Details for: P2RY4

Gene ID: 5030

Symbol: P2RY4

Ensembl ID: ENSG00000186912

Description: pyrimidinergic receptor P2Y4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.4106
    Cell Significance Index: 3.9000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0803
    Cell Significance Index: 0.8700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0607
    Cell Significance Index: 0.7400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0504
    Cell Significance Index: 0.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0489
    Cell Significance Index: 1.7200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0398
    Cell Significance Index: 0.5700
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.0354
    Cell Significance Index: 0.3900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.0343
    Cell Significance Index: 0.3100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0243
    Cell Significance Index: 0.4200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0206
    Cell Significance Index: 0.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.0163
    Cell Significance Index: 0.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0149
    Cell Significance Index: 0.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0081
    Cell Significance Index: 0.2200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0077
    Cell Significance Index: 0.1300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0073
    Cell Significance Index: 0.1000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.0047
    Cell Significance Index: 0.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0042
    Cell Significance Index: 0.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0017
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0002
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0003
    Cell Significance Index: -0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0003
    Cell Significance Index: -0.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0011
    Cell Significance Index: -0.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0015
    Cell Significance Index: -0.2100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0024
    Cell Significance Index: -0.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0026
    Cell Significance Index: -0.1300
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0035
    Cell Significance Index: -0.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0036
    Cell Significance Index: -0.0900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0044
    Cell Significance Index: -0.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0044
    Cell Significance Index: -0.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0052
    Cell Significance Index: -0.1700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0056
    Cell Significance Index: -0.0900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0058
    Cell Significance Index: -0.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0061
    Cell Significance Index: -0.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0066
    Cell Significance Index: -0.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0069
    Cell Significance Index: -0.2600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0071
    Cell Significance Index: -0.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0079
    Cell Significance Index: -0.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0080
    Cell Significance Index: -0.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0082
    Cell Significance Index: -0.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0086
    Cell Significance Index: -0.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0088
    Cell Significance Index: -0.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0093
    Cell Significance Index: -0.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0095
    Cell Significance Index: -0.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0095
    Cell Significance Index: -0.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0096
    Cell Significance Index: -0.1900
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0102
    Cell Significance Index: -0.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0106
    Cell Significance Index: -0.1100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0106
    Cell Significance Index: -0.1400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0109
    Cell Significance Index: -0.1400
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0111
    Cell Significance Index: -0.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0113
    Cell Significance Index: -0.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0117
    Cell Significance Index: -0.5500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0119
    Cell Significance Index: -0.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0128
    Cell Significance Index: -0.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0128
    Cell Significance Index: -0.2200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0128
    Cell Significance Index: -0.1600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0128
    Cell Significance Index: -0.1700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0129
    Cell Significance Index: -0.1400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0135
    Cell Significance Index: -0.1800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0142
    Cell Significance Index: -0.2000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0147
    Cell Significance Index: -0.1900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0150
    Cell Significance Index: -0.2100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0156
    Cell Significance Index: -0.1800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0160
    Cell Significance Index: -0.1900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0160
    Cell Significance Index: -0.1900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0162
    Cell Significance Index: -0.1900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0168
    Cell Significance Index: -0.5300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0169
    Cell Significance Index: -0.2200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0171
    Cell Significance Index: -0.1700
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0173
    Cell Significance Index: -0.1900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0174
    Cell Significance Index: -0.2200
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0180
    Cell Significance Index: -0.1900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0181
    Cell Significance Index: -0.2100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0181
    Cell Significance Index: -0.2000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0182
    Cell Significance Index: -0.2200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0186
    Cell Significance Index: -0.2200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0188
    Cell Significance Index: -0.2100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0189
    Cell Significance Index: -0.1900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0189
    Cell Significance Index: -0.2200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0190
    Cell Significance Index: -0.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0190
    Cell Significance Index: -0.2800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0191
    Cell Significance Index: -0.2200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0192
    Cell Significance Index: -0.1800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0195
    Cell Significance Index: -0.2400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0195
    Cell Significance Index: -0.2500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0196
    Cell Significance Index: -0.2000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0198
    Cell Significance Index: -0.1900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0198
    Cell Significance Index: -0.2300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0198
    Cell Significance Index: -0.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Structure:** The P2RY4 receptor belongs to the family of G protein-coupled receptors (GPCRs) and consists of seven transmembrane domains. Its structure allows it to bind to extracellular ATP and UTP, triggering a conformational change that activates the receptor. 2. **ligand Binding:** P2RY4 is activated by both ATP and UTP, but its affinity for these ligands is higher for UTP. The binding of these nucleotides to the receptor triggers a signaling cascade that modulates various cellular processes. 3. **Signaling Pathways:** The P2RY4 receptor is coupled to G proteins, specifically Gαi, which activates phospholipase C and leads to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). These second messengers regulate various cellular processes, including calcium signaling, protein kinase C activation, and gene expression. **Pathways and Functions:** 1. **Immune Regulation:** P2RY4 is expressed on various immune cells, including T cells, macrophages, and dendritic cells. Its activation by UTP regulates the production of cytokines, chemokines, and other immune mediators, influencing immune responses and inflammation. 2. **Synaptic Transmission:** P2RY4 is expressed on glutamatergic neurons and plays a crucial role in regulating synaptic transmission. Its activation by UTP modulates the release of glutamate, a key excitatory neurotransmitter, and influences synaptic plasticity and learning. 3. **Cellular Signaling:** P2RY4 is involved in various cellular signaling pathways, including the regulation of cytosolic calcium ion concentration, presynaptic active zone membrane signaling, and phospholipase C-activating G protein-coupled receptor signaling pathway. 4. **Tissue-specific Functions:** P2RY4 is expressed in various tissues, including the intestinal epithelium, cerebral cortex, and blood vessels. Its activation by UTP regulates transepithelial chloride transport, blood vessel contraction, and cerebral blood flow. **Clinical Significance:** Dysregulation of P2RY4 signaling has been implicated in various diseases, including: 1. **Inflammatory Disorders:** Abnormal P2RY4 expression and signaling have been linked to inflammatory diseases, such as rheumatoid arthritis, asthma, and inflammatory bowel disease. 2. **Neurological Disorders:** P2RY4 dysfunction has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke. 3. **Cancer:** P2RY4 expression has been linked to cancer progression, metastasis, and resistance to chemotherapy. In conclusion, the P2RY4 gene plays a critical role in regulating various cellular processes, including immune responses, synaptic transmission, and cellular signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of this receptor in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms of P2RY4 signaling and its therapeutic potential.

Genular Protein ID: 1360748910

Symbol: P2RY4_HUMAN

Name: P2Y purinoceptor 4

UniProtKB Accession Codes:

P51582 Q4VBB7 Q4VBB8 Q502W2 Q5JT22

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8537336

Title: Cloning and functional expression of a human uridine nucleotide receptor.

PubMed ID: 8537336

DOI: 10.1074/jbc.270.52.30849

PubMed ID: 8537335

Title: Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene.

PubMed ID: 8537335

DOI: 10.1074/jbc.270.52.30845

PubMed ID: 8617367

Title: Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor.

PubMed ID: 8617367

DOI: 10.1016/0014-5793(96)00321-3

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11114308

Title: Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. Ser-333 and Ser-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor.

PubMed ID: 11114308

DOI: 10.1074/jbc.m009909200

Sequence Information:

  • Length: 365
  • Mass: 40963
  • Checksum: 23E0AFED3B7BDEED
  • Sequence:
    • MASTESSLLR SLGLSPGPGS SEVELDCWFD EDFKFILLPV SYAVVFVLGL GLNAPTLWLF 
IFRLRPWDAT ATYMFHLALS DTLYVLSLPT LIYYYAAHNH WPFGTEICKF VRFLFYWNLY 
CSVLFLTCIS VHRYLGICHP LRALRWGRPR LAGLLCLAVW LVVAGCLVPN LFFVTTSNKG 
TTVLCHDTTR PEEFDHYVHF SSAVMGLLFG VPCLVTLVCY GLMARRLYQP LPGSAQSSSR 
LRSLRTIAVV LTVFAVCFVP FHITRTIYYL ARLLEADCRV LNIVNVVYKV TRPLASANSC 
LDPVLYLLTG DKYRRQLRQL CGGGKPQPRT AASSLALVSL PEDSSCRWAA TPQDSSCSTP 
RADRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.