IGKV2D 29 | ENSG00000243264 | NCBI 28882

Details for: IGKV2D 29

Gene ID: 28882

Symbol: IGKV2D 29

Ensembl ID: ENSG00000243264

Description: immunoglobulin kappa variable 2D-29

Associated with

Adaptive immune response
(GO:0002250)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0730
Cell Significance Index: 1.1300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0080
Cell Significance Index: -6.0800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0956
Cell Significance Index: -7.3400
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.0998
Cell Significance Index: -1.1200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1048
Cell Significance Index: -13.5400
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1140
Cell Significance Index: -2.9100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1382
Cell Significance Index: -15.8300
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1748
Cell Significance Index: -4.3700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1825
Cell Significance Index: -13.6000
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2056
Cell Significance Index: -4.9800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2202
Cell Significance Index: -5.8900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2289
Cell Significance Index: -4.2300
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2328
Cell Significance Index: -3.9800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2486
Cell Significance Index: -6.3500
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2529
Cell Significance Index: -4.9500
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2819
Cell Significance Index: -4.5700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2850
Cell Significance Index: -13.2900
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.2870
Cell Significance Index: -3.2600
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: -0.2921
Cell Significance Index: -2.7100
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3165
Cell Significance Index: -4.3400
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.3304
Cell Significance Index: -4.3900
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.3348
Cell Significance Index: -3.9800
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.3425
Cell Significance Index: -4.7500
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.3633
Cell Significance Index: -4.0400
Cell Name: ionocyte (CL0005006)
Fold Change: -0.3663
Cell Significance Index: -3.8300
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: -0.3725
Cell Significance Index: -3.9800
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: -0.3795
Cell Significance Index: -4.0500
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.3852
Cell Significance Index: -3.1800
Cell Name: alveolar type 1 fibroblast cell (CL4028004)
Fold Change: -0.3855
Cell Significance Index: -4.0800
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.3891
Cell Significance Index: -4.0300
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: -0.3953
Cell Significance Index: -4.0700
Cell Name: glial cell (CL0000125)
Fold Change: -0.3961
Cell Significance Index: -4.3400
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.4046
Cell Significance Index: -5.2400
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.4063
Cell Significance Index: -3.9000
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.4085
Cell Significance Index: -4.3400
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.4091
Cell Significance Index: -5.9400
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: -0.4178
Cell Significance Index: -4.0800
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.4316
Cell Significance Index: -5.2100
Cell Name: goblet cell (CL0000160)
Fold Change: -0.4356
Cell Significance Index: -3.9400
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.4382
Cell Significance Index: -4.9800
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.4517
Cell Significance Index: -3.9800
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.4538
Cell Significance Index: -5.7500
Cell Name: stromal cell (CL0000499)
Fold Change: -0.4546
Cell Significance Index: -4.6500
Cell Name: neutrophil (CL0000775)
Fold Change: -0.4547
Cell Significance Index: -5.6800
Cell Name: elicited macrophage (CL0000861)
Fold Change: -0.4553
Cell Significance Index: -3.9800
Cell Name: monocyte (CL0000576)
Fold Change: -0.4754
Cell Significance Index: -5.4700
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.4804
Cell Significance Index: -4.0600
Cell Name: blood cell (CL0000081)
Fold Change: -0.4869
Cell Significance Index: -4.1500
Cell Name: platelet (CL0000233)
Fold Change: -0.4870
Cell Significance Index: -5.0100
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.4877
Cell Significance Index: -5.4000
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.4916
Cell Significance Index: -5.3000
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.4938
Cell Significance Index: -5.8100
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: -0.4975
Cell Significance Index: -4.5700
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.5010
Cell Significance Index: -5.7700
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.5068
Cell Significance Index: -6.1600
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.5110
Cell Significance Index: -5.6600
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.5186
Cell Significance Index: -6.0200
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.5220
Cell Significance Index: -4.8600
Cell Name: plasma cell (CL0000786)
Fold Change: -0.5227
Cell Significance Index: -5.8400
Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
Fold Change: -0.5253
Cell Significance Index: -5.6800
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: -0.5271
Cell Significance Index: -4.3600
Cell Name: exhausted T cell (CL0011025)
Fold Change: -0.5301
Cell Significance Index: -4.3200
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.5307
Cell Significance Index: -6.9400
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.5309
Cell Significance Index: -6.8200
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.5310
Cell Significance Index: -5.7100
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.5318
Cell Significance Index: -5.6100
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.5350
Cell Significance Index: -4.7800
Cell Name: peg cell (CL4033014)
Fold Change: -0.5359
Cell Significance Index: -12.3800
Cell Name: thymocyte (CL0000893)
Fold Change: -0.5362
Cell Significance Index: -6.7800
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.5385
Cell Significance Index: -4.7100
Cell Name: dendritic cell, human (CL0001056)
Fold Change: -0.5449
Cell Significance Index: -5.0300
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.5491
Cell Significance Index: -7.8900
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.5544
Cell Significance Index: -5.7500
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.5562
Cell Significance Index: -6.8800
Cell Name: IgM plasma cell (CL0000986)
Fold Change: -0.5587
Cell Significance Index: -4.2900
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.5617
Cell Significance Index: -6.0900
Cell Name: transitional stage B cell (CL0000818)
Fold Change: -0.5691
Cell Significance Index: -5.0000
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.5694
Cell Significance Index: -5.5500
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.5758
Cell Significance Index: -5.6800
Cell Name: obsolete animal cell (CL0000548)
Fold Change: -0.5769
Cell Significance Index: -5.8500
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.5794
Cell Significance Index: -7.4300
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.5831
Cell Significance Index: -5.8200
Cell Name: secretory cell (CL0000151)
Fold Change: -0.5855
Cell Significance Index: -4.0600
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.5886
Cell Significance Index: -4.7300
Cell Name: lung macrophage (CL1001603)
Fold Change: -0.5914
Cell Significance Index: -6.4600
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.5925
Cell Significance Index: -5.5200
Cell Name: macrophage (CL0000235)
Fold Change: -0.5950
Cell Significance Index: -6.0800
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: -0.5959
Cell Significance Index: -4.8900
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.5999
Cell Significance Index: -7.0900
Cell Name: naive B cell (CL0000788)
Fold Change: -0.6002
Cell Significance Index: -6.3200
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: -0.6018
Cell Significance Index: -5.5600
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.6040
Cell Significance Index: -5.6500
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.6058
Cell Significance Index: -7.3700
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.6090
Cell Significance Index: -7.2300
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.6112
Cell Significance Index: -8.7900
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.6191
Cell Significance Index: -5.8700
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.6219
Cell Significance Index: -7.0400
Cell Name: memory B cell (CL0000787)
Fold Change: -0.6223
Cell Significance Index: -6.6200
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -0.6248
Cell Significance Index: -4.9000
Cell Name: intestine goblet cell (CL0019031)
Fold Change: -0.6256
Cell Significance Index: -5.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** The IGKV2D 29 gene is a member of the immunoglobulin kappa family, which is responsible for the production of kappa light chains. These light chains are essential components of antibodies, which are produced by B cells in response to antigens. The IGKV2D 29 gene is characterized by its involvement in the adaptive immune response, extracellular space, and immune response pathways. Its expression is also notable in various cell types, including those involved in the development of the immune system and those that are involved in tissue homeostasis. **Pathways and Functions:** The IGKV2D 29 gene is involved in several key pathways, including: 1. **Adaptive Immune Response:** The IGKV2D 29 gene plays a crucial role in the adaptive immune response by contributing to the production of antibodies. Antibodies are essential for recognizing and binding to specific antigens, leading to the activation of immune cells and the elimination of pathogens. 2. **Extracellular Space:** The IGKV2D 29 gene is also involved in the extracellular space, where it contributes to the formation of immunoglobulin complexes. These complexes are essential for the recognition and binding of antigens by immune cells. 3. **Immune Response:** The IGKV2D 29 gene is involved in the immune response by contributing to the production of antibodies and the activation of immune cells. 4. **Immunoglobulin Complex:** The IGKV2D 29 gene is involved in the formation of immunoglobulin complexes, which are essential for the recognition and binding of antigens by immune cells. 5. **Immunoglobulin Production:** The IGKV2D 29 gene is involved in the production of immunoglobulins, which are essential for the adaptive immune response. **Clinical Significance:** The IGKV2D 29 gene has significant clinical implications, particularly in the context of cancer development and progression. The expression of this gene in neoplastic and abnormal cells suggests its potential role in cancer development and progression. Additionally, the IGKV2D 29 gene may also play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus. In conclusion, the IGKV2D 29 gene is a crucial component of the human immune system, playing a pivotal role in the production of antibodies and the adaptive immune response. Its expression is significant in various cell types, including those involved in the development of the immune system and those that are involved in tissue homeostasis. The clinical significance of this gene is evident, particularly in the context of cancer development and progression. Further research is needed to fully understand the role of the IGKV2D 29 gene in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.