Details for: GGT7

Gene ID: 2686

Symbol: GGT7

Ensembl ID: ENSG00000131067

Description: gamma-glutamyltransferase 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.91
    Marker Score: 18005
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.88
    Marker Score: 69420
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.86
    Marker Score: 1485
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.83
    Marker Score: 768
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.81
    Marker Score: 1057
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.79
    Marker Score: 67990
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.79
    Marker Score: 18480
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.74
    Marker Score: 38971
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.73
    Marker Score: 34438
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.73
    Marker Score: 6135
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.72
    Marker Score: 106034
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.7
    Marker Score: 16175
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.69
    Marker Score: 7017
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.69
    Marker Score: 2830
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.65
    Marker Score: 14138
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.65
    Marker Score: 6363
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.6
    Marker Score: 23974
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.55
    Marker Score: 2387
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.5
    Marker Score: 411
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.5
    Marker Score: 11476
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.36
    Marker Score: 3401
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.35
    Marker Score: 2746
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.35
    Marker Score: 6245
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.31
    Marker Score: 5315
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19522
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.14
    Marker Score: 3249
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.09
    Marker Score: 2383
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.08
    Marker Score: 315
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.05
    Marker Score: 22313
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.04
    Marker Score: 35035
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.03
    Marker Score: 1794
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.01
    Marker Score: 1355
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1
    Marker Score: 2041
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1
    Marker Score: 468
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71762
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47987
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.96
    Marker Score: 2193
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.96
    Marker Score: 303
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.94
    Marker Score: 1037
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.93
    Marker Score: 6904
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.92
    Marker Score: 1115
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.91
    Marker Score: 1047
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.9
    Marker Score: 3785
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.88
    Marker Score: 916
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4975
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.85
    Marker Score: 508
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.83
    Marker Score: 262
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.81
    Marker Score: 565
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.81
    Marker Score: 4854
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.8
    Marker Score: 861
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.78
    Marker Score: 299
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3241
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1230
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.74
    Marker Score: 486
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.74
    Marker Score: 351
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.72
    Marker Score: 895
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.72
    Marker Score: 347
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.71
    Marker Score: 862.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.71
    Marker Score: 390
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.7
    Marker Score: 1687
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.69
    Marker Score: 1318
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.68
    Marker Score: 230
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.68
    Marker Score: 826
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.68
    Marker Score: 285
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.68
    Marker Score: 394
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.68
    Marker Score: 845
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.67
    Marker Score: 597
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.67
    Marker Score: 203
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.67
    Marker Score: 1585
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.66
    Marker Score: 3551
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.66
    Marker Score: 344
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.65
    Marker Score: 616.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.65
    Marker Score: 2563
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.65
    Marker Score: 729
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.64
    Marker Score: 184
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.62
    Marker Score: 349
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.62
    Marker Score: 230.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.61
    Marker Score: 532
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.61
    Marker Score: 151
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.61
    Marker Score: 303
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.61
    Marker Score: 862
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.6
    Marker Score: 289
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.59
    Marker Score: 2448
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.58
    Marker Score: 388
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.57
    Marker Score: 279
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.56
    Marker Score: 178
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.56
    Marker Score: 203
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.56
    Marker Score: 190
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.56
    Marker Score: 311

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** - GGT7 is a protein of the glutathione family, a group of enzymes that are involved in the metabolism of glutathione, a molecule that can act as a antioxidant and protect cells from damage. - GGT7 is a transmembrane protein that is expressed in the plasma membrane of cells. - It is a key enzyme in the detoxification of gamma-glutamyl compounds, and it is involved in the regulation of inflammation and cell death. **Pathways and functions** - GGT7 is involved in the detoxification of gamma-glutamyl compounds in the plasma membrane. - It is a key enzyme in the biosynthesis of leukotrienes, a class of lipid mediators that are involved in inflammation and pain. - GGT7 is also involved in the metabolism of paracetamol, a pain reliever that can be metabolized by the liver. **Clinical significance** - Mutations in the GGT7 gene have been linked to an increased risk of liver damage and cancer. - GGT7 inhibitors are being investigated as a treatment for liver diseases and cancer. - By understanding the role of GGT7 in the metabolism of gamma-glutamyl compounds, scientists may be able to develop new treatments for liver diseases and cancer.

Genular Protein ID: 913002821

Symbol: GGT7_HUMAN

Name: Gamma-glutamyltransferase 7

UniProtKB Accession Codes:

Q9UJ14 Q8N899 Q8NF66 Q9BYP5 Q9BYP6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 8 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12270127

Title: Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism.

PubMed ID: 12270127

DOI: 10.1016/s0006-291x(02)02227-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12693554

Title: Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.

PubMed ID: 12693554

DOI: 10.1093/dnares/10.1.49

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 18357469

Title: The human gamma-glutamyltransferase gene family.

PubMed ID: 18357469

DOI: 10.1007/s00439-008-0487-7

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 662
  • Mass: 70467
  • Checksum: 29DDBC719CADD195
  • Sequence:
    • MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAAP LRGRKDEDAF LGDPDTDPDS 
FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAAAEC SCRQDGLTVI VTACLTFATG 
VTVALVMQIY FGDPQIFQQG AVVTDAARCT SLGIEVLSKQ GSSVDAAVAA ALCLGIVAPH 
SSGLGGGGVM LVHDIRRNES HLIDFRESAP GALREETLQR SWETKPGLLV GVPGMVKGLH 
EAHQLYGRLP WSQVLAFAAA VAQDGFNVTH DLARALAEQL PPNMSERFRE TFLPSGRPPL 
PGSLLHRPDL AEVLDVLGTS GPAAFYAGGN LTLEMVAEAQ HAGGVITEED FSNYSALVEK 
PVCGVYRGHL VLSPPPPHTG PALISALNIL EGFNLTSLVS REQALHWVAE TLKIALALAS 
RLGDPVYDST ITESMDDMLS KVEAAYLRGH INDSQAAPAP LLPVYELDGA PTAAQVLIMG 
PDDFIVAMVS SLNQPFGSGL ITPSGILLNS QMLDFSWPNR TANHSAPSLE NSVQPGKRPL 
SFLLPTVVRP AEGLCGTYLA LGANGAARGL SGLTQVLLNV LTLNRNLSDS LARGRLHPDL 
QSNLLQVDSE FTEEEIEFLE ARGHHVEKVD VLSWVHGSRR TNNFIIAVKD PRSPDAAGAT 
IL

Genular Protein ID: 1128198455

Symbol: A0PJJ9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0PJJ9

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 EC 3 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 5 RuleBase 1 SAM 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 592
  • Mass: 62566
  • Checksum: 2166F66FF0A949EB
  • Sequence:
    • MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAAP LRGRKDEDAF LGDPDTDPDS 
FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAAAEC SCRQDGLTVI VTACLTFATG 
VTVALVMQIY FGDPQIFQQG AVVTDAARCT SLGIEVLSKQ GSSVDAAVAA ALCLGIVAPH 
SSGLGGGGVM LVHDIRRNES HLIDFRESAP GALREETLQR SWETKPGLLV GVPGMVKGLH 
EAHQLYGRLP WSQVLAFAAA VAQDGFNVTH DLARALAEQL PPNMSERFRE TFLPSGRPPL 
PGSLLHRPDL AEVLDVLGTS GPAAFYAGGN LTLEMVAEAQ HAGGVITEED FSNYSALVEK 
PVCGVYRGHL VLSPPPPHTG PALISALNIL EGFNLTSLVS REQALHWVAE TLKIALALAS 
RLGDPVYDST ITESMDDMLS KVEAAYLRGH INDSQAAPAP LLPVYELDGA PTAAQVLIMG 
PDDFIVAMVS SLNQPFGSGL ITPSGILLNS QMLDFSWPNR TANHSAPSLE NSVQPGKRPL 
SFLLPTVVRP AEGLCGTYLA LGANGAARGL SGLTQVLLNV LTLNRNLSDS LA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.