Details for: TRBV10 1

Gene ID: 28585

Symbol: TRBV10 1

Ensembl ID: ENSG00000211717

Description: T cell receptor beta variable 10-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0684
    Cell Significance Index: 0.7700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0147
    Cell Significance Index: 0.0800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0033
    Cell Significance Index: -0.0600
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0043
    Cell Significance Index: -0.8700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0044
    Cell Significance Index: -0.0600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0060
    Cell Significance Index: -0.0700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0141
    Cell Significance Index: -0.2100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0165
    Cell Significance Index: -0.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0198
    Cell Significance Index: -0.4800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0231
    Cell Significance Index: -0.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0262
    Cell Significance Index: -0.7000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0270
    Cell Significance Index: -0.3200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0294
    Cell Significance Index: -0.4000
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0300
    Cell Significance Index: -0.2700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0311
    Cell Significance Index: -0.3400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0315
    Cell Significance Index: -0.4600
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0318
    Cell Significance Index: -0.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0327
    Cell Significance Index: -0.4900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0328
    Cell Significance Index: -0.4600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0332
    Cell Significance Index: -0.3000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0337
    Cell Significance Index: -0.3400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0374
    Cell Significance Index: -0.6100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0404
    Cell Significance Index: -0.6900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0421
    Cell Significance Index: -0.5500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0424
    Cell Significance Index: -0.5300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0439
    Cell Significance Index: -0.7500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0459
    Cell Significance Index: -0.5800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0464
    Cell Significance Index: -0.4700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0468
    Cell Significance Index: -0.4800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0481
    Cell Significance Index: -0.4100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0488
    Cell Significance Index: -0.4200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0495
    Cell Significance Index: -0.6500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0512
    Cell Significance Index: -0.6400
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0520
    Cell Significance Index: -0.4100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0525
    Cell Significance Index: -0.6500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0526
    Cell Significance Index: -1.3400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0529
    Cell Significance Index: -0.6900
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0539
    Cell Significance Index: -0.4900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0543
    Cell Significance Index: -0.7100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0545
    Cell Significance Index: -0.5900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0552
    Cell Significance Index: -0.6500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0567
    Cell Significance Index: -0.5300
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0625
    Cell Significance Index: -0.7000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0626
    Cell Significance Index: -0.8600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0628
    Cell Significance Index: -0.6300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0631
    Cell Significance Index: -0.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0644
    Cell Significance Index: -1.1900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0661
    Cell Significance Index: -0.5700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0665
    Cell Significance Index: -0.6900
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0669
    Cell Significance Index: -0.4600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0685
    Cell Significance Index: -1.0400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0686
    Cell Significance Index: -0.6500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0690
    Cell Significance Index: -0.8000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0690
    Cell Significance Index: -0.9800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0692
    Cell Significance Index: -0.8300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0701
    Cell Significance Index: -1.3700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0708
    Cell Significance Index: -0.8700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0710
    Cell Significance Index: -0.7200
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0711
    Cell Significance Index: -0.8200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0717
    Cell Significance Index: -0.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0739
    Cell Significance Index: -0.7100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0741
    Cell Significance Index: -0.6000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0747
    Cell Significance Index: -0.8600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0756
    Cell Significance Index: -0.8700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0771
    Cell Significance Index: -0.9900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0784
    Cell Significance Index: -0.7900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0806
    Cell Significance Index: -0.8500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0813
    Cell Significance Index: -0.8300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0834
    Cell Significance Index: -0.9400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0842
    Cell Significance Index: -0.8600
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0855
    Cell Significance Index: -0.9500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0858
    Cell Significance Index: -0.9500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0872
    Cell Significance Index: -1.0300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0873
    Cell Significance Index: -0.8900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0882
    Cell Significance Index: -0.8700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0884
    Cell Significance Index: -0.9400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0897
    Cell Significance Index: -1.0600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0909
    Cell Significance Index: -0.9800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0916
    Cell Significance Index: -0.7000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0919
    Cell Significance Index: -0.8500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0927
    Cell Significance Index: -0.8700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0937
    Cell Significance Index: -1.1400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0944
    Cell Significance Index: -0.9200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0946
    Cell Significance Index: -1.1300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0956
    Cell Significance Index: -0.7900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0958
    Cell Significance Index: -1.0700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0963
    Cell Significance Index: -0.7700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0969
    Cell Significance Index: -0.8800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0970
    Cell Significance Index: -0.8200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0995
    Cell Significance Index: -0.8400
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1003
    Cell Significance Index: -0.8700
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1005
    Cell Significance Index: -0.8400
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.1005
    Cell Significance Index: -0.8200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1012
    Cell Significance Index: -1.0100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1066
    Cell Significance Index: -1.1800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1076
    Cell Significance Index: -1.1200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1093
    Cell Significance Index: -0.8500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1118
    Cell Significance Index: -0.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV10-1 is a member of the TCR beta variable (TRBV) family, which comprises a diverse array of Vβ domains that contribute to the TCR's ability to recognize and respond to antigens. The TRBV10-1 gene is characterized by its unique Vβ domain, which is distinct from other TRBV family members. This gene is also notable for its broad expression profile, with significant expression in various hematopoietic cells, including granulocytes, monocytes, and T lymphocytes. **Pathways and Functions:** The TRBV10-1 gene is involved in the adaptive immune response, specifically in the recognition and binding to antigens through the TCR complex. The TCR complex, comprising the TRBV10-1 gene product, TRDVβ10-1, and TRDCβ10-1 domains, interacts with major histocompatibility complex (MHC) molecules on antigen-presenting cells to recognize and respond to specific antigens. This interaction triggers a cascade of signaling events that ultimately lead to the activation of T cells and the initiation of an immune response. The TRBV10-1 gene also plays a role in the development and maturation of T cells. The unique Vβ domain of the TRBV10-1 gene product interacts with other TCR components to facilitate the proper assembly and functioning of the TCR complex during T cell development. **Clinical Significance:** Dysregulation of the TRBV10-1 gene has been implicated in various autoimmune and immunodeficiency disorders, including multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. These disorders are characterized by an imbalance in the adaptive immune response, with an overactive or underactive T cell response to specific antigens. Furthermore, the TRBV10-1 gene has been identified as a potential target for cancer immunotherapy. Tumor cells often display aberrant MHC molecules, which can be recognized by T cells expressing TRBV10-1. Targeting the TRBV10-1 gene or its product may provide a novel therapeutic strategy for cancer treatment. In conclusion, the TRBV10-1 gene is a critical component of the adaptive immune system, with a unique Vβ domain that plays a pivotal role in recognizing and binding to specific antigens. Its expression profile and functional significance make it an essential target for understanding the mechanisms of the adaptive immune response and developing novel therapeutic strategies for autoimmune and immunodeficiency disorders, as well as cancer treatment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.