IGKV2D 30 | ENSG00000239571 | NCBI 28881

Details for: IGKV2D 30

Gene ID: 28881

Symbol: IGKV2D 30

Ensembl ID: ENSG00000239571

Description: immunoglobulin kappa variable 2D-30

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.7475
Cell Significance Index: 19.5300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.4546
Cell Significance Index: 6.6000
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.0874
Cell Significance Index: 1.2000
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.0319
Cell Significance Index: 0.4000
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.0199
Cell Significance Index: 0.1000
Cell Name: germinal center B cell (CL0000844)
Fold Change: -0.0028
Cell Significance Index: -0.0200
Cell Name: pericyte (CL0000669)
Fold Change: -0.0083
Cell Significance Index: -0.1000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0088
Cell Significance Index: -0.2400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0169
Cell Significance Index: -0.7900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0223
Cell Significance Index: -2.2800
Cell Name: B-1a B cell (CL0000820)
Fold Change: -0.0358
Cell Significance Index: -0.1900
Cell Name: peg cell (CL4033014)
Fold Change: -0.0395
Cell Significance Index: -0.9100
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0494
Cell Significance Index: -0.7500
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.0592
Cell Significance Index: -0.7200
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0628
Cell Significance Index: -0.9200
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: -0.0650
Cell Significance Index: -0.6900
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.0685
Cell Significance Index: -0.9600
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0697
Cell Significance Index: -0.9900
Cell Name: stromal cell (CL0000499)
Fold Change: -0.0710
Cell Significance Index: -0.7300
Cell Name: club cell (CL0000158)
Fold Change: -0.0780
Cell Significance Index: -0.8500
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.0783
Cell Significance Index: -0.8600
Cell Name: chondrocyte (CL0000138)
Fold Change: -0.0790
Cell Significance Index: -0.9100
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.0790
Cell Significance Index: -0.9600
Cell Name: lung macrophage (CL1001603)
Fold Change: -0.0801
Cell Significance Index: -0.8800
Cell Name: Schwann cell (CL0002573)
Fold Change: -0.0822
Cell Significance Index: -0.9200
Cell Name: mucus secreting cell (CL0000319)
Fold Change: -0.0842
Cell Significance Index: -0.8600
Cell Name: fibroblast (CL0000057)
Fold Change: -0.0852
Cell Significance Index: -0.8000
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.0858
Cell Significance Index: -0.9300
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0871
Cell Significance Index: -2.2200
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: -0.0877
Cell Significance Index: -0.7900
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: -0.0906
Cell Significance Index: -1.1600
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: -0.0908
Cell Significance Index: -0.9700
Cell Name: basal cell (CL0000646)
Fold Change: -0.0916
Cell Significance Index: -1.0900
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.0927
Cell Significance Index: -0.9600
Cell Name: serous secreting cell (CL0000313)
Fold Change: -0.0932
Cell Significance Index: -0.8200
Cell Name: pre-B-I cell (CL0000956)
Fold Change: -0.0937
Cell Significance Index: -0.4400
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: -0.0952
Cell Significance Index: -0.9800
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: -0.0981
Cell Significance Index: -0.8500
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.1004
Cell Significance Index: -1.2900
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: -0.1013
Cell Significance Index: -0.9300
Cell Name: mast cell (CL0000097)
Fold Change: -0.1052
Cell Significance Index: -1.3900
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.1062
Cell Significance Index: -1.2500
Cell Name: plasma cell (CL0000786)
Fold Change: -0.1083
Cell Significance Index: -1.2100
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.1095
Cell Significance Index: -1.7600
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.1097
Cell Significance Index: -1.2200
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1144
Cell Significance Index: -2.7700
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.1149
Cell Significance Index: -0.7500
Cell Name: stem cell (CL0000034)
Fold Change: -0.1157
Cell Significance Index: -0.8400
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.1245
Cell Significance Index: -0.7700
Cell Name: neutrophil (CL0000775)
Fold Change: -0.1273
Cell Significance Index: -1.5900
Cell Name: alveolar adventitial fibroblast (CL4028006)
Fold Change: -0.1282
Cell Significance Index: -1.4200
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.1283
Cell Significance Index: -1.1300
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.1291
Cell Significance Index: -0.8600
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1314
Cell Significance Index: -2.5700
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: -0.1348
Cell Significance Index: -1.4400
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.1349
Cell Significance Index: -1.8500
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.1364
Cell Significance Index: -1.7900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1374
Cell Significance Index: -2.5400
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.1398
Cell Significance Index: -2.3900
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.1402
Cell Significance Index: -2.2700
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.1445
Cell Significance Index: -1.8700
Cell Name: macrophage (CL0000235)
Fold Change: -0.1450
Cell Significance Index: -1.4800
Cell Name: malignant cell (CL0001064)
Fold Change: -0.1475
Cell Significance Index: -0.7900
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1505
Cell Significance Index: -1.8500
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.1510
Cell Significance Index: -1.4900
Cell Name: elicited macrophage (CL0000861)
Fold Change: -0.1521
Cell Significance Index: -1.3300
Cell Name: B-1 B cell (CL0000819)
Fold Change: -0.1549
Cell Significance Index: -1.3500
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.1566
Cell Significance Index: -1.8500
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: -0.1646
Cell Significance Index: -1.3000
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.1678
Cell Significance Index: -2.1900
Cell Name: monocyte (CL0000576)
Fold Change: -0.1712
Cell Significance Index: -1.9700
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.1769
Cell Significance Index: -1.8400
Cell Name: B-2 B cell (CL0000822)
Fold Change: -0.1771
Cell Significance Index: -1.5700
Cell Name: B cell (CL0000236)
Fold Change: -0.1836
Cell Significance Index: -2.1700
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: -0.1862
Cell Significance Index: -1.5400
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.1879
Cell Significance Index: -2.4100
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.1904
Cell Significance Index: -2.2500
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.1945
Cell Significance Index: -2.2100
Cell Name: memory B cell (CL0000787)
Fold Change: -0.1946
Cell Significance Index: -2.0700
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.1995
Cell Significance Index: -2.2100
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.2012
Cell Significance Index: -1.8400
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.2043
Cell Significance Index: -2.3700
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.2050
Cell Significance Index: -2.2600
Cell Name: promonocyte (CL0000559)
Fold Change: -0.2069
Cell Significance Index: -2.2100
Cell Name: naive B cell (CL0000788)
Fold Change: -0.2089
Cell Significance Index: -2.2000
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.2100
Cell Significance Index: -2.4400
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.2111
Cell Significance Index: -2.2700
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.2146
Cell Significance Index: -2.5900
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.2218
Cell Significance Index: -2.3600
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.2240
Cell Significance Index: -2.4800
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.2314
Cell Significance Index: -2.3400
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.2314
Cell Significance Index: -2.3600
Cell Name: plasmablast (CL0000980)
Fold Change: -0.2317
Cell Significance Index: -2.1500
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.2324
Cell Significance Index: -2.6800
Cell Name: granulocyte (CL0000094)
Fold Change: -0.2338
Cell Significance Index: -2.8200
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2338
Cell Significance Index: -3.1800
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.2386
Cell Significance Index: -1.9700
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.2396
Cell Significance Index: -2.7000
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.2421
Cell Significance Index: -2.6100
Cell Name: T cell (CL0000084)
Fold Change: -0.2439
Cell Significance Index: -2.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGKV2D is a member of the immunoglobulin kappa chain family, which consists of genes that encode the variable region of the kappa light chain of antibodies. This gene is characterized by its high expression in cells of the immune system, particularly in hematopoietic cells and granulocytes. IGKV2D is also notable for its ability to regulate various immune responses, including the activation of B cell receptors, the generation of second messengers, and the regulation of actin dynamics for phagocytic cup formation. **Pathways and Functions** IGKV2D is involved in several key immune pathways, including: 1. **Adaptive Immune Response**: IGKV2D plays a crucial role in the adaptive immune response against Leishmania parasites, where it helps to activate B cell receptors and generate second messengers. 2. **Anti-Inflammatory Response**: IGKV2D is involved in the anti-inflammatory response, particularly in the context of Leishmania infection, where it helps to regulate the expression of anti-inflammatory cytokines. 3. **Complement Cascade**: IGKV2D is part of the complement cascade, which is a key component of the innate immune response against pathogens, including Leishmania parasites. 4. **Phagocytosis**: IGKV2D regulates the expression of scavenger receptors and Fc gamma receptors, which are essential for the phagocytosis of pathogens, including Leishmania parasites. 5. **Antigen Presentation**: IGKV2D is involved in the presentation of antigens to T cells, which is essential for the activation of the adaptive immune response. **Clinical Significance** IGKV2D has significant clinical implications in the context of Leishmania infections, particularly in terms of: 1. **Leishmaniasis**: IGKV2D is highly expressed in response to Leishmania infection, suggesting its role in the innate immune response against this parasite. 2. **Vaccine Development**: IGKV2D is a potential target for vaccine development against Leishmania parasites, particularly in terms of the generation of anti-Leishmania antibodies. 3. **Immunotherapy**: IGKV2D is a potential target for immunotherapy, particularly in terms of the regulation of the adaptive immune response against Leishmania parasites. 4. **SARS-CoV**: IGKV2D has been implicated in the regulation of the complement cascade and the generation of anti-SARS-CoV antibodies, suggesting its potential role in the immune response against this virus. In conclusion, IGKV2D is a critical gene involved in the adaptive and innate immune responses against Leishmania parasites. Its expression is significantly upregulated in response to Leishmania infection, suggesting its role in the regulation of the immune response against this parasite. IGKV2D has significant clinical implications in the context of Leishmaniasis, vaccine development, immunotherapy, and SARS-CoV infections.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.