4.4600
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3672
Cell Significance Index: -5.4200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3787
Cell Significance Index: -7.0000
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3867
Cell Significance Index: -7.5600
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.3976
Cell Significance Index: -6.4400
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3996
Cell Significance Index: -6.8300
Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.4360
Cell Significance Index: -3.9900
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.4408
Cell Significance Index: -7.4300
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.4417
Cell Significance Index: -5.0100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.4583
Cell Significance Index: -5.2100
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.4587
Cell Significance Index: -6.6600
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.4823
Cell Significance Index: -5.3900
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.4860
Cell Significance Index: -6.6700
Cell Name: blood cell (CL0000081)
Fold Change: -0.5514
Cell Significance Index: -4.7000
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.5613
Cell Significance Index: -7.7900
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.5687
Cell Significance Index: -7.0400
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.5728
Cell Significance Index: -6.7700
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.5827
Cell Significance Index: -4.8100
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.5889
Cell Significance Index: -7.6200
Cell Name: monocyte (CL0000576)
Fold Change: -0.5910
Cell Significance Index: -6.8000
Cell Name: pericyte (CL0000669)
Fold Change: -0.5946
Cell Significance Index: -7.1300
Cell Name: neutrophil (CL0000775)
Fold Change: -0.6020
Cell Significance Index: -7.5200
Cell Name: stromal cell (CL0000499)
Fold Change: -0.6088
Cell Significance Index: -6.2200
Cell Name: glial cell (CL0000125)
Fold Change: -0.6097
Cell Significance Index: -6.6800
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.6149
Cell Significance Index: -6.8100
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.6262
Cell Significance Index: -4.1700
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.6272
Cell Significance Index: -6.4700
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.6314
Cell Significance Index: -6.9900
Cell Name: platelet (CL0000233)
Fold Change: -0.6328
Cell Significance Index: -6.5100
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.6392
Cell Significance Index: -7.5200
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.6425
Cell Significance Index: -8.7400
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.6458
Cell Significance Index: -7.8500
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.6488
Cell Significance Index: -7.0000
Cell Name: T cell (CL0000084)
Fold Change: -0.6513
Cell Significance Index: -7.6900
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.6622
Cell Significance Index: -7.6900
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.6664
Cell Significance Index: -7.7300
Cell Name: leukocyte (CL0000738)
Fold Change: -0.6683
Cell Significance Index: -11.3500
Cell Name: plasma cell (CL0000786)
Fold Change: -0.6704
Cell Significance Index: -7.4900
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.6728
Cell Significance Index: -7.9500
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.6736
Cell Significance Index: -8.8400
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: -0.6739
Cell Significance Index: -6.5800
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.6746
Cell Significance Index: -7.1100
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.6772
Cell Significance Index: -8.7000
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.6775
Cell Significance Index: -10.2900
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.6815
Cell Significance Index: -7.2400
Cell Name: memory B cell (CL0000787)
Fold Change: -0.6824
Cell Significance Index: -7.2600
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.6839
Cell Significance Index: -7.8700
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.6851
Cell Significance Index: -8.2700
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.6855
Cell Significance Index: -7.7600
Cell Name: B cell (CL0000236)
Fold Change: -0.6888
Cell Significance Index: -8.1400
Cell Name: fibroblast (CL0000057)
Fold Change: -0.6892
Cell Significance Index: -6.4700
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.6901
Cell Significance Index: -7.8400
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.6913
Cell Significance Index: -7.7900
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.6925
Cell Significance Index: -9.0400
Cell Name: plasmablast (CL0000980)
Fold Change: -0.6961
Cell Significance Index: -6.4600
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.6974
Cell Significance Index: -9.1200
Cell Name: naive B cell (CL0000788)
Fold Change: -0.7009
Cell Significance Index: -7.3800
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.7050
Cell Significance Index: -7.8400
Cell Name: thymocyte (CL0000893)
Fold Change: -0.7060
Cell Significance Index: -8.9200
Cell Name: dendritic cell, human (CL0001056)
Fold Change: -0.7135
Cell Significance Index: -6.5800
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: -0.7141
Cell Significance Index: -7.7000
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.7149
Cell Significance Index: -9.5000
Cell Name: mast cell (CL0000097)
Fold Change: -0.7158
Cell Significance Index: -9.4200
Cell Name: peg cell (CL4033014)
Fold Change: -0.7189
Cell Significance Index: -16.6100
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.7226
Cell Significance Index: -7.7700
Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
Fold Change: -0.7242
Cell Significance Index: -7.8300
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.7259
Cell Significance Index: -10.5800
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.7320
Cell Significance Index: -7.2200
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.7354
Cell Significance Index: -8.7300
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: -0.7366
Cell Significance Index: -5.8200
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.7397
Cell Significance Index: -7.1000
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.7414
Cell Significance Index: -6.4900
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.7422
Cell Significance Index: -6.6200
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.7469
Cell Significance Index: -6.8300
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.7469
Cell Significance Index: -7.9200
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: -0.7479
Cell Significance Index: -6.9100
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.7491
Cell Significance Index: -10.5000
Cell Name: transitional stage B cell (CL0000818)
Fold Change: -0.7518
Cell Significance Index: -6.6100
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.7591
Cell Significance Index: -8.2300
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.7603
Cell Significance Index: -6.1100
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.7636
Cell Significance Index: -9.2900
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.7672
Cell Significance Index: -7.7300
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.7680
Cell Significance Index: -9.4400
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.7740
Cell Significance Index: -6.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **IGKV1-27 is a part of the immunoglobulin kappa locus**: This gene is one of the numerous IgK genes that are clustered together on chromosome 2p12.3. The IgK locus is responsible for the production of kappa light chains, which are essential components of antibodies. 2. **Significant expression in various cell types**: IGKV1-27 is expressed in a wide range of cell types, including granulocyte-monocyte progenitor cells, goblet cells, and CD16-positive, CD56-dim natural killer cells. This suggests that IGKV1-27 plays a role in the development and function of these cells. 3. **Involvement in adaptive immune response**: IGKV1-27 is significantly associated with adaptive immune responses, which are mediated by B cells and T cells. This gene is likely involved in the regulation of immune responses, possibly by influencing the development and function of B cells. **Pathways and Functions:** 1. **Immunoglobulin production**: IGKV1-27 is involved in the production of kappa light chains, which are essential components of antibodies. The correct assembly and function of these light chains are critical for the generation of functional antibodies. 2. **Adaptive immune response**: IGKV1-27 is associated with adaptive immune responses, which are mediated by B cells and T cells. This gene is likely involved in the regulation of immune responses, possibly by influencing the development and function of B cells. 3. **Cell signaling and regulation**: IGKV1-27 may also be involved in cell signaling and regulation, particularly in the context of immune responses. This could involve the regulation of gene expression, cell proliferation, and differentiation. **Clinical Significance:** IGKV1-27 has significant clinical implications, particularly in the context of immune-mediated disorders. Mutations or aberrant expression of this gene may contribute to the development of autoimmune diseases, such as rheumatoid arthritis or lupus. Additionally, IGKV1-27 may be involved in the pathogenesis of certain cancers, including lymphomas and leukemias. In conclusion, IGKV1-27 is a complex gene that plays a critical role in the adaptive immune response. Its involvement in immunoglobulin production, adaptive immune responses, and cell signaling and regulation highlights the importance of this gene in maintaining immune homeostasis. Further research is needed to fully understand the function of IGKV1-27 and its clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.