Details for: TRBV9

Gene ID: 28586

Symbol: TRBV9

Ensembl ID: ENSG00000211716

Description: T cell receptor beta variable 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.7702
    Cell Significance Index: 4.2000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.2830
    Cell Significance Index: 3.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0029
    Cell Significance Index: -0.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0000
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0125
    Cell Significance Index: -0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0171
    Cell Significance Index: -3.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0297
    Cell Significance Index: -4.0800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0309
    Cell Significance Index: -0.3900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0345
    Cell Significance Index: -0.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0349
    Cell Significance Index: -3.5700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0353
    Cell Significance Index: -0.6000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0358
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0449
    Cell Significance Index: -0.5700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0466
    Cell Significance Index: -0.5500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0526
    Cell Significance Index: -0.7700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0643
    Cell Significance Index: -0.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0682
    Cell Significance Index: -3.5500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0716
    Cell Significance Index: -0.6100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0790
    Cell Significance Index: -0.6400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0848
    Cell Significance Index: -2.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0892
    Cell Significance Index: -4.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0928
    Cell Significance Index: -4.3600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0945
    Cell Significance Index: -2.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1180
    Cell Significance Index: -3.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1333
    Cell Significance Index: -2.8300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1393
    Cell Significance Index: -3.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1406
    Cell Significance Index: -2.7800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1481
    Cell Significance Index: -1.4900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1518
    Cell Significance Index: -1.5400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1652
    Cell Significance Index: -2.6800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1667
    Cell Significance Index: -1.5800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1689
    Cell Significance Index: -1.4000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1752
    Cell Significance Index: -1.7700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1760
    Cell Significance Index: -1.8300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1802
    Cell Significance Index: -2.1200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1841
    Cell Significance Index: -3.6000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1878
    Cell Significance Index: -2.4300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1884
    Cell Significance Index: -1.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1946
    Cell Significance Index: -1.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2002
    Cell Significance Index: -3.7000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2020
    Cell Significance Index: -1.8900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2024
    Cell Significance Index: -3.4900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2034
    Cell Significance Index: -1.7000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2048
    Cell Significance Index: -2.8400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2075
    Cell Significance Index: -2.8500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2120
    Cell Significance Index: -2.2800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2168
    Cell Significance Index: -2.7800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2169
    Cell Significance Index: -2.2500
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2188
    Cell Significance Index: -2.6600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2211
    Cell Significance Index: -3.7800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2237
    Cell Significance Index: -1.7400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2252
    Cell Significance Index: -2.8200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2293
    Cell Significance Index: -2.3100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2336
    Cell Significance Index: -3.9400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2339
    Cell Significance Index: -2.2800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2376
    Cell Significance Index: -2.0500
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.2384
    Cell Significance Index: -1.6400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2388
    Cell Significance Index: -2.7700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2407
    Cell Significance Index: -2.8300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2433
    Cell Significance Index: -2.5800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2449
    Cell Significance Index: -3.5700
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.2469
    Cell Significance Index: -2.6700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2505
    Cell Significance Index: -2.7400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2512
    Cell Significance Index: -3.5700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2565
    Cell Significance Index: -2.8900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2569
    Cell Significance Index: -2.7700
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.2600
    Cell Significance Index: -2.5700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2606
    Cell Significance Index: -3.4300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2607
    Cell Significance Index: -3.4100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2627
    Cell Significance Index: -3.4300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2655
    Cell Significance Index: -2.8200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2663
    Cell Significance Index: -3.0300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2670
    Cell Significance Index: -3.4300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2677
    Cell Significance Index: -3.0800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2685
    Cell Significance Index: -3.0900
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2685
    Cell Significance Index: -2.8300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2698
    Cell Significance Index: -2.9400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2711
    Cell Significance Index: -3.0200
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.2723
    Cell Significance Index: -3.0300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2734
    Cell Significance Index: -3.3600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2736
    Cell Significance Index: -3.5900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2739
    Cell Significance Index: -2.6500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2744
    Cell Significance Index: -3.2900
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.2792
    Cell Significance Index: -2.9800
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.2800
    Cell Significance Index: -2.9900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2800
    Cell Significance Index: -3.3800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2827
    Cell Significance Index: -3.3600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2861
    Cell Significance Index: -3.4800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2881
    Cell Significance Index: -3.4100
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.2881
    Cell Significance Index: -2.8200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2881
    Cell Significance Index: -3.4200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2886
    Cell Significance Index: -3.6100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2934
    Cell Significance Index: -2.9900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2943
    Cell Significance Index: -3.5500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2953
    Cell Significance Index: -4.0500
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.2963
    Cell Significance Index: -2.7000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2969
    Cell Significance Index: -3.9500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2996
    Cell Significance Index: -3.5400
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.2999
    Cell Significance Index: -2.9700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3008
    Cell Significance Index: -3.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV9 is a member of the TCR beta family, which is composed of variable (V), diversity (D), and joining (J) regions. The V region of TRBV9 is responsible for recognizing and binding to specific antigens, while the D and J regions contribute to the diversity and specificity of the TCR. TRBV9 is specifically expressed in a range of cell types, including T lymphocytes, granulocytes, and neoplastic cells, highlighting its broad involvement in the immune response. **Pathways and Functions:** TRBV9 is integral to the adaptive immune response, which is mediated by T lymphocytes. The TCR, including TRBV9, recognizes and binds to specific antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells. This binding event triggers a cascade of signaling pathways that ultimately lead to T cell activation, proliferation, and differentiation. TRBV9 is also involved in the regulation of immune responses, including the coordination of T cell responses and the modulation of immune cell activation and tolerance. TRBV9 has been shown to be involved in various immune-related processes, including: * Antigen recognition and presentation * T cell activation and proliferation * Cytotoxicity and apoptosis * Immune cell regulation and tolerance **Clinical Significance:** Dysregulation of TRBV9 expression or function has been implicated in various immune-related disorders, including autoimmune diseases, cancer, and immunodeficiency. For example: * Autoimmune diseases: TRBV9 has been shown to contribute to the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, by promoting T cell activation and proliferation. * Cancer: TRBV9 has been implicated in the development and progression of certain types of cancer, including leukemia and lymphoma, by contributing to T cell activation and immune evasion. * Immunodeficiency: TRBV9 has been shown to be involved in the regulation of immune responses in immunodeficiency disorders, such as HIV infection and immunosuppression. In conclusion, TRBV9 is a critical component of the adaptive immune response, playing a vital role in recognizing and responding to pathogens. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of further research into the mechanisms and significance of TRBV9.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.