Gene ITGAV - ENSG00000138448 | NCBI Gene ID: 3685

Details for: ITGAV

Gene ID: 3685

Symbol: ITGAV

Ensembl ID: ENSG00000138448

Description: integrin subunit alpha V

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Axon guidance
(R-HSA-422475)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cross-presentation of particulate exogenous antigens (phagosomes)
(R-HSA-1236973)
Developmental biology
(R-HSA-1266738)
Ecm proteoglycans
(R-HSA-3000178)
Elastic fibre formation
(R-HSA-1566948)
Extracellular matrix organization
(R-HSA-1474244)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Integrin cell surface interactions
(R-HSA-216083)
L1cam interactions
(R-HSA-373760)
Laminin interactions
(R-HSA-3000157)
Molecules associated with elastic fibres
(R-HSA-2129379)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Non-integrin membrane-ecm interactions
(R-HSA-3000171)
Pecam1 interactions
(R-HSA-210990)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Signal transduction by l1
(R-HSA-445144)
Syndecan interactions
(R-HSA-3000170)
Tgf-beta receptor signaling activates smads
(R-HSA-2173789)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Angiogenesis
(GO:0001525)
Apolipoprotein a-i-mediated signaling pathway
(GO:0038027)
Apoptotic cell clearance
(GO:0043277)
C-x3-c chemokine binding
(GO:0019960)
Calcium ion transmembrane transport
(GO:0070588)
Cell-cell adhesion
(GO:0098609)
Cell-matrix adhesion
(GO:0007160)
Cell-substrate adhesion
(GO:0031589)
Cell adhesion
(GO:0007155)
Cell adhesion mediated by integrin
(GO:0033627)
Cell migration
(GO:0016477)
Coreceptor activity
(GO:0015026)
Cytosol
(GO:0005829)
Endodermal cell differentiation
(GO:0035987)
Entry into host cell by a symbiont-containing vacuole
(GO:0085017)
Erk1 and erk2 cascade
(GO:0070371)
Extracellular matrix binding
(GO:0050840)
Extracellular matrix protein binding
(GO:1990430)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Fibroblast growth factor binding
(GO:0017134)
Fibronectin binding
(GO:0001968)
Focal adhesion
(GO:0005925)
Heterotypic cell-cell adhesion
(GO:0034113)
Insulin-like growth factor i binding
(GO:0031994)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Metal ion binding
(GO:0046872)
Negative chemotaxis
(GO:0050919)
Negative regulation of entry of bacterium into host cell
(GO:2000536)
Negative regulation of extrinsic apoptotic signaling pathway
(GO:2001237)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of lipid transport
(GO:0032369)
Negative regulation of lipoprotein metabolic process
(GO:0050748)
Negative regulation of low-density lipoprotein receptor activity
(GO:1905598)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Neuregulin binding
(GO:0038132)
Opsonin binding
(GO:0001846)
Plasma membrane
(GO:0005886)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of intracellular signal transduction
(GO:1902533)
Positive regulation of osteoblast proliferation
(GO:0033690)
Positive regulation of small gtpase mediated signal transduction
(GO:0051057)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein kinase c binding
(GO:0005080)
Regulation of phagocytosis
(GO:0050764)
Regulation of transforming growth factor beta activation
(GO:1901388)
Substrate adhesion-dependent cell spreading
(GO:0034446)
Symbiont entry into host cell
(GO:0046718)
Transforming growth factor beta binding
(GO:0050431)
Transforming growth factor beta production
(GO:0071604)
Vasculogenesis
(GO:0001570)
Virus receptor activity
(GO:0001618)
Voltage-gated calcium channel activity
(GO:0005245)
Wound healing, spreading of epidermal cells
(GO:0035313)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.2
Marker Score: 56795
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 2.81
Marker Score: 1470
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 2.75
Marker Score: 2260
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.43
Marker Score: 54380
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.43
Marker Score: 2942
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.3
Marker Score: 671.5
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.3
Marker Score: 48994.5
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.22
Marker Score: 1323
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.2
Marker Score: 75008
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.18
Marker Score: 3168
Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.07
Marker Score: 2780
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.05
Marker Score: 8570
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.04
Marker Score: 4470.5
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2
Marker Score: 1051
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.98
Marker Score: 4752
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.97
Marker Score: 4958
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.88
Marker Score: 1793
Cell Name: podocyte (CL0000653)
Fold Change: 1.88
Marker Score: 693.5
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.87
Marker Score: 1091.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.7
Marker Score: 1798
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.68
Marker Score: 2481.5
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.67
Marker Score: 2364
Cell Name: osteoclast (CL0000092)
Fold Change: 1.67
Marker Score: 832
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.62
Marker Score: 1681
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.62
Marker Score: 1701
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.61
Marker Score: 893
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.59
Marker Score: 3052
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.58
Marker Score: 1219
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.57
Marker Score: 1735
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.57
Marker Score: 1335
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.56
Marker Score: 6455
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.55
Marker Score: 644
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.54
Marker Score: 1916
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.53
Marker Score: 522
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.52
Marker Score: 1881
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.47
Marker Score: 535
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.47
Marker Score: 2439
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.47
Marker Score: 2018
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.47
Marker Score: 13937
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.47
Marker Score: 3582
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.43
Marker Score: 818
Cell Name: endocardial cell (CL0002350)
Fold Change: 1.38
Marker Score: 782
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.38
Marker Score: 808
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.38
Marker Score: 1483
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.37
Marker Score: 389
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.37
Marker Score: 3666.5
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.36
Marker Score: 893
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.36
Marker Score: 305
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.35
Marker Score: 2085
Cell Name: astrocyte (CL0000127)
Fold Change: 1.34
Marker Score: 1158
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.33
Marker Score: 1179
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.33
Marker Score: 837.5
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.32
Marker Score: 1035.5
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.32
Marker Score: 3243
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.32
Marker Score: 4682
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.28
Marker Score: 2915
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.28
Marker Score: 44273
Cell Name: basal cell (CL0000646)
Fold Change: 1.28
Marker Score: 1649
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.27
Marker Score: 2087.5
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.27
Marker Score: 1464
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.27
Marker Score: 7538
Cell Name: keratocyte (CL0002363)
Fold Change: 1.26
Marker Score: 291
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.26
Marker Score: 472
Cell Name: osteoblast (CL0000062)
Fold Change: 1.25
Marker Score: 673
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.25
Marker Score: 47326
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.25
Marker Score: 1330
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.24
Marker Score: 309
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.23
Marker Score: 418
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.23
Marker Score: 1064
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.23
Marker Score: 309
Cell Name: stromal cell (CL0000499)
Fold Change: 1.22
Marker Score: 1424
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.2
Marker Score: 854
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.19
Marker Score: 7605
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.19
Marker Score: 4673
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.19
Marker Score: 18544.5
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.17
Marker Score: 476
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.16
Marker Score: 579
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.15
Marker Score: 990
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 1.15
Marker Score: 612
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.14
Marker Score: 461
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.14
Marker Score: 443
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.14
Marker Score: 429
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.13
Marker Score: 358
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.13
Marker Score: 4009
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.12
Marker Score: 405.5
Cell Name: lactocyte (CL0002325)
Fold Change: 1.12
Marker Score: 17925
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.11
Marker Score: 2267
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.1
Marker Score: 765
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.1
Marker Score: 4238
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.08
Marker Score: 1099
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.07
Marker Score: 2811
Cell Name: supporting cell (CL0000630)
Fold Change: 1.07
Marker Score: 2010
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.06
Marker Score: 1060
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.05
Marker Score: 612
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.05
Marker Score: 438.5
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.04
Marker Score: 11696
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.04
Marker Score: 503
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.02
Marker Score: 251
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.01
Marker Score: 907
Cell Name: neural cell (CL0002319)
Fold Change: 1.01
Marker Score: 488

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**Key characteristics:** * ITGAV is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed on the cell surface of endothelial cells, where it is involved in the formation and maintenance of blood-brain barrier. * ITGAV is also expressed on the surface of immune cells, including dendritic cells, macrophages, and lymphocytes. * It is a key regulator of cell migration, adhesion, and signaling. **Pathways and functions:** * ITGAV is involved in cell adhesion to extracellular matrix proteins, including laminin and elastic fibers. * It is also involved in cell migration, adhesion, and signaling pathways. * ITGAV is a key regulator of angiogenesis, as it is expressed in high levels on endothelial cells and is involved in the formation and maintenance of blood-brain barrier. * It is also involved in the regulation of inflammation and tissue remodeling. **Clinical significance:** * Mutations in ITGAV have been linked to several human diseases, including cerebral vascular disorder, stroke, and cancer. * ITGAV is a potential therapeutic target for these diseases, as it can inhibit the adhesion of endothelial cells to the extracellular matrix and promote the formation of blood-brain barrier. **Additional notes:** * ITGAV is a highly conserved protein, with a similar sequence found in mammals, birds, and reptiles. * It is a key player in the development and maintenance of the blood-brain barrier. * It is also involved in the regulation of inflammation and tissue remodeling.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Integrin alpha-V

Genular Protein ID: 2415039762

Symbol: ITAV_HUMAN

Name: Integrin alpha-V

UniProtKB Accession Codes:

P06756 A0AV67 B0LPF4 B7Z883 B7ZLX0 D3DPG8 E7EWZ6 Q53SK4 Q59EB7 Q6LD15

Database IDs:

Citations:

PubMed ID: 2443500

Title: Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs.

PubMed ID: 2443500

DOI: 10.1016/s0021-9258(18)47907-0

PubMed ID: 10965141

Title: Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51.

PubMed ID: 10965141

DOI: 10.1159/000015631

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7522056

Title: The integrin alpha v gene: identification and characterization of the promoter region.

PubMed ID: 7522056

DOI: 10.1016/0167-4781(94)90278-x

PubMed ID: 2430295

Title: cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors.

PubMed ID: 2430295

DOI: 10.1073/pnas.83.22.8614

PubMed ID: 2467745

Title: A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells.

PubMed ID: 2467745

DOI: 10.1016/0092-8674(89)90172-4

PubMed ID: 7519807

Title: Entry of coxsackievirus A9 into host cells: specific interactions with alpha v beta 3 integrin, the vitronectin receptor.

PubMed ID: 7519807

DOI: 10.1006/viro.1994.1494

PubMed ID: 9426447

Title: Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells.

PubMed ID: 9426447

DOI: 10.1006/viro.1997.8831

PubMed ID: 10397733

Title: The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.

PubMed ID: 10397733

PubMed ID: 11160695

Title: Entry of human parechovirus 1.

PubMed ID: 11160695

DOI: 10.1128/jvi.75.4.1958-1967.2001

PubMed ID: 12695522

Title: CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family.

PubMed ID: 12695522

DOI: 10.1074/jbc.m302028200

PubMed ID: 12807887

Title: Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins.

PubMed ID: 12807887

DOI: 10.1074/jbc.m303159200

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 14596610

Title: Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains.

PubMed ID: 14596610

DOI: 10.1021/bi034726u

PubMed ID: 15184403

Title: Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.

PubMed ID: 15184403

DOI: 10.1083/jcb.200312172

PubMed ID: 15194773

Title: Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9.

PubMed ID: 15194773

DOI: 10.1128/jvi.78.13.6967-6973.2004

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16982628

Title: Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans.

PubMed ID: 16982628

DOI: 10.1074/jbc.m605291200

PubMed ID: 17925226

Title: Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.

PubMed ID: 17925226

DOI: 10.1016/j.devcel.2007.08.012

PubMed ID: 17158881

Title: alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity.

PubMed ID: 17158881

DOI: 10.1074/jbc.m607008200

PubMed ID: 18441324

Title: Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.

PubMed ID: 18441324

DOI: 10.1074/jbc.m801213200

PubMed ID: 18635536

Title: Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.

PubMed ID: 18635536

DOI: 10.1074/jbc.m804835200

PubMed ID: 18045938

Title: Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor.

PubMed ID: 18045938

DOI: 10.1128/jvi.01673-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19141530

Title: Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta.

PubMed ID: 19141530

DOI: 10.1096/fj.08-117564

PubMed ID: 19578119

Title: The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.

PubMed ID: 19578119

DOI: 10.1074/jbc.m109.013201

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 20682778

Title: Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.

PubMed ID: 20682778

DOI: 10.1074/jbc.m110.113878

PubMed ID: 20615244

Title: Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells.

PubMed ID: 20615244

DOI: 10.1186/1743-422x-7-148

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23125415

Title: Integrins alphavbeta3 and alpha4beta1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.

PubMed ID: 23125415

DOI: 10.4049/jimmunol.1200889

PubMed ID: 24011356

Title: Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity.

PubMed ID: 24011356

DOI: 10.1021/bi400678y

PubMed ID: 24367260

Title: alphavbeta6- and alphavbeta8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion.

PubMed ID: 24367260

DOI: 10.1371/journal.ppat.1003806

PubMed ID: 23658209

Title: Integrins modulate the infection efficiency of West Nile virus into cells.

PubMed ID: 23658209

DOI: 10.1099/vir.0.052613-0

PubMed ID: 22278742

Title: GARP regulates the bioavailability and activation of TGFbeta.

PubMed ID: 22278742

DOI: 10.1091/mbc.e11-12-1018

PubMed ID: 24942591

Title: Herpes simplex virus type 2 glycoprotein H interacts with integrin alphavbeta3 to facilitate viral entry and calcium signaling in human genital tract epithelial cells.

PubMed ID: 24942591

DOI: 10.1128/jvi.00725-14

PubMed ID: 25398877

Title: Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins alphavbeta3, alpha4beta1, and alpha5beta1.

PubMed ID: 25398877

DOI: 10.1074/jbc.m114.579946

PubMed ID: 27993971

Title: The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin alphavbeta3.

PubMed ID: 27993971

DOI: 10.1042/bcj20160998

PubMed ID: 28302677

Title: The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis.

PubMed ID: 28302677

DOI: 10.1042/bsr20170173

PubMed ID: 29030430

Title: Direct binding to integrins and loss of disulfide linkage in interleukin-1beta (IL-1beta) are involved in the agonistic action of IL-1beta.

PubMed ID: 29030430

DOI: 10.1074/jbc.m117.818302

PubMed ID: 28873464

Title: Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.

PubMed ID: 28873464

DOI: 10.1371/journal.pone.0184285

PubMed ID: 31331973

Title: Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.

PubMed ID: 31331973

DOI: 10.4049/jimmunol.1801630

PubMed ID: 11546839

Title: Crystal structure of the extracellular segment of integrin alpha Vbeta3.

PubMed ID: 11546839

DOI: 10.1126/science.1064535

PubMed ID: 19704023

Title: Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.

PubMed ID: 19704023

DOI: 10.1083/jcb.200905085

PubMed ID: 28117447

Title: Force interacts with macromolecular structure in activation of TGF-beta.

PubMed ID: 28117447

DOI: 10.1038/nature21035

Sequence Information:

Length: 1048
Mass: 116038
Checksum: 364EE25C5303A2D7
Sequence:

MAFPPRRRLR LGPRGLPLLL SGLLLPLCRA FNLDVDSPAE YSGPEGSYFG FAVDFFVPSA 
SSRMFLLVGA PKANTTQPGI VEGGQVLKCD WSSTRRCQPI EFDATGNRDY AKDDPLEFKS 
HQWFGASVRS KQDKILACAP LYHWRTEMKQ EREPVGTCFL QDGTKTVEYA PCRSQDIDAD 
GQGFCQGGFS IDFTKADRVL LGGPGSFYWQ GQLISDQVAE IVSKYDPNVY SIKYNNQLAT 
RTAQAIFDDS YLGYSVAVGD FNGDGIDDFV SGVPRAARTL GMVYIYDGKN MSSLYNFTGE 
QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ RASGDFQTTK 
LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK GIVYIFNGRS TGLNAVPSQI 
LEGQWAARSM PPSFGYSMKG ATDIDKNGYP DLIVGAFGVD RAILYRARPV ITVNAGLEVY 
PSILNQDNKT CSLPGTALKV SCFNVRFCLK ADGKGVLPRK LNFQVELLLD KLKQKGAIRR 
ALFLYSRSPS HSKNMTISRG GLMQCEELIA YLRDESEFRD KLTPITIFME YRLDYRTAAD 
TTGLQPILNQ FTPANISRQA HILLDCGEDN VCKPKLEVSV DSDQKKIYIG DDNPLTLIVK 
AQNQGEGAYE AELIVSIPLQ ADFIGVVRNN EALARLSCAF KTENQTRQVV CDLGNPMKAG 
TQLLAGLRFS VHQQSEMDTS VKFDLQIQSS NLFDKVSPVV SHKVDLAVLA AVEIRGVSSP 
DHVFLPIPNW EHKENPETEE DVGPVVQHIY ELRNNGPSSF SKAMLHLQWP YKYNNNTLLY 
ILHYDIDGPM NCTSDMEINP LRIKISSLQT TEKNDTVAGQ GERDHLITKR DLALSEGDIH 
TLGCGVAQCL KIVCQVGRLD RGKSAILYVK SLLWTETFMN KENQNHSYSL KSSASFNVIE 
FPYKNLPIED ITNSTLVTTN VTWGIQPAPM PVPVWVIILA VLAGLLLLAV LVFVMYRMGF 
FKRVRPPQEE QEREQLQPHE NGEGNSET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ITGAV

Associated with

Cells (max top 100)

Other Information

Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs. PubMed ID: 2443500

Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51. PubMed ID: 10965141

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The integrin alpha v gene: identification and characterization of the promoter region. PubMed ID: 7522056

cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors. PubMed ID: 2430295

A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells. PubMed ID: 2467745

Entry of coxsackievirus A9 into host cells: specific interactions with alpha v beta 3 integrin, the vitronectin receptor. PubMed ID: 7519807

Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells. PubMed ID: 9426447

The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor. PubMed ID: 10397733

Entry of human parechovirus 1. PubMed ID: 11160695

CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. PubMed ID: 12695522

Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins. PubMed ID: 12807887

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains. PubMed ID: 14596610

Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. PubMed ID: 15184403

Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9. PubMed ID: 15194773

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans. PubMed ID: 16982628

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. PubMed ID: 17925226

alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity. PubMed ID: 17158881

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. PubMed ID: 18441324

Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner. PubMed ID: 18635536

Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor. PubMed ID: 18045938

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta. PubMed ID: 19141530

The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling. PubMed ID: 19578119

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling. PubMed ID: 20682778

Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells. PubMed ID: 20615244

Initial characterization of the human central proteome. PubMed ID: 21269460

Integrins alphavbeta3 and alpha4beta1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1. PubMed ID: 23125415

Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity. PubMed ID: 24011356

alphavbeta6- and alphavbeta8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion. PubMed ID: 24367260

Integrins modulate the infection efficiency of West Nile virus into cells. PubMed ID: 23658209

GARP regulates the bioavailability and activation of TGFbeta. PubMed ID: 22278742

Herpes simplex virus type 2 glycoprotein H interacts with integrin alphavbeta3 to facilitate viral entry and calcium signaling in human genital tract epithelial cells. PubMed ID: 24942591

Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins alphavbeta3, alpha4beta1, and alpha5beta1. PubMed ID: 25398877

The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin alphavbeta3. PubMed ID: 27993971

The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis. PubMed ID: 28302677

Direct binding to integrins and loss of disulfide linkage in interleukin-1beta (IL-1beta) are involved in the agonistic action of IL-1beta. PubMed ID: 29030430

Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling. PubMed ID: 28873464

Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling. PubMed ID: 31331973

Crystal structure of the extracellular segment of integrin alpha Vbeta3. PubMed ID: 11546839

Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment. PubMed ID: 19704023

Force interacts with macromolecular structure in activation of TGF-beta. PubMed ID: 28117447