Details for: TMOD4

Gene ID: 29765

Symbol: TMOD4

Ensembl ID: ENSG00000163157

Description: tropomodulin 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 4.5045
    Cell Significance Index: -1.8300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 1.9691
    Cell Significance Index: -1.8800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1773
    Cell Significance Index: 2.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1725
    Cell Significance Index: 2.4700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.1367
    Cell Significance Index: 1.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0709
    Cell Significance Index: 1.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0484
    Cell Significance Index: 1.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0347
    Cell Significance Index: 5.0500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0336
    Cell Significance Index: 0.4300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0235
    Cell Significance Index: 0.2800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0168
    Cell Significance Index: 0.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0124
    Cell Significance Index: 0.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0083
    Cell Significance Index: 5.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0073
    Cell Significance Index: 11.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0049
    Cell Significance Index: 0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0043
    Cell Significance Index: 7.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0011
    Cell Significance Index: 1.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: -0.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0010
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0021
    Cell Significance Index: -0.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0027
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0029
    Cell Significance Index: -1.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0038
    Cell Significance Index: -2.1200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0044
    Cell Significance Index: -0.0500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0048
    Cell Significance Index: -0.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0071
    Cell Significance Index: -2.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0073
    Cell Significance Index: -0.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0094
    Cell Significance Index: -0.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0122
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0127
    Cell Significance Index: -2.1700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0164
    Cell Significance Index: -0.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0180
    Cell Significance Index: -1.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0185
    Cell Significance Index: -2.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0210
    Cell Significance Index: -0.4400
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.0229
    Cell Significance Index: -0.1800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0274
    Cell Significance Index: -0.3700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0283
    Cell Significance Index: -0.2000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0288
    Cell Significance Index: -0.4200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0290
    Cell Significance Index: -0.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0294
    Cell Significance Index: -0.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0307
    Cell Significance Index: -1.7200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0314
    Cell Significance Index: -0.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0317
    Cell Significance Index: -1.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0321
    Cell Significance Index: -1.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0328
    Cell Significance Index: -1.1500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0338
    Cell Significance Index: -0.4500
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: -0.0341
    Cell Significance Index: -0.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0342
    Cell Significance Index: -1.1200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0359
    Cell Significance Index: -0.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0363
    Cell Significance Index: -2.2300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0364
    Cell Significance Index: -0.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0368
    Cell Significance Index: -2.3800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0375
    Cell Significance Index: -0.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0432
    Cell Significance Index: -0.5900
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0433
    Cell Significance Index: -0.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0453
    Cell Significance Index: -2.1100
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0454
    Cell Significance Index: -0.4400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0459
    Cell Significance Index: -0.5400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0489
    Cell Significance Index: -1.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0523
    Cell Significance Index: -1.0400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0531
    Cell Significance Index: -0.6200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0541
    Cell Significance Index: -0.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0544
    Cell Significance Index: -1.9100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0569
    Cell Significance Index: -1.2300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0570
    Cell Significance Index: -0.9200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0573
    Cell Significance Index: -0.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0576
    Cell Significance Index: -1.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0588
    Cell Significance Index: -2.1600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0594
    Cell Significance Index: -0.6800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0598
    Cell Significance Index: -1.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0632
    Cell Significance Index: -1.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0635
    Cell Significance Index: -1.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0670
    Cell Significance Index: -2.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0686
    Cell Significance Index: -1.1000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0697
    Cell Significance Index: -1.7400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0714
    Cell Significance Index: -1.4900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0734
    Cell Significance Index: -1.4500
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0735
    Cell Significance Index: -0.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0750
    Cell Significance Index: -1.9100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0767
    Cell Significance Index: -0.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0771
    Cell Significance Index: -2.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0778
    Cell Significance Index: -2.2300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0804
    Cell Significance Index: -1.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0825
    Cell Significance Index: -1.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0827
    Cell Significance Index: -2.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0829
    Cell Significance Index: -1.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0830
    Cell Significance Index: -2.1200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0856
    Cell Significance Index: -1.0800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0866
    Cell Significance Index: -0.9800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0867
    Cell Significance Index: -0.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0889
    Cell Significance Index: -1.0600
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0896
    Cell Significance Index: -1.0400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0903
    Cell Significance Index: -1.2900
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0915
    Cell Significance Index: -0.9800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0929
    Cell Significance Index: -1.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0950
    Cell Significance Index: -2.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1001
    Cell Significance Index: -2.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **TMOD4 is a tropomodulin isoform**: Tropomodulin is a family of proteins that regulate the organization and dynamics of the actin cytoskeleton. TMOD4 is one of the three tropomodulin isoforms, which are distinct in their amino-terminal domains. 2. **Interaction with tropomyosin and actin**: TMOD4 binds to tropomyosin and actin, modulating the interaction between these molecules and influencing muscle contraction. 3. **Expression in diverse cell types**: TMOD4 is expressed in various cell types, including striated muscle cells, neurons, endothelial cells, and immune cells, highlighting its broad functional relevance. 4. **Regulation of actin filament organization**: TMOD4 regulates the organization and dynamics of actin filaments, which is essential for maintaining cell shape, motility, and signaling. **Pathways and Functions:** 1. **Muscle contraction**: TMOD4 plays a critical role in striated muscle contraction by regulating the interaction between tropomyosin and actin. This interaction modulates the sliding of actin filaments past myosin heads, leading to muscle contraction. 2. **Actin filament organization**: TMOD4 regulates the organization and dynamics of actin filaments, which is essential for maintaining cell shape, motility, and signaling. 3. **Cytoskeleton regulation**: TMOD4 interacts with other cytoskeletal proteins to regulate the organization and dynamics of the actin cytoskeleton. 4. **Cell signaling**: TMOD4 may also play a role in cell signaling, particularly in the context of immune cell function. **Clinical Significance:** 1. **Muscular dystrophy**: Mutations in the TMOD4 gene have been associated with muscular dystrophy, highlighting the importance of TMOD4 in striated muscle function. 2. **Neurological disorders**: TMOD4 is expressed in neurons, and alterations in TMOD4 expression have been linked to neurological disorders, such as autism and schizophrenia. 3. **Cardiovascular disease**: TMOD4 is expressed in cardiac endothelial cells, and alterations in TMOD4 expression may contribute to cardiovascular disease. 4. **Immunological disorders**: TMOD4 is expressed in immune cells, and alterations in TMOD4 expression may contribute to immunological disorders, such as autoimmune diseases. In conclusion, TMOD4 is a multifaceted protein that plays a critical role in the organization and regulation of the actin cytoskeleton. Its expression in diverse cell types highlights its broad functional relevance, and alterations in TMOD4 expression have been linked to various disease contexts. Further research is needed to fully elucidate the role of TMOD4 in human disease.

Genular Protein ID: 2587983082

Symbol: TMOD4_HUMAN

Name: Tropomodulin-4

UniProtKB Accession Codes:

Q9NZQ9 B7Z6N9 Q5JR83 Q8WVL3 Q9UKH2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10497209

Title: Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle.

PubMed ID: 10497209

DOI: 10.1074/jbc.274.40.28466

PubMed ID: 10662549

Title: Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs.

PubMed ID: 10662549

DOI: 10.1006/geno.1999.6061

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25250574

Title: Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

PubMed ID: 25250574

DOI: 10.1172/jci75199

Sequence Information:

  • Length: 345
  • Mass: 39335
  • Checksum: 3ACE2692EF52E2CB
  • Sequence:
    • MSSYQKELEK YRDIDEDEIL RTLSPEELEQ LDCELQEMDP ENMLLPAGLR QRDQTKKSPT 
GPLDREALLQ YLEQQALEVK ERDDLVPFTG EKKGKPYIQP KREIPAEEQI TLEPELEEAL 
AHATDAEMCD IAAILDMYTL MSNKQYYDAL CSGEICNTEG ISSVVQPDKY KPVPDEPPNP 
TNIEEILKRV RSNDKELEEV NLNNIQDIPI PMLSELCEAM KANTYVRSFS LVATRSGDPI 
ANAVADMLRE NRSLQSLNIE SNFISSTGLM AVLKAVRENA TLTELRVDNQ RQWPGDAVEM 
EMATVLEQCP SIVRFGYHFT QQGPRARAAQ AMTRNNELRR QQKKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.