Gene RAB7A - ENSG00000075785 | NCBI Gene ID: 7879

Details for: RAB7A

Gene ID: 7879

Symbol: RAB7A

Ensembl ID: ENSG00000075785

Description: RAB7A, member RAS oncogene family

Associated with

Adaptive immune system
(R-HSA-1280218)
Bacterial infection pathways
(R-HSA-9824439)
Cdc42 gtpase cycle
(R-HSA-9013148)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infection with mycobacterium tuberculosis
(R-HSA-9635486)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Neutrophil degranulation
(R-HSA-6798695)
Post-translational protein modification
(R-HSA-597592)
Prevention of phagosomal-lysosomal fusion
(R-HSA-9636383)
Rab gefs exchange gtp for gdp on rabs
(R-HSA-8876198)
Rab geranylgeranylation
(R-HSA-8873719)
Rab regulation of trafficking
(R-HSA-9007101)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Response of mtb to phagocytosis
(R-HSA-9637690)
Rhod gtpase cycle
(R-HSA-9013405)
Rhof gtpase cycle
(R-HSA-9035034)
Rhog gtpase cycle
(R-HSA-9013408)
Rho gtpase cycle
(R-HSA-9012999)
Rhoh gtpase cycle
(R-HSA-9013407)
Rhoj gtpase cycle
(R-HSA-9013409)
Rhoq gtpase cycle
(R-HSA-9013406)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Suppression of autophagy
(R-HSA-9636569)
Suppression of phagosomal maturation
(R-HSA-9637687)
Tbc/rabgaps
(R-HSA-8854214)
Vesicle-mediated transport
(R-HSA-5653656)
Alveolar lamellar body
(GO:0097208)
Autophagosome assembly
(GO:0000045)
Autophagosome membrane
(GO:0000421)
Bone resorption
(GO:0045453)
Cytosol
(GO:0005829)
Early endosome to late endosome transport
(GO:0045022)
Endocytosis
(GO:0006897)
Endosome membrane
(GO:0010008)
Endosome to lysosome transport
(GO:0008333)
Endosome to plasma membrane protein transport
(GO:0099638)
Epidermal growth factor catabolic process
(GO:0007174)
Establishment of vesicle localization
(GO:0051650)
Extracellular exosome
(GO:0070062)
Gdp binding
(GO:0019003)
Golgi apparatus
(GO:0005794)
G protein activity
(GO:0003925)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Intracellular transport
(GO:0046907)
Late endosome
(GO:0005770)
Late endosome membrane
(GO:0031902)
Lipid catabolic process
(GO:0016042)
Lipid droplet
(GO:0005811)
Lipophagy
(GO:0061724)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Melanosome membrane
(GO:0033162)
Mitochondrial membrane
(GO:0031966)
Mitochondrion
(GO:0005739)
Negative regulation of exosomal secretion
(GO:1903542)
Negative regulation of intralumenal vesicle formation
(GO:1905366)
Phagocytic vesicle
(GO:0045335)
Phagocytic vesicle membrane
(GO:0030670)
Phagophore assembly site membrane
(GO:0034045)
Phagosome-lysosome fusion
(GO:0090385)
Phagosome acidification
(GO:0090383)
Phagosome maturation
(GO:0090382)
Plasma membrane
(GO:0005886)
Positive regulation of exosomal secretion
(GO:1903543)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of viral process
(GO:0048524)
Protein binding
(GO:0005515)
Protein targeting to lysosome
(GO:0006622)
Protein to membrane docking
(GO:0022615)
Protein transport
(GO:0015031)
Response to bacterium
(GO:0009617)
Retrograde transport, endosome to golgi
(GO:0042147)
Retromer complex
(GO:0030904)
Retromer complex binding
(GO:1905394)
Secretory granule membrane
(GO:0030667)
Small gtpase binding
(GO:0031267)
Synaptic vesicle membrane
(GO:0030672)
Viral release from host cell
(GO:0019076)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.32
Marker Score: 112881
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 3.24
Marker Score: 8112.5
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.18
Marker Score: 7755.5
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.73
Marker Score: 10523
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.62
Marker Score: 3803
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.61
Marker Score: 3774
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.58
Marker Score: 1074
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.56
Marker Score: 2014
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.53
Marker Score: 56522
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.5
Marker Score: 1454
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.5
Marker Score: 2628
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.44
Marker Score: 10218
Cell Name: blood cell (CL0000081)
Fold Change: 2.42
Marker Score: 28188
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.4
Marker Score: 134454
Cell Name: decidual cell (CL2000002)
Fold Change: 2.4
Marker Score: 10338
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.39
Marker Score: 20610
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.38
Marker Score: 1621
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.38
Marker Score: 5220
Cell Name: microglial cell (CL0000129)
Fold Change: 2.38
Marker Score: 4325
Cell Name: basal cell (CL0000646)
Fold Change: 2.37
Marker Score: 3064
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.37
Marker Score: 2019
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.37
Marker Score: 60575
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.36
Marker Score: 41949
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 2.35
Marker Score: 1142
Cell Name: melanocyte (CL0000148)
Fold Change: 2.34
Marker Score: 949
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.34
Marker Score: 559
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.33
Marker Score: 4540
Cell Name: erythroblast (CL0000765)
Fold Change: 2.33
Marker Score: 1453
Cell Name: stromal cell (CL0000499)
Fold Change: 2.32
Marker Score: 2721
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.31
Marker Score: 4697
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 2.31
Marker Score: 940.5
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 2.28
Marker Score: 2150
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 2.26
Marker Score: 563
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.26
Marker Score: 713
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 2.25
Marker Score: 2066
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.24
Marker Score: 5417
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.24
Marker Score: 2710
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.24
Marker Score: 1938
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 2.24
Marker Score: 563
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.23
Marker Score: 3779.5
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.23
Marker Score: 5558
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.22
Marker Score: 2539
Cell Name: neutrophil (CL0000775)
Fold Change: 2.21
Marker Score: 1348
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.2
Marker Score: 5767
Cell Name: ependymal cell (CL0000065)
Fold Change: 2.2
Marker Score: 766
Cell Name: podocyte (CL0000653)
Fold Change: 2.19
Marker Score: 811
Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.18
Marker Score: 788
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.18
Marker Score: 6015
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.17
Marker Score: 16906
Cell Name: lactocyte (CL0002325)
Fold Change: 2.16
Marker Score: 34669
Cell Name: fibroblast (CL0000057)
Fold Change: 2.15
Marker Score: 2077
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 2.15
Marker Score: 1357
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.15
Marker Score: 5459
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.15
Marker Score: 1925
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.14
Marker Score: 4477.5
Cell Name: secretory cell (CL0000151)
Fold Change: 2.13
Marker Score: 3891
Cell Name: club cell (CL0000158)
Fold Change: 2.13
Marker Score: 2482
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.13
Marker Score: 868
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.12
Marker Score: 1055
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.12
Marker Score: 1168
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.12
Marker Score: 2264
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.12
Marker Score: 2375
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.11
Marker Score: 3743
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.11
Marker Score: 13736
Cell Name: astrocyte (CL0000127)
Fold Change: 2.1
Marker Score: 1823
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.1
Marker Score: 3450
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.1
Marker Score: 2258
Cell Name: dendritic cell (CL0000451)
Fold Change: 2.1
Marker Score: 1438
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.09
Marker Score: 1195
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.09
Marker Score: 709
Cell Name: adventitial cell (CL0002503)
Fold Change: 2.09
Marker Score: 517
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.08
Marker Score: 3314
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.08
Marker Score: 8171
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.07
Marker Score: 3330
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.06
Marker Score: 2062.5
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 2.04
Marker Score: 2196
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 2.03
Marker Score: 1069
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.03
Marker Score: 8291
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.02
Marker Score: 786
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 2.02
Marker Score: 918
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 2.01
Marker Score: 591
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2
Marker Score: 2305
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2
Marker Score: 42706
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2
Marker Score: 3392
Cell Name: pericyte (CL0000669)
Fold Change: 1.99
Marker Score: 1164
Cell Name: fat cell (CL0000136)
Fold Change: 1.99
Marker Score: 1113
Cell Name: basophil (CL0000767)
Fold Change: 1.99
Marker Score: 945
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.99
Marker Score: 2162
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.98
Marker Score: 12656
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 1.98
Marker Score: 488
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.98
Marker Score: 3949
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.97
Marker Score: 2908
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.97
Marker Score: 2180
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.97
Marker Score: 962.5
Cell Name: Schwann cell (CL0002573)
Fold Change: 1.97
Marker Score: 683
Cell Name: kidney cell (CL1000497)
Fold Change: 1.97
Marker Score: 1313
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.97
Marker Score: 741
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 1.96
Marker Score: 450
Cell Name: acinar cell (CL0000622)
Fold Change: 1.96
Marker Score: 1382
Cell Name: Unknown (CL0000548)
Fold Change: 1.96
Marker Score: 1425

Hover over a box to see details here...

**Key Characteristics** RAB7A is a small GTPase that belongs to the RAS superfamily of proteins. It is characterized by its ability to bind and hydrolyze GTP, which regulates its activity and interactions with other proteins. RAB7A is highly expressed in cells involved in immune response, such as neutrophils and macrophages, where it regulates phagosome maturation and autophagy. Additionally, RAB7A is involved in the regulation of endocytosis, exocytosis, and vesicle trafficking, which are essential for maintaining cellular homeostasis. **Pathways and Functions** RAB7A is involved in several cellular pathways, including: 1. **Autophagy**: RAB7A regulates autophagosome assembly and maturation, which is essential for the degradation of damaged or dysfunctional cellular components. 2. **Vesicular Transport**: RAB7A regulates the transport of vesicles between the endoplasmic reticulum, Golgi apparatus, and lysosomes, which is essential for maintaining cellular homeostasis. 3. **Immune Response**: RAB7A regulates phagosome maturation and autophagy, which are essential for the elimination of pathogens and the presentation of antigens to the immune system. 4. **Endocytosis and Exocytosis**: RAB7A regulates the transport of endocytosed molecules to the Golgi apparatus and lysosomes, which is essential for the regulation of cellular homeostasis. 5. **Cell Signaling**: RAB7A regulates the activity of downstream effectors, such as Rho GTPases, which are involved in cell signaling and cytoskeletal remodeling. **Clinical Significance** Dysregulation of RAB7A has been implicated in various diseases, including: 1. **Autophagy-related disorders**: Mutations in RAB7A have been associated with autophagy-related disorders, such as Birt-Hogg-Dubé syndrome and Li-Fraumeni syndrome. 2. **Immune disorders**: RAB7A is involved in the regulation of immune response, and dysregulation of RAB7A has been implicated in immune disorders, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer**: RAB7A is involved in the regulation of cell growth and survival, and dysregulation of RAB7A has been implicated in the development of various cancers, including breast cancer and lung cancer. In conclusion, RAB7A is a small GTPase that plays a crucial role in various cellular processes, including vesicular transport, autophagy, and immune response. Its dysregulation has been implicated in various diseases, and further research is needed to understand the mechanisms underlying its involvement in disease pathology.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

RAB7A_HUMAN

Genular Protein ID: 4210262283

Symbol: RAB7A_HUMAN

Name: N/A

UniProtKB Accession Codes:

P51149 A8K3V6 Q9NWJ0 Q9UPB0

Database IDs:

Citations:

PubMed ID: 8954989

Title: Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid.

PubMed ID: 8954989

DOI: 10.1006/bbrc.1996.1897

PubMed ID: 9126495

Title: Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene.

PubMed ID: 9126495

DOI: 10.1006/geno.1997.4644

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11179213

Title: Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes.

PubMed ID: 11179213

DOI: 10.1093/emboj/20.4.683

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 12944476

Title: Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP.

PubMed ID: 12944476

DOI: 10.1128/mcb.23.18.6494-6506.2003

PubMed ID: 14617358

Title: Human VPS34 and p150 are Rab7 interacting partners.

PubMed ID: 14617358

DOI: 10.1034/j.1600-0854.2003.00133.x

PubMed ID: 14998988

Title: The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes.

PubMed ID: 14998988

DOI: 10.1074/jbc.m401022200

PubMed ID: 14668488

Title: A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34.

PubMed ID: 14668488

DOI: 10.1091/mbc.e03-06-0413

PubMed ID: 16176980

Title: The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments.

PubMed ID: 16176980

DOI: 10.1091/mbc.e05-03-0189

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16925951

Title: Novel RING E3 ubiquitin ligases in breast cancer.

PubMed ID: 16925951

DOI: 10.1593/neo.06469

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19392663

Title: Rab7: roles in membrane trafficking and disease.

PubMed ID: 19392663

DOI: 10.1042/bsr20090032

PubMed ID: 20048159

Title: Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9.

PubMed ID: 20048159

DOI: 10.1074/jbc.m109.069088

PubMed ID: 20100911

Title: FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport.

PubMed ID: 20100911

DOI: 10.1083/jcb.200907015

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20851765

Title: Rab7: role of its protein interaction cascades in endo-lysosomal traffic.

PubMed ID: 20851765

DOI: 10.1016/j.cellsig.2010.09.012

PubMed ID: 21255211

Title: Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.

PubMed ID: 21255211

DOI: 10.1111/j.1600-0854.2011.01165.x

PubMed ID: 22261744

Title: Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments.

PubMed ID: 22261744

DOI: 10.1007/s00018-011-0913-1

PubMed ID: 22431521

Title: The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.

PubMed ID: 22431521

DOI: 10.1128/mcb.06726-11

PubMed ID: 22660413

Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

PubMed ID: 22660413

DOI: 10.1038/ncb2502

PubMed ID: 23179371

Title: Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin.

PubMed ID: 23179371

DOI: 10.1007/s00401-012-1063-8

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26416964

Title: RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.

PubMed ID: 26416964

DOI: 10.1083/jcb.201501059

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28325809

Title: The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.

PubMed ID: 28325809

DOI: 10.1083/jcb.201607085

PubMed ID: 30709847

Title: VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation.

PubMed ID: 30709847

DOI: 10.1242/dmm.036681

PubMed ID: 33147445

Title: Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.

PubMed ID: 33147445

DOI: 10.1016/j.cell.2020.10.030

PubMed ID: 34432599

Title: C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

PubMed ID: 34432599

DOI: 10.1080/15548627.2021.1960116

PubMed ID: 34159616

Title: TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells.

PubMed ID: 34159616

DOI: 10.15252/embj.2021107821

PubMed ID: 36476874

Title: USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction.

PubMed ID: 36476874

DOI: 10.1016/j.celrep.2022.111653

PubMed ID: 15933719

Title: Structural basis for recruitment of RILP by small GTPase Rab7.

PubMed ID: 15933719

DOI: 10.1038/sj.emboj.7600643

PubMed ID: 20028791

Title: Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation.

PubMed ID: 20028791

DOI: 10.1093/hmg/ddp567

PubMed ID: 12545426

Title: Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy.

PubMed ID: 12545426

DOI: 10.1086/367847

PubMed ID: 15455439

Title: A novel RAB7 mutation associated with ulcero-mutilating neuropathy.

PubMed ID: 15455439

DOI: 10.1002/ana.20281

PubMed ID: 17060578

Title: Charcot-Marie-Tooth disease due to a de novo mutation of the RAB7 gene.

PubMed ID: 17060578

DOI: 10.1212/01.wnl.0000240068.21499.f5

PubMed ID: 21151572

Title: Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling.

PubMed ID: 21151572

DOI: 10.1371/journal.pone.0015351

Sequence Information:

Length: 207
Mass: 23490
Checksum: A2AF33B16A672971
Sequence:

MTSRKKVLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV MVDDRLVTMQ 
IWDTAGQERF QSLGVAFYRG ADCCVLVFDV TAPNTFKTLD SWRDEFLIQA SPRDPENFPF 
VVLGNKIDLE NRQVATKRAQ AWCYSKNNIP YFETSAKEAI NVEQAFQTIA RNALKQETEV 
ELYNEFPEPI KLDKNDRAKA SAESCSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RAB7A

Associated with

Cells (max top 100)

Other Information

Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid. PubMed ID: 8954989

Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene. PubMed ID: 9126495

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. PubMed ID: 11179213

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. PubMed ID: 12643545

Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP. PubMed ID: 12944476

Human VPS34 and p150 are Rab7 interacting partners. PubMed ID: 14617358

The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes. PubMed ID: 14998988

A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. PubMed ID: 14668488

The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments. PubMed ID: 16176980

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

Novel RING E3 ubiquitin ligases in breast cancer. PubMed ID: 16925951

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Rab7: roles in membrane trafficking and disease. PubMed ID: 19392663

Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9. PubMed ID: 20048159

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. PubMed ID: 20100911

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Rab7: role of its protein interaction cascades in endo-lysosomal traffic. PubMed ID: 20851765

Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. PubMed ID: 21255211

Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments. PubMed ID: 22261744

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting. PubMed ID: 22431521

Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. PubMed ID: 22660413

Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin. PubMed ID: 23179371

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4. PubMed ID: 26416964

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes. PubMed ID: 28325809

VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation. PubMed ID: 30709847

Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. PubMed ID: 33147445

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy. PubMed ID: 34432599

TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells. PubMed ID: 34159616

USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction. PubMed ID: 36476874

Structural basis for recruitment of RILP by small GTPase Rab7. PubMed ID: 15933719

Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. PubMed ID: 20028791

Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. PubMed ID: 12545426

A novel RAB7 mutation associated with ulcero-mutilating neuropathy. PubMed ID: 15455439

Charcot-Marie-Tooth disease due to a de novo mutation of the RAB7 gene. PubMed ID: 17060578

Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling. PubMed ID: 21151572