Details for: IGHV3 64

Gene ID: 28414

Symbol: IGHV3 64

Ensembl ID: ENSG00000223648

Description: immunoglobulin heavy variable 3-64

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4743
    Cell Significance Index: 11.4900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0698
    Cell Significance Index: -1.0800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1028
    Cell Significance Index: -2.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3089
    Cell Significance Index: -3.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3179
    Cell Significance Index: -14.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3832
    Cell Significance Index: -10.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4086
    Cell Significance Index: -10.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4139
    Cell Significance Index: -12.1900
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.4252
    Cell Significance Index: -3.5100
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.4836
    Cell Significance Index: -5.2500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.5447
    Cell Significance Index: -5.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5697
    Cell Significance Index: -10.5300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.5779
    Cell Significance Index: -9.3600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5910
    Cell Significance Index: -14.7600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.6184
    Cell Significance Index: -10.5700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.6464
    Cell Significance Index: -9.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6722
    Cell Significance Index: -15.5300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.7163
    Cell Significance Index: -8.0100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.7256
    Cell Significance Index: -9.9500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.7387
    Cell Significance Index: -8.5000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.7681
    Cell Significance Index: -8.1600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.8242
    Cell Significance Index: -10.2000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.8260
    Cell Significance Index: -10.8400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.8393
    Cell Significance Index: -10.8600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.8415
    Cell Significance Index: -9.2200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.8630
    Cell Significance Index: -10.4100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.8674
    Cell Significance Index: -10.2100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.8936
    Cell Significance Index: -10.5500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.9142
    Cell Significance Index: -13.3300
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.9147
    Cell Significance Index: -9.4100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.9237
    Cell Significance Index: -10.6300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.9295
    Cell Significance Index: -10.4800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.9565
    Cell Significance Index: -10.3700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.9595
    Cell Significance Index: -10.9000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.9631
    Cell Significance Index: -10.7600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.9699
    Cell Significance Index: -9.3100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.9822
    Cell Significance Index: -10.5900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.9845
    Cell Significance Index: -16.7200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.9863
    Cell Significance Index: -10.9200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -1.0084
    Cell Significance Index: -13.4000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -1.0151
    Cell Significance Index: -10.6400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -1.0215
    Cell Significance Index: -9.5900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -1.0395
    Cell Significance Index: -16.7200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.0437
    Cell Significance Index: -14.8300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -1.0441
    Cell Significance Index: -13.6300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -1.0446
    Cell Significance Index: -13.4200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -1.0491
    Cell Significance Index: -13.5100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -1.0539
    Cell Significance Index: -12.4600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -1.0572
    Cell Significance Index: -10.9500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -1.0621
    Cell Significance Index: -11.5000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -1.0695
    Cell Significance Index: -13.3600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -1.0782
    Cell Significance Index: -12.8000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -1.0805
    Cell Significance Index: -11.5000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.0818
    Cell Significance Index: -16.4300
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -1.0932
    Cell Significance Index: -7.2800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -1.0951
    Cell Significance Index: -11.5300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -1.0959
    Cell Significance Index: -11.5600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -1.0965
    Cell Significance Index: -13.3400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -1.0967
    Cell Significance Index: -13.4800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -1.1104
    Cell Significance Index: -10.3100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -1.1203
    Cell Significance Index: -10.9200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -1.1276
    Cell Significance Index: -10.6700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -1.1308
    Cell Significance Index: -13.5600
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -1.1313
    Cell Significance Index: -10.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -1.1330
    Cell Significance Index: -10.8900
  • Cell Name: B cell (CL0000236)
    Fold Change: -1.1331
    Cell Significance Index: -13.3900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -1.1382
    Cell Significance Index: -13.4500
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -1.1395
    Cell Significance Index: -10.4200
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -1.1435
    Cell Significance Index: -9.1900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -1.1475
    Cell Significance Index: -9.7800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -1.1565
    Cell Significance Index: -13.9600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -1.1578
    Cell Significance Index: -10.7800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -1.1581
    Cell Significance Index: -15.2400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -1.1673
    Cell Significance Index: -13.5400
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -1.1705
    Cell Significance Index: -10.4400
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -1.1757
    Cell Significance Index: -12.0200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -1.1774
    Cell Significance Index: -12.6600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.1786
    Cell Significance Index: -16.5200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -1.1812
    Cell Significance Index: -12.9200
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -1.1826
    Cell Significance Index: -10.3900
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -1.1895
    Cell Significance Index: -10.9900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -1.1921
    Cell Significance Index: -12.6400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -1.1945
    Cell Significance Index: -13.2300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -1.2039
    Cell Significance Index: -10.5300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -1.2084
    Cell Significance Index: -13.6800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -1.2166
    Cell Significance Index: -12.9200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -1.2275
    Cell Significance Index: -10.8200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -1.2344
    Cell Significance Index: -10.9900
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -1.2371
    Cell Significance Index: -13.6400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -1.2490
    Cell Significance Index: -10.5400
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -1.2610
    Cell Significance Index: -10.9900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -1.2613
    Cell Significance Index: -12.7900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -1.2674
    Cell Significance Index: -12.6500
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -1.2682
    Cell Significance Index: -11.3300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -1.2755
    Cell Significance Index: -10.5500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -1.2764
    Cell Significance Index: -11.9400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -1.2853
    Cell Significance Index: -15.3000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -1.3017
    Cell Significance Index: -13.5000
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -1.3043
    Cell Significance Index: -13.9300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -1.3086
    Cell Significance Index: -13.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** IGHV3-64 is situated on chromosome 14q32.33, a region rich in immunoglobulin genes. This gene encodes a heavy chain variable region, which is essential for the recognition and binding of antigens. 2. **Expression:** IGHV3-64 is significantly expressed in various cell types, including goblet cells, monocytes, granulocytes, and hematopoietic cells. Its expression is also observed in neoplastic cells, abnormal cells, and cells from the fallopian tube and intestinal crypts. 3. **Diversity:** IGHV3-64 is part of the IGHV family, which comprises a diverse range of heavy chain variable regions. This diversity is crucial for the recognition of a vast array of antigens, allowing the immune system to respond effectively to pathogens and foreign substances. **Pathways and Functions:** 1. **Antigen Binding:** IGHV3-64 plays a critical role in the binding of antigens to the B cell receptor complex. This interaction triggers a series of signaling events that ultimately lead to the activation of B cells and the production of antibodies. 2. **Immunoglobulin Complex Formation:** IGHV3-64 is essential for the formation of the immunoglobulin complex, which is composed of heavy and light chain variable regions. This complex is responsible for the recognition and binding of antigens. 3. **Immunoglobulin-Mediated Immune Response:** IGHV3-64 is a key player in the immunoglobulin-mediated immune response, which involves the production of antibodies and the activation of immune cells. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Alterations in IGHV3-64 have been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). This condition is characterized by a deficiency in antibody production, making individuals susceptible to recurrent infections. 2. **Cancer:** IGHV3-64 has been implicated in the development of certain types of cancer, including lymphoma and leukemia. Abnormal expression of this gene can lead to the activation of B cells and the production of antibodies that contribute to tumor growth and progression. 3. **Autoimmune Diseases:** IGHV3-64 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. In these conditions, the immune system produces antibodies that target self-antigens, leading to tissue damage and inflammation. In conclusion, IGHV3-64 is a critical component of the B cell receptor complex, playing a pivotal role in the humoral immune response. Its unique characteristics, pathways, and functions make it an essential target for the understanding of immunological processes. Further research is necessary to fully elucidate the clinical significance of IGHV3-64 and its contributions to the complex mechanisms of the immune system.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.