Details for: MAPK10

Gene ID: 5602

Symbol: MAPK10

Ensembl ID: ENSG00000109339

Description: mitogen-activated protein kinase 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.33
    Marker Score: 94540
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 4.93
    Marker Score: 3244
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 4.46
    Marker Score: 14953
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.17
    Marker Score: 19311
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 4.03
    Marker Score: 7763
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.85
    Marker Score: 2967
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.78
    Marker Score: 3263
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.4
    Marker Score: 18278
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.35
    Marker Score: 2329
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.32
    Marker Score: 112185
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.31
    Marker Score: 1592
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.3
    Marker Score: 3797
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.26
    Marker Score: 69521
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 3.24
    Marker Score: 1817
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.19
    Marker Score: 7010.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.14
    Marker Score: 3801
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.06
    Marker Score: 4115
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.01
    Marker Score: 1588
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3
    Marker Score: 877
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.97
    Marker Score: 4993
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.91
    Marker Score: 57818
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.87
    Marker Score: 12010
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.85
    Marker Score: 6824
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.84
    Marker Score: 1656
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.84
    Marker Score: 8100
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.83
    Marker Score: 1646
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.83
    Marker Score: 14856
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.82
    Marker Score: 42127
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.8
    Marker Score: 1563
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.76
    Marker Score: 877
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.76
    Marker Score: 11523
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.74
    Marker Score: 20636
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.73
    Marker Score: 20952
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.69
    Marker Score: 102229
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.68
    Marker Score: 2320
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.62
    Marker Score: 2495
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.61
    Marker Score: 10814
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.54
    Marker Score: 854
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.54
    Marker Score: 2253
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.47
    Marker Score: 895
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.45
    Marker Score: 90288
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.44
    Marker Score: 634
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.42
    Marker Score: 2719
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.4
    Marker Score: 8517
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.39
    Marker Score: 1329
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.35
    Marker Score: 859
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.33
    Marker Score: 9018
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.33
    Marker Score: 2573.5
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.3
    Marker Score: 885
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.27
    Marker Score: 953
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.27
    Marker Score: 5218
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.21
    Marker Score: 1310
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.2
    Marker Score: 2719
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20661
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.19
    Marker Score: 1279
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.14
    Marker Score: 1009
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.09
    Marker Score: 692
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127942
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.03
    Marker Score: 20996
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.03
    Marker Score: 642
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.03
    Marker Score: 1050
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.02
    Marker Score: 8233
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.02
    Marker Score: 6935
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.98
    Marker Score: 2466
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.96
    Marker Score: 3992
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18313
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.89
    Marker Score: 2033
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.88
    Marker Score: 30185
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16142
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.83
    Marker Score: 675
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.8
    Marker Score: 1356
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.78
    Marker Score: 486
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.69
    Marker Score: 3429
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.68
    Marker Score: 427
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.66
    Marker Score: 5898
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.65
    Marker Score: 1996
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2546
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1161
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.58
    Marker Score: 417
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.58
    Marker Score: 478
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.56
    Marker Score: 1473.5
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.56
    Marker Score: 2193
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.52
    Marker Score: 2245
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.51
    Marker Score: 1876
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.5
    Marker Score: 3525
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.49
    Marker Score: 807
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.49
    Marker Score: 300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.47
    Marker Score: 12798
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.46
    Marker Score: 666
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167228
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.44
    Marker Score: 683
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.42
    Marker Score: 1708
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.37
    Marker Score: 824
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.36
    Marker Score: 360
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.36
    Marker Score: 1919
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.35
    Marker Score: 2560
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.31
    Marker Score: 876
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.3
    Marker Score: 815
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.29
    Marker Score: 439
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.24
    Marker Score: 649

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Other Information

**Key Characteristics** MAPK10 is a serine/threonine kinase that exhibits a specific substrate specificity, with a preference for phosphorylating specific residues in its substrates. This kinase is activated by a variety of stimuli, including cytokines, stress, and growth factors. Once activated, MAPK10 phosphorylates and activates downstream targets, including transcription factors, kinases, and other signaling molecules. The kinase has a unique ability to regulate the activity of multiple signaling pathways, including those involved in immune responses, stress, and cell survival. **Pathways and Functions** MAPK10 is involved in various signaling pathways, including: 1. **Activation of AP-1 family of transcription factors**: MAPK10 phosphorylates and activates components of the AP-1 transcription factor complex, leading to the regulation of gene expression involved in immune responses and cell survival. 2. **Cytokine signaling in immune system**: MAPK10 modulates the activity of cytokine receptors, influencing the production of pro-inflammatory and anti-inflammatory cytokines. 3. **Innate immune system**: MAPK10 regulates the activity of pattern recognition receptors, such as TLR4, TLR9, and TLR10, which recognize pathogen-associated molecular patterns (PAMPs) and initiate immune responses. 4. **Cellular responses to stress**: MAPK10 is activated in response to stress, including oxidative stress, and regulates the activity of downstream targets involved in cell survival and apoptosis. 5. **Regulation of circadian rhythm**: MAPK10 is involved in the regulation of the circadian clock, influencing the expression of genes involved in clock-related processes. **Clinical Significance** Dysregulation of MAPK10 has been implicated in various diseases, including: 1. **Autoimmune disorders**: MAPK10 has been shown to play a role in the regulation of immune responses and the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: MAPK10 has been implicated in the regulation of cell growth, survival, and apoptosis in various types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders**: MAPK10 has been linked to the regulation of neuronal function and the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: MAPK10 has been shown to play a role in the regulation of immune responses to infections, including the activation of cytokine signaling pathways. In conclusion, MAPK10 is a crucial signaling molecule involved in various cellular processes, including immune responses, stress, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of MAPK10 in maintaining cellular homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which MAPK10 regulates cellular processes and to explore its therapeutic potential in disease prevention and treatment.

Genular Protein ID: 1171285266

Symbol: MK10_HUMAN

Name: Mitogen-activated protein kinase 10

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7826642

Title: p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system.

PubMed ID: 7826642

DOI: 10.1016/0896-6273(95)90241-4

PubMed ID: 8654373

Title: Selective interaction of JNK protein kinase isoforms with transcription factors.

PubMed ID: 8654373

DOI: 10.1002/j.1460-2075.1996.tb00636.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10715136

Title: Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.

PubMed ID: 10715136

DOI: 10.1021/bi992410+

PubMed ID: 11062067

Title: Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.

PubMed ID: 11062067

DOI: 10.1042/bj3520145

PubMed ID: 11718727

Title: c-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10.

PubMed ID: 11718727

DOI: 10.1016/s0014-5793(01)03090-3

PubMed ID: 15693750

Title: Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein.

PubMed ID: 15693750

DOI: 10.1042/bj20041577

PubMed ID: 16249883

Title: Truncation of the CNS-expressed JNK3 in a patient with a severe developmental epileptic encephalopathy.

PubMed ID: 16249883

DOI: 10.1007/s00439-005-0084-y

PubMed ID: 16737965

Title: Visual and both non-visual arrestins in their 'inactive' conformation bind JNK3 and Mdm2 and relocalize them from the nucleus to the cytoplasm.

PubMed ID: 16737965

DOI: 10.1074/jbc.m603659200

PubMed ID: 16611996

Title: Neuroprotection by histone deacetylase-related protein.

PubMed ID: 16611996

DOI: 10.1128/mcb.26.9.3550-3564.2006

PubMed ID: 18435604

Title: Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs.

PubMed ID: 18435604

DOI: 10.1042/bj20080685

PubMed ID: 21941371

Title: Isoform-specific palmitoylation of JNK regulates axonal development.

PubMed ID: 21941371

DOI: 10.1038/cdd.2011.124

PubMed ID: 22441692

Title: JNK regulates the photic response of the mammalian circadian clock.

PubMed ID: 22441692

DOI: 10.1038/embor.2012.37

PubMed ID: 22327296

Title: The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

PubMed ID: 22327296

DOI: 10.1038/nature10806

PubMed ID: 9739089

Title: Crystal structure of JNK3: a kinase implicated in neuronal apoptosis.

PubMed ID: 9739089

DOI: 10.1016/s0969-2126(98)00100-2

Sequence Information:

  • Length: 464
  • Mass: 52585
  • Checksum: 2E20C05EB89CDA66
  • Sequence:
  • MSLHFLYYCS EPTLDVKIAF CQGFDKQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV 
    LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH 
    KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL 
    HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY 
    KENVDIWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN 
    RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN 
    VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA 
    VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCR

Genular Protein ID: 2602293855

Symbol: Q499Y8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 319
  • Mass: 35736
  • Checksum: 26A417744949F448
  • Sequence:
  • MELMDANLCQ VIQMELDHER MSYLLYQMLC GIKHLHSAGI IHRDLKPSNI VVKSDCTLKI 
    LDFGLARTAG TSFMMTPYVV TRYYRAPEVI LGMGYKENVD MWSVGCIMGE MIKGAVLFPG 
    TDHIDQWNKV IEQLGTPCPE FMKKLQPTVR NYVENRPKYA GLTFPKLFPD SLFPADSEHN 
    KLKASQARDL LSKMLVIDPA KRISVDDALQ HPYINVWYDP AEVEAPPPQI YDKQLDEREH 
    TIEEWKELIY KEVMNSEEKT KNGVVKGQPS PSGAAVNSSE SLPPSSSVND ISSMSTDQTL 
    ASDTDSSLEA SAGPLGCCR

Genular Protein ID: 2854620592

Symbol: F8W9R5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 478
  • Mass: 54214
  • Checksum: 83B2E47D95B81C42
  • Sequence:
  • MSLHFLYYCS EPTLDVKIAF CQGFDKQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV 
    LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH 
    KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL 
    HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY 
    KENVDIWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN 
    RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN 
    VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA 
    VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCRXLAACL RNPAFFRR

Genular Protein ID: 1374868106

Symbol: A0A286YF97_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 464
  • Mass: 52357
  • Checksum: BDF23C2BAEFDEFFC
  • Sequence:
  • MSLHFLYYCS EPTLDVKIAF CQGFDKQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV 
    LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH 
    KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL 
    HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY 
    KENVDMWSVG CIMGEMIKGA VLFPGTDHID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN 
    RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN 
    VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA 
    VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.