Details for: PRR23E

Gene ID: 285311

Symbol: PRR23E

Ensembl ID: ENSG00000214324

Description: PRR23 family member E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 15.1775
    Cell Significance Index: 386.6900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 6.8902
    Cell Significance Index: 111.6000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.8108
    Cell Significance Index: 82.2400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 2.6462
    Cell Significance Index: 28.1100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.4275
    Cell Significance Index: 4.0600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2073
    Cell Significance Index: 3.0100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0987
    Cell Significance Index: 1.3000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0616
    Cell Significance Index: 0.4700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0548
    Cell Significance Index: 0.6700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0529
    Cell Significance Index: 0.5400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0405
    Cell Significance Index: 0.5400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0382
    Cell Significance Index: 0.3700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0370
    Cell Significance Index: 0.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0362
    Cell Significance Index: 0.9700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0339
    Cell Significance Index: 0.4400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0324
    Cell Significance Index: 0.4100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0163
    Cell Significance Index: 0.2100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0150
    Cell Significance Index: 0.1600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.0125
    Cell Significance Index: 0.1200
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.0099
    Cell Significance Index: 0.1100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.0047
    Cell Significance Index: 0.0300
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0043
    Cell Significance Index: 0.0400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0022
    Cell Significance Index: 0.0300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0021
    Cell Significance Index: 0.0100
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0002
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0007
    Cell Significance Index: -0.1400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0015
    Cell Significance Index: -0.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0018
    Cell Significance Index: -0.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0022
    Cell Significance Index: -0.0500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0025
    Cell Significance Index: -0.1700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0042
    Cell Significance Index: -0.1500
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0045
    Cell Significance Index: -0.0500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0046
    Cell Significance Index: -0.0500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0056
    Cell Significance Index: -0.1600
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0059
    Cell Significance Index: -0.1500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0063
    Cell Significance Index: -0.0700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0065
    Cell Significance Index: -0.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0071
    Cell Significance Index: -0.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0073
    Cell Significance Index: -0.1400
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0073
    Cell Significance Index: -0.0800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0075
    Cell Significance Index: -0.1500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0076
    Cell Significance Index: -0.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0076
    Cell Significance Index: -0.1500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0077
    Cell Significance Index: -0.1100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0083
    Cell Significance Index: -0.0800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0090
    Cell Significance Index: -0.1200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0090
    Cell Significance Index: -0.0900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0100
    Cell Significance Index: -0.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0102
    Cell Significance Index: -0.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0102
    Cell Significance Index: -0.1500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0104
    Cell Significance Index: -0.1400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0104
    Cell Significance Index: -0.1300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0105
    Cell Significance Index: -0.1400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0109
    Cell Significance Index: -0.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0114
    Cell Significance Index: -0.2500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0118
    Cell Significance Index: -0.1400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0119
    Cell Significance Index: -0.1500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0122
    Cell Significance Index: -0.1500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0127
    Cell Significance Index: -0.1500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0128
    Cell Significance Index: -0.1800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0128
    Cell Significance Index: -0.1500
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0129
    Cell Significance Index: -0.1300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0139
    Cell Significance Index: -0.1500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0149
    Cell Significance Index: -0.1400
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0152
    Cell Significance Index: -0.1100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0154
    Cell Significance Index: -0.1400
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0159
    Cell Significance Index: -0.1500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0165
    Cell Significance Index: -0.2200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0166
    Cell Significance Index: -0.2300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0172
    Cell Significance Index: -0.1900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0188
    Cell Significance Index: -0.1200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0203
    Cell Significance Index: -0.2200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0205
    Cell Significance Index: -0.2200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0207
    Cell Significance Index: -0.2300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0207
    Cell Significance Index: -0.2400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0215
    Cell Significance Index: -0.1400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0222
    Cell Significance Index: -0.2700
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.0222
    Cell Significance Index: -0.1700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0227
    Cell Significance Index: -0.2600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0261
    Cell Significance Index: -0.1400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0262
    Cell Significance Index: -0.2400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0273
    Cell Significance Index: -0.2600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0348
    Cell Significance Index: -0.3300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0390
    Cell Significance Index: -0.5400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0447
    Cell Significance Index: -0.2700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0564
    Cell Significance Index: -0.6300
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0616
    Cell Significance Index: -0.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Type-Specific Expression:** PRR23E is expressed in a wide range of cell types, including erythrocytes, oocytes, hematopoietic stem cells, and T cells, highlighting its potential role in various cellular processes. 2. **Protein Binding Domain:** The presence of a proline-rich domain in PRR23E suggests its ability to interact with other proteins, influencing cellular signaling and interactions. 3. **Evolutionary Conservation:** The conservation of PRR23E across species (e.g., human, mouse, and zebrafish) indicates its fundamental importance in cellular biology. **Pathways and Functions:** 1. **Protein Binding Pathways:** PRR23E's proline-rich domain enables it to interact with other proteins, modulating signaling pathways involved in cellular processes such as cell proliferation, differentiation, and survival. 2. **Cellular Adhesion:** PRR23E's expression in cell types like pericytes and smooth muscle myoblasts suggests its involvement in cellular adhesion, a critical process in tissue development and maintenance. 3. **Immune Response:** The presence of PRR23E in T cells and plasmacytoid dendritic cells implies its role in regulating immune responses, potentially influencing T cell activation and antigen presentation. **Clinical Significance:** 1. **Immunological Disorders:** Alterations in PRR23E expression or function may contribute to immunological disorders, such as autoimmune diseases or immunodeficiencies, highlighting the need for further research into its role in immune regulation. 2. **Cancer Research:** The expression of PRR23E in hematopoietic stem cells and T cells suggests its potential involvement in cancer development and progression, warranting further investigation into its role in tumorigenesis. 3. **Neurological Disorders:** PRR23E's expression in neuronal receptor cells and smooth muscle myoblasts implies its potential involvement in neurological disorders, such as neurodegenerative diseases or neuromuscular disorders. In conclusion, the PRR23E gene represents a fascinating area of research, with its unique expression pattern and protein binding capabilities offering insights into its potential roles in various cellular processes. Further investigation into the immunological significance of PRR23E is warranted, with implications for understanding and treating immunological and neurological disorders.

Genular Protein ID: 3876234895

Symbol: PR23E_HUMAN

Name: Proline-rich protein 23E

UniProtKB Accession Codes:

Q8N813 B2RNW5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CTD 1 DMDM 1 DNASU 1 EMBL 4 Ensembl 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 242
  • Mass: 26007
  • Checksum: 5A34DA32ED3B8474
  • Sequence:
    • MGTGASEKQA EQKVRRAFEA SEEAHGTLAA STPWVAMGSA YGSCTCLGAQ PVTDLALWPV 
IYSCMGFSPQ AYPAFWAYPW VLYGGYLWMG YPPPAALVPS VWLYWRGASS FDPLIGSPYL 
AALAPNLFPF PMKFPPTYSL ASPTLGGATS SHCPQVGCWT PASSAPRAAV EGPSRGAPYL 
KTCKAPPSEW ASRFGIWAPL PCCSSELRPL PPSPIEDSQL DPGCSRSSSR SPCRARRRLF 
EC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.