Details for: IGKV1D 8

Gene ID: 28904

Symbol: IGKV1D 8

Ensembl ID: ENSG00000239819

Description: immunoglobulin kappa variable 1D-8

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,822
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.48
    Marker Score: 290
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.31
    Marker Score: 85
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.12
    Marker Score: 100
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.12
    Marker Score: 139
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.09
    Marker Score: 94
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.09
    Marker Score: 71
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.08
    Marker Score: 177
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.08
    Marker Score: 90
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.08
    Marker Score: 183
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.07
    Marker Score: 99
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 133
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.06
    Marker Score: 170
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.06
    Marker Score: 691
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.06
    Marker Score: 96
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.05
    Marker Score: 48
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.05
    Marker Score: 54
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 51
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 37
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.03
    Marker Score: 6
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.02
    Marker Score: 61
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.01
    Marker Score: 33
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.01
    Marker Score: 10

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV1D8 belongs to the kappa light chain gene family, which encodes the variable region of the kappa light chain of immunoglobulins. This gene is characterized by its high degree of polymorphism, allowing for the generation of a diverse repertoire of antibodies. The IGKV1D8 gene is specifically involved in the production of IgG and IgA antibodies, which are critical for the defense against extracellular pathogens. The gene's expression is tightly regulated, with significant expression observed in early T lineage precursors, neutrophil progenitors, and plasma cells, highlighting its role in the development and function of immune cells. **Pathways and Functions:** IGKV1D8 is integral to several key pathways, including: 1. **Adaptive Immune Response:** IGKV1D8 plays a crucial role in the adaptive immune response by contributing to the production of antibodies against pathogens. The gene's expression in immune cells, such as B cells and plasma cells, enables the generation of a diverse repertoire of antibodies, ensuring effective defense against a wide range of pathogens. 2. **Immunoglobulin Complex Formation:** IGKV1D8 is involved in the formation of immunoglobulin complexes, which are essential for the activation of complement and the elimination of pathogens from the body. 3. **Immunoglobulin Production:** The gene is essential for the production of IgG and IgA antibodies, which are critical for the defense against extracellular pathogens. 4. **Plasma Membrane Signaling:** IGKV1D8 is also involved in plasma membrane signaling, where it interacts with other proteins to regulate cell signaling and immune responses. **Clinical Significance:** The dysregulation of IGKV1D8 has significant clinical implications, including: 1. **Immunodeficiency Disorders:** Altered expression or function of IGKV1D8 can lead to immunodeficiency disorders, such as antibody deficiency syndromes, where individuals are unable to produce sufficient antibodies to defend against pathogens. 2. **Autoimmune Diseases:** Dysregulation of IGKV1D8 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system mistakenly attacks healthy tissues. 3. **Cancer:** IGKV1D8 has been identified as a potential target for cancer immunotherapy, where it can be used to stimulate an immune response against cancer cells. In conclusion, IGKV1D8 is a critical component of the adaptive immune system, playing a pivotal role in the production of antibodies and the regulation of immune responses. Further research into the mechanisms of IGKV1D8 is essential to understand its clinical significance and develop novel therapeutic strategies for immunodeficiency disorders and autoimmune diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.