Details for: TMOD4

Gene ID: 29765

Symbol: TMOD4

Ensembl ID: ENSG00000163157

Description: tropomodulin 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,841
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,066
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.31
    Marker Score: 163
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.29
    Marker Score: 175
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.26
    Marker Score: 494
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.25
    Marker Score: 3,917
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.25
    Marker Score: 79
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.22
    Marker Score: 455
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.19
    Marker Score: 197
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.17
    Marker Score: 153
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 339
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.16
    Marker Score: 173
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.14
    Marker Score: 165
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 805
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.09
    Marker Score: 121
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.08
    Marker Score: 216
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.08
    Marker Score: 313
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 142
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 60
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.05
    Marker Score: 132
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.04
    Marker Score: 54
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.04
    Marker Score: 155
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.03
    Marker Score: 135
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.03
    Marker Score: 264
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.03
    Marker Score: 91
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.03
    Marker Score: 44
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 42
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.02
    Marker Score: 83
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.02
    Marker Score: 36
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.02
    Marker Score: 44
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.02
    Marker Score: 182
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.02
    Marker Score: 6
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.02
    Marker Score: 5
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.02
    Marker Score: 9

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **TMOD4 is a tropomodulin isoform**: Tropomodulin is a family of proteins that regulate the organization and dynamics of the actin cytoskeleton. TMOD4 is one of the three tropomodulin isoforms, which are distinct in their amino-terminal domains. 2. **Interaction with tropomyosin and actin**: TMOD4 binds to tropomyosin and actin, modulating the interaction between these molecules and influencing muscle contraction. 3. **Expression in diverse cell types**: TMOD4 is expressed in various cell types, including striated muscle cells, neurons, endothelial cells, and immune cells, highlighting its broad functional relevance. 4. **Regulation of actin filament organization**: TMOD4 regulates the organization and dynamics of actin filaments, which is essential for maintaining cell shape, motility, and signaling. **Pathways and Functions:** 1. **Muscle contraction**: TMOD4 plays a critical role in striated muscle contraction by regulating the interaction between tropomyosin and actin. This interaction modulates the sliding of actin filaments past myosin heads, leading to muscle contraction. 2. **Actin filament organization**: TMOD4 regulates the organization and dynamics of actin filaments, which is essential for maintaining cell shape, motility, and signaling. 3. **Cytoskeleton regulation**: TMOD4 interacts with other cytoskeletal proteins to regulate the organization and dynamics of the actin cytoskeleton. 4. **Cell signaling**: TMOD4 may also play a role in cell signaling, particularly in the context of immune cell function. **Clinical Significance:** 1. **Muscular dystrophy**: Mutations in the TMOD4 gene have been associated with muscular dystrophy, highlighting the importance of TMOD4 in striated muscle function. 2. **Neurological disorders**: TMOD4 is expressed in neurons, and alterations in TMOD4 expression have been linked to neurological disorders, such as autism and schizophrenia. 3. **Cardiovascular disease**: TMOD4 is expressed in cardiac endothelial cells, and alterations in TMOD4 expression may contribute to cardiovascular disease. 4. **Immunological disorders**: TMOD4 is expressed in immune cells, and alterations in TMOD4 expression may contribute to immunological disorders, such as autoimmune diseases. In conclusion, TMOD4 is a multifaceted protein that plays a critical role in the organization and regulation of the actin cytoskeleton. Its expression in diverse cell types highlights its broad functional relevance, and alterations in TMOD4 expression have been linked to various disease contexts. Further research is needed to fully elucidate the role of TMOD4 in human disease.

Genular Protein ID: 2587983082

Symbol: TMOD4_HUMAN

Name: Tropomodulin-4

UniProtKB Accession Codes:

Q9NZQ9 B7Z6N9 Q5JR83 Q8WVL3 Q9UKH2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10497209

Title: Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle.

PubMed ID: 10497209

DOI: 10.1074/jbc.274.40.28466

PubMed ID: 10662549

Title: Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs.

PubMed ID: 10662549

DOI: 10.1006/geno.1999.6061

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25250574

Title: Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

PubMed ID: 25250574

DOI: 10.1172/jci75199

Sequence Information:

  • Length: 345
  • Mass: 39335
  • Checksum: 3ACE2692EF52E2CB
  • Sequence:
    • MSSYQKELEK YRDIDEDEIL RTLSPEELEQ LDCELQEMDP ENMLLPAGLR QRDQTKKSPT 
GPLDREALLQ YLEQQALEVK ERDDLVPFTG EKKGKPYIQP KREIPAEEQI TLEPELEEAL 
AHATDAEMCD IAAILDMYTL MSNKQYYDAL CSGEICNTEG ISSVVQPDKY KPVPDEPPNP 
TNIEEILKRV RSNDKELEEV NLNNIQDIPI PMLSELCEAM KANTYVRSFS LVATRSGDPI 
ANAVADMLRE NRSLQSLNIE SNFISSTGLM AVLKAVRENA TLTELRVDNQ RQWPGDAVEM 
EMATVLEQCP SIVRFGYHFT QQGPRARAAQ AMTRNNELRR QQKKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.