Details for: IGLV8 61

Gene ID: 28774

Symbol: IGLV8 61

Ensembl ID: ENSG00000211638

Description: immunoglobulin lambda variable 8-61

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,691
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,814
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,320
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 653
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.83
    Marker Score: 1,425
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1,328
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.75
    Marker Score: 1,034
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.75
    Marker Score: 432
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 181
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 488
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.43
    Marker Score: 477
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.42
    Marker Score: 379
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.39
    Marker Score: 301
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.36
    Marker Score: 204
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.27
    Marker Score: 435
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.24
    Marker Score: 205
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.24
    Marker Score: 728
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.2
    Marker Score: 135
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.19
    Marker Score: 205
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.17
    Marker Score: 92
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.16
    Marker Score: 162
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.16
    Marker Score: 153
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.15
    Marker Score: 367
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.15
    Marker Score: 196
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.15
    Marker Score: 198
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.12
    Marker Score: 117
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.12
    Marker Score: 81
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 110
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.1
    Marker Score: 261
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1
    Marker Score: 55
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.1
    Marker Score: 70
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.09
    Marker Score: 110
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.08
    Marker Score: 165
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.08
    Marker Score: 70
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.07
    Marker Score: 52
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.07
    Marker Score: 760
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 64
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.06
    Marker Score: 61
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.06
    Marker Score: 50
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.05
    Marker Score: 123
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.05
    Marker Score: 50
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.05
    Marker Score: 83
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 63
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.05
    Marker Score: 37
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.04
    Marker Score: 82
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.04
    Marker Score: 37
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 22

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** IGLV8-61 is a lambda light chain gene, which is one of the three main types of light chains found in antibodies (IgM, IgA, and IgD). The lambda light chain is characterized by a unique variable region that determines the specificity of the antibody. 2. **Expression:** This gene is expressed in a range of cell types, including granulocyte-monocyte progenitor cells, goblet cells, and T cells. Its expression is not limited to the immune system, as it is also found in epithelial cells, such as those in the fallopian tubes and intestinal crypts. 3. **Significance:** The IGLV8-61 gene plays a critical role in the adaptive immune response, which is the body's specific defense against pathogens. It is involved in the production of antibodies, which recognize and bind to specific antigens, triggering an immune response. **Pathways and Functions:** 1. **Adaptive Immunity:** IGLV8-61 is a key component of the adaptive immune response, which is characterized by the activation of specific immune cells, such as T cells and B cells, in response to pathogens. 2. **Immunoglobulin Production:** The IGLV8-61 gene is involved in the production of antibodies, which are crucial for neutralizing pathogens and eliminating them from the body. 3. **Immune Response:** This gene is also involved in the regulation of the immune response, modulating the activity of immune cells and the production of cytokines, which are signaling molecules that coordinate the immune response. 4. **Extracellular Space:** IGLV8-61 is secreted into the extracellular space, where it can interact with antigens and trigger an immune response. **Clinical Significance:** The IGLV8-61 gene has significant clinical implications, particularly in the context of immune-related disorders. Abnormalities in this gene have been associated with various diseases, including: 1. **Immunodeficiency Disorders:** Mutations in the IGLV8-61 gene can lead to impaired antibody production, resulting in immunodeficiency disorders, such as common variable immunodeficiency. 2. **Autoimmune Diseases:** Dysregulation of the IGLV8-61 gene has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system mistakenly attacks healthy tissues. 3. **Cancer:** Abnormal expression of IGLV8-61 has been observed in various types of cancer, including lymphoma and leukemia, where it may contribute to tumor progression and immune evasion. In conclusion, the IGLV8-61 gene plays a vital role in the adaptive immune response, and its dysregulation can have significant clinical implications. Further research is needed to fully understand the mechanisms by which this gene influences immune function and to develop effective therapeutic strategies for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.