Details for: IGKV1D 17

Gene ID: 28900

Symbol: IGKV1D 17

Ensembl ID: ENSG00000242766

Description: immunoglobulin kappa variable 1D-17

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.17
    Marker Score: 2,972
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,670
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 1
    Marker Score: 5,696
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,396
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.97
    Marker Score: 554
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1,565
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.75
    Marker Score: 1,697
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 549
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.62
    Marker Score: 1,013
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.49
    Marker Score: 1,499
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.46
    Marker Score: 596
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.19
    Marker Score: 246
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.16
    Marker Score: 43
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.15
    Marker Score: 182
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.12
    Marker Score: 81
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.12
    Marker Score: 280
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.1
    Marker Score: 404
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.08
    Marker Score: 56
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 90
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.05
    Marker Score: 614
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.04
    Marker Score: 36
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.03
    Marker Score: 48
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.03
    Marker Score: 54
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.03
    Marker Score: 44
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.02
    Marker Score: 44
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 84
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 71
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0
    Marker Score: 9

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin production:** IGKV1D17 is a gene that contributes to the production of immunoglobulins, which are crucial for neutralizing pathogens and toxins. 2. **Adaptive immune response:** This gene is involved in the adaptive immune response, which is a highly specific and targeted response to specific pathogens or antigens. 3. **Expression in various cell types:** IGKV1D17 is expressed in a range of cell types, including intestinal epithelial cells, leukocytes, and neoplastic cells, highlighting its broad functional scope. 4. **Pathway involvement:** This gene is implicated in various pathways, including the adaptive immune response, extracellular space, and immunoglobulin complex formation. **Pathways and Functions:** 1. **Adaptive immune response:** IGKV1D17 is involved in the adaptive immune response, which is characterized by the activation of specific immune cells, such as T cells and B cells, in response to antigens. 2. **Immunoglobulin complex formation:** This gene contributes to the formation of immunoglobulin complexes, which are essential for the neutralization of pathogens and toxins. 3. **Extracellular space:** IGKV1D17 is also involved in the regulation of the extracellular space, which is critical for the proper functioning of immune cells and the prevention of immune evasion by pathogens. 4. **Immune response regulation:** This gene plays a role in regulating the immune response, which is essential for maintaining immune homeostasis and preventing excessive or inappropriate immune activation. **Clinical Significance:** IGKV1D17 has significant clinical implications, particularly in the context of immune-related disorders and diseases. Some potential clinical applications of this gene include: 1. **Immunoglobulin deficiency:** IGKV1D17 deficiency may contribute to immunoglobulin deficiency, which is characterized by impaired immune function and increased susceptibility to infections. 2. **Autoimmune diseases:** Abnormal expression or function of IGKV1D17 may contribute to autoimmune diseases, such as rheumatoid arthritis, lupus, or multiple sclerosis. 3. **Cancer:** IGKV1D17 expression in neoplastic cells may influence tumor progression and immune evasion. 4. **Vaccine development:** Understanding the function and regulation of IGKV1D17 may inform the development of novel vaccines that target specific immune responses. In conclusion, IGKV1D17 is a gene that plays a critical role in the adaptive immune response, immunoglobulin production, and regulation of immune function. Further research into the function and regulation of this gene may provide valuable insights into the pathogenesis of immune-related disorders and diseases, ultimately informing the development of novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.