Details for: MIR4307HG

Gene ID: 101927081

Symbol: MIR4307HG

Ensembl ID: ENSG00000257612

Description: MIR4307 host gene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2982
    Cell Significance Index: 7.9900
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.1669
    Cell Significance Index: 1.9000
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.0982
    Cell Significance Index: 1.0900
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.0863
    Cell Significance Index: 0.9800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0571
    Cell Significance Index: 0.8200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0563
    Cell Significance Index: 0.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0525
    Cell Significance Index: 1.5500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0404
    Cell Significance Index: 0.6800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0269
    Cell Significance Index: 0.2600
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.0268
    Cell Significance Index: 0.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0215
    Cell Significance Index: 0.4700
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.0164
    Cell Significance Index: 0.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0130
    Cell Significance Index: 0.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0071
    Cell Significance Index: 0.3600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0063
    Cell Significance Index: 0.0700
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.0042
    Cell Significance Index: 0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0024
    Cell Significance Index: 0.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0020
    Cell Significance Index: 0.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0008
    Cell Significance Index: -0.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0010
    Cell Significance Index: -0.2900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0020
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0024
    Cell Significance Index: -0.4100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0029
    Cell Significance Index: -0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0029
    Cell Significance Index: -0.1200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0036
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0039
    Cell Significance Index: -0.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0040
    Cell Significance Index: -0.1400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0058
    Cell Significance Index: -0.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0063
    Cell Significance Index: -0.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0078
    Cell Significance Index: -0.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0105
    Cell Significance Index: -0.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0116
    Cell Significance Index: -0.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0176
    Cell Significance Index: -0.3800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0182
    Cell Significance Index: -0.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0184
    Cell Significance Index: -0.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0194
    Cell Significance Index: -0.3900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0202
    Cell Significance Index: -0.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0213
    Cell Significance Index: -0.6100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0218
    Cell Significance Index: -0.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0219
    Cell Significance Index: -0.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0221
    Cell Significance Index: -0.5900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0230
    Cell Significance Index: -0.2900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0233
    Cell Significance Index: -0.4600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0242
    Cell Significance Index: -0.2600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0242
    Cell Significance Index: -0.3100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0245
    Cell Significance Index: -0.3100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0248
    Cell Significance Index: -0.6000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0253
    Cell Significance Index: -0.3300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0254
    Cell Significance Index: -0.3800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0254
    Cell Significance Index: -0.5000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0260
    Cell Significance Index: -0.3100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0262
    Cell Significance Index: -0.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0263
    Cell Significance Index: -0.6300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0263
    Cell Significance Index: -0.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0264
    Cell Significance Index: -0.2500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0281
    Cell Significance Index: -0.5600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0286
    Cell Significance Index: -0.5600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0295
    Cell Significance Index: -0.4000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0306
    Cell Significance Index: -0.1900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0318
    Cell Significance Index: -0.3800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0318
    Cell Significance Index: -0.5500
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0327
    Cell Significance Index: -0.4100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0341
    Cell Significance Index: -0.4600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0341
    Cell Significance Index: -0.4500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0344
    Cell Significance Index: -0.4000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0352
    Cell Significance Index: -0.3600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0360
    Cell Significance Index: -0.4800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0366
    Cell Significance Index: -0.3900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0367
    Cell Significance Index: -0.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0367
    Cell Significance Index: -0.5300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0377
    Cell Significance Index: -0.5300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0379
    Cell Significance Index: -0.4100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0389
    Cell Significance Index: -0.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0394
    Cell Significance Index: -0.4700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0394
    Cell Significance Index: -0.5200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0399
    Cell Significance Index: -0.5300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0401
    Cell Significance Index: -0.4300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0408
    Cell Significance Index: -0.4300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0411
    Cell Significance Index: -0.5700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0415
    Cell Significance Index: -0.3900
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0416
    Cell Significance Index: -0.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0418
    Cell Significance Index: -0.7000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0421
    Cell Significance Index: -0.5100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0424
    Cell Significance Index: -0.4800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0430
    Cell Significance Index: -0.4800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0435
    Cell Significance Index: -0.5100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0447
    Cell Significance Index: -0.5500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0465
    Cell Significance Index: -0.5800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0470
    Cell Significance Index: -0.5900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0474
    Cell Significance Index: -0.5600
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0474
    Cell Significance Index: -0.5500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0478
    Cell Significance Index: -0.5100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0480
    Cell Significance Index: -0.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tissue-specific expression**: MIR4307HG is predominantly expressed in cells of the gastrointestinal tract, including colon goblet cells, enterocytes, and intestinal stem cells. 2. **Non-coding RNA**: MIR4307HG is a host gene, meaning it does not encode a protein but instead regulates the expression of nearby target genes through microRNA-mediated mechanisms. 3. **Regulation of gene expression**: MIR4307HG influences the expression of target genes involved in various cellular processes, including cell proliferation, differentiation, and survival. 4. **GABAergic signaling**: MIR4307HG is also involved in regulating GABAergic signaling, which is essential for maintaining neural homeostasis and modulating gut-brain interactions. **Pathways and Functions:** 1. **Intestinal homeostasis**: MIR4307HG regulates the expression of genes involved in maintaining intestinal homeostasis, including those involved in cell proliferation, differentiation, and survival. 2. **GABAergic signaling**: MIR4307HG modulates GABAergic signaling, which is crucial for regulating neural activity and modulating gut-brain interactions. 3. **Cellular differentiation**: MIR4307HG influences the expression of genes involved in cellular differentiation, including those involved in the development and maintenance of intestinal epithelial cells. 4. **Immune response**: MIR4307HG may also play a role in regulating the immune response in the gut, particularly in the context of inflammatory disorders. **Clinical Significance:** Dysregulation of MIR4307HG has been implicated in various gastrointestinal disorders, including: 1. **Inflammatory bowel disease (IBD)**: Alterations in MIR4307HG expression have been observed in patients with IBD, suggesting a role in the pathogenesis of the disease. 2. **Gastrointestinal cancer**: MIR4307HG may also play a role in the development and progression of gastrointestinal cancer, particularly in the context of intestinal stem cell dysregulation. 3. **Neurogastroenterology**: Dysregulation of MIR4307HG has been implicated in neurogastroenterological disorders, including irritable bowel syndrome (IBS) and functional dyspepsia. In conclusion, MIR4307HG is a critical regulator of intestinal homeostasis and GABAergic signaling. Further research is needed to elucidate the mechanisms by which MIR4307HG influences cellular behavior and to explore its potential as a therapeutic target for gastrointestinal disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.