Details for: CRIPTO3

Gene ID: 6998

Symbol: CRIPTO3

Ensembl ID: ENSG00000225366

Description: cripto, EGF-CFC family member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.2232
    Cell Significance Index: 3.1000
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1449
    Cell Significance Index: 1.7400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.1386
    Cell Significance Index: 1.5100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1325
    Cell Significance Index: 1.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1202
    Cell Significance Index: 3.2200
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0913
    Cell Significance Index: 1.0800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.0201
    Cell Significance Index: 0.4200
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.0161
    Cell Significance Index: 0.1700
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0148
    Cell Significance Index: 0.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0075
    Cell Significance Index: 0.1100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0021
    Cell Significance Index: 0.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0019
    Cell Significance Index: 0.0900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0024
    Cell Significance Index: -0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0026
    Cell Significance Index: -0.5200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0039
    Cell Significance Index: -0.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0047
    Cell Significance Index: -0.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0058
    Cell Significance Index: -0.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0072
    Cell Significance Index: -0.1800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0096
    Cell Significance Index: -0.1900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0096
    Cell Significance Index: -0.1900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0099
    Cell Significance Index: -0.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0107
    Cell Significance Index: -0.3500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0119
    Cell Significance Index: -0.1100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0138
    Cell Significance Index: -0.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0153
    Cell Significance Index: -0.3300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0156
    Cell Significance Index: -0.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0202
    Cell Significance Index: -0.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0206
    Cell Significance Index: -0.4500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0229
    Cell Significance Index: -0.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0358
    Cell Significance Index: -0.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0384
    Cell Significance Index: -0.7600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0513
    Cell Significance Index: -0.5900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0526
    Cell Significance Index: -0.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0552
    Cell Significance Index: -1.5000
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0597
    Cell Significance Index: -0.6800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0616
    Cell Significance Index: -0.7000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0662
    Cell Significance Index: -0.7100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0699
    Cell Significance Index: -0.8000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0724
    Cell Significance Index: -0.8900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0732
    Cell Significance Index: -0.7600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0744
    Cell Significance Index: -0.8500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0783
    Cell Significance Index: -0.7300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0809
    Cell Significance Index: -0.9000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0833
    Cell Significance Index: -1.0400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0901
    Cell Significance Index: -0.9500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0916
    Cell Significance Index: -0.9400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0924
    Cell Significance Index: -1.1700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0928
    Cell Significance Index: -1.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0940
    Cell Significance Index: -1.1200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0945
    Cell Significance Index: -1.3300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0953
    Cell Significance Index: -0.9400
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0967
    Cell Significance Index: -1.1200
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.1000
    Cell Significance Index: -1.1100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1003
    Cell Significance Index: -1.2000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1006
    Cell Significance Index: -0.6300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1011
    Cell Significance Index: -1.1200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1020
    Cell Significance Index: -1.1200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1035
    Cell Significance Index: -1.3000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1043
    Cell Significance Index: -1.4300
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1101
    Cell Significance Index: -1.1600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1107
    Cell Significance Index: -1.2000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1124
    Cell Significance Index: -0.9300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1129
    Cell Significance Index: -1.0600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1161
    Cell Significance Index: -1.2900
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.1169
    Cell Significance Index: -1.1600
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.1223
    Cell Significance Index: -1.1400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1259
    Cell Significance Index: -1.3500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1287
    Cell Significance Index: -1.1600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1296
    Cell Significance Index: -1.1900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1351
    Cell Significance Index: -1.1900
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1361
    Cell Significance Index: -1.1900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1391
    Cell Significance Index: -1.0700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1454
    Cell Significance Index: -1.2000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1461
    Cell Significance Index: -1.3600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1510
    Cell Significance Index: -1.3000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1532
    Cell Significance Index: -1.3400
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1740
    Cell Significance Index: -1.5700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1776
    Cell Significance Index: -1.3800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1878
    Cell Significance Index: -1.7800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2337
    Cell Significance Index: -1.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Cripto3 is a type II transmembrane protein that belongs to the EGF-CFC family, which is characterized by the presence of an EGF-like domain and a Cripto/FRL1/Cripto (CFR) motif. The protein is expressed in various tissues and cell types, including embryonic stem cells, immune cells, and cells of the central nervous system. Cripto3 is highly conserved across species, suggesting its importance in fundamental biological processes. **Pathways and Functions:** Cripto3's primary function is to activate the Nodal signaling pathway, which is crucial for anterior/posterior pattern specification, blood vessel development, and determination of left/right symmetry. The Nodal signaling pathway involves the binding of Cripto3 to the Nodal ligand, which activates the Smad2/3 pathway, leading to the transcription of target genes involved in these developmental processes. In addition to its role in developmental biology, Cripto3 has been implicated in the regulation of signaling by Nodal, growth factor activity, and cell surface signaling. **Clinical Significance:** Cripto3's expression has been observed in various types of cancers, including malignant cell tumors, suggesting its potential as a biomarker for cancer diagnosis and treatment. Furthermore, its involvement in the Nodal signaling pathway has led to its investigation as a therapeutic target for diseases involving abnormal development and patterning, such as congenital heart defects and left/right asymmetry disorders. In the context of immunology, Cripto3's expression in immune cells, such as dendritic cells and microglial cells, highlights its potential role in modulating immune responses. In conclusion, Cripto3 is a multifunctional protein that plays a crucial role in developmental biology and immunology. Its involvement in the Nodal signaling pathway and its expression in a wide range of cell types make it an attractive target for further research and potential therapeutic applications. Further studies are needed to fully elucidate the complexities of Cripto3 and its role in human disease. **Recommendations for Future Research:** 1. Investigate the role of Cripto3 in cancer diagnosis and treatment. 2. Elucidate the mechanisms by which Cripto3 regulates signaling by Nodal. 3. Examine the potential of Cripto3 as a therapeutic target for diseases involving abnormal development and patterning. 4. Explore the immunological functions of Cripto3 and its potential role in modulating immune responses. By continuing to investigate the complexities of Cripto3, we can gain a deeper understanding of its role in fundamental biological processes and its potential applications in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.