Details for: IGKV1D 8

Gene ID: 28904

Symbol: IGKV1D 8

Ensembl ID: ENSG00000239819

Description: immunoglobulin kappa variable 1D-8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.6084
    Cell Significance Index: 6.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3484
    Cell Significance Index: 5.3900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0995
    Cell Significance Index: 1.4500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0090
    Cell Significance Index: -6.8000
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0890
    Cell Significance Index: -0.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1113
    Cell Significance Index: -7.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1543
    Cell Significance Index: -30.9500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1720
    Cell Significance Index: -2.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1759
    Cell Significance Index: -4.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1815
    Cell Significance Index: -8.0300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1970
    Cell Significance Index: -2.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2213
    Cell Significance Index: -8.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2882
    Cell Significance Index: -6.9800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3254
    Cell Significance Index: -8.2900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3383
    Cell Significance Index: -4.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3728
    Cell Significance Index: -6.8900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3741
    Cell Significance Index: -5.2500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3974
    Cell Significance Index: -7.7700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3975
    Cell Significance Index: -6.8000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4358
    Cell Significance Index: -6.2500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4419
    Cell Significance Index: -6.0600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4550
    Cell Significance Index: -7.3700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.4641
    Cell Significance Index: -6.0700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.4665
    Cell Significance Index: -6.4500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.5049
    Cell Significance Index: -5.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5055
    Cell Significance Index: -26.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5081
    Cell Significance Index: -23.6900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.5178
    Cell Significance Index: -6.1200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5232
    Cell Significance Index: -5.6100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.5253
    Cell Significance Index: -5.5800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5759
    Cell Significance Index: -6.4900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.5979
    Cell Significance Index: -6.8800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.6022
    Cell Significance Index: -4.0100
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.6250
    Cell Significance Index: -6.4300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.6252
    Cell Significance Index: -8.0900
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.6348
    Cell Significance Index: -6.4500
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.6390
    Cell Significance Index: -7.2500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.6395
    Cell Significance Index: -7.0800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.6444
    Cell Significance Index: -7.0600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.6616
    Cell Significance Index: -7.4900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.6650
    Cell Significance Index: -6.9700
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.6664
    Cell Significance Index: -6.7700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.6714
    Cell Significance Index: -6.5500
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.6751
    Cell Significance Index: -7.2100
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.6773
    Cell Significance Index: -7.8700
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.6840
    Cell Significance Index: -6.3200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.6851
    Cell Significance Index: -8.9900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.6901
    Cell Significance Index: -11.7200
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.7000
    Cell Significance Index: -7.4800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.7028
    Cell Significance Index: -5.9900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.7058
    Cell Significance Index: -7.6100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.7079
    Cell Significance Index: -8.3700
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.7171
    Cell Significance Index: -6.3000
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.7219
    Cell Significance Index: -7.3700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.7232
    Cell Significance Index: -8.0800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.7241
    Cell Significance Index: -8.0200
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.7279
    Cell Significance Index: -5.8500
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.7292
    Cell Significance Index: -7.0000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.7294
    Cell Significance Index: -9.3700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.7326
    Cell Significance Index: -5.6000
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.7390
    Cell Significance Index: -7.9900
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.7396
    Cell Significance Index: -7.3000
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.7492
    Cell Significance Index: -6.9800
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.7525
    Cell Significance Index: -7.1200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.7535
    Cell Significance Index: -8.7400
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.7603
    Cell Significance Index: -6.5500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.7657
    Cell Significance Index: -6.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.7777
    Cell Significance Index: -7.4800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.7781
    Cell Significance Index: -9.7200
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.7791
    Cell Significance Index: -6.9600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.7794
    Cell Significance Index: -8.3800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.7799
    Cell Significance Index: -9.4800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.7806
    Cell Significance Index: -8.2900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7811
    Cell Significance Index: -9.8600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.7821
    Cell Significance Index: -9.0000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.7900
    Cell Significance Index: -6.9100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.7907
    Cell Significance Index: -7.0400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.7950
    Cell Significance Index: -9.4500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.7981
    Cell Significance Index: -9.7100
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.8003
    Cell Significance Index: -7.0900
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.8058
    Cell Significance Index: -8.6100
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.8073
    Cell Significance Index: -6.1600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.8086
    Cell Significance Index: -7.3500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.8105
    Cell Significance Index: -8.6200
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.8194
    Cell Significance Index: -8.3700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.8214
    Cell Significance Index: -9.8500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.8367
    Cell Significance Index: -8.8100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.8383
    Cell Significance Index: -7.8100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.8618
    Cell Significance Index: -8.9300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.8661
    Cell Significance Index: -6.1000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.8669
    Cell Significance Index: -11.5200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.8779
    Cell Significance Index: -11.4600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.8783
    Cell Significance Index: -10.3700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.8803
    Cell Significance Index: -10.0000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.8941
    Cell Significance Index: -9.4800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.8953
    Cell Significance Index: -9.0200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.8979
    Cell Significance Index: -9.3000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.8986
    Cell Significance Index: -9.7900
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.9014
    Cell Significance Index: -9.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV1D8 belongs to the kappa light chain gene family, which encodes the variable region of the kappa light chain of immunoglobulins. This gene is characterized by its high degree of polymorphism, allowing for the generation of a diverse repertoire of antibodies. The IGKV1D8 gene is specifically involved in the production of IgG and IgA antibodies, which are critical for the defense against extracellular pathogens. The gene's expression is tightly regulated, with significant expression observed in early T lineage precursors, neutrophil progenitors, and plasma cells, highlighting its role in the development and function of immune cells. **Pathways and Functions:** IGKV1D8 is integral to several key pathways, including: 1. **Adaptive Immune Response:** IGKV1D8 plays a crucial role in the adaptive immune response by contributing to the production of antibodies against pathogens. The gene's expression in immune cells, such as B cells and plasma cells, enables the generation of a diverse repertoire of antibodies, ensuring effective defense against a wide range of pathogens. 2. **Immunoglobulin Complex Formation:** IGKV1D8 is involved in the formation of immunoglobulin complexes, which are essential for the activation of complement and the elimination of pathogens from the body. 3. **Immunoglobulin Production:** The gene is essential for the production of IgG and IgA antibodies, which are critical for the defense against extracellular pathogens. 4. **Plasma Membrane Signaling:** IGKV1D8 is also involved in plasma membrane signaling, where it interacts with other proteins to regulate cell signaling and immune responses. **Clinical Significance:** The dysregulation of IGKV1D8 has significant clinical implications, including: 1. **Immunodeficiency Disorders:** Altered expression or function of IGKV1D8 can lead to immunodeficiency disorders, such as antibody deficiency syndromes, where individuals are unable to produce sufficient antibodies to defend against pathogens. 2. **Autoimmune Diseases:** Dysregulation of IGKV1D8 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system mistakenly attacks healthy tissues. 3. **Cancer:** IGKV1D8 has been identified as a potential target for cancer immunotherapy, where it can be used to stimulate an immune response against cancer cells. In conclusion, IGKV1D8 is a critical component of the adaptive immune system, playing a pivotal role in the production of antibodies and the regulation of immune responses. Further research into the mechanisms of IGKV1D8 is essential to understand its clinical significance and develop novel therapeutic strategies for immunodeficiency disorders and autoimmune diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.