Details for: KRT2

Gene ID: 3849

Symbol: KRT2

Ensembl ID: ENSG00000172867

Description: keratin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8283
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.54
    Marker Score: 4626
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.33
    Marker Score: 2347
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.21
    Marker Score: 1525
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1176
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 507
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 663
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.03
    Marker Score: 1369
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.03
    Marker Score: 1148
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71838
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48063
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 656
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.82
    Marker Score: 3454
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 327
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 619.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 417
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.62
    Marker Score: 482
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 471
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.53
    Marker Score: 8275
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 311
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.49
    Marker Score: 923
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.46
    Marker Score: 201
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.45
    Marker Score: 723
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.44
    Marker Score: 123
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 406
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.38
    Marker Score: 218
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 376
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.34
    Marker Score: 328
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.34
    Marker Score: 961
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 87
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.31
    Marker Score: 184
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.31
    Marker Score: 632
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.3
    Marker Score: 1974
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.28
    Marker Score: 118
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.28
    Marker Score: 234
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.25
    Marker Score: 325
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.25
    Marker Score: 262.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.23
    Marker Score: 81
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.23
    Marker Score: 221
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.22
    Marker Score: 137
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.21
    Marker Score: 89
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.2
    Marker Score: 330
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.2
    Marker Score: 119
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.19
    Marker Score: 1161
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.17
    Marker Score: 57
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.16
    Marker Score: 69
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.15
    Marker Score: 154
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.15
    Marker Score: 72
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.15
    Marker Score: 84
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.14
    Marker Score: 69
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.14
    Marker Score: 34
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.13
    Marker Score: 196.5
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.12
    Marker Score: 86
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.11
    Marker Score: 202
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.1
    Marker Score: 175
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 111
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 102
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 195
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.09
    Marker Score: 324
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.09
    Marker Score: 153
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.08
    Marker Score: 96
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.08
    Marker Score: 235
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.08
    Marker Score: 71
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.07
    Marker Score: 55
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.07
    Marker Score: 58
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.07
    Marker Score: 106
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.06
    Marker Score: 98
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.05
    Marker Score: 37
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.05
    Marker Score: 55

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Other Information

**Key characteristics:** - KRT2 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a key component of the cornified envelope, a protective barrier that covers the surface of skin and other stratified squamous epithelia. - It is also involved in the organization of the cytoskeleton, which is a network of protein filaments that provides structural support for cells. - KRT2 is also expressed in the skin of the eyes, nose, and mouth. **Pathways and functions:** - KRT2 is involved in various cellular processes, including cell adhesion, migration, proliferation, and differentiation. - It is essential for the formation of the cornified envelope, which protects the underlying tissues from damage. - It is also involved in the organization of the skin's barrier function, which helps to protect against pathogens and toxins. - KRT2 is a key regulator of epidermal development, and its expression is often upregulated in skin tumors. **Clinical significance:** - Mutations in the KRT2 gene have been linked to several skin disorders, including psoriasis, eczema, and skin cancer. - These disorders are characterized by abnormal skin growth and differentiation, which is often caused by defects in the cornified envelope. - Targeting KRT2 has been investigated as a potential treatment for these disorders.

Genular Protein ID: 592569752

Symbol: K22E_HUMAN

Name: Keratin, type II cytoskeletal 2 epidermal

UniProtKB Accession Codes:

P35908 Q4VAQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 7 EPD 1 Ensembl 1 GO 21 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1380918

Title: Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation.

PubMed ID: 1380918

DOI: 10.1016/0014-4827(92)90412-2

PubMed ID: 9804344

Title: Genomic organization and fine mapping of the keratin 2e gene (KRT2E): K2e V1 domain polymorphism and novel mutations in ichthyosis bullosa of Siemens.

PubMed ID: 9804344

DOI: 10.1046/j.1523-1747.1998.00371.x

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10233306

Title: Ontogeny and regional variability of keratin 2e (K2e) in developing human fetal skin: a unique spatial and temporal pattern of keratin expression in development.

PubMed ID: 10233306

DOI: 10.1046/j.1365-2133.1999.02755.x

PubMed ID: 12598329

Title: Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization.

PubMed ID: 12598329

DOI: 10.1016/s0002-9440(10)63891-6

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32179842

Title: Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes.

PubMed ID: 32179842

DOI: 10.1038/s41598-020-61640-9

PubMed ID: 7521371

Title: Ichthyosis bullosa of Siemens -- a disease involving keratin 2e.

PubMed ID: 7521371

DOI: 10.1111/1523-1747.ep12394307

PubMed ID: 8077693

Title: Ichthyosis bullosa of Siemens is caused by mutations in the keratin 2e gene.

PubMed ID: 8077693

DOI: 10.1111/1523-1747.ep12394414

PubMed ID: 7524919

Title: Mutations in the rod domain of keratin 2e in patients with ichthyosis bullosa of Siemens.

PubMed ID: 7524919

DOI: 10.1038/ng0894-485

PubMed ID: 9036938

Title: A new keratin 2e mutation in ichthyosis bullosa of Siemens.

PubMed ID: 9036938

DOI: 10.1111/1523-1747.ep12286487

PubMed ID: 9204966

Title: A novel threonine-to-proline mutation at the end of 2B rod domain in the keratin 2e chain in ichthyosis bullosa of Siemens.

PubMed ID: 9204966

DOI: 10.1111/1523-1747.ep12276775

PubMed ID: 9833038

Title: A glutamate to lysine mutation at the end of 2B rod domain of keratin 2e gene in ichthyosis bullosa of Siemens.

PubMed ID: 9833038

DOI: 10.1080/000155598442683

PubMed ID: 10233323

Title: Ichthyosis bullosa of Siemens: report of a family with evidence of a keratin 2e mutation, and a review of the literature.

PubMed ID: 10233323

DOI: 10.1046/j.1365-2133.1999.02772.x

PubMed ID: 10084318

Title: A novel mutation in the 1A domain of keratin 2e in ichthyosis bullosa of Siemens.

PubMed ID: 10084318

DOI: 10.1046/j.1523-1747.1999.00529.x

PubMed ID: 10564334

Title: Ichthyosis bullosa of Siemens resulting from a novel missense mutation near the helix termination motif of the keratin 2e gene.

PubMed ID: 10564334

DOI: 10.1046/j.1365-2230.1999.00514.x

PubMed ID: 11167982

Title: A novel mutation in the 2B domain of keratin 2e causing ichthyosis bullosa of Siemens.

PubMed ID: 11167982

DOI: 10.1046/j.1365-2230.2000.00728.x

PubMed ID: 10688369

Title: Hot spot mutations in keratin 2e suggest a correlation between genotype and phenotype in patients with ichthyosis bullosa of Siemens.

PubMed ID: 10688369

DOI: 10.1034/j.1600-0625.2000.009001011.x

PubMed ID: 10620137

Title: A novel asparagine-->aspartic acid mutation in the rod 1A domain in keratin 2e in a Japanese family with ichthyosis bullosa of Siemens.

PubMed ID: 10620137

DOI: 10.1046/j.1523-1747.2000.00817.x

PubMed ID: 11531804

Title: New mutations in keratin 1 that cause bullous congenital ichthyosiform erythroderma and keratin 2e that cause ichthyosis bullosa of Siemens.

PubMed ID: 11531804

DOI: 10.1046/j.1365-2133.2001.04327.x

PubMed ID: 15949009

Title: Ichthyosis bullosa of Siemens: its correct diagnosis facilitated by molecular genetic testing.

PubMed ID: 15949009

DOI: 10.1111/j.1365-2133.2005.06598.x

PubMed ID: 17408392

Title: A novel H1 domain mutation in the keratin 2 gene in a Japanese family with ichthyosis bullosa of Siemens.

PubMed ID: 17408392

DOI: 10.1111/j.1365-2133.2007.07832.x

Sequence Information:

  • Length: 639
  • Mass: 65433
  • Checksum: B80526BAF70078A7
  • Sequence:
    • MSCQISCKSR GRGGGGGGFR GFSSGSAVVS GGSRRSTSSF SCLSRHGGGG GGFGGGGFGS 
RSLVGLGGTK SISISVAGGG GGFGAAGGFG GRGGGFGGGS SFGGGSGFSG GGFGGGGFGG 
GRFGGFGGPG GVGGLGGPGG FGPGGYPGGI HEVSVNQSLL QPLNVKVDPE IQNVKAQERE 
QIKTLNNKFA SFIDKVRFLE QQNQVLQTKW ELLQQMNVGT RPINLEPIFQ GYIDSLKRYL 
DGLTAERTSQ NSELNNMQDL VEDYKKKYED EINKRTAAEN DFVTLKKDVD NAYMIKVELQ 
SKVDLLNQEI EFLKVLYDAE ISQIHQSVTD TNVILSMDNS RNLDLDSIIA EVKAQYEEIA 
QRSKEEAEAL YHSKYEELQV TVGRHGDSLK EIKIEISELN RVIQRLQGEI AHVKKQCKNV 
QDAIADAEQR GEHALKDARN KLNDLEEALQ QAKEDLARLL RDYQELMNVK LALDVEIATY 
RKLLEGEECR MSGDLSSNVT VSVTSSTISS NVASKAAFGG SGGRGSSSGG GYSSGSSSYG 
SGGRQSGSRG GSGGGGSISG GGYGSGGGSG GRYGSGGGSK GGSISGGGYG SGGGKHSSGG 
GSRGGSSSGG GYGSGGGGSS SVKGSSGEAF GSSVTFSFR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.