Details for: LCE2A

Gene ID: 353139

Symbol: LCE2A

Ensembl ID: ENSG00000187173

Description: late cornified envelope 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0750
    Cell Significance Index: 0.9800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0554
    Cell Significance Index: 0.1200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0132
    Cell Significance Index: 0.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0051
    Cell Significance Index: 0.0700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0352
    Cell Significance Index: -0.5000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0515
    Cell Significance Index: -1.0300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0612
    Cell Significance Index: -0.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0628
    Cell Significance Index: -0.9000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0638
    Cell Significance Index: -0.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0697
    Cell Significance Index: -1.6900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0775
    Cell Significance Index: -0.9400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0775
    Cell Significance Index: -1.5200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0911
    Cell Significance Index: -0.8000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0918
    Cell Significance Index: -1.1000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1208
    Cell Significance Index: -1.3100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1218
    Cell Significance Index: -1.4300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1365
    Cell Significance Index: -1.6600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1409
    Cell Significance Index: -1.5600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1444
    Cell Significance Index: -1.4900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1761
    Cell Significance Index: -1.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1781
    Cell Significance Index: -5.2500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1903
    Cell Significance Index: -2.0800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2045
    Cell Significance Index: -5.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2090
    Cell Significance Index: -5.5800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2233
    Cell Significance Index: -2.5900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2265
    Cell Significance Index: -2.9100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2333
    Cell Significance Index: -2.4200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2343
    Cell Significance Index: -2.8100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2494
    Cell Significance Index: -4.0100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2538
    Cell Significance Index: -6.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2550
    Cell Significance Index: -5.2900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2801
    Cell Significance Index: -3.3100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2917
    Cell Significance Index: -4.4300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2970
    Cell Significance Index: -4.8100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2981
    Cell Significance Index: -1.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3086
    Cell Significance Index: -5.1700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3117
    Cell Significance Index: -4.2800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3177
    Cell Significance Index: -5.4300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3398
    Cell Significance Index: -3.1900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3403
    Cell Significance Index: -4.9600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3417
    Cell Significance Index: -4.7900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.3426
    Cell Significance Index: -4.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3447
    Cell Significance Index: -4.0700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3756
    Cell Significance Index: -4.4700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3795
    Cell Significance Index: -4.9800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3875
    Cell Significance Index: -5.1000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.4019
    Cell Significance Index: -4.8900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4065
    Cell Significance Index: -4.1500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4076
    Cell Significance Index: -5.5900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.4086
    Cell Significance Index: -4.7500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.4092
    Cell Significance Index: -5.2400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.4169
    Cell Significance Index: -4.2600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.4236
    Cell Significance Index: -5.5300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4302
    Cell Significance Index: -4.9500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4312
    Cell Significance Index: -5.3000
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.4373
    Cell Significance Index: -5.0400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4440
    Cell Significance Index: -4.9600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4479
    Cell Significance Index: -4.8800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.4544
    Cell Significance Index: -5.3700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4569
    Cell Significance Index: -4.8200
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.4609
    Cell Significance Index: -5.1600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.4665
    Cell Significance Index: -5.4200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4701
    Cell Significance Index: -5.1600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4959
    Cell Significance Index: -6.5900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.4990
    Cell Significance Index: -4.7400
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.4999
    Cell Significance Index: -5.2400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.5061
    Cell Significance Index: -5.3500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.5063
    Cell Significance Index: -6.5200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.5213
    Cell Significance Index: -5.6800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.5290
    Cell Significance Index: -5.2800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.5387
    Cell Significance Index: -5.3300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.5429
    Cell Significance Index: -5.6000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.5476
    Cell Significance Index: -6.0000
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.5481
    Cell Significance Index: -5.9500
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.5486
    Cell Significance Index: -5.1400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.6007
    Cell Significance Index: -5.7000
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.6094
    Cell Significance Index: -5.2500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6340
    Cell Significance Index: -6.0100
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.6346
    Cell Significance Index: -6.0500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.6492
    Cell Significance Index: -5.7200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.6672
    Cell Significance Index: -5.6300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.6874
    Cell Significance Index: -5.8100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.6891
    Cell Significance Index: -5.7000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.6986
    Cell Significance Index: -5.4400
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.7119
    Cell Significance Index: -5.6200
  • Cell Name: contractile cell (CL0000183)
    Fold Change: -0.7512
    Cell Significance Index: -1.4500
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.7531
    Cell Significance Index: -5.3000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7542
    Cell Significance Index: -6.1500
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.8049
    Cell Significance Index: -5.3600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.8214
    Cell Significance Index: -5.9700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.8382
    Cell Significance Index: -5.2000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.9105
    Cell Significance Index: -5.7000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.9141
    Cell Significance Index: -5.6800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.9381
    Cell Significance Index: -5.0200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.0162
    Cell Significance Index: -6.1400
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: -1.1319
    Cell Significance Index: -6.4900
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -2.8106
    Cell Significance Index: -6.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** LCE2A is highly expressed in a variety of cell types, including immune cells, epithelial cells, and melanocytes. This widespread expression suggests that LCE2A plays a critical role in maintaining tissue homeostasis and immune function. 2. **Protein Structure:** The LCE2A protein is a member of the late cornified envelope protein family, which consists of four subunits. The structure of LCE2A is characterized by four transmembrane domains and a cytoplasmic tail. 3. **Function:** LCE2A has been implicated in the formation of the cornified envelope, a complex structure composed of multiple proteins and lipids. The cornified envelope plays a crucial role in maintaining the integrity of epithelial tissues, particularly in the skin. **Pathways and Functions:** 1. **Developmental Biology:** LCE2A is involved in the development of epithelial tissues, particularly in the skin. The gene's expression is essential for the formation of the cornified envelope, which is critical for maintaining tissue integrity. 2. **Keratinization:** LCE2A is also involved in the process of keratinization, which is essential for maintaining the integrity of epithelial tissues. Keratinization involves the formation of keratin filaments, which provide mechanical strength to epithelial cells. 3. **Protein Binding:** LCE2A has been shown to interact with other proteins, including keratin proteins and lipids. These interactions are critical for the formation and maintenance of the cornified envelope. **Clinical Significance:** 1. **Skin Diseases:** Mutations in the LCE2A gene have been associated with several skin diseases, including epidermolysis bullosa simplex. These mutations disrupt the formation of the cornified envelope, leading to blistering and skin fragility. 2. **Immune System:** LCE2A's expression in immune cells suggests that it plays a critical role in the immune response. The gene's involvement in keratinization and protein binding also highlights its importance in maintaining tissue homeostasis. 3. **Cancer:** LCE2A's expression in epithelial cells and its involvement in keratinization and protein binding make it a potential biomarker for cancer. Aberrant expression of LCE2A has been observed in several types of cancer, including breast and lung cancer. In conclusion, LCE2A is a critical gene that plays a central role in maintaining epithelial homeostasis and immune response. Its widespread expression and involvement in developmental biology, keratinization, and protein binding suggest that it is a key player in maintaining tissue integrity and immune function. Further research is needed to fully elucidate the functions of LCE2A and its potential applications in cancer and other diseases.

Genular Protein ID: 1680779513

Symbol: LCE2A_HUMAN

Name: Late cornified envelope protein 2A

UniProtKB Accession Codes:

Q5TA79 A4QMZ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 3 Ensembl 1 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15854049

Title: Late cornified envelope family in differentiating epithelia -- response to calcium and ultraviolet irradiation.

PubMed ID: 15854049

DOI: 10.1111/j.0022-202x.2005.23699.x

PubMed ID: 36804407

Title: CYSRT1: An Antimicrobial Epidermal Protein that Can Interact with Late Cornified Envelope Proteins.

PubMed ID: 36804407

DOI: 10.1016/j.jid.2023.01.022

Sequence Information:

  • Length: 106
  • Mass: 10846
  • Checksum: 7F29B511D282B6AA
  • Sequence:
    • MSCQQNQQQC QPPPKCPPKC PPKCPPKCRP QCPAPCPPPV SSCCGPSSGG CCGSSSGGCC 
SSGGGGCCLS HHRPRLFHRH RHQSPDCCEC EPSGGSGCCH SSGDCC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.