Details for: XAGE2

Gene ID: 9502

Symbol: XAGE2

Ensembl ID: ENSG00000155622

Description: X antigen family member 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 4.02
    Marker Score: 3,584
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.36
    Marker Score: 9,269
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.6
    Marker Score: 10,629
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.49
    Marker Score: 1,221
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,581
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,657
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.06
    Marker Score: 584
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,733
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,331
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 738
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.56
    Marker Score: 769
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.42
    Marker Score: 798
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 225
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.39
    Marker Score: 323
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.35
    Marker Score: 182
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.32
    Marker Score: 651
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.3
    Marker Score: 223
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.27
    Marker Score: 157
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.25
    Marker Score: 450
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.25
    Marker Score: 148
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 101
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.22
    Marker Score: 143
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.21
    Marker Score: 1,290
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2
    Marker Score: 3,190
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.19
    Marker Score: 1,242
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.16
    Marker Score: 45
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.13
    Marker Score: 90
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.13
    Marker Score: 62
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.12
    Marker Score: 133
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.09
    Marker Score: 177
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.08
    Marker Score: 427
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.07
    Marker Score: 109
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.05
    Marker Score: 202
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.05
    Marker Score: 9
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.05
    Marker Score: 94
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.04
    Marker Score: 48
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.04
    Marker Score: 477
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.04
    Marker Score: 8,506
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.03
    Marker Score: 54
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 37
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.03
    Marker Score: 246
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 40
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 39
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 33
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.01
    Marker Score: 29
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.01
    Marker Score: 11

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** XAGE2 is a non-coding gene that belongs to the X antigen family, which is characterized by its expression on various cell types, including extravillous trophoblast, placental villous trophoblast, goblet cell, syncytiotrophoblast cell, and neoplastic cells. The gene is highly expressed in cells that are involved in immune modulation, tissue repair, and cancer progression. Notably, XAGE2 is also expressed in normal intestinal crypt stem cells and transit amplifying cells, suggesting its potential role in maintaining tissue homeostasis. **Pathways and Functions:** The XAGE2 gene is involved in various cellular pathways, including protein binding, which is a critical mechanism for regulating protein-protein interactions and modulating cellular processes. Research has shown that XAGE2 interacts with several proteins, including immunoglobulins and complement components, which suggests its potential role in modulating the immune response. Specifically, XAGE2 has been shown to bind to the Fc region of immunoglobulins, which can affect the functioning of immune cells, such as natural killer cells and macrophages. In addition to its immunomodulatory functions, XAGE2 has been implicated in cancer progression, particularly in trophoblastic tumors. The gene's expression is upregulated in neoplastic cells, suggesting its potential role in promoting tumor growth and metastasis. Furthermore, XAGE2 has been shown to interact with other cancer-related genes, such as those involved in cell cycle regulation and apoptosis. **Clinical Significance:** The discovery of the XAGE2 gene has significant clinical implications, particularly in the context of pregnancy and cancer. Research has shown that XAGE2 is highly expressed in placental villous trophoblast cells, which are involved in immune modulation and fetal development. Alterations in XAGE2 expression may be associated with pregnancy complications, such as preeclampsia and placental insufficiency. In the context of cancer, XAGE2's expression in neoplastic cells suggests its potential role as a diagnostic biomarker or therapeutic target. Further research is needed to fully elucidate the clinical significance of XAGE2 and its potential applications in cancer therapy. In conclusion, the XAGE2 gene is a novel immunomodulatory player that has been implicated in various cellular pathways, including protein binding and immune response modulation. Its expression in normal and neoplastic cells suggests its potential role in maintaining tissue homeostasis and promoting cancer progression. Further research is needed to fully elucidate the clinical significance of XAGE2 and its potential applications in cancer therapy.

Genular Protein ID: 983416401

Symbol: XAGE2_HUMAN

Name: X antigen family member 2

UniProtKB Accession Codes:

Q96GT9 Q5HYR4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11992404

Title: The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma.

PubMed ID: 11992404

DOI: 10.1002/ijc.10371

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10197611

Title: Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database.

PubMed ID: 10197611

Sequence Information:

  • Length: 111
  • Mass: 12354
  • Checksum: 38C93332C5BA0E14
  • Sequence:
    • MSWRGRSTYR PRPRRSLQPP ELIGAMLEPT DEEPKEEKPP TKSRNPTPDQ KREDDQGAAE 
IQVPDLEADL QELCQTKTGD GCEGGTDVKG KILPKAEHFK MPEAGEGKSQ V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.