IGKJ5 | ENSG00000211593 | NCBI 28946

Details for: IGKJ5

Gene ID: 28946

Symbol: IGKJ5

Ensembl ID: ENSG00000211593

Description: immunoglobulin kappa joining 5

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 12.6433
Cell Significance Index: 247.2000
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 7.4175
Cell Significance Index: 114.7600
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 2.2939
Cell Significance Index: 55.5700
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.9846
Cell Significance Index: 10.5900
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.6816
Cell Significance Index: 9.9400
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.0493
Cell Significance Index: 0.4400
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.0343
Cell Significance Index: 0.4400
Cell Name: obsolete animal cell (CL0000548)
Fold Change: 0.0118
Cell Significance Index: 0.1200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0004
Cell Significance Index: -0.0200
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0024
Cell Significance Index: -0.0600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0038
Cell Significance Index: -0.7600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0054
Cell Significance Index: -0.0600
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0065
Cell Significance Index: -0.0900
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0066
Cell Significance Index: -0.2900
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.0152
Cell Significance Index: -0.1500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0183
Cell Significance Index: -0.8500
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.0184
Cell Significance Index: -0.2000
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0187
Cell Significance Index: -0.2600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0251
Cell Significance Index: -0.6700
Cell Name: naive B cell (CL0000788)
Fold Change: -0.0285
Cell Significance Index: -0.3000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0366
Cell Significance Index: -0.9800
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.0374
Cell Significance Index: -0.3500
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0398
Cell Significance Index: -0.6800
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0454
Cell Significance Index: -1.1300
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0529
Cell Significance Index: -0.6900
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0535
Cell Significance Index: -0.7000
Cell Name: plasma cell (CL0000786)
Fold Change: -0.0546
Cell Significance Index: -0.6100
Cell Name: immature B cell (CL0000816)
Fold Change: -0.0571
Cell Significance Index: -0.5400
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0600
Cell Significance Index: -0.7600
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.0632
Cell Significance Index: -0.7000
Cell Name: B cell (CL0000236)
Fold Change: -0.0652
Cell Significance Index: -0.7700
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.0660
Cell Significance Index: -0.7500
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.0672
Cell Significance Index: -0.7300
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.0698
Cell Significance Index: -0.7500
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0700
Cell Significance Index: -0.9600
Cell Name: podocyte (CL0000653)
Fold Change: -0.0706
Cell Significance Index: -0.8100
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.0732
Cell Significance Index: -0.9000
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.0739
Cell Significance Index: -0.7100
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: -0.0742
Cell Significance Index: -0.8000
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.0754
Cell Significance Index: -0.7600
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0756
Cell Significance Index: -1.2300
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: -0.0771
Cell Significance Index: -0.8100
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.0791
Cell Significance Index: -0.7800
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.0792
Cell Significance Index: -0.9200
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.0805
Cell Significance Index: -0.8200
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: -0.0816
Cell Significance Index: -0.7700
Cell Name: T cell (CL0000084)
Fold Change: -0.0822
Cell Significance Index: -0.9700
Cell Name: mast cell (CL0000097)
Fold Change: -0.0828
Cell Significance Index: -1.0900
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.0834
Cell Significance Index: -0.7800
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: -0.0869
Cell Significance Index: -0.7500
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0880
Cell Significance Index: -1.1700
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.0887
Cell Significance Index: -0.7900
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.0897
Cell Significance Index: -0.9100
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0902
Cell Significance Index: -1.3100
Cell Name: macrophage (CL0000235)
Fold Change: -0.0911
Cell Significance Index: -0.9300
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: -0.0913
Cell Significance Index: -0.7700
Cell Name: microglial cell (CL0000129)
Fold Change: -0.0944
Cell Significance Index: -1.1100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0974
Cell Significance Index: -1.8000
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: -0.0992
Cell Significance Index: -0.9500
Cell Name: fibroblast (CL0000057)
Fold Change: -0.0999
Cell Significance Index: -0.9400
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.1006
Cell Significance Index: -1.3200
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.1030
Cell Significance Index: -0.8500
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.1032
Cell Significance Index: -0.9300
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.1041
Cell Significance Index: -1.2100
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.1047
Cell Significance Index: -0.8000
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.1049
Cell Significance Index: -1.2400
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.1076
Cell Significance Index: -0.9600
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: -0.1081
Cell Significance Index: -0.9900
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: -0.1082
Cell Significance Index: -0.8100
Cell Name: neutrophil (CL0000775)
Fold Change: -0.1113
Cell Significance Index: -1.3900
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.1136
Cell Significance Index: -1.2800
Cell Name: amacrine cell (CL0000561)
Fold Change: -0.1150
Cell Significance Index: -1.4400
Cell Name: mural cell (CL0008034)
Fold Change: -0.1158
Cell Significance Index: -1.4100
Cell Name: enterocyte (CL0000584)
Fold Change: -0.1161
Cell Significance Index: -0.7200
Cell Name: late promyelocyte (CL0002151)
Fold Change: -0.1161
Cell Significance Index: -0.7700
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.1181
Cell Significance Index: -1.3700
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: -0.1193
Cell Significance Index: -0.6900
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1200
Cell Significance Index: -1.4300
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.1208
Cell Significance Index: -1.7400
Cell Name: early promyelocyte (CL0002154)
Fold Change: -0.1222
Cell Significance Index: -0.7800
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: -0.1240
Cell Significance Index: -1.3200
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.1261
Cell Significance Index: -1.3300
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.1290
Cell Significance Index: -1.3700
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.1292
Cell Significance Index: -1.3700
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.1318
Cell Significance Index: -1.3700
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.1366
Cell Significance Index: -1.3800
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.1371
Cell Significance Index: -1.7900
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.1386
Cell Significance Index: -1.7100
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.1422
Cell Significance Index: -1.3000
Cell Name: monocyte (CL0000576)
Fold Change: -0.1430
Cell Significance Index: -1.6500
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.1442
Cell Significance Index: -0.9600
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.1443
Cell Significance Index: -1.1600
Cell Name: neuron (CL0000540)
Fold Change: -0.1509
Cell Significance Index: -1.4300
Cell Name: granulocyte (CL0000094)
Fold Change: -0.1525
Cell Significance Index: -1.8400
Cell Name: pericyte (CL0000669)
Fold Change: -0.1550
Cell Significance Index: -1.8600
Cell Name: memory B cell (CL0000787)
Fold Change: -0.1570
Cell Significance Index: -1.6700
Cell Name: respiratory hillock cell (CL4030023)
Fold Change: -0.1580
Cell Significance Index: -1.5000
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.1634
Cell Significance Index: -1.4400
Cell Name: exhausted T cell (CL0011025)
Fold Change: -0.1681
Cell Significance Index: -1.3700
Cell Name: platelet (CL0000233)
Fold Change: -0.1682
Cell Significance Index: -1.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** IGKJ5 is a gene that encodes a protein essential for the proper functioning of the immune system. It is part of the immunoglobulin kappa joining family, which is involved in the joining of kappa light chains to heavy chains in immunoglobulins. IGKJ5 is specifically expressed in plasma cells, dendritic cells, and B cells, suggesting its role in the maturation and activation of these cells. Interestingly, IGKJ5 is also expressed in erythrocytes, CD8-positive alpha-beta T cells, and double-negative thymocytes, indicating its broader involvement in immune cell development. **Pathways and Functions:** The exact pathways through which IGKJ5 operates are not yet fully elucidated. However, studies suggest that IGKJ5 plays a crucial role in the activation and maturation of plasma cells, which are responsible for producing antibodies. IGKJ5 may also be involved in the regulation of dendritic cell maturation and function, which is essential for the initiation of immune responses. Furthermore, IGKJ5 may contribute to the development and function of B cells, including memory B cells and plasmacytoid dendritic cells. The protein may also regulate the expression of genes involved in immune cell function, such as cytokines and chemokines. **Clinical Significance:** IGKJ5's role in the immune system has significant implications for our understanding of immune-mediated diseases. Dysregulation of IGKJ5 expression has been implicated in various autoimmune and inflammatory disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. For example, studies have shown that IGKJ5 is downregulated in patients with rheumatoid arthritis, suggesting that this gene may play a protective role in the development of autoimmune diseases. Additionally, IGKJ5's involvement in the regulation of plasma cell function may have implications for the treatment of B-cell malignancies, such as non-Hodgkin lymphoma. In conclusion, IGKJ5 is a gene that plays a critical role in the development and functioning of the immune system. Further research is needed to fully elucidate the mechanisms by which IGKJ5 operates and to explore its potential therapeutic applications. As our understanding of IGKJ5's role in immune regulation continues to evolve, it is likely that this gene will emerge as a key player in the treatment of immune-mediated diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.