Details for: MAGEC2

Gene ID: 51438

Symbol: MAGEC2

Ensembl ID: ENSG00000046774

Description: MAGE family member C2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6629
    Cell Significance Index: 5.0100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1063
    Cell Significance Index: 1.2900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1029
    Cell Significance Index: 1.1800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0272
    Cell Significance Index: 0.3900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0146
    Cell Significance Index: 0.2900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0060
    Cell Significance Index: -0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0067
    Cell Significance Index: -1.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0167
    Cell Significance Index: -1.1200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0197
    Cell Significance Index: -0.2000
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0210
    Cell Significance Index: -0.2300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0270
    Cell Significance Index: -0.3500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0284
    Cell Significance Index: -0.3400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0322
    Cell Significance Index: -0.3400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0346
    Cell Significance Index: -0.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0367
    Cell Significance Index: -0.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0384
    Cell Significance Index: -1.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0392
    Cell Significance Index: -1.1200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0443
    Cell Significance Index: -0.5300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0461
    Cell Significance Index: -0.7000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0471
    Cell Significance Index: -0.6100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0476
    Cell Significance Index: -0.5800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0502
    Cell Significance Index: -0.5400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0570
    Cell Significance Index: -0.8100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0578
    Cell Significance Index: -1.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0586
    Cell Significance Index: -0.9800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0598
    Cell Significance Index: -0.6200
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.0609
    Cell Significance Index: -0.2800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0609
    Cell Significance Index: -0.7700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0619
    Cell Significance Index: -0.4500
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0634
    Cell Significance Index: -0.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0660
    Cell Significance Index: -1.3200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0669
    Cell Significance Index: -0.7900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0670
    Cell Significance Index: -0.9400
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0681
    Cell Significance Index: -0.4900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0684
    Cell Significance Index: -1.1000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0690
    Cell Significance Index: -0.9000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0693
    Cell Significance Index: -0.8300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0699
    Cell Significance Index: -0.9800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0704
    Cell Significance Index: -0.8100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0724
    Cell Significance Index: -0.9500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0730
    Cell Significance Index: -0.7900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0734
    Cell Significance Index: -1.0700
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0740
    Cell Significance Index: -0.7300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0748
    Cell Significance Index: -0.8800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0750
    Cell Significance Index: -1.0300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0758
    Cell Significance Index: -0.8400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0759
    Cell Significance Index: -0.7000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0764
    Cell Significance Index: -0.9300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0781
    Cell Significance Index: -0.9600
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0786
    Cell Significance Index: -0.8800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0799
    Cell Significance Index: -0.8700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0802
    Cell Significance Index: -0.9300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0805
    Cell Significance Index: -1.0600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0810
    Cell Significance Index: -0.8700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0812
    Cell Significance Index: -1.0600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0829
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0831
    Cell Significance Index: -0.7800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0833
    Cell Significance Index: -1.0700
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: -0.0842
    Cell Significance Index: -0.5200
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0842
    Cell Significance Index: -0.9700
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0851
    Cell Significance Index: -0.8700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0855
    Cell Significance Index: -0.8600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0863
    Cell Significance Index: -1.1100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0867
    Cell Significance Index: -0.8900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0871
    Cell Significance Index: -0.5800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0898
    Cell Significance Index: -1.0600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0909
    Cell Significance Index: -1.0200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0912
    Cell Significance Index: -1.1100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0939
    Cell Significance Index: -0.8900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0941
    Cell Significance Index: -1.2500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0948
    Cell Significance Index: -0.8200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0970
    Cell Significance Index: -1.0300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0982
    Cell Significance Index: -1.1600
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0990
    Cell Significance Index: -1.0800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1028
    Cell Significance Index: -1.0600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1029
    Cell Significance Index: -1.1300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1037
    Cell Significance Index: -1.1300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1052
    Cell Significance Index: -1.1200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1055
    Cell Significance Index: -1.0700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1064
    Cell Significance Index: -1.1200
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1069
    Cell Significance Index: -1.1000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1096
    Cell Significance Index: -1.0600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1109
    Cell Significance Index: -1.1200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1115
    Cell Significance Index: -1.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1134
    Cell Significance Index: -1.0900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1144
    Cell Significance Index: -1.0900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1148
    Cell Significance Index: -1.0900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1251
    Cell Significance Index: -0.8300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1272
    Cell Significance Index: -1.1900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1279
    Cell Significance Index: -1.8700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1281
    Cell Significance Index: -1.1200
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1293
    Cell Significance Index: -1.1300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1307
    Cell Significance Index: -0.7000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1311
    Cell Significance Index: -1.0200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1313
    Cell Significance Index: -1.1100
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.1325
    Cell Significance Index: -1.0800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1374
    Cell Significance Index: -1.0900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1428
    Cell Significance Index: -0.9100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1487
    Cell Significance Index: -1.3400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1497
    Cell Significance Index: -0.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **MAGE Family Member:** MAGEC2 belongs to the MAGE family, a group of genes that have been implicated in immune evasion by tumor cells. 2. **Wide Tissue Expression:** MAGEC2 is expressed in various cell types, including germ cells, squamous epithelial cells, astrocytes, and neural cells, highlighting its diverse biological functions. 3. **RNA Polymerase II Regulation:** MAGEC2 is regulated by RNA polymerase II, a key enzyme involved in transcriptional regulation. 4. **Ubiquitin-Protein Transferase Activity:** MAGEC2 interacts with ubiquitin-protein transferases, enzymes involved in protein degradation and modification. **Pathways and Functions:** 1. **Negative Regulation of Transcription by RNA Polymerase II:** MAGEC2 acts as a transcriptional regulator, influencing the expression of genes involved in immune responses and cellular development. 2. **Positive Regulation of Ubiquitin-Protein Transferase Activity:** MAGEC2 enhances the activity of ubiquitin-protein transferases, which play a crucial role in protein degradation and modification. 3. **Protein Catabolic Process:** MAGEC2 is involved in the degradation of proteins, which is essential for cellular homeostasis and immune regulation. 4. **Protein Binding:** MAGEC2 interacts with various proteins, including ubiquitin-protein transferases and RNA polymerase II, highlighting its role in protein-protein interactions. **Clinical Significance:** 1. **Immunotherapy:** MAGEC2 has been identified as a potential target for immunotherapy, particularly in the treatment of cancer. 2. **Neurodevelopmental Disorders:** MAGEC2's involvement in neural cell development and function highlights its potential role in neurodevelopmental disorders, such as autism and schizophrenia. 3. **Cancer Research:** MAGEC2's expression in cancer cells underscores its potential as a biomarker for cancer diagnosis and treatment. 4. **Gene Therapy:** MAGEC2's role in immune regulation and neurodevelopmental processes makes it a promising candidate for gene therapy applications. In conclusion, MAGEC2 is a multifaceted gene with diverse biological functions, including immune regulation, neurodevelopment, and protein degradation. Its expression in various cell types and its interactions with key regulatory enzymes highlight its significance in human biology and disease. Further research is necessary to fully elucidate the mechanisms by which MAGEC2 regulates immune responses and neural cell development, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 4233738935

Symbol: MAGC2_HUMAN

Name: Melanoma-associated antigen C2

UniProtKB Accession Codes:

Q9UBF1 Q5JZ00 Q96D45 Q9P1M6 Q9P1M7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10699956

Title: CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational difference analysis.

PubMed ID: 10699956

DOI: 10.1002/(sici)1097-0215(20000301)85:5<726::aid-ijc21>3.0.co;2-f

PubMed ID: 10861452

Title: MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression.

PubMed ID: 10861452

DOI: 10.1002/1097-0215(20000701)87:1<55::aid-ijc8>3.3.co;2-a

PubMed ID: 12097419

Title: Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.

PubMed ID: 12097419

DOI: 10.4049/jimmunol.169.2.1102

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12920247

Title: HCA587 antigen expression in normal tissues and cancers: correlation with tumor differentiation in hepatocellular carcinoma.

PubMed ID: 12920247

DOI: 10.1097/01.lab.0000080605.73839.96

PubMed ID: 17942928

Title: MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines.

PubMed ID: 17942928

DOI: 10.1158/0008-5472.can-07-1478

PubMed ID: 20864041

Title: MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.

PubMed ID: 20864041

DOI: 10.1016/j.molcel.2010.08.029

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 373
  • Mass: 41163
  • Checksum: D55867D7972BF49F
  • Sequence:
    • MPPVPGVPFR NVDNDSPTSV ELEDWVDAQH PTDEEEEEAS SASSTLYLVF SPSSFSTSSS 
LILGGPEEEE VPSGVIPNLT ESIPSSPPQG PPQGPSQSPL SSCCSSFSWS SFSEESSSQK 
GEDTGTCQGL PDSESSFTYT LDEKVAELVE FLLLKYEAEE PVTEAEMLMI VIKYKDYFPV 
ILKRAREFME LLFGLALIEV GPDHFCVFAN TVGLTDEGSD DEGMPENSLL IIILSVIFIK 
GNCASEEVIW EVLNAVGVYA GREHFVYGEP RELLTKVWVQ GHYLEYREVP HSSPPYYEFL 
WGPRAHSESI KKKVLEFLAK LNNTVPSSFP SWYKDALKDV EERVQATIDT ADDATVMASE 
SLSVMSSNVS FSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.