Details for: KIR2DL4

Gene ID: 3805

Symbol: KIR2DL4

Ensembl ID: ENSG00000189013

Description: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.78
    Marker Score: 1462
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.4
    Marker Score: 6637
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 1999
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.36
    Marker Score: 569
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.1
    Marker Score: 363
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251816
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1397.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.85
    Marker Score: 696
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 633
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 501.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.65
    Marker Score: 210
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 465
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.57
    Marker Score: 1673
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.53
    Marker Score: 135
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.42
    Marker Score: 242
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 396
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.34
    Marker Score: 195
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.31
    Marker Score: 180
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.25
    Marker Score: 210
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.23
    Marker Score: 297
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.23
    Marker Score: 164
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.2
    Marker Score: 132
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.18
    Marker Score: 140.5
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.18
    Marker Score: 89
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.18
    Marker Score: 148
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.16
    Marker Score: 75
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.15
    Marker Score: 171
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.13
    Marker Score: 90
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.13
    Marker Score: 284
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.12
    Marker Score: 90
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.12
    Marker Score: 94
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 123
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.1
    Marker Score: 179
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 88
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.09
    Marker Score: 124
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.08
    Marker Score: 94
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.08
    Marker Score: 113
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 77
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.07
    Marker Score: 766
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.06
    Marker Score: 161
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.06
    Marker Score: 122
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.06
    Marker Score: 116.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.05
    Marker Score: 80
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.05
    Marker Score: 73
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.04
    Marker Score: 102.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.04
    Marker Score: 29

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Other Information

**Key characteristics:** * KIR2DL4 is a type I transmembrane receptor that belongs to the killer cell immunoglobulin-like receptor (KIR) family. * It is composed of two Ig domains and a long cytoplasmic tail. * KIR2DL4 is expressed on the surface of hematopoietic stem cells, decidual natural killer cells, and some immune cells. * It is also expressed on a variety of epithelial cells, including enterocytes, goblet cells, and intestinal crypt stem cells. **Pathways and functions:** * KIR2DL4 is a negative regulator of natural killer cell mediated cytotoxicity. * It interacts with the immune checkpoint receptor PD-1, which is expressed on natural killer cells. * By binding to PD-1, KIR2DL4 inhibits the activation of the immune checkpoint receptor and allows natural killer cells to kill target cells. * KIR2DL4 also plays a role in the regulation of cellular senescence. **Clinical significance:** * Kir2DL4 mutations are associated with several human diseases, including cancer and autoimmune disorders. * Inhibition of KIR2DL4 has been shown to enhance the antitumor activity of immune checkpoint blockade therapies. * Therefore, KIR2DL4 is a promising target for cancer immunotherapy.

Genular Protein ID: 97069506

Symbol: KI2L4_HUMAN

Name: Killer cell immunoglobulin-like receptor 2DL4

UniProtKB Accession Codes:

Q99706 A8W795 O14621 O14622 O14623 O14624 O43534 P78400 P78401 Q8N738 Q99559 Q99560 Q99561 Q99562 Q9UQJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 28 Ensembl 34 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8946682

Title: NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains.

PubMed ID: 8946682

DOI: 10.1111/j.1399-0039.1996.tb02647.x

PubMed ID: 9430220

Title: Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors.

PubMed ID: 9430220

DOI: 10.1016/s1074-7613(00)80393-3

PubMed ID: 9059894

Title: Polymorphism and domain variability of human killer cell inhibitory receptors.

PubMed ID: 9059894

DOI: 10.1111/j.1600-065x.1997.tb00951.x

PubMed ID: 9234477

Title: Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103.

PubMed ID: 9234477

DOI: 10.1111/j.1399-0039.1997.tb02803.x

PubMed ID: 18082267

Title: The elucidation of KIR2DL4 gene polymorphism.

PubMed ID: 18082267

DOI: 10.1016/j.molimm.2007.10.038

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 10190900

Title: A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells.

PubMed ID: 10190900

DOI: 10.1084/jem.189.7.1093

PubMed ID: 16366734

Title: Activation of NK cells by an endocytosed receptor for soluble HLA-G.

PubMed ID: 16366734

DOI: 10.1371/journal.pbio.0040009

PubMed ID: 18604210

Title: An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.

PubMed ID: 18604210

DOI: 10.1038/ni.1635

PubMed ID: 19304799

Title: HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells.

PubMed ID: 19304799

DOI: 10.1073/pnas.0901173106

PubMed ID: 20179272

Title: DNA-PKcs controls an endosomal signaling pathway for a proinflammatory response by natural killer cells.

PubMed ID: 20179272

DOI: 10.1126/scisignal.2000467

PubMed ID: 23184984

Title: Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling.

PubMed ID: 23184984

DOI: 10.1073/pnas.1208248109

PubMed ID: 29262349

Title: Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.

PubMed ID: 29262349

DOI: 10.1016/j.immuni.2017.11.018

Sequence Information:

  • Length: 377
  • Mass: 41487
  • Checksum: 888B3297332D6C59
  • Sequence:
    • MSMSPTVIIL ACLGFFLDQS VWAHVGGQDK PFCSAWPSAV VPQGGHVTLR CHYRRGFNIF 
TLYKKDGVPV PELYNRIFWN SFLISPVTPA HAGTYRCRGF HPHSPTEWSA PSNPLVIMVT 
GLYEKPSLTA RPGPTVRAGE NVTLSCSSQS SFDIYHLSRE GEAHELRLPA VPSINGTFQA 
DFPLGPATHG ETYRCFGSFH GSPYEWSDPS DPLPVSVTGN PSSSWPSPTE PSFKTGIARH 
LHAVIRYSVA IILFTILPFF LLHRWCSKKK DAAVMNQEPA GHRTVNREDS DEQDPQEVTY 
AQLDHCIFTQ RKITGPSQRS KRPSTDTSVC IELPNAEPRA LSPAHEHHSQ ALMGSSRETT 
ALSQTQLASS NVPAAGI

Genular Protein ID: 3183418545

Symbol: A0A376A929_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A376A929

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 342
  • Mass: 37356
  • Checksum: 963B74BC0E5C7B64
  • Sequence:
    • MSMSPTVIIL ACLGFFLDQS VWAHVGGQDK PFCSAWPSAV VPQGGHVTLR CHYRRGFNIF 
TLYKKDGVPV PELYNRIFWN SFLISPVTPA HAGTYRCRGF HPHSPTEWSA PSNPLVIMVT 
GLYEKPSLTA RPGPTVRAGE NVTLSCSSQS SFDIYHLSRE GEAHELRLPA VPSINGTFQA 
DFPLGPATHG ETYRCFGSFH GSPYEWSDPS DPLPVSVTGN PSSSWPSPTE PSFKTDAAVM 
NQEPAGHRTV NREDSDEQDP QEVTYAQLDH CIFTQRKITG PSQRSKRPST DTSVCIELPN 
AEPRALSPAH EHHSQALMGS SRETTALSQT QLASSNVPAA GI

Genular Protein ID: 2115014714

Symbol: A0A0B4J1S6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0B4J1S6 A0A1W2PQ98

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 18 Ensembl 11 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 2 SMART 2 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 273
  • Mass: 30257
  • Checksum: EC2E612396346831
  • Sequence:
    • MSMSPTVIIL ACLGFFLDQS VWAHVGGQDK PFCSAWPSAV VPQGGHVTLR CHYRRGFNIF 
TLYKKDGVPV PELYNRIFWN SFLISPVTPA HAGTYRCRGF HPHSPTEWSA PSNPLVIMVT 
GLYEKPSLTA RPGPTVRAGE NVTLSCSSQS SFDIYHLSRE GEAHELRLPA VPSINGTFQA 
DFPLGPATHG ETYRCFGSFH GSPYEWSDPS DPLPVSVTGN PSSSWPSPTE PSFKTGIARH 
LHAVIRYSVA IILFTILPFF LLHRWCSKKK MLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.