Details for: CPXCR1

Gene ID: 53336

Symbol: CPXCR1

Ensembl ID: ENSG00000147183

Description: CPX chromosome region candidate 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.2442
    Cell Significance Index: 6.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.1036
    Cell Significance Index: 2.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0705
    Cell Significance Index: 1.0100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0587
    Cell Significance Index: 0.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0584
    Cell Significance Index: 0.6100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0548
    Cell Significance Index: 0.6400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0268
    Cell Significance Index: 0.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0235
    Cell Significance Index: 0.6300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0194
    Cell Significance Index: 0.2500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0150
    Cell Significance Index: 0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0012
    Cell Significance Index: -0.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0022
    Cell Significance Index: -0.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0024
    Cell Significance Index: -0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0029
    Cell Significance Index: -0.5800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0042
    Cell Significance Index: -0.7200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0047
    Cell Significance Index: -0.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0054
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0062
    Cell Significance Index: -0.7100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0082
    Cell Significance Index: -0.1200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0105
    Cell Significance Index: -0.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0114
    Cell Significance Index: -0.2500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0120
    Cell Significance Index: -0.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0126
    Cell Significance Index: -0.2500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0129
    Cell Significance Index: -0.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0130
    Cell Significance Index: -0.2800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0142
    Cell Significance Index: -0.2800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0147
    Cell Significance Index: -0.1900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0151
    Cell Significance Index: -0.1800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0157
    Cell Significance Index: -0.1700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0160
    Cell Significance Index: -0.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0169
    Cell Significance Index: -0.4500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0170
    Cell Significance Index: -0.1400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0177
    Cell Significance Index: -0.1300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0180
    Cell Significance Index: -0.2400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0184
    Cell Significance Index: -0.4400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0186
    Cell Significance Index: -0.1800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0188
    Cell Significance Index: -0.2000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0190
    Cell Significance Index: -0.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0199
    Cell Significance Index: -0.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0202
    Cell Significance Index: -0.6600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0205
    Cell Significance Index: -0.2600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0210
    Cell Significance Index: -0.2200
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0218
    Cell Significance Index: -0.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0219
    Cell Significance Index: -0.4400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0221
    Cell Significance Index: -0.4400
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0222
    Cell Significance Index: -0.2200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0225
    Cell Significance Index: -0.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0229
    Cell Significance Index: -0.2500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0230
    Cell Significance Index: -0.2700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0233
    Cell Significance Index: -0.2500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0240
    Cell Significance Index: -0.1500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0242
    Cell Significance Index: -0.2900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0248
    Cell Significance Index: -0.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0248
    Cell Significance Index: -0.4100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0251
    Cell Significance Index: -0.3300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0251
    Cell Significance Index: -0.3300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0255
    Cell Significance Index: -0.2300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0260
    Cell Significance Index: -0.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0262
    Cell Significance Index: -0.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0262
    Cell Significance Index: -0.6100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0284
    Cell Significance Index: -0.3300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0299
    Cell Significance Index: -0.4100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0311
    Cell Significance Index: -0.3300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0314
    Cell Significance Index: -0.3800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0328
    Cell Significance Index: -0.3400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0332
    Cell Significance Index: -0.3800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0350
    Cell Significance Index: -0.7300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0361
    Cell Significance Index: -0.3600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0365
    Cell Significance Index: -0.5000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0374
    Cell Significance Index: -0.3300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0376
    Cell Significance Index: -0.6200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0377
    Cell Significance Index: -0.4400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0388
    Cell Significance Index: -0.4200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0391
    Cell Significance Index: -0.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0410
    Cell Significance Index: -0.6100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0412
    Cell Significance Index: -0.4200
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0416
    Cell Significance Index: -0.4500
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0417
    Cell Significance Index: -0.4500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0437
    Cell Significance Index: -0.6000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0440
    Cell Significance Index: -0.4300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0449
    Cell Significance Index: -0.6100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0455
    Cell Significance Index: -0.6100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0464
    Cell Significance Index: -0.5300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0479
    Cell Significance Index: -0.4500
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0482
    Cell Significance Index: -0.6100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0483
    Cell Significance Index: -0.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0491
    Cell Significance Index: -0.5900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0514
    Cell Significance Index: -0.6500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0521
    Cell Significance Index: -0.6400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0521
    Cell Significance Index: -0.3900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0523
    Cell Significance Index: -0.6600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0540
    Cell Significance Index: -0.4400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0551
    Cell Significance Index: -0.6000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0556
    Cell Significance Index: -0.7300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0567
    Cell Significance Index: -0.6700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0569
    Cell Significance Index: -0.4300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0570
    Cell Significance Index: -0.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CPXCR1 is a non-coding gene, meaning that it does not encode a protein. Instead, it is believed to regulate gene expression through the modulation of chromatin structure and transcriptional activity. The gene is predominantly expressed in cells of the immune system, including keratinocytes, erythrocytes, and megakaryocytes, as well as in cells derived from the nervous system, such as interneurons and neural progenitor cells. Interestingly, CPXCR1 is also expressed in cells of the adrenal gland and intestinal epithelium, highlighting its broad tissue-specific expression. **Pathways and Functions** The functional mechanisms of CPXCR1 are not yet fully elucidated, but several pathways have been implicated in its regulation. One of the most significant pathways is the Wnt/β-catenin signaling pathway, which is involved in cell proliferation, differentiation, and migration. CPXCR1 is thought to modulate this pathway by regulating the expression of Wnt ligands and their receptors. Additionally, CPXCR1 has been shown to interact with other signaling pathways, including the Notch and PI3K/AKT pathways, which are involved in cell survival, differentiation, and immune responses. The functions of CPXCR1 are multifaceted, with potential roles in: 1. Immune cell migration and homing 2. Cell differentiation and maturation 3. Regulating the expression of immune-related genes 4. Modulating the Wnt/β-catenin signaling pathway 5. Interacting with other signaling pathways to regulate cell survival and differentiation **Clinical Significance** The clinical significance of CPXCR1 is an area of ongoing research. While the gene's expression in various tissues and cell types suggests a broad range of potential functions, its dysregulation has been implicated in several diseases, including: 1. Autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis 2. Cancer, including leukemia and lymphoma 3. Neurological disorders, such as Alzheimer's disease and Parkinson's disease 4. Gastrointestinal disorders, such as inflammatory bowel disease Further studies are needed to fully elucidate the clinical significance of CPXCR1 and its role in human disease. However, the gene's involvement in multiple cellular processes and signaling pathways makes it an attractive target for therapeutic intervention in various diseases. In conclusion, CPXCR1 is a novel immunological gene that has the potential to play a significant role in various cellular processes, including immune responses and cell migration. Further research is needed to fully elucidate its functions and clinical significance, but the gene's multifaceted expression and interactions with other signaling pathways make it an exciting area of investigation.

Genular Protein ID: 1449604573

Symbol: CPXCR_HUMAN

Name: CPX chromosomal region candidate gene 1 protein

UniProtKB Accession Codes:

Q8N123 B2R9F9 D3DTE7 Q96RS3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11499681

Title: Physical and transcriptional mapping of the X-linked cleft palate and ankyloglossia (CPX) critical region.

PubMed ID: 11499681

DOI: 10.1007/s004390100518

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 301
  • Mass: 34727
  • Checksum: DB2A6AB3F225564B
  • Sequence:
    • MSYPTKEGSD TAGNAHKNSE NEPPNDCSTD IESPSADPNM IYQVETNPIN REPGTATSQE 
DVVPQAAENS ELETEIQKDQ REEDLKEELL LLQTPIPRKL VSHKPLNDRS RSHSGKVEMK 
ANNFPINHKT RFRLSTSWRV PFINSHEIRS MILHLLCDRY FSQAAGCQNT MWVKRKYIAC 
LYHPNSFTHH ERAITFRRPS RVHYYRPLTE RMTSGKFCKS TDTKGKCRFR AIVRSVLFVS 
QIQIESIFNI KGFVDILTYI HTMNVMITNT NNGWKYFCPI CGRLFNTYSE LRQHSCSSSG 
N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.