Details for: TRBV7 4

Gene ID: 28594

Symbol: TRBV7 4

Ensembl ID: ENSG00000253409

Description: T cell receptor beta variable 7-4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0550
    Cell Significance Index: 0.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0052
    Cell Significance Index: -1.0400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0078
    Cell Significance Index: -0.0700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0176
    Cell Significance Index: -0.2400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0186
    Cell Significance Index: -0.4500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0212
    Cell Significance Index: -0.2500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0218
    Cell Significance Index: -0.3200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0242
    Cell Significance Index: -0.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0283
    Cell Significance Index: -0.9000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0306
    Cell Significance Index: -0.4000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0332
    Cell Significance Index: -0.5600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0340
    Cell Significance Index: -0.2900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0348
    Cell Significance Index: -0.8700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0368
    Cell Significance Index: -0.7200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0420
    Cell Significance Index: -1.0700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0449
    Cell Significance Index: -0.4200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0459
    Cell Significance Index: -0.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0460
    Cell Significance Index: -0.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0468
    Cell Significance Index: -0.9400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0490
    Cell Significance Index: -0.5000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0502
    Cell Significance Index: -0.5300
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0507
    Cell Significance Index: -0.4200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0518
    Cell Significance Index: -0.6700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0519
    Cell Significance Index: -0.5300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0540
    Cell Significance Index: -0.8800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0574
    Cell Significance Index: -0.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0574
    Cell Significance Index: -1.0600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0611
    Cell Significance Index: -1.0500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0617
    Cell Significance Index: -0.7800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0621
    Cell Significance Index: -0.6300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0642
    Cell Significance Index: -0.5200
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0674
    Cell Significance Index: -0.5800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0701
    Cell Significance Index: -0.9200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0717
    Cell Significance Index: -0.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0728
    Cell Significance Index: -0.7000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0737
    Cell Significance Index: -1.2700
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0739
    Cell Significance Index: -0.7600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0751
    Cell Significance Index: -1.0300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0753
    Cell Significance Index: -0.9300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0756
    Cell Significance Index: -0.8200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0778
    Cell Significance Index: -1.1100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0784
    Cell Significance Index: -1.2600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0786
    Cell Significance Index: -0.8600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0790
    Cell Significance Index: -1.0400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0805
    Cell Significance Index: -1.0200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0810
    Cell Significance Index: -0.9400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0832
    Cell Significance Index: -0.9300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0836
    Cell Significance Index: -1.2700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0843
    Cell Significance Index: -0.7800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0846
    Cell Significance Index: -0.7300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0846
    Cell Significance Index: -0.7200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0859
    Cell Significance Index: -1.0200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0863
    Cell Significance Index: -0.8700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0879
    Cell Significance Index: -0.9900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0885
    Cell Significance Index: -1.1600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0886
    Cell Significance Index: -0.9500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0893
    Cell Significance Index: -0.9500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0895
    Cell Significance Index: -1.0300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0899
    Cell Significance Index: -1.3100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0902
    Cell Significance Index: -0.9200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0918
    Cell Significance Index: -0.9800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0924
    Cell Significance Index: -1.1900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0927
    Cell Significance Index: -0.9300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0931
    Cell Significance Index: -1.1000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0931
    Cell Significance Index: -1.1000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0932
    Cell Significance Index: -1.2800
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.0933
    Cell Significance Index: -0.9600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0939
    Cell Significance Index: -1.0400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0943
    Cell Significance Index: -0.8300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0950
    Cell Significance Index: -1.2200
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.0952
    Cell Significance Index: -0.9300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0952
    Cell Significance Index: -1.1200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0955
    Cell Significance Index: -0.9900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0967
    Cell Significance Index: -1.1100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0970
    Cell Significance Index: -1.0300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0986
    Cell Significance Index: -0.7800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0990
    Cell Significance Index: -0.7700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0993
    Cell Significance Index: -1.3200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1002
    Cell Significance Index: -1.4100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1007
    Cell Significance Index: -1.1200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1008
    Cell Significance Index: -1.2000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1013
    Cell Significance Index: -0.8600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1013
    Cell Significance Index: -0.9600
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1018
    Cell Significance Index: -0.7000
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1023
    Cell Significance Index: -1.0000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1032
    Cell Significance Index: -0.8800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1040
    Cell Significance Index: -0.8600
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.1049
    Cell Significance Index: -0.7900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1053
    Cell Significance Index: -1.0700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1053
    Cell Significance Index: -0.8100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1062
    Cell Significance Index: -1.0400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1064
    Cell Significance Index: -0.8500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1064
    Cell Significance Index: -1.3400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1065
    Cell Significance Index: -1.0000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1067
    Cell Significance Index: -1.2800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1068
    Cell Significance Index: -0.9700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1068
    Cell Significance Index: -1.0900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1073
    Cell Significance Index: -1.1300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1077
    Cell Significance Index: -1.3100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1115
    Cell Significance Index: -1.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** The TRBV7-4 gene is located on the X chromosome (Ensembl ID: ENSG00000253409) and is expressed in a wide range of T cell populations, including central memory CD4-positive, alpha-beta T cells, effector CD8-positive, alpha-beta T cells, and naive thymus-derived CD4-positive and CD8-positive T cells. 2. **Cell Surface Receptor Signaling:** The TRBV7-4 gene is part of the T cell receptor complex, which is a cell surface receptor that recognizes and binds to antigens. This receptor signaling pathway is essential for the activation of T cells and the initiation of the immune response. 3. **Adaptive Immune Response:** The TRBV7-4 gene is involved in the adaptive immune response, which is a specific and targeted response to pathogens and tumor cells. This response is characterized by the activation of T cells, which recognize and bind to antigens, resulting in the elimination of infected cells or tumor cells. **Pathways and Functions:** 1. **Adaptive Immune Response:** The TRBV7-4 gene is involved in the adaptive immune response, which is a specific and targeted response to pathogens and tumor cells. 2. **Cell Surface Receptor Signaling:** The TRBV7-4 gene is part of the T cell receptor complex, which is a cell surface receptor that recognizes and binds to antigens. This receptor signaling pathway is essential for the activation of T cells and the initiation of the immune response. 3. **T Cell Receptor Complex:** The TRBV7-4 gene is part of the T cell receptor complex, which is a complex of molecules that recognizes and binds to antigens. This complex includes the T cell receptor alpha chain, beta chain, gamma chain, and delta chain. 4. **MHC Binding:** The TRBV7-4 gene is involved in the binding of the T cell receptor complex to major histocompatibility complex (MHC) molecules, which are essential for the recognition of antigens. **Clinical Significance:** 1. **Cancer Immunotherapy:** The TRBV7-4 gene has been identified as a potential target for cancer immunotherapy. The recognition of tumor cells by T cells expressing the TRBV7-4 gene may lead to the activation of T cells and the elimination of tumor cells. 2. **Vaccine Development:** The TRBV7-4 gene may be used as a target for vaccine development, as the recognition of antigens by T cells expressing the TRBV7-4 gene may lead to the activation of T cells and the development of immune responses. 3. **Autoimmune Diseases:** The TRBV7-4 gene has been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes. The recognition of self-antigens by T cells expressing the TRBV7-4 gene may lead to the activation of T cells and the development of autoimmune responses. 4. **Immunodeficiency Diseases:** The TRBV7-4 gene has been identified as a potential target for the treatment of immunodeficiency diseases, such as HIV and immunodeficiency diseases caused by genetic mutations. In conclusion, the TRBV7-4 gene is a crucial component of the adaptive immune system, and its dysregulation may lead to various diseases, including autoimmune diseases and immunodeficiency diseases. Further research is needed to fully understand the role of the TRBV7-4 gene in the immune response and to develop new therapeutic strategies for the treatment of diseases associated with this gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.