Details for: IGHV2 26

Gene ID: 28455

Symbol: IGHV2 26

Ensembl ID: ENSG00000211951

Description: immunoglobulin heavy variable 2-26

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.5318
    Cell Significance Index: 4.3900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1481
    Cell Significance Index: 1.6600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1319
    Cell Significance Index: 2.0400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
    Fold Change: -0.0015
    Cell Significance Index: -0.0100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0100
    Cell Significance Index: -0.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0184
    Cell Significance Index: -3.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0258
    Cell Significance Index: -3.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0304
    Cell Significance Index: -17.1700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0436
    Cell Significance Index: -1.0900
  • Cell Name: lymphocyte of B lineage (CL0000945)
    Fold Change: -0.0481
    Cell Significance Index: -0.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0674
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0993
    Cell Significance Index: -16.9600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1105
    Cell Significance Index: -1.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1130
    Cell Significance Index: -1.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1295
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1544
    Cell Significance Index: -17.6900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1667
    Cell Significance Index: -2.3400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1697
    Cell Significance Index: -4.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1726
    Cell Significance Index: -4.4100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2197
    Cell Significance Index: -2.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2278
    Cell Significance Index: -4.2100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2281
    Cell Significance Index: -4.4600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2305
    Cell Significance Index: -3.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2492
    Cell Significance Index: -11.6200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2544
    Cell Significance Index: -4.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2640
    Cell Significance Index: -6.7300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2692
    Cell Significance Index: -3.3300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2742
    Cell Significance Index: -3.7600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2750
    Cell Significance Index: -3.2500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2852
    Cell Significance Index: -3.7300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.3004
    Cell Significance Index: -3.1900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3097
    Cell Significance Index: -3.2900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3250
    Cell Significance Index: -2.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3357
    Cell Significance Index: -17.4400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3431
    Cell Significance Index: -4.4400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3434
    Cell Significance Index: -4.0400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3457
    Cell Significance Index: -4.3800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3459
    Cell Significance Index: -4.3700
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3551
    Cell Significance Index: -3.8900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3627
    Cell Significance Index: -3.9100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3685
    Cell Significance Index: -4.3800
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.3713
    Cell Significance Index: -3.8200
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3738
    Cell Significance Index: -3.8000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3763
    Cell Significance Index: -4.3300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3828
    Cell Significance Index: -4.4100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3842
    Cell Significance Index: -4.8000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.3875
    Cell Significance Index: -4.0200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3886
    Cell Significance Index: -4.4200
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3917
    Cell Significance Index: -3.7600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3922
    Cell Significance Index: -4.1300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.3937
    Cell Significance Index: -3.0100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3949
    Cell Significance Index: -4.4700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3983
    Cell Significance Index: -4.4100
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.4094
    Cell Significance Index: -3.2900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.4124
    Cell Significance Index: -3.7300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4206
    Cell Significance Index: -4.7400
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.4207
    Cell Significance Index: -3.8800
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.4249
    Cell Significance Index: -3.7900
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.4287
    Cell Significance Index: -3.8300
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.4290
    Cell Significance Index: -4.3800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.4315
    Cell Significance Index: -3.9200
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.4325
    Cell Significance Index: -3.8000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.4329
    Cell Significance Index: -4.4200
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.4340
    Cell Significance Index: -4.0100
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.4401
    Cell Significance Index: -4.3500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4413
    Cell Significance Index: -4.9300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.4448
    Cell Significance Index: -4.5100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.4453
    Cell Significance Index: -3.9000
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.4461
    Cell Significance Index: -4.4000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.4511
    Cell Significance Index: -4.2000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.4523
    Cell Significance Index: -4.2800
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.4527
    Cell Significance Index: -4.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.4533
    Cell Significance Index: -4.6000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.4536
    Cell Significance Index: -4.5700
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.4556
    Cell Significance Index: -4.4200
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.4577
    Cell Significance Index: -3.5900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.4641
    Cell Significance Index: -4.9900
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.4643
    Cell Significance Index: -4.0000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.4650
    Cell Significance Index: -4.9300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4651
    Cell Significance Index: -5.1100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.4692
    Cell Significance Index: -4.7400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.4722
    Cell Significance Index: -5.1200
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.4741
    Cell Significance Index: -3.8700
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.4777
    Cell Significance Index: -3.9800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.4784
    Cell Significance Index: -4.4400
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.4788
    Cell Significance Index: -5.1100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4815
    Cell Significance Index: -4.5200
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.4830
    Cell Significance Index: -5.0900
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.4841
    Cell Significance Index: -4.5100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4867
    Cell Significance Index: -5.3900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4892
    Cell Significance Index: -6.4200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.4904
    Cell Significance Index: -5.0800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.4920
    Cell Significance Index: -4.3800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.4942
    Cell Significance Index: -3.9500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.4969
    Cell Significance Index: -6.7600
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.4987
    Cell Significance Index: -4.4200
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.5063
    Cell Significance Index: -5.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin superfamily**: IGHV2-26 belongs to the immunoglobulin superfamily, which consists of proteins that recognize and bind to specific antigens. 2. **Heavy chain variable region**: IGHV2-26 encodes the heavy chain variable region, which is responsible for recognizing and binding to antigens. 3. **Significant expression**: IGHV2-26 is significantly expressed in various cell types, including immune cells, endothelial cells, and epithelial cells. 4. **Multiple pathways involvement**: IGHV2-26 is involved in multiple pathways, including antigen binding, extracellular region, and immunoglobulin-mediated immune response. **Pathways and Functions:** 1. **Antigen binding**: IGHV2-26 recognizes and binds to specific antigens, which triggers an immune response. 2. **Extracellular region**: IGHV2-26 is part of the extracellular region of the antibody, which interacts with antigens. 3. **Immunoglobulin-mediated immune response**: IGHV2-26 plays a crucial role in the immunoglobulin-mediated immune response, which involves the production of antibodies to neutralize pathogens. 4. **Immunoglobulin complex**: IGHV2-26 is part of the immunoglobulin complex, which is composed of heavy and light chains. **Clinical Significance:** 1. **Immune-related disorders**: Dysregulation of IGHV2-26 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. 2. **Antibody production**: IGHV2-26 plays a critical role in the production of antibodies, which are essential for recognizing and neutralizing pathogens. 3. **Immunotherapy**: IGHV2-26 has been a target for immunotherapy, which involves the use of antibodies to target specific antigens. 4. **Cancer**: IGHV2-26 has been implicated in cancer, as it can contribute to the development and progression of tumors. In conclusion, the IGHV2-26 gene is a critical component of the human immune system, playing a pivotal role in the production of antibodies and recognition of antigens. Understanding the key characteristics, pathways, and functions of this gene is essential for the development of novel immunotherapies and treatments for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.