Details for: GP1BB

Gene ID: 2812

Symbol: GP1BB

Ensembl ID: ENSG00000203618

Description: glycoprotein Ib platelet subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: platelet (CL0000233)
    Fold Change: 4.98
    Marker Score: 2254
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1993
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.38
    Marker Score: 1269
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.21
    Marker Score: 2149
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.16
    Marker Score: 9985
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 500
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.07
    Marker Score: 4372
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1
    Marker Score: 528
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.96
    Marker Score: 401
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.9
    Marker Score: 34345
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.88
    Marker Score: 3387
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.87
    Marker Score: 8173
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.86
    Marker Score: 8125
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.85
    Marker Score: 3519
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.83
    Marker Score: 16522
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.82
    Marker Score: 947
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.82
    Marker Score: 1010
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.82
    Marker Score: 1128
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.81
    Marker Score: 257
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.81
    Marker Score: 1250
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.79
    Marker Score: 48660.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.77
    Marker Score: 11558
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.74
    Marker Score: 219
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.74
    Marker Score: 3048
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.69
    Marker Score: 239
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.69
    Marker Score: 188
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.68
    Marker Score: 312
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.64
    Marker Score: 4912.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.62
    Marker Score: 22878
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.58
    Marker Score: 192
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 193
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.4
    Marker Score: 730
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.39
    Marker Score: 881
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.37
    Marker Score: 7880
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.35
    Marker Score: 216
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.34
    Marker Score: 229
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.33
    Marker Score: 116
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.32
    Marker Score: 396
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 0.3
    Marker Score: 110
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.3
    Marker Score: 876
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.27
    Marker Score: 88
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.27
    Marker Score: 97
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.25
    Marker Score: 79.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.22
    Marker Score: 154
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.22
    Marker Score: 259
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 117
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.19
    Marker Score: 85
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.19
    Marker Score: 390
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.19
    Marker Score: 122
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.18
    Marker Score: 111
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.17
    Marker Score: 504
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.17
    Marker Score: 1413
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.17
    Marker Score: 403
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.17
    Marker Score: 161
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.16
    Marker Score: 68
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.16
    Marker Score: 105
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.16
    Marker Score: 92
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.16
    Marker Score: 63.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.15
    Marker Score: 171
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.15
    Marker Score: 76
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.15
    Marker Score: 369
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.14
    Marker Score: 124
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.14
    Marker Score: 49
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.14
    Marker Score: 94
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.14
    Marker Score: 392
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.13
    Marker Score: 98
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.13
    Marker Score: 71
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.13
    Marker Score: 4303.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.12
    Marker Score: 94
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.12
    Marker Score: 88
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.11
    Marker Score: 297
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 113
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.11
    Marker Score: 109
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.11
    Marker Score: 63.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.1
    Marker Score: 24

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Other Information

**Key characteristics:** - GP1BB is a glycoprotein that is found in platelets. - It is a key component of the platelet adhesion complex. - It is involved in blood clotting. **Pathways and functions:** - GP1BB is expressed in platelets and is involved in the platelet adhesion complex. - The platelet adhesion complex is responsible for the adhesion of platelets to collagen. - GP1BB is also involved in the formation of fibrin clots. - It is a key component of the intrinsic pathway of fibrin clot formation. **Clinical significance:** - Mutations in GP1BB have been linked to hemophilia b, a genetic disorder that is caused by a deficiency of GP1BB. - GP1BB is also involved in other blood clotting disorders, such as von Willebrand disease and thrombocytopenia. - Targeting GP1BB has been investigated as a treatment for these disorders.

Genular Protein ID: 1453802334

Symbol: GP1BB_HUMAN

Name: Platelet glycoprotein Ib beta chain

UniProtKB Accession Codes:

P13224 Q14422 Q8NG40

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3353370

Title: The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence.

PubMed ID: 3353370

DOI: 10.1073/pnas.85.7.2135

PubMed ID: 8021244

Title: Structural characterization and chromosomal location of the gene encoding human platelet glycoprotein Ib beta.

PubMed ID: 8021244

DOI: 10.1016/s0021-9258(17)32456-0

PubMed ID: 8200976

Title: Complementary DNA cloning of the alternatively expressed endothelial cell glycoprotein Ib beta (GPIb beta) and localization of the GPIb beta gene to chromosome 22.

PubMed ID: 8200976

DOI: 10.1172/jci117249

PubMed ID: 9022087

Title: Alternative expression of platelet glycoprotein Ib(beta) mRNA from an adjacent 5' gene with an imperfect polyadenylation signal sequence.

PubMed ID: 9022087

DOI: 10.1172/jci119188

PubMed ID: 9116284

Title: Missense mutations of the glycoprotein (GP) Ib beta gene impairing the GPIb alpha/beta disulfide linkage in a family with giant platelet disorder.

PubMed ID: 9116284

PubMed ID: 3632685

Title: Isolation and characterization of the alpha and beta chains of human platelet glycoprotein Ib.

PubMed ID: 3632685

DOI: 10.1016/0006-291x(87)90963-6

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 2504723

Title: Platelet glycoprotein Ib beta is phosphorylated on serine 166 by cyclic AMP-dependent protein kinase.

PubMed ID: 2504723

DOI: 10.1016/s0021-9258(19)84882-2

PubMed ID: 17008541

Title: Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet.

PubMed ID: 17008541

DOI: 10.1182/blood-2006-05-024091

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 20946164

Title: TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets.

PubMed ID: 20946164

DOI: 10.1111/j.1538-7836.2010.04091.x

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21908432

Title: Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbbeta and a GPIbbeta/GPIX chimera.

PubMed ID: 21908432

DOI: 10.1182/blood-2011-05-356253

Sequence Information:

  • Length: 206
  • Mass: 21718
  • Checksum: B5E81EB6F57DE0D9
  • Sequence:
    • MGSGPRGALS LLLLLLAPPS RPAAGCPAPC SCAGTLVDCG RRGLTWASLP TAFPVDTTEL 
VLTGNNLTAL PPGLLDALPA LRTAHLGANP WRCDCRLVPL RAWLAGRPER APYRDLRCVA 
PPALRGRLLP YLAEDELRAA CAPGPLCWGA LAAQLALLGL GLLHALLLVL LLCRLRRLRA 
RARARAAARL SLTDPLVAER AGTDES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.