Details for: NPPB

Gene ID: 4879

Symbol: NPPB

Ensembl ID: ENSG00000120937

Description: natriuretic peptide B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 23.71
    Marker Score: 38005
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 18.73
    Marker Score: 20921
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.73
    Marker Score: 2747
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.6
    Marker Score: 9242
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.54
    Marker Score: 1281
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.17
    Marker Score: 1269
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.72
    Marker Score: 10313
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10808
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.58
    Marker Score: 875
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.51
    Marker Score: 858
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170092
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.24
    Marker Score: 7541
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19366
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.24
    Marker Score: 2343
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3647
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32724
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.04
    Marker Score: 708
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5314
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.89
    Marker Score: 955
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 737
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1250
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.74
    Marker Score: 243
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.71
    Marker Score: 337
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.7
    Marker Score: 868
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.68
    Marker Score: 283
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.66
    Marker Score: 906
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.48
    Marker Score: 432
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.47
    Marker Score: 955
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.41
    Marker Score: 9068
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.39
    Marker Score: 5224
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.38
    Marker Score: 166.5
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.38
    Marker Score: 157
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.36
    Marker Score: 249
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.35
    Marker Score: 168
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.34
    Marker Score: 123
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 142
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.27
    Marker Score: 162.5
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.25
    Marker Score: 511
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.22
    Marker Score: 108
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.22
    Marker Score: 227
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.2
    Marker Score: 109
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.17
    Marker Score: 143
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.17
    Marker Score: 96
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.16
    Marker Score: 147.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.16
    Marker Score: 155
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.16
    Marker Score: 318
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.14
    Marker Score: 58
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.14
    Marker Score: 137
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.13
    Marker Score: 93
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.13
    Marker Score: 67
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.11
    Marker Score: 178
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1
    Marker Score: 119
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.09
    Marker Score: 83
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.09
    Marker Score: 48
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.09
    Marker Score: 77
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.08
    Marker Score: 34
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.08
    Marker Score: 99
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.07
    Marker Score: 83
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.06
    Marker Score: 119
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 56.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.06
    Marker Score: 225
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.05
    Marker Score: 105
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.05
    Marker Score: 115.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.05
    Marker Score: 84.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.04
    Marker Score: 180
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.04
    Marker Score: 79
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 19

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Other Information

**Key characteristics:** * NPPB is a protein of the natriuretic peptide family, which are a group of proteins involved in regulating water and electrolyte balance in the body. * It is a secreted protein that is primarily produced in the kidney and then released into the bloodstream. * NPPB has a molecular weight of approximately 120 kDa. * It is a transmembrane protein that is expressed on the surface of blood vessels and cardiac cells. **Pathways and functions:** * NPPB is involved in several important physiological processes, including: * Blood pressure regulation: NPPB acts as a potent vasodilator, meaning it causes blood vessels to dilate. This helps to lower blood pressure and reduce systemic arterial blood pressure. * Cardiac conduction system development: NPPB is crucial for the development and function of the cardiac conduction system, which allows blood to flow from the heart to the rest of the body. * Cell surface receptor signaling pathway: NPPB is a ligand for several cell surface receptors, including ANP-1 and ANP-2. These receptors are expressed on a variety of cell types, including blood vessel endothelial cells, cardiac cells, and immune cells. When NPPB binds to these receptors, it activates these receptors and triggers intracellular signaling pathways that ultimately lead to changes in blood pressure. * Diuretic hormone activity: NPPB is a potent diuretic hormone, meaning it promotes the removal of excess water and sodium from the body. This helps to regulate blood volume and electrolyte balance. * Hormone activity: NPPB can also exert endocrine effects, including vasodilation and vasoconstriction. These effects are mediated by the interaction of NPPB with G protein-coupled receptors on blood vessels. **Clinical significance:** Mutations in the NPPB gene have been linked to several human diseases, including hypertension, heart failure, and stroke. These diseases are characterized by abnormal blood pressure and cardiovascular dysfunction. Therefore, understanding the role of NPPB in blood pressure regulation is of great importance for the development of new therapeutic strategies for these conditions.

Genular Protein ID: 3958346944

Symbol: ANFB_HUMAN

Name: Natriuretic peptides B

UniProtKB Accession Codes:

P16860 B0ZBE9 Q6FGY0 Q9P2Q7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 25 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2597152

Title: Human and canine gene homologs of porcine brain natriuretic peptide.

PubMed ID: 2597152

DOI: 10.1016/s0006-291x(89)80015-4

PubMed ID: 2522777

Title: Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide.

PubMed ID: 2522777

DOI: 10.1016/0006-291x(89)92269-9

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2138890

Title: Isolation and identification of human brain natriuretic peptides in cardiac atrium.

PubMed ID: 2138890

DOI: 10.1016/0006-291x(90)92081-a

PubMed ID: 2136732

Title: Isolation and sequence determination of human brain natriuretic peptide in human atrium.

PubMed ID: 2136732

DOI: 10.1016/0014-5793(90)80043-i

PubMed ID: 1914098

Title: Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure.

PubMed ID: 1914098

DOI: 10.1161/01.cir.84.4.1581

PubMed ID: 1672777

Title: Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP).

PubMed ID: 1672777

DOI: 10.1126/science.1672777

PubMed ID: 9458824

Title: Effect of BNP on renal hemodynamics, tubular function and vasoactive hormones in humans.

PubMed ID: 9458824

DOI: 10.1152/ajprenal.1998.274.1.f63

PubMed ID: 9794555

Title: The renal natriuretic peptide urodilatin is present in human kidney.

PubMed ID: 9794555

DOI: 10.1093/ndt/13.10.2529

PubMed ID: 10880574

Title: Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme.

PubMed ID: 10880574

DOI: 10.1073/pnas.150149097

PubMed ID: 16750161

Title: The precursor to B-type natriuretic peptide is an O-linked glycoprotein.

PubMed ID: 16750161

DOI: 10.1016/j.abb.2006.03.028

PubMed ID: 16254193

Title: Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form.

PubMed ID: 16254193

DOI: 10.1373/clinchem.2005.057638

PubMed ID: 17372040

Title: Immunoreactivity and guanosine 3',5'-cyclic monophosphate activating actions of various molecular forms of human B-type natriuretic peptide.

PubMed ID: 17372040

DOI: 10.1161/hypertensionaha.106.081083

PubMed ID: 17349887

Title: Evidence for functional heterogeneity of circulating B-type natriuretic peptide.

PubMed ID: 17349887

DOI: 10.1016/j.jacc.2006.10.063

PubMed ID: 17367664

Title: Alternate circulating pro-B-type natriuretic peptide and B-type natriuretic peptide forms in the general population.

PubMed ID: 17367664

DOI: 10.1016/j.jacc.2006.12.024

PubMed ID: 19808300

Title: Detection of endogenous B-type natriuretic peptide at very low concentrations in patients with heart failure.

PubMed ID: 19808300

DOI: 10.1161/circheartfailure.108.790774

PubMed ID: 18466803

Title: Pro-B-type natriuretic peptide levels in acute decompensated heart failure.

PubMed ID: 18466803

DOI: 10.1016/j.jacc.2007.12.051

PubMed ID: 20489134

Title: Processing of pro-B-type natriuretic peptide: furin and corin as candidate convertases.

PubMed ID: 20489134

DOI: 10.1373/clinchem.2010.143883

PubMed ID: 21763278

Title: Glycosylation and processing of pro-B-type natriuretic peptide in cardiomyocytes.

PubMed ID: 21763278

DOI: 10.1016/j.bbrc.2011.06.192

PubMed ID: 21482747

Title: Secretion of glycosylated pro-B-type natriuretic peptide from normal cardiomyocytes.

PubMed ID: 21482747

DOI: 10.1373/clinchem.2010.157438

PubMed ID: 21314817

Title: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha.

PubMed ID: 21314817

DOI: 10.1111/j.1742-4658.2011.08051.x

PubMed ID: 25339504

Title: Pro-B-type natriuretic peptide-1-108 processing and degradation in human heart failure.

PubMed ID: 25339504

DOI: 10.1161/circheartfailure.114.001174

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 16870210

Title: Structural determinants of natriuretic peptide receptor specificity and degeneracy.

PubMed ID: 16870210

DOI: 10.1016/j.jmb.2006.06.060

PubMed ID: 21098034

Title: Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response.

PubMed ID: 21098034

DOI: 10.1074/jbc.m110.173252

Sequence Information:

  • Length: 134
  • Mass: 14726
  • Checksum: DC884D9408462146
  • Sequence:
    • MDPQTAPSRA LLLLLFLHLA FLGGRSHPLG SPGSASDLET SGLQEQRNHL QGKLSELQVE 
QTSLEPLQES PRPTGVWKSR EVATEGIRGH RKMVLYTLRA PRSPKMVQGS GCFGRKMDRI 
SSSSGLGCKV LRRH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.