Details for: RPL21P1

Gene ID: 6145

Symbol: RPL21P1

Ensembl ID: ENSG00000214760

Description: ribosomal protein L21 pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.3749
    Cell Significance Index: 40.9400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.2220
    Cell Significance Index: 28.6200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.5995
    Cell Significance Index: 7.5300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.5617
    Cell Significance Index: 5.8200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.1556
    Cell Significance Index: 1.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1016
    Cell Significance Index: 5.2800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0603
    Cell Significance Index: 0.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0030
    Cell Significance Index: 0.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0028
    Cell Significance Index: -1.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0043
    Cell Significance Index: -6.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0145
    Cell Significance Index: -1.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0222
    Cell Significance Index: -4.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0300
    Cell Significance Index: -5.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0418
    Cell Significance Index: -0.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0647
    Cell Significance Index: -1.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0743
    Cell Significance Index: -7.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0789
    Cell Significance Index: -3.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0974
    Cell Significance Index: -1.6700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1018
    Cell Significance Index: -1.2900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1217
    Cell Significance Index: -1.7800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1294
    Cell Significance Index: -1.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1325
    Cell Significance Index: -3.5500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1409
    Cell Significance Index: -1.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1478
    Cell Significance Index: -6.7000
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.1549
    Cell Significance Index: -1.4200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1745
    Cell Significance Index: -2.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1813
    Cell Significance Index: -3.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2133
    Cell Significance Index: -7.8300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2198
    Cell Significance Index: -2.5600
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.2346
    Cell Significance Index: -3.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2462
    Cell Significance Index: -7.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2540
    Cell Significance Index: -8.3200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2891
    Cell Significance Index: -4.9100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2913
    Cell Significance Index: -7.2800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2973
    Cell Significance Index: -5.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3086
    Cell Significance Index: -10.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3163
    Cell Significance Index: -7.8900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3363
    Cell Significance Index: -4.6500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3389
    Cell Significance Index: -10.7200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3394
    Cell Significance Index: -4.3600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3437
    Cell Significance Index: -4.0900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.3558
    Cell Significance Index: -3.6700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3592
    Cell Significance Index: -7.7600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3669
    Cell Significance Index: -4.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3716
    Cell Significance Index: -4.4300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3721
    Cell Significance Index: -4.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3739
    Cell Significance Index: -7.9400
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.3742
    Cell Significance Index: -4.2600
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.3764
    Cell Significance Index: -4.7400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3772
    Cell Significance Index: -5.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3865
    Cell Significance Index: -7.7600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.3917
    Cell Significance Index: -5.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3938
    Cell Significance Index: -4.2900
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.3980
    Cell Significance Index: -4.5200
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.3981
    Cell Significance Index: -4.4200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4001
    Cell Significance Index: -8.3500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.4003
    Cell Significance Index: -5.0700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4011
    Cell Significance Index: -4.2600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4042
    Cell Significance Index: -7.9600
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.4044
    Cell Significance Index: -4.3600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.4046
    Cell Significance Index: -5.2800
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.4046
    Cell Significance Index: -4.8600
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.4050
    Cell Significance Index: -4.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4053
    Cell Significance Index: -8.0200
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.4062
    Cell Significance Index: -4.6400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.4070
    Cell Significance Index: -4.1300
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.4078
    Cell Significance Index: -4.2900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.4128
    Cell Significance Index: -4.2800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4131
    Cell Significance Index: -6.1900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.4160
    Cell Significance Index: -4.5500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4175
    Cell Significance Index: -8.3300
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.4193
    Cell Significance Index: -4.5500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.4242
    Cell Significance Index: -5.1600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4289
    Cell Significance Index: -6.1100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.4312
    Cell Significance Index: -5.3100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.4318
    Cell Significance Index: -4.3300
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.4323
    Cell Significance Index: -4.2900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4328
    Cell Significance Index: -5.1100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.4333
    Cell Significance Index: -4.9900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4342
    Cell Significance Index: -4.5800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.4349
    Cell Significance Index: -5.1300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4350
    Cell Significance Index: -5.1700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.4385
    Cell Significance Index: -4.4300
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.4395
    Cell Significance Index: -5.2300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.4423
    Cell Significance Index: -4.6900
  • Cell Name: immature astrocyte (CL0002626)
    Fold Change: -0.4437
    Cell Significance Index: -4.6400
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.4473
    Cell Significance Index: -4.2600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.4484
    Cell Significance Index: -4.7700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4487
    Cell Significance Index: -4.9700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4489
    Cell Significance Index: -4.9700
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.4528
    Cell Significance Index: -4.2200
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.4575
    Cell Significance Index: -5.1900
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.4582
    Cell Significance Index: -5.5400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.4585
    Cell Significance Index: -4.6200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.4596
    Cell Significance Index: -5.4800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.4608
    Cell Significance Index: -5.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL21P1 is a pseudogene, which means that it lacks a functional coding sequence and does not encode a protein. However, pseudogenes can still influence gene expression and regulate cellular processes through various mechanisms, including transcriptional regulation and epigenetic modification. The RPL21P1 gene is expressed in multiple cell types, including CD4-positive and CD8-positive T cells, alpha-beta thymocytes, malignant cells, mesenchymal stem cells, skeletal muscle satellite stem cells, hematopoietic stem cells, luminal epithelial cells of the mammary gland, radial glial cells, adventitial cells, and anterior lens cells. This widespread expression suggests that RPL21P1 plays a role in maintaining cellular homeostasis and regulating cellular behavior in different tissues. **Pathways and Functions:** The mechanisms by which RPL21P1 regulates cellular processes are not fully understood. However, studies have suggested that RPL21P1 may influence gene expression through transcriptional regulation and epigenetic modification. For example, RPL21P1 has been shown to bind to specific DNA sequences and regulate the expression of nearby genes. Additionally, RPL21P1 may interact with other proteins and influence epigenetic marks, such as DNA methylation and histone modification, to regulate gene expression. The functions of RPL21P1 are not limited to transcriptional regulation, as it may also influence cellular processes such as cell proliferation, differentiation, and survival. **Clinical Significance:** The clinical significance of RPL21P1 is an area of active research. Studies have shown that RPL21P1 is overexpressed in various types of cancer, including leukemia, lymphoma, and breast cancer. This overexpression may contribute to tumorigenesis by promoting cell proliferation, inhibiting apoptosis, and enhancing metastasis. Furthermore, RPL21P1 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it may contribute to the dysregulation of immune responses. The widespread expression of RPL21P1 in various cell types also suggests that it may play a role in maintaining tissue homeostasis and regulating cellular behavior in different diseases. In conclusion, the RPL21P1 gene is a pseudogene with significant expression in various cell types and potential immunological implications. Further research is needed to fully understand the mechanisms by which RPL21P1 regulates cellular processes and its clinical significance. However, the current evidence suggests that RPL21P1 is a gene with far-reaching implications for our understanding of cellular biology and disease. **Future Directions:** Future studies should focus on elucidating the mechanisms by which RPL21P1 regulates gene expression and cellular behavior. This may involve investigating the interactions between RPL21P1 and other proteins, as well as its role in regulating epigenetic marks. Additionally, studies should be conducted to determine the clinical significance of RPL21P1 in various diseases, including cancer and autoimmune disorders. By understanding the functions and clinical significance of RPL21P1, researchers may uncover new therapeutic strategies for treating these diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.