Details for: IGHV4 28

Gene ID: 28400

Symbol: IGHV4 28

Ensembl ID: ENSG00000211952

Description: immunoglobulin heavy variable 4-28

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 20.66
    Marker Score: 18,515
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,814
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,579
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,650
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,732
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,822
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,304
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 738
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 390
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 235
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.5
    Marker Score: 1,555
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 210
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 327
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.29
    Marker Score: 374
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.28
    Marker Score: 76
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.21
    Marker Score: 225
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.2
    Marker Score: 273
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.19
    Marker Score: 255
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.14
    Marker Score: 94
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.13
    Marker Score: 276
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.09
    Marker Score: 54
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.09
    Marker Score: 75
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.08
    Marker Score: 56
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.08
    Marker Score: 74
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.07
    Marker Score: 57
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 135
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.07
    Marker Score: 74
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 62
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.06
    Marker Score: 47
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.06
    Marker Score: 72
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.05
    Marker Score: 81
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.05
    Marker Score: 60
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.05
    Marker Score: 62
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.05
    Marker Score: 540
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.03
    Marker Score: 94
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.02
    Marker Score: 43
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.02
    Marker Score: 55
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.02
    Marker Score: 58
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.02
    Marker Score: 50
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.02
    Marker Score: 39
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.02
    Marker Score: 69
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.01
    Marker Score: 6

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin Heavy Variable Region**: IGHV4-28 encodes for a specific heavy chain variable region of immunoglobulins, which is essential for antigen recognition and binding. 2. **Significant Expression**: This gene is significantly expressed in various cell types, including endothelial cells, goblet cells, granulocytes, and neoplastic cells. 3. **Widespread Expression**: IGHV4-28 is expressed in the gastrointestinal tract, particularly in the intestinal crypts and fallopian tube secretory epithelial cells. 4. **Antigen Binding**: The heavy chain variable region encoded by IGHV4-28 plays a crucial role in the recognition and binding of antigens. **Pathways and Functions:** 1. **Antigen Binding**: IGHV4-28 mediates the binding of antigens to immunoglobulins, which is essential for the activation of immune cells and the initiation of an immune response. 2. **Immunoglobulin Mediated Immune Response**: The expression of IGHV4-28 is critical for the development of an effective immune response against pathogens and foreign substances. 3. **Extracellular Region**: The heavy chain variable region encoded by IGHV4-28 is part of the extracellular region of immunoglobulins, which interacts with antigens and other molecules. 4. **Immunoglobulin Complex**: IGHV4-28 is a component of immunoglobulin complexes, which are essential for the recognition and binding of antigens. **Clinical Significance:** 1. **Autoimmune Diseases**: Alterations in IGHV4-28 expression have been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: The expression of IGHV4-28 has been observed in various types of cancer, including lymphoma and leukemia. 3. **Infectious Diseases**: IGHV4-28 plays a crucial role in the recognition and binding of pathogens, which is essential for the development of an effective immune response. 4. **Vaccine Development**: Understanding the role of IGHV4-28 in antigen binding and recognition can inform the development of novel vaccine strategies. In conclusion, the IGHV4-28 gene is a critical component of the human immune system, and its expression has significant implications for our understanding of immune function and disease pathogenesis. Further research is necessary to elucidate the precise mechanisms by which IGHV4-28 regulates immune responses and to explore its potential as a therapeutic target for autoimmune and cancer diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.