Details for: CMTR1

Gene ID: 23070

Symbol: CMTR1

Ensembl ID: ENSG00000137200

Description: cap methyltransferase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.25
    Marker Score: 2,187
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.13
    Marker Score: 6,716
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.12
    Marker Score: 1,030
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.07
    Marker Score: 10,208
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.02
    Marker Score: 8,769
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.02
    Marker Score: 62,721
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,743
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,967
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,399
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.97
    Marker Score: 1,498
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14,935
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,718
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.87
    Marker Score: 8,197
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,957
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.82
    Marker Score: 653
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.81
    Marker Score: 3,313
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.81
    Marker Score: 29,954
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.8
    Marker Score: 12,005
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8
    Marker Score: 3,089
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8
    Marker Score: 8,241
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.79
    Marker Score: 526
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,257
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.75
    Marker Score: 28,583
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 295
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 560
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.72
    Marker Score: 778
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,961
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.69
    Marker Score: 13,777
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.69
    Marker Score: 5,268
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.67
    Marker Score: 737
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 605
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.66
    Marker Score: 191
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.65
    Marker Score: 388
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.64
    Marker Score: 2,210
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.64
    Marker Score: 371
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.61
    Marker Score: 2,535
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6
    Marker Score: 2,513
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.58
    Marker Score: 1,278
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.58
    Marker Score: 202
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.58
    Marker Score: 828
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.57
    Marker Score: 559
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.55
    Marker Score: 11,716
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.55
    Marker Score: 1,116
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.55
    Marker Score: 5,511
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.54
    Marker Score: 1,919
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.54
    Marker Score: 173
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.53
    Marker Score: 437
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.53
    Marker Score: 217
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.53
    Marker Score: 1,210
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.53
    Marker Score: 2,084
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 350
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.52
    Marker Score: 1,233
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.51
    Marker Score: 621
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.51
    Marker Score: 1,902
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.51
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.51
    Marker Score: 213
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.51
    Marker Score: 685
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.51
    Marker Score: 504
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.51
    Marker Score: 3,041
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.5
    Marker Score: 667
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.5
    Marker Score: 573
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.49
    Marker Score: 223
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.49
    Marker Score: 152
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.48
    Marker Score: 348
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.48
    Marker Score: 193
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.48
    Marker Score: 199
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.47
    Marker Score: 508
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.46
    Marker Score: 316
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.46
    Marker Score: 288
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.46
    Marker Score: 170
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.46
    Marker Score: 483
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.46
    Marker Score: 268
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.45
    Marker Score: 183
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.45
    Marker Score: 125
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.45
    Marker Score: 564
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.45
    Marker Score: 2,075
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.45
    Marker Score: 155
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.44
    Marker Score: 140
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.44
    Marker Score: 752
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.44
    Marker Score: 5,066
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.43
    Marker Score: 829
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.43
    Marker Score: 99
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.43
    Marker Score: 1,663
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.43
    Marker Score: 208
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 203
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.42
    Marker Score: 102
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.42
    Marker Score: 1,154
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.42
    Marker Score: 105
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.42
    Marker Score: 94
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.42
    Marker Score: 92
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.42
    Marker Score: 191

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** CMTR1 is a nucleoside-2'-O'-methyltransferase that catalyzes the formation of the 7-methylguanosine (m7G) cap on messenger RNA (mRNA), a crucial modification that protects the mRNA from degradation and regulates its translation. 2. **Cellular Expression:** CMTR1 is widely expressed in various cell types, including germ cells, Sertoli cells, choroid plexus epithelial cells, and neurons, suggesting its importance in different developmental and physiological contexts. 3. **Methyltransferase Activity:** CMTR1 exhibits high specificity for m7G, demonstrating its ability to regulate mRNA methylation patterns and influence gene expression. 4. **Regulation of mRNA Localization:** CMTR1 has been implicated in the regulation of mRNA localization, particularly in neurons, where it influences the trafficking of mRNAs to specific subcellular compartments. **Pathways and Functions:** 1. **mRNA Cap Formation:** CMTR1 catalyzes the formation of the m7G cap on mRNA, which protects it from degradation and regulates its translation. 2. **mRNA Methylation:** CMTR1 is involved in the methylation of specific mRNAs, influencing their stability, localization, and translation efficiency. 3. **Regulation of Gene Expression:** CMTR1 plays a crucial role in regulating gene expression by controlling the stability, localization, and translation of mRNAs. 4. **Neuronal Development and Function:** CMTR1 is essential for neuronal development, differentiation, and function, particularly in the regulation of mRNA localization and translation in neurons. **Clinical Significance:** Dysregulation of CMTR1 has been implicated in various neurological disorders, including: 1. **Neurodevelopmental Disorders:** Mutations in CMTR1 have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Neurodegenerative Diseases:** CMTR1 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where dysregulation of mRNA cap formation and methylation patterns contributes to disease progression. 3. **Cancer:** CMTR1 has been shown to be overexpressed in certain types of cancer, suggesting its potential role in tumorigenesis and cancer progression. In conclusion, CMTR1 is a critical enzyme involved in mRNA regulation, particularly in the formation of the 7-methylguanosine cap and the regulation of mRNA methylation patterns. Its dysregulation has been implicated in various neurological disorders and cancer, highlighting the importance of its proper function in maintaining cellular homeostasis. Further research is necessary to elucidate the complex mechanisms underlying CMTR1's role in gene regulation and its implications for human disease.

Genular Protein ID: 1569742327

Symbol: CMTR1_HUMAN

Name: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

UniProtKB Accession Codes:

Q8N1G2 A8K949 Q14670 Q96FJ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EC 1 EMBL 5 EMDB 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 5 PRO 1 PROSITE 3 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 3 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12743294

Title: Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein.

PubMed ID: 12743294

DOI: 10.1128/jvi.77.11.6367-6375.2003

PubMed ID: 12743306

Title: Cellular gene expression survey of vaccinia virus infection of human HeLa cells.

PubMed ID: 12743306

DOI: 10.1128/jvi.77.11.6493-6506.2003

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18533109

Title: The human interferon-regulated ISG95 protein interacts with RNA polymerase II and shows methyltransferase activity.

PubMed ID: 18533109

DOI: 10.1016/j.bbrc.2008.05.137

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20713356

Title: Characterization of hMTr1, a human Cap1 2'-O-Ribose methyltransferase.

PubMed ID: 20713356

DOI: 10.1074/jbc.m110.155283

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21310715

Title: 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.

PubMed ID: 21310715

DOI: 10.1093/nar/gkr038

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24402442

Title: Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.

PubMed ID: 24402442

DOI: 10.1038/ncomms4004

Sequence Information:

  • Length: 835
  • Mass: 95321
  • Checksum: 03919512A73C30FB
  • Sequence:
    • MKRRTDPECT APIKKQKKRV AELALSLSST SDDEPPSSVS HGAKASTTSL SGSDSETEGK 
QHSSDSFDDA FKADSLVEGT SSRYSMYNSV SQKLMAKMGF REGEGLGKYS QGRKDIVEAS 
SQKGRRGLGL TLRGFDQELN VDWRDEPEPS ACEQVSWFPE CTTEIPDTQE MSDWMVVGKR 
KMIIEDETEF CGEELLHSVL QCKSVFDVLD GEEMRRARTR ANPYEMIRGV FFLNRAAMKM 
ANMDFVFDRM FTNPRDSYGK PLVKDREAEL LYFADVCAGP GGFSEYVLWR KKWHAKGFGM 
TLKGPNDFKL EDFYSASSEL FEPYYGEGGI DGDGDITRPE NISAFRNFVL DNTDRKGVHF 
LMADGGFSVE GQENLQEILS KQLLLCQFLM ALSIVRTGGH FICKTFDLFT PFSVGLVYLL 
YCCFERVCLF KPITSRPANS ERYVVCKGLK VGIDDVRDYL FAVNIKLNQL RNTDSDVNLV 
VPLEVIKGDH EFTDYMIRSN ESHCSLQIKA LAKIHAFVQD TTLSEPRQAE IRKECLRLWG 
IPDQARVAPS SSDPKSKFFE LIQGTEIDIF SYKPTLLTSK TLEKIRPVFD YRCMVSGSEQ 
KFLIGLGKSQ IYTWDGRQSD RWIKLDLKTE LPRDTLLSVE IVHELKGEGK AQRKISAIHI 
LDVLVLNGTD VREQHFNQRI QLAEKFVKAV SKPSRPDMNP IRVKEVYRLE EMEKIFVRLE 
MKIIKGSSGT PKLSYTGRDD RHFVPMGLYI VRTVNEPWTM GFSKSFKKKF FYNKKTKDST 
FDLPADSIAP FHICYYGRLF WEWGDGIRVH DSQKPQDQDK LSKEDVLSFI QMHRA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.