Details for: TRNI

Gene ID: 4565

Symbol: TRNI

Ensembl ID: ENSG00000210100

Description: tRNA-Ile

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.6069
    Cell Significance Index: 118.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1349
    Cell Significance Index: 61.5100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.9306
    Cell Significance Index: 48.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.6269
    Cell Significance Index: 47.9200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.3148
    Cell Significance Index: 12.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3087
    Cell Significance Index: 19.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1077
    Cell Significance Index: 30.1500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.8544
    Cell Significance Index: 9.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6485
    Cell Significance Index: 33.6900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.4454
    Cell Significance Index: 4.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4414
    Cell Significance Index: 20.5800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3905
    Cell Significance Index: 6.2000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.2107
    Cell Significance Index: 2.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1533
    Cell Significance Index: 17.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0889
    Cell Significance Index: 15.1800
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.0778
    Cell Significance Index: 0.6800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0580
    Cell Significance Index: 1.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0570
    Cell Significance Index: 0.6800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0342
    Cell Significance Index: 0.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0315
    Cell Significance Index: 0.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0217
    Cell Significance Index: 0.4700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0087
    Cell Significance Index: 0.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0018
    Cell Significance Index: -0.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0030
    Cell Significance Index: -0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0038
    Cell Significance Index: -2.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0091
    Cell Significance Index: -0.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0122
    Cell Significance Index: -7.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0169
    Cell Significance Index: -3.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0193
    Cell Significance Index: -0.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0377
    Cell Significance Index: -7.5600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0534
    Cell Significance Index: -0.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0546
    Cell Significance Index: -7.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0825
    Cell Significance Index: -5.0600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0854
    Cell Significance Index: -0.7900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0875
    Cell Significance Index: -1.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1436
    Cell Significance Index: -5.0300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1454
    Cell Significance Index: -1.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1512
    Cell Significance Index: -3.2200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1707
    Cell Significance Index: -2.4300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1747
    Cell Significance Index: -2.4200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1838
    Cell Significance Index: -1.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1905
    Cell Significance Index: -6.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2049
    Cell Significance Index: -5.2200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2080
    Cell Significance Index: -2.8900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2178
    Cell Significance Index: -2.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2468
    Cell Significance Index: -8.0800
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.2498
    Cell Significance Index: -2.3900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2551
    Cell Significance Index: -2.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2703
    Cell Significance Index: -8.6100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2717
    Cell Significance Index: -2.9600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2878
    Cell Significance Index: -5.7400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.2962
    Cell Significance Index: -3.7300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2990
    Cell Significance Index: -3.1000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3002
    Cell Significance Index: -3.0100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3150
    Cell Significance Index: -5.3900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3200
    Cell Significance Index: -3.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3343
    Cell Significance Index: -8.3400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.3374
    Cell Significance Index: -2.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3779
    Cell Significance Index: -8.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3820
    Cell Significance Index: -5.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3821
    Cell Significance Index: -8.1100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3881
    Cell Significance Index: -4.7700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3905
    Cell Significance Index: -3.9900
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.3949
    Cell Significance Index: -4.2900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4019
    Cell Significance Index: -4.2400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4102
    Cell Significance Index: -4.7200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4157
    Cell Significance Index: -5.3400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4167
    Cell Significance Index: -8.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4179
    Cell Significance Index: -8.3900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4181
    Cell Significance Index: -8.2300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4199
    Cell Significance Index: -7.2600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4266
    Cell Significance Index: -8.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4282
    Cell Significance Index: -5.0600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.4286
    Cell Significance Index: -4.6100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.4312
    Cell Significance Index: -5.3100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4381
    Cell Significance Index: -5.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4415
    Cell Significance Index: -4.8100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.4460
    Cell Significance Index: -5.4300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4474
    Cell Significance Index: -5.3500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4522
    Cell Significance Index: -7.6800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.4553
    Cell Significance Index: -5.2900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4643
    Cell Significance Index: -4.7400
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.4718
    Cell Significance Index: -3.9000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.4720
    Cell Significance Index: -7.0600
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.4725
    Cell Significance Index: -3.5600
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.4756
    Cell Significance Index: -4.7100
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.4878
    Cell Significance Index: -5.1000
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.4919
    Cell Significance Index: -5.3400
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.4944
    Cell Significance Index: -5.0500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.4966
    Cell Significance Index: -5.9900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4971
    Cell Significance Index: -7.1500
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.5104
    Cell Significance Index: -5.3500
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.5135
    Cell Significance Index: -5.7500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.5137
    Cell Significance Index: -6.7600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.5177
    Cell Significance Index: -6.7700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5179
    Cell Significance Index: -6.4700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.5187
    Cell Significance Index: -3.7700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.5261
    Cell Significance Index: -6.8900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.5292
    Cell Significance Index: -5.6200
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.5295
    Cell Significance Index: -5.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **tRNA structure and function**: The TRNI gene encodes for a tRNA molecule that recognizes the codon CUA on messenger RNA (mRNA), facilitating the incorporation of isoleucine into proteins. 2. **Cellular expression**: TRNI is significantly expressed in T cells, plasma cells, goblet cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, mast cells, and intestinal epithelial cells, underscoring its broad impact on immune regulation and tissue maintenance. 3. **Evolutionary conservation**: The TRNI gene is highly conserved across species, suggesting its essential role in fundamental biological processes. 4. **Regulatory mechanisms**: The expression of TRNI is tightly regulated by various transcriptional factors and post-transcriptional mechanisms, ensuring precise control over its function. **Pathways and Functions:** 1. **Protein synthesis**: tRNA-Ile is a crucial component of the translation machinery, ensuring the accurate incorporation of isoleucine into proteins. 2. **Immune regulation**: TRNI plays a significant role in regulating immune responses, particularly in the context of T cell and plasma cell development and function. 3. **Cellular homeostasis**: TRNI is involved in maintaining cellular homeostasis by regulating the expression of genes involved in cell growth, differentiation, and survival. 4. **Epithelial maintenance**: The expression of TRNI in intestinal epithelial cells highlights its role in maintaining the integrity of the epithelial barrier. **Clinical Significance:** 1. **Immunodeficiency disorders**: Altered expression or mutations in the TRNI gene have been implicated in various immunodeficiency disorders, including autoimmune diseases and cancer. 2. **Cancer**: The dysregulation of TRNI expression has been linked to cancer development and progression, particularly in the context of intestinal and hematological malignancies. 3. **Inflammatory bowel disease**: The TRNI gene has been shown to play a role in regulating inflammatory responses in the gut, making it a potential therapeutic target for inflammatory bowel disease. 4. **Gene therapy**: The understanding of TRNI's role in immune regulation and cellular homeostasis has implications for the development of gene therapies aimed at treating immunodeficiency disorders and cancer. In conclusion, the TRNI gene plays a critical role in maintaining cellular homeostasis and regulating immune responses. Further research into the mechanisms of TRNI expression and function will provide valuable insights into its clinical significance and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.