Details for: IGHV3 64

Gene ID: 28414

Symbol: IGHV3 64

Ensembl ID: ENSG00000223648

Description: immunoglobulin heavy variable 3-64

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,812
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.63
    Marker Score: 2,113
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 877
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,577
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,654
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.12
    Marker Score: 742
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,727
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 803
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,816
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,403
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,339
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 738
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.76
    Marker Score: 437
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.58
    Marker Score: 356
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.53
    Marker Score: 702
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 481
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.42
    Marker Score: 212
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.4
    Marker Score: 110
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 216
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.34
    Marker Score: 344
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.27
    Marker Score: 262
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.25
    Marker Score: 140
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.24
    Marker Score: 265
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.2
    Marker Score: 614
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.17
    Marker Score: 45
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.15
    Marker Score: 331
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.13
    Marker Score: 89
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.13
    Marker Score: 147
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.12
    Marker Score: 117
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.11
    Marker Score: 98
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1
    Marker Score: 54
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.09
    Marker Score: 65
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 64
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.09
    Marker Score: 141
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 67
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.07
    Marker Score: 150
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.07
    Marker Score: 78
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 138
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.07
    Marker Score: 87
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.06
    Marker Score: 52
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.05
    Marker Score: 40
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.05
    Marker Score: 83
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.05
    Marker Score: 195
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.04
    Marker Score: 407
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.03
    Marker Score: 79
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.03
    Marker Score: 35
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.02
    Marker Score: 51
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.02
    Marker Score: 35
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 17
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0
    Marker Score: 17
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 40
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 37

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** IGHV3-64 is situated on chromosome 14q32.33, a region rich in immunoglobulin genes. This gene encodes a heavy chain variable region, which is essential for the recognition and binding of antigens. 2. **Expression:** IGHV3-64 is significantly expressed in various cell types, including goblet cells, monocytes, granulocytes, and hematopoietic cells. Its expression is also observed in neoplastic cells, abnormal cells, and cells from the fallopian tube and intestinal crypts. 3. **Diversity:** IGHV3-64 is part of the IGHV family, which comprises a diverse range of heavy chain variable regions. This diversity is crucial for the recognition of a vast array of antigens, allowing the immune system to respond effectively to pathogens and foreign substances. **Pathways and Functions:** 1. **Antigen Binding:** IGHV3-64 plays a critical role in the binding of antigens to the B cell receptor complex. This interaction triggers a series of signaling events that ultimately lead to the activation of B cells and the production of antibodies. 2. **Immunoglobulin Complex Formation:** IGHV3-64 is essential for the formation of the immunoglobulin complex, which is composed of heavy and light chain variable regions. This complex is responsible for the recognition and binding of antigens. 3. **Immunoglobulin-Mediated Immune Response:** IGHV3-64 is a key player in the immunoglobulin-mediated immune response, which involves the production of antibodies and the activation of immune cells. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Alterations in IGHV3-64 have been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). This condition is characterized by a deficiency in antibody production, making individuals susceptible to recurrent infections. 2. **Cancer:** IGHV3-64 has been implicated in the development of certain types of cancer, including lymphoma and leukemia. Abnormal expression of this gene can lead to the activation of B cells and the production of antibodies that contribute to tumor growth and progression. 3. **Autoimmune Diseases:** IGHV3-64 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. In these conditions, the immune system produces antibodies that target self-antigens, leading to tissue damage and inflammation. In conclusion, IGHV3-64 is a critical component of the B cell receptor complex, playing a pivotal role in the humoral immune response. Its unique characteristics, pathways, and functions make it an essential target for the understanding of immunological processes. Further research is necessary to fully elucidate the clinical significance of IGHV3-64 and its contributions to the complex mechanisms of the immune system.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.