Gene PAX4 - ENSG00000106331 | NCBI Gene ID: 5078

Details for: PAX4

Gene ID: 5078

Symbol: PAX4

Ensembl ID: ENSG00000106331

Description: paired box 4

Associated with

Developmental biology
(R-HSA-1266738)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of gene expression in endocrine-committed (neurog3+) progenitor cells
(R-HSA-210746)
Anatomical structure development
(GO:0048856)
Animal organ morphogenesis
(GO:0009887)
Cell differentiation
(GO:0030154)
Chromatin
(GO:0000785)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Nucleoplasm
(GO:0005654)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 9.35
Marker Score: 3633
Cell Name: erythrocyte (CL0000232)
Fold Change: 6.71
Marker Score: 3715.5
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 6.69
Marker Score: 8271
Cell Name: microglial cell (CL0000129)
Fold Change: 3.75
Marker Score: 6837
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 3.15
Marker Score: 3171.5
Cell Name: megakaryocyte (CL0000556)
Fold Change: 2.33
Marker Score: 1324
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.01
Marker Score: 2000
Cell Name: plasma cell (CL0000786)
Fold Change: 1.99
Marker Score: 2220.5
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1177
Cell Name: T cell (CL0000084)
Fold Change: 1.39
Marker Score: 2394
Cell Name: B cell (CL0000236)
Fold Change: 1.25
Marker Score: 1195
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4813
Cell Name: goblet cell (CL0000160)
Fold Change: 1.14
Marker Score: 7574
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.07
Marker Score: 493
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.04
Marker Score: 548
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1
Marker Score: 516
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71818.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48045.5
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.99
Marker Score: 469
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.99
Marker Score: 1362
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.98
Marker Score: 410
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.95
Marker Score: 380
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5342
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.94
Marker Score: 388
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.93
Marker Score: 333
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: mast cell (CL0000097)
Fold Change: 0.85
Marker Score: 495
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 713
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.78
Marker Score: 403
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.75
Marker Score: 1188
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.74
Marker Score: 1191
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.71
Marker Score: 457
Cell Name: fibroblast (CL0000057)
Fold Change: 0.71
Marker Score: 687
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.71
Marker Score: 154
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7
Marker Score: 476
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.67
Marker Score: 530.5
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.57
Marker Score: 179
Cell Name: pericyte (CL0000669)
Fold Change: 0.55
Marker Score: 319
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.48
Marker Score: 284
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.42
Marker Score: 379
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.42
Marker Score: 275
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.41
Marker Score: 213
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.4
Marker Score: 752
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.32
Marker Score: 649
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.28
Marker Score: 76
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.28
Marker Score: 1074
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.25
Marker Score: 3904
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.24
Marker Score: 106
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.24
Marker Score: 68
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 76
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.21
Marker Score: 124.5
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.2
Marker Score: 102
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.2
Marker Score: 1183
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.18
Marker Score: 45
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.18
Marker Score: 366.5
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.17
Marker Score: 159
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.16
Marker Score: 673
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.14
Marker Score: 145
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.13
Marker Score: 63
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.12
Marker Score: 31
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.11
Marker Score: 29
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.11
Marker Score: 108
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.1
Marker Score: 27
Cell Name: stromal cell (CL0000499)
Fold Change: 0.1
Marker Score: 121.5
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.1
Marker Score: 32
Cell Name: type D enteroendocrine cell (CL0000502)
Fold Change: 0.1
Marker Score: 30
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 0.1
Marker Score: 27.5
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.1
Marker Score: 29
Cell Name: glial cell (CL0000125)
Fold Change: 0.1
Marker Score: 105
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.09
Marker Score: 23
Cell Name: GIP cell (CL0002278)
Fold Change: 0.09
Marker Score: 29.5
Cell Name: Unknown (CL0000003)
Fold Change: 0.09
Marker Score: 279
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.09
Marker Score: 39
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.09
Marker Score: 27.5
Cell Name: secretory cell (CL0000151)
Fold Change: 0.08
Marker Score: 148
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.08
Marker Score: 29
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.08
Marker Score: 52
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.08
Marker Score: 36
Cell Name: podocyte (CL0000653)
Fold Change: 0.08
Marker Score: 28.5
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.07
Marker Score: 23
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.07
Marker Score: 16.5
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.07
Marker Score: 52
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.07
Marker Score: 31.5
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.07
Marker Score: 108
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.06
Marker Score: 32
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.06
Marker Score: 31.5
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.05
Marker Score: 28
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.05
Marker Score: 19.5
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.05
Marker Score: 29.5
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.05
Marker Score: 139
Cell Name: neutrophil (CL0000775)
Fold Change: 0.05
Marker Score: 31.5
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.05
Marker Score: 30
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.05
Marker Score: 31.5
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.05
Marker Score: 31
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.04
Marker Score: 30
Cell Name: acinar cell (CL0000622)
Fold Change: 0.04
Marker Score: 28.5

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Other Information

Description

**Key Characteristics:** 1. **Paired Box Domain:** PAX4 contains a characteristic paired box (PAX) domain, which is a conserved DNA-binding motif essential for its transcriptional regulatory functions. 2. **Tissue-Specific Expression:** PAX4 is expressed in a wide range of cell types, including neuroendocrine cells, blood vessel endothelial cells, and immune cells, suggesting its role in regulating cell-specific gene expression. 3. **Transcriptional Regulation:** PAX4 acts as a transcription factor, binding to specific DNA sequences to regulate the expression of target genes involved in development, differentiation, and endocrine function. 4. **Cis-Regulatory Elements:** PAX4 interacts with cis-regulatory elements, such as enhancers and promoters, to regulate gene expression in response to developmental cues. **Pathways and Functions:** 1. **Regulation of Endocrine Development:** PAX4 plays a critical role in regulating endocrine development, particularly in the regulation of beta-cell development and the differentiation of endocrine-committed progenitor cells. 2. **Cell Differentiation:** PAX4 is involved in regulating cell differentiation, including the differentiation of oligodendrocyte precursor cells and microglial cells. 3. **Transcriptional Regulation:** PAX4 regulates the expression of target genes involved in transcriptional regulation, including the regulation of RNA polymerase II-specific transcription. 4. **Chromatin Remodeling:** PAX4 interacts with chromatin remodeling complexes to regulate chromatin structure and gene expression. **Clinical Significance:** 1. **Endocrine Disorders:** PAX4 dysregulation has been implicated in various endocrine disorders, including diabetes and thyroid dysfunction, highlighting its importance in endocrine development and regulation. 2. **Cancer:** PAX4 has been identified as a potential oncogene in certain types of cancer, including pancreatic and thyroid cancer, suggesting its role in tumorigenesis. 3. **Neurological Disorders:** PAX4 has been implicated in the regulation of neuronal development and function, making it a potential target for treating neurological disorders, such as Parkinson's disease. 4. **Immunological Disorders:** PAX4 is expressed in immune cells, suggesting its role in regulating immune responses and potentially contributing to immunological disorders. In conclusion, PAX4 is a critical transcription factor involved in regulating development, differentiation, and endocrine function. Its dysregulation has been implicated in various diseases, including endocrine disorders, cancer, and neurological disorders. Further research is needed to fully elucidate the molecular mechanisms underlying PAX4's functions and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.