Details for: A4GNT

Gene ID: 51146

Symbol: A4GNT

Ensembl ID: ENSG00000118017

Description: alpha-1,4-N-acetylglucosaminyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: 1.5789
    Cell Significance Index: 11.3100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7569
    Cell Significance Index: 18.3400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3875
    Cell Significance Index: 5.0900
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.3842
    Cell Significance Index: 1.8300
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.3043
    Cell Significance Index: 2.7900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.3019
    Cell Significance Index: 5.1600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2489
    Cell Significance Index: 3.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2227
    Cell Significance Index: 3.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1864
    Cell Significance Index: 2.6700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1477
    Cell Significance Index: 2.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1400
    Cell Significance Index: 1.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0882
    Cell Significance Index: 10.1100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0670
    Cell Significance Index: 0.9300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0630
    Cell Significance Index: 1.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0118
    Cell Significance Index: 1.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0034
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0005
    Cell Significance Index: -0.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0011
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0011
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0012
    Cell Significance Index: -0.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0012
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0014
    Cell Significance Index: -0.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0014
    Cell Significance Index: -0.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0015
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0015
    Cell Significance Index: -0.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0021
    Cell Significance Index: -0.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0032
    Cell Significance Index: -0.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0041
    Cell Significance Index: -0.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0045
    Cell Significance Index: -0.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0053
    Cell Significance Index: -0.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0059
    Cell Significance Index: -0.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0075
    Cell Significance Index: -0.7700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0094
    Cell Significance Index: -0.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0108
    Cell Significance Index: -0.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0129
    Cell Significance Index: -0.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0138
    Cell Significance Index: -0.9300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0147
    Cell Significance Index: -0.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0160
    Cell Significance Index: -0.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0169
    Cell Significance Index: -0.9500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0174
    Cell Significance Index: -0.3800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0181
    Cell Significance Index: -0.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0184
    Cell Significance Index: -0.8200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0190
    Cell Significance Index: -0.3200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0196
    Cell Significance Index: -0.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0198
    Cell Significance Index: -0.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0217
    Cell Significance Index: -0.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0226
    Cell Significance Index: -0.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0240
    Cell Significance Index: -0.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0282
    Cell Significance Index: -0.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0304
    Cell Significance Index: -0.7600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0305
    Cell Significance Index: -0.7600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0306
    Cell Significance Index: -0.6100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0320
    Cell Significance Index: -0.3300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0329
    Cell Significance Index: -0.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0333
    Cell Significance Index: -0.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0338
    Cell Significance Index: -0.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0343
    Cell Significance Index: -0.7400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0348
    Cell Significance Index: -0.4400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0348
    Cell Significance Index: -0.4700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0352
    Cell Significance Index: -0.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0353
    Cell Significance Index: -0.7500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0356
    Cell Significance Index: -0.4200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0358
    Cell Significance Index: -0.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0367
    Cell Significance Index: -0.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0373
    Cell Significance Index: -1.0700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0373
    Cell Significance Index: -0.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0379
    Cell Significance Index: -0.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0389
    Cell Significance Index: -0.7700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0391
    Cell Significance Index: -0.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0395
    Cell Significance Index: -0.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0401
    Cell Significance Index: -1.0300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0402
    Cell Significance Index: -0.8400
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0416
    Cell Significance Index: -0.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0417
    Cell Significance Index: -1.0000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0430
    Cell Significance Index: -0.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0433
    Cell Significance Index: -0.7300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0435
    Cell Significance Index: -0.8500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0436
    Cell Significance Index: -0.4600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0443
    Cell Significance Index: -0.3900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0445
    Cell Significance Index: -0.7700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0451
    Cell Significance Index: -0.5100
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0466
    Cell Significance Index: -0.4600
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0480
    Cell Significance Index: -0.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0487
    Cell Significance Index: -1.0200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0489
    Cell Significance Index: -0.8300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0494
    Cell Significance Index: -0.7300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0494
    Cell Significance Index: -0.6200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0495
    Cell Significance Index: -0.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0514
    Cell Significance Index: -0.8600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0517
    Cell Significance Index: -0.6800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0520
    Cell Significance Index: -0.4700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0525
    Cell Significance Index: -0.7000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0570
    Cell Significance Index: -0.6800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0571
    Cell Significance Index: -0.8200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0572
    Cell Significance Index: -0.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Biological function:** A4GNT is a glycosyltransferase enzyme that catalyzes the transfer of GlcNAc residues to core oligosaccharides of glycoproteins. 2. **Expression:** A4GNT is expressed in a wide range of cell types, including immune cells, epithelial cells, and hematopoietic stem cells. 3. **Signaling pathways:** A4GNT is involved in various signaling pathways, including the regulation of epithelial cell proliferation, negative regulation of epithelial cell proliferation, and immune responses. 4. **Glycoprotein biosynthesis:** A4GNT plays a critical role in the biosynthesis of glycoproteins, which are essential for cell-cell interactions, signaling, and immune recognition. **Pathways and Functions:** 1. **Acetylglucosaminyltransferase activity:** A4GNT catalyzes the transfer of GlcNAc residues to core oligosaccharides of glycoproteins, resulting in the formation of a wide range of glycoforms. 2. **Carbohydrate metabolic process:** A4GNT is involved in the regulation of carbohydrate metabolic processes, including glycoprotein biosynthesis and immune responses. 3. **Epithelial cell proliferation:** A4GNT regulates epithelial cell proliferation, which is essential for tissue homeostasis and immune function. 4. **Glycoprotein biosynthetic process:** A4GNT plays a critical role in the biosynthesis of glycoproteins, which are essential for cell-cell interactions, signaling, and immune recognition. 5. **Golgi membrane and membrane:** A4GNT is localized to the Golgi membrane and is involved in the processing of glycoproteins. 6. **Metabolism of proteins:** A4GNT is involved in the metabolism of proteins, including the regulation of protein o-linked glycosylation. 7. **Negative regulation of epithelial cell proliferation:** A4GNT regulates epithelial cell proliferation, which is essential for tissue homeostasis and immune function. 8. **O-glycan processing:** A4GNT is involved in the processing of O-glycans, which are essential for cell-cell interactions and immune recognition. 9. **O-linked glycosylation:** A4GNT catalyzes the transfer of GlcNAc residues to O-glycans, resulting in the formation of a wide range of glycoforms. 10. **O-linked glycosylation of mucins:** A4GNT is involved in the glycosylation of mucins, which are essential for the formation of mucus and the protection of epithelial surfaces. 11. **Post-translational protein modification:** A4GNT is involved in post-translational protein modification, including the regulation of protein o-linked glycosylation. 12. **Protein o-linked glycosylation:** A4GNT catalyzes the transfer of GlcNAc residues to proteins, resulting in the formation of a wide range of glycoforms. **Clinical Significance:** A4GNT has significant implications for various diseases, including: 1. **Immune disorders:** A4GNT plays a critical role in immune regulation, and dysregulation of A4GNT has been implicated in various immune disorders, including autoimmune diseases and cancer. 2. **Cancer:** A4GNT is involved in the regulation of epithelial cell proliferation, and dysregulation of A4GNT has been implicated in cancer development and progression. 3. **Gastrointestinal disorders:** A4GNT is expressed in epithelial cells and plays a critical role in the regulation of epithelial cell proliferation, making it a potential target for the treatment of gastrointestinal disorders, such as inflammatory bowel disease. 4. **Neurological disorders:** A4GNT is involved in the regulation of immune responses and has been implicated in various neurological disorders, including multiple sclerosis and Alzheimer's disease. In conclusion, A4GNT is a critical enzyme involved in the biosynthesis of glycoproteins and the regulation of immune responses. Its dysregulation has been implicated in various diseases, including immune disorders, cancer, gastrointestinal disorders, and neurological disorders. Further research is needed to fully understand the role of A4GNT in human health and disease.

Genular Protein ID: 167073228

Symbol: A4GCT_HUMAN

Name: Alpha-1,4-N-acetylglucosaminyltransferase

UniProtKB Accession Codes:

Q9UNA3 Q0VDK1 Q0VDK2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10430883

Title: Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin.

PubMed ID: 10430883

DOI: 10.1073/pnas.96.16.8991

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 340
  • Mass: 39497
  • Checksum: 00D667A8394300AB
  • Sequence:
    • MRKELQLSLS VTLLLVCGFL YQFTLKSSCL FCLPSFKSHQ GLEALLSHRR GIVFLETSER 
MEPPHLVSCS VESAAKIYPE WPVVFFMKGL TDSTPMPSNS TYPAFSFLSA IDNVFLFPLD 
MKRLLEDTPL FSWYNQINAS AERNWLHISS DASRLAIIWK YGGIYMDTDV ISIRPIPEEN 
FLAAQASRYS SNGIFGFLPH HPFLWECMEN FVEHYNSAIW GNQGPELMTR MLRVWCKLED 
FQEVSDLRCL NISFLHPQRF YPISYREWRR YYEVWDTEPS FNVSYALHLW NHMNQEGRAV 
IRGSNTLVEN LYRKHCPRTY RDLIKGPEGS VTGELGPGNK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.