Details for: CFLAR

Gene ID: 8837

Symbol: CFLAR

Ensembl ID: ENSG00000003402

Description: CASP8 and FADD like apoptosis regulator

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.32
    Marker Score: 96,520
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.5
    Marker Score: 8,903
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.36
    Marker Score: 8,422
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.93
    Marker Score: 10,423
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.92
    Marker Score: 4,239
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.85
    Marker Score: 3,431
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.8
    Marker Score: 1,207
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.78
    Marker Score: 2,189
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.6
    Marker Score: 1,552
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.59
    Marker Score: 144,739
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.59
    Marker Score: 1,445
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.58
    Marker Score: 2,222
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.56
    Marker Score: 1,245
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.56
    Marker Score: 3,711
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.55
    Marker Score: 40,894
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.49
    Marker Score: 6,128
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.47
    Marker Score: 2,838
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.46
    Marker Score: 1,677
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.43
    Marker Score: 7,656
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.42
    Marker Score: 5,322
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.4
    Marker Score: 2,530
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.4
    Marker Score: 8,244
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.39
    Marker Score: 2,580
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.38
    Marker Score: 4,581
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.35
    Marker Score: 6,606
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.35
    Marker Score: 1,188
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.34
    Marker Score: 816
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.32
    Marker Score: 902
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.32
    Marker Score: 848
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.32
    Marker Score: 2,476
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.31
    Marker Score: 2,070
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.31
    Marker Score: 5,640
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.28
    Marker Score: 77,538
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.24
    Marker Score: 19,432
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.22
    Marker Score: 25,809
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.22
    Marker Score: 2,374
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 2.21
    Marker Score: 827
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.2
    Marker Score: 2,365
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.19
    Marker Score: 2,646
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.17
    Marker Score: 801
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.16
    Marker Score: 1,843
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.16
    Marker Score: 1,023
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.15
    Marker Score: 514
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.14
    Marker Score: 1,467
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.13
    Marker Score: 1,669
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.12
    Marker Score: 656
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.12
    Marker Score: 13,786
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.1
    Marker Score: 489
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.09
    Marker Score: 3,085
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.07
    Marker Score: 1,245
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.06
    Marker Score: 1,022
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.05
    Marker Score: 5,116
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.05
    Marker Score: 5,988
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.05
    Marker Score: 10,771
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.04
    Marker Score: 107,713
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.03
    Marker Score: 1,666
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.03
    Marker Score: 1,180
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.02
    Marker Score: 665
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.02
    Marker Score: 3,927
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.01
    Marker Score: 1,137
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.01
    Marker Score: 19,903
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.01
    Marker Score: 579
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.01
    Marker Score: 4,012
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 2.01
    Marker Score: 1,222
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2
    Marker Score: 2,033
  • Cell Name: club cell (CL0000158)
    Fold Change: 2
    Marker Score: 2,331
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2
    Marker Score: 2,486
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.99
    Marker Score: 1,831
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.99
    Marker Score: 2,166
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.98
    Marker Score: 8,223
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.98
    Marker Score: 503
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.97
    Marker Score: 491
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.97
    Marker Score: 802
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.96
    Marker Score: 5,266
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.96
    Marker Score: 578
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.95
    Marker Score: 792
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.95
    Marker Score: 1,645
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.95
    Marker Score: 2,519
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.94
    Marker Score: 732
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.94
    Marker Score: 477
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.94
    Marker Score: 672
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.93
    Marker Score: 494
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.92
    Marker Score: 376
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.92
    Marker Score: 1,094
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 1.9
    Marker Score: 493
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.9
    Marker Score: 3,462
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.89
    Marker Score: 1,710
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.89
    Marker Score: 1,087
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.88
    Marker Score: 1,260
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.88
    Marker Score: 1,654
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.87
    Marker Score: 463
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.87
    Marker Score: 660
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.86
    Marker Score: 2,506
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.86
    Marker Score: 1,743
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.86
    Marker Score: 4,485
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.86
    Marker Score: 420
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.85
    Marker Score: 509
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.84
    Marker Score: 3,505
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.84
    Marker Score: 795
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.83
    Marker Score: 6,505

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Apoptosis regulation:** CFLAR is a negative regulator of apoptosis, inhibiting caspase-8 activation and thereby preventing excessive cell death. 2. **Cellular localization:** CFLAR is expressed in various cell types, including cardiac myocytes, endothelial cells, skeletal muscle fibers, and immune cells. 3. **Signaling pathways:** CFLAR is involved in multiple signaling pathways, including the extrinsic apoptotic pathway, NF-κB signaling, and the ERK1/2 cascade. 4. **Protein binding:** CFLAR interacts with various proteins, including FADD, caspase-8, and TRAF2, to regulate apoptosis and other cellular processes. 5. **Dimerization:** CFLAR forms dimers with caspase-8, which is essential for inhibiting apoptosis. **Pathways and Functions:** CFLAR's involvement in various signaling pathways and cellular processes can be summarized as follows: 1. **Apoptosis:** CFLAR inhibits caspase-8 activation, thereby preventing excessive cell death. 2. **NF-κB signaling:** CFLAR regulates NF-κB activity, which is crucial for immune responses and inflammation. 3. **ERK1/2 cascade:** CFLAR promotes the activation of the ERK1/2 cascade, which regulates cell growth, differentiation, and survival. 4. **Cell growth and differentiation:** CFLAR regulates cellular processes, including cell growth, differentiation, and survival, in various cell types. 5. **Immune responses:** CFLAR is expressed in immune cells and regulates their activation and function. **Clinical Significance:** CFLAR's dysregulation has been implicated in various diseases, including: 1. **Cancer:** CFLAR's overexpression is observed in various types of cancer, where it contributes to tumor progression and resistance to apoptosis. 2. **Autoimmune diseases:** CFLAR's dysregulation is associated with autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurodegenerative diseases:** CFLAR's involvement in neurodegenerative diseases, such as Alzheimer's and Parkinson's, is an area of active research. 4. **Cardiovascular disease:** CFLAR's dysregulation is associated with cardiovascular disease, including atherosclerosis and cardiac hypertrophy. In conclusion, CFLAR is a critical regulator of apoptosis and other cellular processes, playing a pivotal role in maintaining tissue homeostasis and responding to external stimuli. Its dysregulation has been implicated in various diseases, highlighting the importance of CFLAR in understanding human disease and developing novel therapeutic strategies.

Genular Protein ID: 2648898646

Symbol: CFLAR_HUMAN

Name: CASP8 and FADD-like apoptosis regulator

UniProtKB Accession Codes:

O15519 B4DJE0 B7Z9F9 O14673 O14674 O14675 O15137 O15138 O15356 O15510 O43618 O43619 O43620 O60458 O60459 Q53TS6 Q54AF1 Q96TE4 Q9UEW1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 31 EPD 1 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 45 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 14 RNAct 1 Reactome 6 RefSeq 18 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9208847

Title: Casper is a FADD- and caspase-related inducer of apoptosis.

PubMed ID: 9208847

DOI: 10.1016/s1074-7613(00)80450-1

PubMed ID: 9326610

Title: MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death.

PubMed ID: 9326610

DOI: 10.1073/pnas.94.21.11333

PubMed ID: 9217161

Title: Inhibition of death receptor signals by cellular FLIP.

PubMed ID: 9217161

DOI: 10.1038/40657

PubMed ID: 9228018

Title: FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.

PubMed ID: 9228018

DOI: 10.1074/jbc.272.30.18542

PubMed ID: 9211860

Title: I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis.

PubMed ID: 9211860

DOI: 10.1074/jbc.272.28.17255

PubMed ID: 9289491

Title: CASH, a novel caspase homologue with death effector domains.

PubMed ID: 9289491

DOI: 10.1074/jbc.272.32.19641

PubMed ID: 9380701

Title: CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis.

PubMed ID: 9380701

DOI: 10.1073/pnas.94.20.10717

PubMed ID: 10200473

Title: Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.

PubMed ID: 10200473

DOI: 10.1038/sj.cdd.4400370

PubMed ID: 11161814

Title: Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2.

PubMed ID: 11161814

DOI: 10.1006/geno.2000.6392

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9880531

Title: The role of c-FLIP in modulation of CD95-induced apoptosis.

PubMed ID: 9880531

DOI: 10.1074/jbc.274.3.1541

PubMed ID: 10227994

Title: Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis.

PubMed ID: 10227994

PubMed ID: 12727877

Title: Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal.

PubMed ID: 12727877

DOI: 10.1093/emboj/cdg210

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

Sequence Information:

  • Length: 480
  • Mass: 55344
  • Checksum: 8C6D7E92AE1EB672
  • Sequence:
    • MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP 
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP 
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY 
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP 
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

Genular Protein ID: 4109926072

Symbol: Q59F61_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59F61

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 254
  • Mass: 29042
  • Checksum: 5171E44F113204B3
  • Sequence:
    • SKSRMSAEVI HQVEEALDTD EKEMLLFLCR DVAIDVVPPN VRDLLDILRE RGKLSVGDLA 
ELLYRVRRFD LLKRILKMDR KAVETHLLRN PHLVSDYRVL MAEIGEDLDK SDVSSLIFLM 
KDYMGRGKIS KEKSFLDLVV ELEKLNLVAP DQLDLLEKCL KNIHRIDLKT KIQKYKQSGG 
WNGTWMTKAS FSLWLEIASL YILHIPDLPT PLPCIFMISA KCCQAVLNIS VFKKESGICT 
GWQSYGHSGV LHVC

Genular Protein ID: 2315923885

Symbol: E9PAP3_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PAP3

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 250
  • Mass: 28584
  • Checksum: C5B5FEC0DD80FDF5
  • Sequence:
    • MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSGGWNGT 
WMTKASFSLW LEIASLYILH IPDLPTPLPC IFMISAKCCQ AVLNISVFKK ESGICTGWQS 
YGHSGVLHVC

Genular Protein ID: 1757378455

Symbol: B4E361_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E361

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 366
  • Mass: 41320
  • Checksum: B5D6D73C15DB3382
  • Sequence:
    • MAEIGEDLDK SDVSSLIFLM KDYMGRGKIS KEKSFLDLVV ELEKLNLVAP DQLDLLEKCL 
KNIHRIDLKT KIQKYKQSVQ GAGTSYRNVL QAAIQKSLKD PSNNFRLHNG RSKEQRLKEQ 
LGAQQEPVKK SIQESEAFLP QSIPEERYKM KSKPLGICLI IDCIGNETEL LRDTFTSLGY 
EVQKFLHLSM HGISQILGQF ACMPEHRDYD SFVCVLVSRG GSQSVYGVDQ THSGLPLHHI 
RRMFMGDSCP YLAGKPKMFF IQNYVVSEGQ LEDSSLLEVD GPAMKNVEFK AQERGLCTVH 
READFFWSLC TADMSLLEQS HSSPSLYLQC LSQKLRQERG TIPGSGITES KDMHFSSLGC 
ILLDVL

Genular Protein ID: 1619320215

Symbol: A0A336TY74_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A336TY74

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 4 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 Pfam 2 RefSeq 4 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 27690003

Title: Decreased Expression of SRSF2 Splicing Factor Inhibits Apoptotic Pathways in Renal Cancer.

PubMed ID: 27690003

Sequence Information:

  • Length: 462
  • Mass: 52551
  • Checksum: D4E0109CBA47EAA3
  • Sequence:
    • MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP 
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP 
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY 
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP 
SLYLQCLSQK LRQERGTIPG SGITESKDMH FSSLGCILLD VL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.