Details for: OR2B2

Gene ID: 81697

Symbol: OR2B2

Ensembl ID: ENSG00000168131

Description: olfactory receptor family 2 subfamily B member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.0118
    Cell Significance Index: 76.7400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.9109
    Cell Significance Index: 15.5700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2735
    Cell Significance Index: 3.7500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.0508
    Cell Significance Index: 0.6000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0469
    Cell Significance Index: 0.4900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0413
    Cell Significance Index: 0.4000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0170
    Cell Significance Index: 0.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0015
    Cell Significance Index: -0.0300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0033
    Cell Significance Index: -0.0500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0043
    Cell Significance Index: -0.0400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0091
    Cell Significance Index: -0.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0094
    Cell Significance Index: -0.2500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0120
    Cell Significance Index: -0.1500
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.0129
    Cell Significance Index: -0.1300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0133
    Cell Significance Index: -0.1700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0143
    Cell Significance Index: -0.1800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0151
    Cell Significance Index: -0.1800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0152
    Cell Significance Index: -0.1800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0155
    Cell Significance Index: -0.1800
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0168
    Cell Significance Index: -0.1300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0178
    Cell Significance Index: -0.2200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0179
    Cell Significance Index: -0.1800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0184
    Cell Significance Index: -0.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0211
    Cell Significance Index: -6.0700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0252
    Cell Significance Index: -0.2100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0254
    Cell Significance Index: -0.2100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0269
    Cell Significance Index: -0.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0274
    Cell Significance Index: -5.5000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0281
    Cell Significance Index: -0.1900
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0282
    Cell Significance Index: -0.3500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0332
    Cell Significance Index: -0.3000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0337
    Cell Significance Index: -0.2900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0391
    Cell Significance Index: -0.3700
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.0399
    Cell Significance Index: -0.2800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0430
    Cell Significance Index: -0.2800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0455
    Cell Significance Index: -0.2700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0584
    Cell Significance Index: -0.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0855
    Cell Significance Index: -5.7500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1034
    Cell Significance Index: -1.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1100
    Cell Significance Index: -6.1700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1301
    Cell Significance Index: -1.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1619
    Cell Significance Index: -6.1300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1636
    Cell Significance Index: -1.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1707
    Cell Significance Index: -5.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1755
    Cell Significance Index: -5.5900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1798
    Cell Significance Index: -1.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1803
    Cell Significance Index: -4.8300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2034
    Cell Significance Index: -2.4200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2060
    Cell Significance Index: -2.3700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2201
    Cell Significance Index: -5.4900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2334
    Cell Significance Index: -3.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2406
    Cell Significance Index: -4.8300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2422
    Cell Significance Index: -4.7900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2499
    Cell Significance Index: -5.4000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2586
    Cell Significance Index: -3.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2601
    Cell Significance Index: -5.5200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2624
    Cell Significance Index: -4.2200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2630
    Cell Significance Index: -5.4900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2690
    Cell Significance Index: -2.7900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2772
    Cell Significance Index: -4.2100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2813
    Cell Significance Index: -5.6100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2961
    Cell Significance Index: -3.4400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2968
    Cell Significance Index: -4.1600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2975
    Cell Significance Index: -4.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2983
    Cell Significance Index: -3.2500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3008
    Cell Significance Index: -3.6600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3034
    Cell Significance Index: -3.3600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3125
    Cell Significance Index: -4.0200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.3128
    Cell Significance Index: -3.7300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3153
    Cell Significance Index: -4.1500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3190
    Cell Significance Index: -3.7000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3193
    Cell Significance Index: -5.5200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3277
    Cell Significance Index: -4.3000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3299
    Cell Significance Index: -6.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3333
    Cell Significance Index: -6.1600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3362
    Cell Significance Index: -4.9000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3363
    Cell Significance Index: -4.3900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3739
    Cell Significance Index: -4.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3862
    Cell Significance Index: -5.5300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.4175
    Cell Significance Index: -5.7900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4353
    Cell Significance Index: -5.3500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.4406
    Cell Significance Index: -4.9000
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.4408
    Cell Significance Index: -5.0800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4426
    Cell Significance Index: -4.9500
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.4448
    Cell Significance Index: -4.9800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.4465
    Cell Significance Index: -5.7900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4596
    Cell Significance Index: -5.2600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4627
    Cell Significance Index: -5.7800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.4773
    Cell Significance Index: -5.4200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.4810
    Cell Significance Index: -5.7100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.5072
    Cell Significance Index: -5.3500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5139
    Cell Significance Index: -5.5100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.5441
    Cell Significance Index: -6.4300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.5447
    Cell Significance Index: -5.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR2B2 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family, which is characterized by its seven transmembrane domains and the presence of a conserved extracellular N-terminus. The OR2B2 gene is located on chromosome 11q13.1 and is part of the olfactory receptor subfamily B. The protein product, OR2B2_HUMAN, is a GPCR that can bind to odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. **Pathways and Functions:** OR2B2 is involved in several signaling pathways, including: 1. **Detection of chemical stimulus involved in sensory perception of smell:** OR2B2 binds to odorant molecules, triggering a G protein-coupled signaling cascade that activates downstream effectors, leading to the perception of smell. 2. **Expression and translocation of olfactory receptors:** OR2B2 is involved in the expression and translocation of olfactory receptors to the plasma membrane, where they can interact with odorant molecules. 3. **G protein-coupled receptor activity:** OR2B2 is a GPCR that can activate G proteins, leading to the activation of downstream effectors, such as adenylyl cyclase. 4. **G protein-coupled receptor signaling pathway:** OR2B2 is part of the G protein-coupled receptor signaling pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and survival. 5. **Olfactory receptor activity:** OR2B2 is an olfactory receptor that can bind to odorant molecules, triggering a signaling cascade that leads to the perception of smell. 6. **Olfactory signaling pathway:** OR2B2 is part of the olfactory signaling pathway, which is involved in the detection of chemical stimuli involved in sensory perception of smell. **Clinical Significance:** OR2B2 has been implicated in various diseases and disorders, including: 1. **Olfactory disorders:** OR2B2 has been associated with olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Neurodegenerative diseases:** OR2B2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer:** OR2B2 has been found to be overexpressed in certain types of cancer, including glioblastoma and osteosarcoma. 4. **Infectious diseases:** OR2B2 has been implicated in infectious diseases, such as tuberculosis and malaria. In conclusion, OR2B2 is a key player in the detection of chemical stimuli involved in sensory perception of smell, but its functions extend beyond olfaction. Further research is needed to fully understand the clinical significance of OR2B2 and its role in various diseases and disorders.

Genular Protein ID: 3289717607

Symbol: OR2B2_HUMAN

Name: Olfactory receptor 2B2

UniProtKB Accession Codes:

Q9GZK3 B2RNH2 Q9GZL2 Q9Y299

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 357
  • Mass: 40412
  • Checksum: 53E2F82820EC440A
  • Sequence:
    • MNWVNKSVPQ EFILLVFSDQ PWLEIPPFVM FLFSYILTIF GNLTIILVSH VDFKLHTPMY 
FFLSNLSLLD LCYTTSTVPQ MLVNICNTRK VISYGGCVAQ LFIFLALGST ECLLLAVMCF 
DRFVAICRPL HYSIIMHQRL CFQLAAASWI SGFSNSVLQS TWTLKMPLCG HKEVDHFFCE 
VPALLKLSCV DTTANEAELF FISVLFLLIP VTLILISYAF IVQAVLRIQS AEGQRKAFGT 
CGSHLIVVSL FYGTAISMYL QPPSPSSKDR GKMVSLFCGI IAPMLNPLIY TLRNKEVKEA 
FKRLVAKSLL NQEIRNMQMI SFAKDTVLTY LTNFSASCPI FVITIENYCN LPQRKFP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.