Details for: IGHV1 69 2

Gene ID: 28458

Symbol: IGHV1 69 2

Ensembl ID: ENSG00000281990

Description: immunoglobulin heavy variable 1-69-2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,814
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 877
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,579
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,656
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,731
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 804
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,276
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 739
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.69
    Marker Score: 455
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 392
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.55
    Marker Score: 1,689
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.43
    Marker Score: 556
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.41
    Marker Score: 1,707
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 215
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.31
    Marker Score: 706
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 114
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.18
    Marker Score: 297
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.17
    Marker Score: 232
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.15
    Marker Score: 210
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.14
    Marker Score: 132
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.12
    Marker Score: 83
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.12
    Marker Score: 98
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.11
    Marker Score: 146
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1
    Marker Score: 104
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.1
    Marker Score: 243
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.1
    Marker Score: 74
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 87
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.07
    Marker Score: 47
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.06
    Marker Score: 67
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.06
    Marker Score: 138
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.05
    Marker Score: 634
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.05
    Marker Score: 52
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 59
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.05
    Marker Score: 43
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.05
    Marker Score: 89
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.02
    Marker Score: 66
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 31
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.01
    Marker Score: 457
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.01
    Marker Score: 352
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 11

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV1 69 2 belongs to the immunoglobulin heavy variable region (IGHV) family, which is responsible for encoding the variable region of the heavy chain of antibodies. This gene exhibits a high degree of diversity, allowing it to recognize a wide range of antigens. The IGHV1 69 2 gene is characterized by its unique sequence and structure, which enables it to interact with specific antigen-binding sites on the light chain. **Pathways and Functions:** IGHV1 69 2 is involved in several key signaling pathways, including: 1. **Antigen binding**: IGHV1 69 2 recognizes and binds to specific antigens, triggering a cascade of downstream events that lead to the activation of immune cells. 2. **Extracellular region**: The extracellular region of IGHV1 69 2 is crucial for antigen recognition and binding, allowing the antibody to interact with its specific antigen. 3. **Immunoglobulin complex**: IGHV1 69 2 plays a critical role in the formation of immunoglobulin complexes, which are essential for the development of immune responses against pathogens. 4. **Immunoglobulin-mediated immune response**: IGHV1 69 2 is involved in the activation of immune cells, such as B cells and T cells, which are essential for the development of immune responses against antigens. **Clinical Significance:** IGHV1 69 2 has significant implications for our understanding of immune function and disease. Abnormalities in this gene have been linked to various immunological disorders, including: 1. **Autoimmune diseases**: IGHV1 69 2 has been implicated in the development of autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system mistakenly targets self-antigens. 2. **Cancer**: IGHV1 69 2 has been found to be overexpressed in certain types of cancer, such as multiple myeloma and lymphoma, where it can contribute to tumor progression and immune evasion. 3. **Gastrointestinal disorders**: IGHV1 69 2 is significantly expressed in gastrointestinal cells, where it contributes to the development of immune responses against pathogens and tumor cells. In conclusion, IGHV1 69 2 is a critical gene involved in the recognition and response to antigens, with significant implications for our understanding of immune function and disease. Further research into this gene is essential for the development of novel therapeutic strategies for immunological disorders and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.