Details for: KRT84

Gene ID: 3890

Symbol: KRT84

Ensembl ID: ENSG00000161849

Description: keratin 84

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 4.8318
    Cell Significance Index: 120.6800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.2642
    Cell Significance Index: 83.1700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.8865
    Cell Significance Index: 30.5600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.4676
    Cell Significance Index: 18.9900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 1.4265
    Cell Significance Index: 19.2500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0975
    Cell Significance Index: 0.9600
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0366
    Cell Significance Index: 0.2700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0077
    Cell Significance Index: -0.0800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0144
    Cell Significance Index: -9.9900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0159
    Cell Significance Index: -0.1000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0209
    Cell Significance Index: -0.2200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0233
    Cell Significance Index: -0.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0274
    Cell Significance Index: -1.5400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0309
    Cell Significance Index: -0.2100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0324
    Cell Significance Index: -0.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0330
    Cell Significance Index: -0.3900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0334
    Cell Significance Index: -0.4000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0336
    Cell Significance Index: -0.2200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0346
    Cell Significance Index: -0.4400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0351
    Cell Significance Index: -0.4100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0412
    Cell Significance Index: -0.4300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0450
    Cell Significance Index: -0.3800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0462
    Cell Significance Index: -0.4300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0472
    Cell Significance Index: -0.5000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0493
    Cell Significance Index: -0.9600
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0684
    Cell Significance Index: -0.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0732
    Cell Significance Index: -14.6900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0849
    Cell Significance Index: -0.8700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0880
    Cell Significance Index: -1.0100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1062
    Cell Significance Index: -1.3300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1149
    Cell Significance Index: -1.0100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1153
    Cell Significance Index: -0.9000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1168
    Cell Significance Index: -1.2700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1249
    Cell Significance Index: -1.4300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1419
    Cell Significance Index: -0.9200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1509
    Cell Significance Index: -2.5800
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1582
    Cell Significance Index: -1.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2876
    Cell Significance Index: -14.9800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3189
    Cell Significance Index: -6.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3298
    Cell Significance Index: -14.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4190
    Cell Significance Index: -14.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4527
    Cell Significance Index: -14.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4685
    Cell Significance Index: -14.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5249
    Cell Significance Index: -14.9800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.5361
    Cell Significance Index: -6.3800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.5615
    Cell Significance Index: -7.3900
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.5709
    Cell Significance Index: -6.6100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.5880
    Cell Significance Index: -6.9800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.6175
    Cell Significance Index: -6.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6322
    Cell Significance Index: -16.9400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.6494
    Cell Significance Index: -11.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6500
    Cell Significance Index: -13.8000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6569
    Cell Significance Index: -14.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6721
    Cell Significance Index: -16.7700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7048
    Cell Significance Index: -14.7100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.7399
    Cell Significance Index: -8.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7446
    Cell Significance Index: -16.3100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7450
    Cell Significance Index: -15.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7462
    Cell Significance Index: -14.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7495
    Cell Significance Index: -14.8200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.7721
    Cell Significance Index: -9.9000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.8017
    Cell Significance Index: -11.6400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.8218
    Cell Significance Index: -10.7900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8219
    Cell Significance Index: -11.7700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.8287
    Cell Significance Index: -10.8200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.9239
    Cell Significance Index: -11.2500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.9617
    Cell Significance Index: -12.7800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.9832
    Cell Significance Index: -14.7100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.9935
    Cell Significance Index: -10.0100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -1.0016
    Cell Significance Index: -10.6400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.0017
    Cell Significance Index: -12.6400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.0308
    Cell Significance Index: -11.2300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.0478
    Cell Significance Index: -13.9700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -1.0692
    Cell Significance Index: -13.7400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -1.0732
    Cell Significance Index: -10.8900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -1.0779
    Cell Significance Index: -10.1200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.0907
    Cell Significance Index: -14.5500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1210
    Cell Significance Index: -16.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -1.1341
    Cell Significance Index: -10.9000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -1.1942
    Cell Significance Index: -14.3200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -1.2053
    Cell Significance Index: -14.8200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -1.2241
    Cell Significance Index: -15.3300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -1.2411
    Cell Significance Index: -13.5800
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -1.2464
    Cell Significance Index: -14.9700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.2514
    Cell Significance Index: -14.9700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -1.2786
    Cell Significance Index: -13.7900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -1.2981
    Cell Significance Index: -6.9500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -1.3113
    Cell Significance Index: -14.9800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.3169
    Cell Significance Index: -14.1200
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -1.3233
    Cell Significance Index: -14.6000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -1.3272
    Cell Significance Index: -14.7000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -1.3286
    Cell Significance Index: -16.8100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -1.3489
    Cell Significance Index: -16.4100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -1.3757
    Cell Significance Index: -14.6100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -1.3794
    Cell Significance Index: -15.6700
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -1.3882
    Cell Significance Index: -17.2600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -1.3961
    Cell Significance Index: -13.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Type II keratin**: KRT84 belongs to the type II keratin family, which is distinct from type I keratins, such as keratin 1 and 5. Type II keratins, like KRT84, are characterized by their ability to form coiled-coil dimers and contribute to the structural integrity of epithelial cells. 2. **Intermediate filament organization**: KRT84 is a component of the intermediate filament network, which provides mechanical support and stability to cells. Its interaction with other intermediate filaments, such as keratin 14 and 19, is essential for maintaining cell shape and resisting mechanical stress. 3. **Epithelial cell differentiation**: KRT84 is specifically expressed during the process of keratinocyte differentiation, which is critical for the formation of the cornified envelope, a key feature of mature epithelial cells. Its expression is also required for the development of hair follicles and nails. 4. **Widespread expression**: KRT84 is expressed in various cell types, including erythrocytes, goblet cells, megakaryocytes, and neoplastic cells, highlighting its importance in multiple tissues and cellular contexts. **Pathways and Functions** 1. **Formation of the cornified envelope**: KRT84 plays a crucial role in the formation of the cornified envelope, a critical structure that provides mechanical strength and resistance to environmental stresses in mature epithelial cells. 2. **Hair follicle development**: KRT84 is essential for the development of hair follicles, as its expression is required for the differentiation of keratinocytes and the formation of the hair follicle structure. 3. **Nail development**: KRT84 is also involved in nail development, as its expression is necessary for the differentiation of keratinocytes in the nail matrix. 4. **Regulation of keratinocyte differentiation**: KRT84 acts as a regulatory protein, influencing the differentiation of keratinocytes and the formation of the cornified envelope. 5. **Extracellular exosome formation**: KRT84 is involved in the formation of extracellular exosomes, which are small vesicles that play a critical role in intercellular communication and the regulation of cellular processes. **Clinical Significance** 1. **Cancer progression**: Aberrant expression of KRT84 has been observed in various types of cancer, including breast, lung, and colon cancer. Its dysregulation may contribute to cancer progression and metastasis. 2. **Epidermal disorders**: Mutations in KRT84 have been associated with epidermal disorders, such as epidermolysis bullosa simplex, which is characterized by blistering and skin fragility. 3. **Nail disorders**: KRT84 mutations have also been linked to nail disorders, such as nail plate thinning and brittleness. 4. **Wound healing**: KRT84 may play a role in wound healing, as its expression is upregulated in response to tissue injury. Its dysregulation may impair wound healing and tissue repair. In conclusion, KRT84 is a critical component of the intermediate filament cytoskeleton, playing a pivotal role in the structural integrity and differentiation of epithelial cells. Its widespread expression and involvement in various cellular processes make it an important protein for understanding the development and progression of diseases.

Genular Protein ID: 261067251

Symbol: KRT84_HUMAN

Name: Keratin, type II cuticular Hb4

UniProtKB Accession Codes:

Q9NSB2 B2RA43 Q6ISB0 Q701L6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10692104

Title: Characterization of a 300 kbp region of human DNA containing the type II hair keratin.

PubMed ID: 10692104

DOI: 10.1046/j.1523-1747.2000.00910.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15737194

Title: Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.

PubMed ID: 15737194

DOI: 10.1111/j.0022-202x.2004.23530.x

Sequence Information:

  • Length: 600
  • Mass: 64842
  • Checksum: 5266B0C4E5AE13F1
  • Sequence:
    • MSCRSYRVSS GHRVGNFSSC SAMTPQNLNR FRANSVSCWS GPGFRGLGSF GSRSVITFGS 
YSPRIAAVGS RPIHCGVRFG AGCGMGFGDG RGVGLGPRAD SCVGLGFGAG SGIGYGFGGP 
GFGYRVGGVG VPAAPSITAV TVNKSLLTPL NLEIDPNAQR VKKDEKEQIK TLNNKFASFI 
DKVRFLEQQN KLLETKWSFL QEQKCIRSNL EPLFESYITN LRRQLEVLVS DQARLQAERN 
HLQDVLEGFK KKYEEEVVCR ANAENEFVAL KKDVDAAFMN KSDLEANVDT LTQEIDFLKT 
LYMEEIQLLQ SHISETSVIV KMDNSRDLNL DGIIAEVKAQ YEEVARRSRA DAEAWYQTKY 
EEMQVTAGQH CDNLRNIRNE INELTRLIQR LKAEIEHAKA QRAKLEAAVA EAEQQGEATL 
SDAKCKLADL ECALQQAKQD MARQLCEYQE LMNAKLGLDI EIATYRRLLE GEESRLCEGV 
GPVNISVSSS RGGLVCGPEP LVAGSTLSRG GVTFSGSSSV CATSGVLASC GPSLGGARVA 
PATGDLLSTG TRSGSMLISE ACVPSVPCPL PTQGGFSSCS GGRSSSVRFV STTTSCRTKY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.