Details for: OR2H1

Gene ID: 26716

Symbol: OR2H1

Ensembl ID: ENSG00000204688

Description: olfactory receptor family 2 subfamily H member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0712
    Cell Significance Index: 1.0200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0445
    Cell Significance Index: 0.7200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0414
    Cell Significance Index: 1.3100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0386
    Cell Significance Index: 0.7700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0256
    Cell Significance Index: 0.2700
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.0193
    Cell Significance Index: 0.2200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0124
    Cell Significance Index: 0.1500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.0118
    Cell Significance Index: 0.1000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0094
    Cell Significance Index: 0.1600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0055
    Cell Significance Index: 0.0600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0049
    Cell Significance Index: 0.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0012
    Cell Significance Index: 0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0003
    Cell Significance Index: -0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0011
    Cell Significance Index: -0.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0011
    Cell Significance Index: -0.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0011
    Cell Significance Index: -0.0600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0043
    Cell Significance Index: -0.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0051
    Cell Significance Index: -0.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0052
    Cell Significance Index: -0.1700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0067
    Cell Significance Index: -0.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0072
    Cell Significance Index: -0.2300
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0079
    Cell Significance Index: -0.0900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0081
    Cell Significance Index: -0.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0084
    Cell Significance Index: -0.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0085
    Cell Significance Index: -0.1700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0092
    Cell Significance Index: -0.0900
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0092
    Cell Significance Index: -0.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0094
    Cell Significance Index: -0.2500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0102
    Cell Significance Index: -0.1400
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0103
    Cell Significance Index: -0.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0104
    Cell Significance Index: -0.3600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0114
    Cell Significance Index: -0.0700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0116
    Cell Significance Index: -0.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0123
    Cell Significance Index: -0.2400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0130
    Cell Significance Index: -0.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0132
    Cell Significance Index: -0.2800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0135
    Cell Significance Index: -0.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0139
    Cell Significance Index: -0.2800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0141
    Cell Significance Index: -0.1500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0143
    Cell Significance Index: -0.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0144
    Cell Significance Index: -0.1700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0147
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0149
    Cell Significance Index: -0.1400
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0157
    Cell Significance Index: -0.1100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0160
    Cell Significance Index: -0.1700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0162
    Cell Significance Index: -0.1600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0163
    Cell Significance Index: -0.1100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0179
    Cell Significance Index: -0.1700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0182
    Cell Significance Index: -0.2200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0183
    Cell Significance Index: -0.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0183
    Cell Significance Index: -0.2700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0185
    Cell Significance Index: -0.2400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0185
    Cell Significance Index: -0.2200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0187
    Cell Significance Index: -0.2200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0191
    Cell Significance Index: -0.2500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0195
    Cell Significance Index: -0.2800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0196
    Cell Significance Index: -0.2600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0198
    Cell Significance Index: -0.2600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0199
    Cell Significance Index: -0.2600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0200
    Cell Significance Index: -0.2400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0200
    Cell Significance Index: -0.2700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0200
    Cell Significance Index: -0.2700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0203
    Cell Significance Index: -0.2500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0203
    Cell Significance Index: -0.2700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0207
    Cell Significance Index: -0.2500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0211
    Cell Significance Index: -0.2300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0211
    Cell Significance Index: -0.2700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0217
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0217
    Cell Significance Index: -0.2200
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0217
    Cell Significance Index: -0.2200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0222
    Cell Significance Index: -0.2800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0223
    Cell Significance Index: -0.2300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0226
    Cell Significance Index: -0.2800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0226
    Cell Significance Index: -0.2100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0227
    Cell Significance Index: -0.2700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0232
    Cell Significance Index: -0.2100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0234
    Cell Significance Index: -0.2800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0235
    Cell Significance Index: -0.2500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0235
    Cell Significance Index: -0.2700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0238
    Cell Significance Index: -0.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0239
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0239
    Cell Significance Index: -0.2300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0242
    Cell Significance Index: -0.2600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0243
    Cell Significance Index: -0.2300
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0243
    Cell Significance Index: -0.2500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0244
    Cell Significance Index: -0.2700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0247
    Cell Significance Index: -0.2600
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0252
    Cell Significance Index: -0.3000
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0255
    Cell Significance Index: -0.2600
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0258
    Cell Significance Index: -0.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Family 2 Subfamily H Member 1:** The OR2H1 gene is part of the olfactory receptor family 2 subfamily H, which consists of a group of genes encoding olfactory receptors responsible for detecting odorant molecules. 2. **G Protein-Coupled Receptor (GPCR) Activity:** OR2H1 belongs to the GPCR family, which is a large group of receptors that respond to a wide variety of ligands, including hormones, neurotransmitters, and odorants. 3. **Expression in Various Cells:** OR2H1 is expressed in a range of cells, including kidney capillary endothelial cells, renal beta-intercalated cells, lens fiber cells, T cells, connective tissue cells, plasma cells, parietal epithelial cells, podocytes, mononuclear cells, and ependymal cells, highlighting its diverse cellular distribution. **Pathways and Functions:** 1. **Detection of Chemical Stimulus:** OR2H1 plays a critical role in detecting chemical stimuli involved in sensory perception of smell, allowing us to perceive and differentiate various odors. 2. **Expression and Translocation of Olfactory Receptors:** OR2H1 is involved in the expression and translocation of olfactory receptors, which is essential for the proper functioning of the olfactory system. 3. **G Protein-Coupled Receptor Signaling Pathway:** OR2H1 activates the G protein-coupled receptor signaling pathway, which is a complex signaling cascade that regulates various cellular processes, including gene expression, cell proliferation, and differentiation. 4. **Sensory Perception and Olfactory Signaling Pathway:** OR2H1 is also involved in the sensory perception and olfactory signaling pathway, which is responsible for transmitting signals from the olfactory receptor to the brain, allowing us to perceive and interpret odors. **Clinical Significance:** 1. **Olfactory Dysfunction:** OR2H1 mutations or alterations have been linked to olfactory dysfunction, a condition characterized by impaired olfactory perception, which can have significant impacts on quality of life and daily functioning. 2. **Neurodegenerative Diseases:** Research has shown that OR2H1 may play a role in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, which often involve olfactory dysfunction. 3. **Kidney Disease:** OR2H1 expression has been found in kidney cells, suggesting that this gene may be involved in kidney disease, particularly in conditions characterized by olfactory dysfunction. 4. **Cancer:** OR2H1 has been implicated in cancer, with studies suggesting that this gene may play a role in cancer progression and metastasis, particularly in tumors with olfactory dysfunction. In conclusion, OR2H1 is a multifaceted gene that plays a crucial role in olfactory perception and sensory processing. Its clinical significance extends beyond olfactory dysfunction, with potential implications in neurodegenerative diseases, kidney disease, and cancer. Further research is necessary to fully elucidate the functions and clinical significance of the OR2H1 gene, highlighting its importance in understanding the complexities of the human olfactory system and its role in maintaining overall health and well-being.

Genular Protein ID: 4071153736

Symbol: OR2H1_HUMAN

Name: Olfactory receptor 2H1

UniProtKB Accession Codes:

Q9GZK4 B0S7T4 O43629 O43661 O43662 Q5SUN6 Q9GZK9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 27 Ensembl 32 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 12 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 12637542

Title: Complex transcription and splicing of odorant receptor genes.

PubMed ID: 12637542

DOI: 10.1074/jbc.m212424200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 316
  • Mass: 35339
  • Checksum: 19140A7FD690CF85
  • Sequence:
    • MVNQSSPMGF LLLGFSEHPA LERTLFVVVF TSYLLTLVGN TLIILLSVLY PRLHSPMYFF 
LSDLSFLDLC FTTSCVPQML VNLWGPKKTI SFLGCSVQLF IFLSLGTTEC ILLTVMAFDR 
YVAVCQPLHY ATIIHPRLCW QLASVAWVMS LVQSIVQTPS TLHLPFCPHQ QIDDFLCEVP 
SLIRLSCGDT SYNEIQLAVS SVIFVVVPLS LILASYGATA QAVLRINSAT AWRKAFGTCS 
SHLTVVTLFY SSVIAVYLQP KNPYAQGRGK FFGLFYAVGT PSLNPLVYTL RNKEIKRALR 
RLLGKERDSR ESWRAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.