Details for: DMRTB1

Gene ID: 63948

Symbol: DMRTB1

Ensembl ID: ENSG00000143006

Description: DMRT like family B with proline rich C-terminal 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.1991
    Cell Significance Index: 16.6100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1621
    Cell Significance Index: 28.1500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4405
    Cell Significance Index: 6.4200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3543
    Cell Significance Index: 3.9600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.3147
    Cell Significance Index: 3.9900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.2979
    Cell Significance Index: 3.6000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1601
    Cell Significance Index: 2.2000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1550
    Cell Significance Index: 1.9600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0969
    Cell Significance Index: 1.1500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0955
    Cell Significance Index: 1.1100
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.0551
    Cell Significance Index: 0.3400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0504
    Cell Significance Index: 1.2600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0283
    Cell Significance Index: 0.3200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.0271
    Cell Significance Index: 0.1600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0269
    Cell Significance Index: 0.3900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0263
    Cell Significance Index: 0.3200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0235
    Cell Significance Index: 0.3300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0191
    Cell Significance Index: 0.2400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0174
    Cell Significance Index: 0.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0156
    Cell Significance Index: 0.4100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0153
    Cell Significance Index: 0.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0123
    Cell Significance Index: 0.3300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0109
    Cell Significance Index: 0.1400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0101
    Cell Significance Index: 0.1700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0100
    Cell Significance Index: 0.1300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0093
    Cell Significance Index: 0.1000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0062
    Cell Significance Index: 0.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0058
    Cell Significance Index: 0.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0050
    Cell Significance Index: 0.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0030
    Cell Significance Index: 0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0020
    Cell Significance Index: 3.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0017
    Cell Significance Index: 0.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0006
    Cell Significance Index: 1.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.1500
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0002
    Cell Significance Index: -0.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0003
    Cell Significance Index: -0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0003
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0004
    Cell Significance Index: -0.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0006
    Cell Significance Index: -0.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0007
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0010
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0015
    Cell Significance Index: -0.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0016
    Cell Significance Index: -0.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0016
    Cell Significance Index: -0.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0023
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0033
    Cell Significance Index: -0.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0036
    Cell Significance Index: -0.2000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0044
    Cell Significance Index: -0.1400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0049
    Cell Significance Index: -0.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0054
    Cell Significance Index: -0.1600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0056
    Cell Significance Index: -0.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0057
    Cell Significance Index: -0.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0061
    Cell Significance Index: -0.2700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0064
    Cell Significance Index: -0.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0067
    Cell Significance Index: -0.1300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0069
    Cell Significance Index: -0.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0069
    Cell Significance Index: -0.2600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0069
    Cell Significance Index: -0.0800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0070
    Cell Significance Index: -0.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0071
    Cell Significance Index: -0.2300
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0072
    Cell Significance Index: -0.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0073
    Cell Significance Index: -0.2400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0079
    Cell Significance Index: -0.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0090
    Cell Significance Index: -0.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0091
    Cell Significance Index: -0.2600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0092
    Cell Significance Index: -0.1800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0094
    Cell Significance Index: -0.1000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0095
    Cell Significance Index: -0.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0096
    Cell Significance Index: -0.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0100
    Cell Significance Index: -0.2600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0101
    Cell Significance Index: -0.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0101
    Cell Significance Index: -0.2400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0102
    Cell Significance Index: -0.1400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0102
    Cell Significance Index: -0.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0102
    Cell Significance Index: -0.2500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0104
    Cell Significance Index: -0.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0106
    Cell Significance Index: -0.2700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0107
    Cell Significance Index: -0.1400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0112
    Cell Significance Index: -0.0900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0118
    Cell Significance Index: -0.1400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0119
    Cell Significance Index: -0.1700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0120
    Cell Significance Index: -0.2600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0123
    Cell Significance Index: -0.2600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0125
    Cell Significance Index: -0.1600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0132
    Cell Significance Index: -0.1600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0132
    Cell Significance Index: -0.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0134
    Cell Significance Index: -0.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0137
    Cell Significance Index: -0.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0137
    Cell Significance Index: -0.2700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0137
    Cell Significance Index: -0.2700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0139
    Cell Significance Index: -0.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0145
    Cell Significance Index: -0.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DMRTB1 is a transcription factor gene that belongs to the DMRT family, which is conserved across species. The gene's structure features a proline-rich C-terminal domain, which is essential for its function. The protein product, DMRTB_HUMAN, exhibits a high degree of sequence homology with other DMRT family members, suggesting a shared evolutionary origin. The gene's expression is significantly elevated in germ cells, immune cells, and progenitor cells, indicating its critical role in these cell types. **Pathways and Functions:** DMRTB1 is involved in several biological pathways, including: 1. **Germ Cell Development:** DMRTB1 is essential for the proper development and differentiation of germ cells, particularly in the formation of sex-specific gonads. 2. **Sex Differentiation:** The gene plays a crucial role in regulating sex-specific gene expression, influencing the development of male and female reproductive organs. 3. **Immune Regulation:** DMRTB1 is expressed in immune cells, such as T cells and dendritic cells, where it may modulate immune responses and inflammation. 4. **Chromatin Remodeling:** The gene's ability to interact with chromatin and RNA polymerase II suggests its role in regulating gene expression and transcriptional control. **Clinical Significance:** The study of DMRTB1 has significant implications for our understanding of reproductive and immune disorders. Abnormalities in DMRTB1 expression have been linked to: 1. **Sex-Determining Disorders:** Mutations in DMRTB1 have been associated with sex-determining disorders, such as Klinefelter syndrome and Turner syndrome. 2. **Immune-Related Diseases:** Dysregulation of DMRTB1 in immune cells may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Reproductive Cancers:** Alterations in DMRTB1 expression have been observed in certain reproductive cancers, such as testicular cancer and ovarian cancer. In conclusion, DMRTB1 is a multifunctional gene that plays a critical role in regulating sex differentiation, germ cell development, and immune responses. Its dysregulation has been implicated in various reproductive and immune disorders, highlighting the need for further research into the molecular mechanisms underlying DMRTB1's functions.

Genular Protein ID: 3432715477

Symbol: DMRTB_HUMAN

Name: Doublesex- and mab-3-related transcription factor B1

UniProtKB Accession Codes:

Q96MA1 Q96SD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 11863363

Title: Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination.

PubMed ID: 11863363

DOI: 10.1006/geno.2002.6711

Sequence Information:

  • Length: 342
  • Mass: 36205
  • Checksum: 18B0D5B0A6DB03EB
  • Sequence:
    • MADKMVRTPK CSRCRNHGFL VPVKGHAGKC RWKQCLCEKC YLISERQKIM AAQKVLKTQA 
AEEEQEAALC AQGPKQASGA AAAAPAPVPV PAASLRPLSP GTPSGDADPG PEGRAAACFF 
EQPPRGRNPG PRALQPVLGG RSHVEPSERA AVAMPSLAGP PFGAEAAGSG YPGPLDLRRP 
MRTVPGPLFT DFVRPLNINP DRALGPEYPG GSSMHPYCPF PLGYLDAPPG VPLQQGFRHV 
SRSQYQGGGL VSEPGGDFQP SYYLPPPPPP LPPLPPLPPQ PQFLPPGYLS ALHFLPPPPP 
PPPPSSFSLT VLFDTDKENT DDQDAEVLSG EPSQPSSQEQ SD

Genular Protein ID: 3694147118

Symbol: I6L9A0_HUMAN

Name: N/A

UniProtKB Accession Codes:

I6L9A0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 IntAct 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 189
  • Mass: 20136
  • Checksum: 460F9DDC9762F8EF
  • Sequence:
    • MPSLAGPPFG AEAAGSGYPG PLDLRRPMRT VPGPLFTDFV RPLNINPDRA LGPEYPGGSS 
MHPYCPFPLG YLDAPPGVPL QQGFRHVSRS QYQGGGLVSE PGGDFQPSYY LPPPPPPLPP 
LPPLPPQPQF LPPGYLSALH FLPPPPPPPP PSSFSLTVLF DTDKENTDDQ DAEVLSGEPS 
QPSSQEQSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.