Details for: IL3

Gene ID: 3562

Symbol: IL3

Ensembl ID: ENSG00000164399

Description: interleukin 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.15
    Marker Score: 1747
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.21
    Marker Score: 1522
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10814
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 878
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7579
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3656
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.19
    Marker Score: 626
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32731
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.93
    Marker Score: 714
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 739
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.79
    Marker Score: 462.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 432
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 451
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.68
    Marker Score: 1282
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 392
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.58
    Marker Score: 1184
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 238
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 481
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 253
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.44
    Marker Score: 6962
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 377
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.28
    Marker Score: 127
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.28
    Marker Score: 1666
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.22
    Marker Score: 104
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 111
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.16
    Marker Score: 207
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.13
    Marker Score: 95
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 121
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.11
    Marker Score: 93
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 60.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.1
    Marker Score: 202.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 43
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.1
    Marker Score: 75
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.07
    Marker Score: 74
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 40.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 84
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.02
    Marker Score: 138
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 48
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 36
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.02
    Marker Score: 49
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 52
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 10.5
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0
    Marker Score: 30
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0
    Marker Score: 14

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Other Information

**Key characteristics:** - IL3 is a cytokine of the interleukin-2 family. - It is produced by a variety of cell types, including endothelial cells, monocytes, macrophages, and lymphocytes. - It is a potent activator of the immune system. - It is involved in the regulation of inflammation and immune responses. **Pathways and functions:** - IL3 binds to its receptor, IL3 receptor, on immune cells. - This binding triggers the activation of the intracellular signaling pathway, which involves the activation of the tyrosine kinase receptor for IL3 (IL3R). - The activated IL3R-IL3 complex recruits and activates the Janus kinase/signal transducer (JAK/STAT) signaling pathway. - The STAT proteins are activated by the JAK/STAT pathway, which leads to the phosphorylation of STAT proteins and the subsequent activation of transcription factors that regulate the expression of IL3 and other immune genes. - IL3 also plays a role in the regulation of inflammation by promoting the production of anti-inflammatory cytokines, such as IL-10. **Clinical significance:** - IL3 is a cytokine that is important in the pathogenesis of many inflammatory diseases, including rheumatoid arthritis, asthma, and psoriasis. - It is also involved in the pathogenesis of cancer. - Blockade of IL3 signaling has been shown to be effective in treating inflammatory diseases. - IL3 is a promising target for the treatment of cancer and other inflammatory diseases.

Genular Protein ID: 3974689166

Symbol: IL3_HUMAN

Name: Interleukin-3

UniProtKB Accession Codes:

P08700 Q6GS87

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PDB 7 PDBsum 4 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 3497843

Title: Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin-3.

PubMed ID: 3497843

DOI: 10.1016/0378-1119(87)90254-x

PubMed ID: 3127463

Title: Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones.

PubMed ID: 3127463

PubMed ID: 3489530

Title: Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.

PubMed ID: 3489530

DOI: 10.1016/0092-8674(86)90360-0

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2544122

Title: Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3.

PubMed ID: 2544122

DOI: 10.1111/j.1749-6632.1989.tb22418.x

PubMed ID: 2556442

Title: Regulation of interleukin 3 gene induction in normal human T cells.

PubMed ID: 2556442

DOI: 10.1172/jci114352

PubMed ID: 10779277

Title: Comparison of mechanisms of IL-3 induced histamine release and IL-3 priming effect on human basophils.

PubMed ID: 10779277

DOI: 10.1111/j.1365-2222.1993.tb00274.x

PubMed ID: 12816992

Title: IL-3 acts directly on osteoclast precursors and irreversibly inhibits receptor activator of NF-kappa B ligand-induced osteoclast differentiation by diverting the cells to macrophage lineage.

PubMed ID: 12816992

DOI: 10.4049/jimmunol.171.1.142

PubMed ID: 23226269

Title: The interleukin 3 gene (IL3) contributes to human brain volume variation by regulating proliferation and survival of neural progenitors.

PubMed ID: 23226269

DOI: 10.1371/journal.pone.0050375

PubMed ID: 27862234

Title: Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells.

PubMed ID: 27862234

DOI: 10.1002/jcb.25790

PubMed ID: 32889153

Title: Interleukin 3-induced GITR promotes the activation of human basophils.

PubMed ID: 32889153

DOI: 10.1016/j.cyto.2020.155268

PubMed ID: 8676386

Title: Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3.

PubMed ID: 8676386

DOI: 10.1006/jmbi.1996.0337

PubMed ID: 29374162

Title: A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.

PubMed ID: 29374162

DOI: 10.1038/s41467-017-02633-7

Sequence Information:

  • Length: 152
  • Mass: 17233
  • Checksum: BB46F23FAC1259A4
  • Sequence:
    • MSRLPVLLLL QLLVRPGLQA PMTQTTPLKT SWVNCSNMID EIITHLKQPP LPLLDFNNLN 
GEDQDILMEN NLRRPNLEAF NRAVKSLQNA SAIESILKNL LPCLPLATAA PTRHPIHIKD 
GDWNEFRRKL TFYLKTLENA QAQQTTLSLA IF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.