Details for: GTF2A1

Gene ID: 2957

Symbol: GTF2A1

Ensembl ID: ENSG00000165417

Description: general transcription factor IIA subunit 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.93
    Marker Score: 3369
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.49
    Marker Score: 6055
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.38
    Marker Score: 84685.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.36
    Marker Score: 11700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.32
    Marker Score: 12501
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.21
    Marker Score: 1869
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.16
    Marker Score: 44197
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.16
    Marker Score: 42864
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.16
    Marker Score: 17301
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.15
    Marker Score: 10841
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 18013
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.12
    Marker Score: 11580
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1
    Marker Score: 4270
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.09
    Marker Score: 21614
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.08
    Marker Score: 348
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.04
    Marker Score: 4312
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2081
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.01
    Marker Score: 2384
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71693.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47918
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.99
    Marker Score: 7612.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30389
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.98
    Marker Score: 269
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.95
    Marker Score: 299
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2391
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.94
    Marker Score: 547
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.92
    Marker Score: 555
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.92
    Marker Score: 3403
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.92
    Marker Score: 537
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2699
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.89
    Marker Score: 1282
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.87
    Marker Score: 252
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.87
    Marker Score: 1907
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.85
    Marker Score: 984
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 304
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4794
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.83
    Marker Score: 3193.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.81
    Marker Score: 284
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.81
    Marker Score: 256
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.8
    Marker Score: 3697
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.79
    Marker Score: 535
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.79
    Marker Score: 537
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.77
    Marker Score: 971.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.77
    Marker Score: 178
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 584
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.76
    Marker Score: 4557
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 302
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.75
    Marker Score: 791
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.75
    Marker Score: 16037
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.74
    Marker Score: 3106.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.74
    Marker Score: 1818.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.74
    Marker Score: 982
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.72
    Marker Score: 781
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.72
    Marker Score: 1383
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.71
    Marker Score: 788
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.7
    Marker Score: 205
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2887
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.68
    Marker Score: 389
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.68
    Marker Score: 626
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 602
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 426
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.64
    Marker Score: 401
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.64
    Marker Score: 828
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.64
    Marker Score: 609
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.64
    Marker Score: 770
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.63
    Marker Score: 640
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.63
    Marker Score: 299
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.62
    Marker Score: 164
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.62
    Marker Score: 215
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.62
    Marker Score: 251
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.62
    Marker Score: 140
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.62
    Marker Score: 616
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.62
    Marker Score: 195
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.62
    Marker Score: 228
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.62
    Marker Score: 152
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.61
    Marker Score: 367
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.61
    Marker Score: 532
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.61
    Marker Score: 2560
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.61
    Marker Score: 1398
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.61
    Marker Score: 317
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.61
    Marker Score: 891.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.6
    Marker Score: 225
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.6
    Marker Score: 1610
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6
    Marker Score: 143
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.6
    Marker Score: 155
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.59
    Marker Score: 1608
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.59
    Marker Score: 395
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.59
    Marker Score: 292
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.59
    Marker Score: 19800.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.59
    Marker Score: 292
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.58
    Marker Score: 721
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.58
    Marker Score: 130
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.58
    Marker Score: 128
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.58
    Marker Score: 164

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * GTF2A1 is a member of the TFII family of transcription factors. * It is a key regulator of gene expression in the developing brain. * It is involved in the regulation of a wide range of genes, including those involved in neuronal development, differentiation, and survival. * It is also involved in the regulation of synaptic plasticity and learning and memory. **Pathways and functions:** * GTF2A1 is involved in a variety of pathways, including the Esr-mediated signaling pathway, the estrogen-dependent gene expression pathway, and the regulation of the HIV life cycle. * It is involved in the regulation of the development and function of neurons. * It is also involved in the regulation of synaptic plasticity and learning and memory. * It is a key regulator of the viral infection pathways of HIV-1 and HIV-2. **Clinical significance:** * Mutations in GTF2A1 have been linked to a number of neurological disorders, including autism, schizophrenia, and Alzheimer's disease. * Targeting GTF2A1 has been shown to be a potential therapeutic strategy for these disorders. **Additional notes:** * GTF2A1 is a highly conserved protein, with a similar protein found in other mammals. * It is a highly regulated protein, with its expression being controlled by a variety of factors, including growth factors, cytokines, and other transcription factors. * It is a key player in the regulation of brain development and function.

Genular Protein ID: 1100392801

Symbol: TF2AA_HUMAN

Name: Transcription initiation factor IIA subunit 1

UniProtKB Accession Codes:

P52655 Q3KNQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 37 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 44 PDBsum 41 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 10 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8224850

Title: Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription.

PubMed ID: 8224850

DOI: 10.1101/gad.7.11.2246

PubMed ID: 8224848

Title: A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA.

PubMed ID: 8224848

DOI: 10.1101/gad.7.11.2220

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11030333

Title: TAC, a TBP-sans-TAFs complex containing the unprocessed TFIIAalphabeta precursor and the TFIIAgamma subunit.

PubMed ID: 11030333

DOI: 10.1016/s1097-2765(00)00052-6

PubMed ID: 11278496

Title: Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity.

PubMed ID: 11278496

DOI: 10.1074/jbc.m009385200

PubMed ID: 15257296

Title: Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

PubMed ID: 15257296

DOI: 10.1038/sj.emboj.7600304

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16537915

Title: Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.

PubMed ID: 16537915

DOI: 10.1128/mcb.26.7.2728-2735.2006

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 376
  • Mass: 41514
  • Checksum: 4BAE1853E7E89218
  • Sequence:
    • MANSANTNTV PKLYRSVIED VINDVRDIFL DDGVDEQVLM ELKTLWENKL MQSRAVDGFH 
SEEQQLLLQV QQQHQPQQQQ HHHHHHHQQA QPQQTVPQQA QTQQVLIPAS QQATAPQVIV 
PDSKLIQHMN ASNMSAAATA ATLALPAGVT PVQQILTNSG QLLQVVRAAN GAQYIFQPQQ 
SVVLQQQVIP QMQPGGVQAP VIQQVLAPLP GGISPQTGVI IQPQQILFTG NKTQVIPTTV 
AAPTPAQAQI TATGQQQPQA QPAQTQAPLV LQVDGTGDTS SEEDEDEEED YDDDEEEDKE 
KDGAEDGQVE EEPLNSEDDV SDEEGQELFD TENVVVCQYD KIHRSKNKWK FHLKDGIMNL 
NGRDYIFSKA IGDAEW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.