Details for: IGKV1D 17

Gene ID: 28900

Symbol: IGKV1D 17

Ensembl ID: ENSG00000242766

Description: immunoglobulin kappa variable 1D-17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0319
    Cell Significance Index: -0.3500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0553
    Cell Significance Index: -1.4100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0555
    Cell Significance Index: -0.6200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0559
    Cell Significance Index: -0.7600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0568
    Cell Significance Index: -0.5800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0571
    Cell Significance Index: -0.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0594
    Cell Significance Index: -1.4400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0611
    Cell Significance Index: -0.7900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0648
    Cell Significance Index: -1.1000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0702
    Cell Significance Index: -1.2000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0729
    Cell Significance Index: -0.7900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0737
    Cell Significance Index: -1.4400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0737
    Cell Significance Index: -1.0700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0768
    Cell Significance Index: -1.4200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0775
    Cell Significance Index: -0.8800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0779
    Cell Significance Index: -0.9200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0780
    Cell Significance Index: -0.8300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0797
    Cell Significance Index: -1.2100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0798
    Cell Significance Index: -0.7300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0801
    Cell Significance Index: -0.9600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0820
    Cell Significance Index: -1.1500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0840
    Cell Significance Index: -0.7800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0868
    Cell Significance Index: -0.7400
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0908
    Cell Significance Index: -0.7300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0910
    Cell Significance Index: -1.0000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0914
    Cell Significance Index: -1.4800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0919
    Cell Significance Index: -0.8600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0933
    Cell Significance Index: -1.2200
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0936
    Cell Significance Index: -0.8300
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0945
    Cell Significance Index: -0.7800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0956
    Cell Significance Index: -1.2700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0960
    Cell Significance Index: -1.0600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0964
    Cell Significance Index: -1.5500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0968
    Cell Significance Index: -1.1700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0969
    Cell Significance Index: -1.0200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0973
    Cell Significance Index: -1.0600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0982
    Cell Significance Index: -1.1600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0984
    Cell Significance Index: -0.8900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0986
    Cell Significance Index: -1.0800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0999
    Cell Significance Index: -1.4200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1003
    Cell Significance Index: -1.2100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1006
    Cell Significance Index: -1.3200
  • Cell Name: parietal cell (CL0000162)
    Fold Change: -0.1011
    Cell Significance Index: -0.9600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1012
    Cell Significance Index: -1.3900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1018
    Cell Significance Index: -1.3400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1024
    Cell Significance Index: -1.2100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1028
    Cell Significance Index: -1.4100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1029
    Cell Significance Index: -1.5000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1044
    Cell Significance Index: -0.9800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1049
    Cell Significance Index: -1.3700
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1069
    Cell Significance Index: -1.0900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1083
    Cell Significance Index: -1.2200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1085
    Cell Significance Index: -1.0100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1086
    Cell Significance Index: -1.2600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1095
    Cell Significance Index: -1.2600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1097
    Cell Significance Index: -1.1800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1102
    Cell Significance Index: -1.1000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1102
    Cell Significance Index: -1.2800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1112
    Cell Significance Index: -1.2800
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1123
    Cell Significance Index: -1.1400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1125
    Cell Significance Index: -1.1100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1139
    Cell Significance Index: -1.2000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1139
    Cell Significance Index: -1.1100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1147
    Cell Significance Index: -1.4100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1156
    Cell Significance Index: -1.1800
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1159
    Cell Significance Index: -1.0100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1160
    Cell Significance Index: -1.3800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1164
    Cell Significance Index: -1.1800
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1164
    Cell Significance Index: -1.2600
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.1166
    Cell Significance Index: -1.2300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1169
    Cell Significance Index: -1.3800
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1178
    Cell Significance Index: -1.2400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1180
    Cell Significance Index: -1.3600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1194
    Cell Significance Index: -1.2600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1208
    Cell Significance Index: -1.1100
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1208
    Cell Significance Index: -1.2900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1219
    Cell Significance Index: -1.1700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1228
    Cell Significance Index: -1.3600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1252
    Cell Significance Index: -1.3500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1254
    Cell Significance Index: -1.2900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1258
    Cell Significance Index: -1.5300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1273
    Cell Significance Index: -1.3500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1284
    Cell Significance Index: -1.6500
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1287
    Cell Significance Index: -1.1900
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1289
    Cell Significance Index: -1.1500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1305
    Cell Significance Index: -1.3200
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1305
    Cell Significance Index: -1.4500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1307
    Cell Significance Index: -1.3200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1310
    Cell Significance Index: -1.2400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1318
    Cell Significance Index: -1.2500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1322
    Cell Significance Index: -1.3700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1338
    Cell Significance Index: -0.8300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1342
    Cell Significance Index: -1.1100
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1346
    Cell Significance Index: -1.3200
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1397
    Cell Significance Index: -1.3700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1399
    Cell Significance Index: -1.4200
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1400
    Cell Significance Index: -1.1700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1402
    Cell Significance Index: -1.5700
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1406
    Cell Significance Index: -1.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin production:** IGKV1D17 is a gene that contributes to the production of immunoglobulins, which are crucial for neutralizing pathogens and toxins. 2. **Adaptive immune response:** This gene is involved in the adaptive immune response, which is a highly specific and targeted response to specific pathogens or antigens. 3. **Expression in various cell types:** IGKV1D17 is expressed in a range of cell types, including intestinal epithelial cells, leukocytes, and neoplastic cells, highlighting its broad functional scope. 4. **Pathway involvement:** This gene is implicated in various pathways, including the adaptive immune response, extracellular space, and immunoglobulin complex formation. **Pathways and Functions:** 1. **Adaptive immune response:** IGKV1D17 is involved in the adaptive immune response, which is characterized by the activation of specific immune cells, such as T cells and B cells, in response to antigens. 2. **Immunoglobulin complex formation:** This gene contributes to the formation of immunoglobulin complexes, which are essential for the neutralization of pathogens and toxins. 3. **Extracellular space:** IGKV1D17 is also involved in the regulation of the extracellular space, which is critical for the proper functioning of immune cells and the prevention of immune evasion by pathogens. 4. **Immune response regulation:** This gene plays a role in regulating the immune response, which is essential for maintaining immune homeostasis and preventing excessive or inappropriate immune activation. **Clinical Significance:** IGKV1D17 has significant clinical implications, particularly in the context of immune-related disorders and diseases. Some potential clinical applications of this gene include: 1. **Immunoglobulin deficiency:** IGKV1D17 deficiency may contribute to immunoglobulin deficiency, which is characterized by impaired immune function and increased susceptibility to infections. 2. **Autoimmune diseases:** Abnormal expression or function of IGKV1D17 may contribute to autoimmune diseases, such as rheumatoid arthritis, lupus, or multiple sclerosis. 3. **Cancer:** IGKV1D17 expression in neoplastic cells may influence tumor progression and immune evasion. 4. **Vaccine development:** Understanding the function and regulation of IGKV1D17 may inform the development of novel vaccines that target specific immune responses. In conclusion, IGKV1D17 is a gene that plays a critical role in the adaptive immune response, immunoglobulin production, and regulation of immune function. Further research into the function and regulation of this gene may provide valuable insights into the pathogenesis of immune-related disorders and diseases, ultimately informing the development of novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.