Details for: LIPE

Gene ID: 3991

Symbol: LIPE

Ensembl ID: ENSG00000079435

Description: lipase E, hormone sensitive type

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 5.37
    Marker Score: 2605
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.35
    Marker Score: 1224
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.28
    Marker Score: 1276
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169385
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16823
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.01
    Marker Score: 267
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48026.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1
    Marker Score: 312
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5152
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 360
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.88
    Marker Score: 593
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5275
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.84
    Marker Score: 14854
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.83
    Marker Score: 1993
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 559.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 664
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2852
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.63
    Marker Score: 6529
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.63
    Marker Score: 263
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.59
    Marker Score: 914
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.57
    Marker Score: 155
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.55
    Marker Score: 955
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 328
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 336.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 346
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.51
    Marker Score: 1212
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.49
    Marker Score: 1003
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.49
    Marker Score: 18070
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.48
    Marker Score: 812
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.47
    Marker Score: 4059.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.47
    Marker Score: 1909
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.46
    Marker Score: 28040
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.43
    Marker Score: 521
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.42
    Marker Score: 563
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.42
    Marker Score: 3968
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.41
    Marker Score: 2468
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.41
    Marker Score: 1700.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.41
    Marker Score: 1458
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4
    Marker Score: 1561
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.39
    Marker Score: 14652
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 182
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.38
    Marker Score: 8486
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.38
    Marker Score: 406
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.36
    Marker Score: 7142
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.36
    Marker Score: 3361
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.35
    Marker Score: 384.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.35
    Marker Score: 357
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.35
    Marker Score: 142
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.35
    Marker Score: 5243
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.34
    Marker Score: 1417
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.34
    Marker Score: 355
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.33
    Marker Score: 199
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.32
    Marker Score: 883
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 143
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 289
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.32
    Marker Score: 382
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.32
    Marker Score: 531
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.31
    Marker Score: 173
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.31
    Marker Score: 300
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.31
    Marker Score: 99
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.31
    Marker Score: 2346
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.31
    Marker Score: 288
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.3
    Marker Score: 138
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.3
    Marker Score: 104
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3
    Marker Score: 147
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.3
    Marker Score: 370
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.29
    Marker Score: 68.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.29
    Marker Score: 78
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.29
    Marker Score: 581
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.29
    Marker Score: 190.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.29
    Marker Score: 426
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.29
    Marker Score: 120
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.28
    Marker Score: 1290
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.28
    Marker Score: 157
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.28
    Marker Score: 81
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.27
    Marker Score: 550
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.27
    Marker Score: 70
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.27
    Marker Score: 254
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.27
    Marker Score: 187
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.26
    Marker Score: 234
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.26
    Marker Score: 259
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.26
    Marker Score: 82
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.26
    Marker Score: 310
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.25
    Marker Score: 219
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.25
    Marker Score: 178
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.25
    Marker Score: 357
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.25
    Marker Score: 419
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.25
    Marker Score: 124

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Other Information

**Key characteristics:** * The LIPE gene is located on chromosome 19p13.1. * It is a member of the lipase superfamily, which is involved in the hydrolysis of fatty acids. * LIPE is a hormone-sensitive protein, meaning that its activity is modulated by hormones. * It is involved in a variety of cellular processes, including lipid catabolism, steroid metabolism, and retinoid metabolism. **Pathways and functions:** * LIPE is involved in the hydrolysis of diacylglycerol and 1,3-diacylglycerol molecules. * It is involved in the regulation of cholesterol metabolism. * It is involved in the metabolism of retinoids, which are a class of hormones that are important for vision. * It is involved in the regulation of inflammation. **Clinical significance:** * Mutations in the LIPE gene have been linked to a number of human diseases, including obesity, diabetes, and cardiovascular disease. * LIPE inhibitors are being investigated as a treatment for these diseases.

Genular Protein ID: 3427804119

Symbol: LIPS_HUMAN

Name: Hormone-sensitive lipase

UniProtKB Accession Codes:

Q05469 Q3LRT2 Q6NSL7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 80 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 4 EMBL 4 EPD 1 ESTHER 1 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 29 SABIO-RK 1 SAM 1 SIGNOR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 5 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8506334

Title: Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium.

PubMed ID: 8506334

DOI: 10.1073/pnas.90.11.4897

PubMed ID: 8812477

Title: Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase.

PubMed ID: 8812477

DOI: 10.1006/geno.1996.0383

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15955102

Title: Identification of a novel keratinocyte retinyl ester hydrolase as a transacylase and lipase.

PubMed ID: 15955102

DOI: 10.1111/j.0022-202x.2005.23761.x

PubMed ID: 15716583

Title: Continuous monitoring of cholesterol oleate hydrolysis by hormone-sensitive lipase and other cholesterol esterases.

PubMed ID: 15716583

DOI: 10.1194/jlr.m400509-jlr200

PubMed ID: 17026959

Title: Association and insulin regulated translocation of hormone-sensitive lipase with PTRF.

PubMed ID: 17026959

DOI: 10.1016/j.bbrc.2006.09.094

PubMed ID: 16803459

Title: Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes; segregation of specific proteins and functions.

PubMed ID: 16803459

DOI: 10.1111/j.1742-4658.2006.05345.x

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19800417

Title: In vitro stereoselective hydrolysis of diacylglycerols by hormone-sensitive lipase.

PubMed ID: 19800417

DOI: 10.1016/j.bbalip.2009.09.020

PubMed ID: 24848981

Title: Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes.

PubMed ID: 24848981

DOI: 10.1056/nejmoa1315496

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1076
  • Mass: 116598
  • Checksum: 1CC0E3880FF64D74
  • Sequence:
    • MEPGSKSVSR SDWQPEPHQR PITPLEPGPE KTPIAQPESK TLQGSNTQQK PASNQRPLTQ 
QETPAQHDAE SQKEPRAQQK SASQEEFLAP QKPAPQQSPY IQRVLLTQQE AASQQGPGLG 
KESITQQEPA LRQRHVAQPG PGPGEPPPAQ QEAESTPAAQ AKPGAKREPS APTESTSQET 
PEQSDKQTTP VQGAKSKQGS LTELGFLTKL QELSIQRSAL EWKALSEWVT DSESESDVGS 
SSDTDSPATM GGMVAQGVKL GFKGKSGYKV MSGYSGTSPH EKTSARNHRH YQDTASRLIH 
NMDLRTMTQS LVTLAEDNIA FFSSQGPGET AQRLSGVFAG VREQALGLEP ALGRLLGVAH 
LFDLDPETPA NGYRSLVHTA RCCLAHLLHK SRYVASNRRS IFFRTSHNLA ELEAYLAALT 
QLRALVYYAQ RLLVTNRPGV LFFEGDEGLT ADFLREYVTL HKGCFYGRCL GFQFTPAIRP 
FLQTISIGLV SFGEHYKRNE TGLSVAASSL FTSGRFAIDP ELRGAEFERI TQNLDVHFWK 
AFWNITEMEV LSSLANMASA TVRVSRLLSL PPEAFEMPLT ADPTLTVTIS PPLAHTGPGP 
VLVRLISYDL REGQDSEELS SLIKSNGQRS LELWPRPQQA PRSRSLIVHF HGGGFVAQTS 
RSHEPYLKSW AQELGAPIIS IDYSLAPEAP FPRALEECFF AYCWAIKHCA LLGSTGERIC 
LAGDSAGGNL CFTVALRAAA YGVRVPDGIM AAYPATMLQP AASPSRLLSL MDPLLPLSVL 
SKCVSAYAGA KTEDHSNSDQ KALGMMGLVR RDTALLLRDF RLGASSWLNS FLELSGRKSQ 
KMSEPIAEPM RRSVSEAALA QPQGPLGTDS LKNLTLRDLS LRGNSETSSD TPEMSLSAET 
LSPSTPSDVN FLLPPEDAGE EAEAKNELSP MDRGLGVRAA FPEGFHPRRS SQGATQMPLY 
SSPIVKNPFM SPLLAPDSML KSLPPVHIVA CALDPMLDDS VMLARRLRNL GQPVTLRVVE 
DLPHGFLTLA ALCRETRQAA ELCVERIRLV LTPPAGAGPS GETGAAGVDG GCGGRH

Genular Protein ID: 3436950947

Symbol: A8K8W7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K8W7

Database IDs:

ARBA 40 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 80 DNASU 1 EC 4 EMBL 2 ESTHER 1 GO 7 Gene3D 1 GenomeRNAi 1 InterPro 5 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 RefSeq 1 Rhea 29 SAM 1 SUPFAM 1 UniPathway 1

Sequence Information:

  • Length: 1076
  • Mass: 116584
  • Checksum: 01AF00E31ABF8CCA
  • Sequence:
    • MEPGSKSVSR SDWQPEPHQR PITPLEPGPE KTPIAQPESK TLQGSNTQQK PASNQRPLTQ 
QETPAQHDAE SQKEPRAQQK SASQEEFLAP QKPAPQQSPY VQRVLLTQQE AASQQGPGLG 
KESITQQEPA LRQRHVAQPG PGPGEPPPAQ QEAESTPAAQ AKPGAKREPS APTESTSQET 
PEQSDKQTTP VQGAKSKQGS LTELGFLTKL QELSIQRSAL EWKALSEWVT DSESESDVGS 
SSDTDSPATM GGMVAQGVKL GFKGKSGYKV MSGYSGTSPH EKTSARNHRH YQDTASRLIH 
NMDLRTMTQS LVTLAEDNIA FFSSQGPGET AQRLSGVFAG VREQALGLEP ALGRLLGVAH 
LFDLDPETPA NGYRSLVHTA RCCLAHLLHK SRYVASNRRS IFFRTSHNLA ELEAYLAALT 
QLRALVYYAQ RLLVTNRPGV LFFEGDEGLT ADFLREYVTL HKGCFYGRCL GFQFTPAIRP 
FLQTISIGLV SFGEHYKRNE TGLSVAASSL FTSGRFAIDP ELRGAEFERI TQNLDVHFWK 
AFWNITEMEV LSSLANMASA TVRVSRLLSL PPEAFEMPLT ADPTLTVTIS PPLAHTGPGP 
VLVRLISYDL REGQDSEELS SLIKSNGQRS LELWPRPQQA PRSRSLIVHF HGGGFVAQTS 
RSHEPYLKSW AQELGAPIIS IDYSLAPEAP FPRALEECFF AYCWAIKHCA LLGSTGERIC 
LAGDSAGGNL CFTVALRAAA YGVRVPDGIM AAYPATMLQP AASPSRLLSL MDPLLPLSVL 
SKCVSAYAGA KTEDHSNSDQ KALGMMGLVR RDTALLLRDF RLGASSWLNS FLELSGRKSQ 
KMSEPIAEPM RRSVSEAALA QPQGPLGTDS LKNLTLRDLS LRGNSETSSD TPEMSLSAET 
LSPSTPSDVN FLLPPEDAGE EAEAKNELSP MDRGLGVRAA FPEGFHPRRS SQGATQMPLY 
SSPIVKNPFM SPLLAPDSML KSLPPVHIVA CALDPMLDDS VMLARRLRNL GQPVTLRVVE 
DLPHGFLTLA ALCRETRQAA ELCVERIRLV LTPPAGAGPS GETGAAGVDG GCGGRH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.