Details for: MAGEB1

Gene ID: 4112

Symbol: MAGEB1

Ensembl ID: ENSG00000214107

Description: MAGE family member B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.5945
    Cell Significance Index: 40.6300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5733
    Cell Significance Index: 38.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.4474
    Cell Significance Index: 28.3000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.7066
    Cell Significance Index: 5.3400
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.5588
    Cell Significance Index: 3.4500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.4358
    Cell Significance Index: 4.6300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4316
    Cell Significance Index: 6.2900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2353
    Cell Significance Index: 3.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2038
    Cell Significance Index: 2.1100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.2022
    Cell Significance Index: 2.5900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1703
    Cell Significance Index: 2.3400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1294
    Cell Significance Index: 1.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1159
    Cell Significance Index: 1.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0827
    Cell Significance Index: 1.2000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.0776
    Cell Significance Index: 0.9700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0659
    Cell Significance Index: 0.7800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0369
    Cell Significance Index: 0.4100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0362
    Cell Significance Index: 0.3500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0245
    Cell Significance Index: 0.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0187
    Cell Significance Index: 0.5000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0096
    Cell Significance Index: 0.1200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0028
    Cell Significance Index: 0.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0005
    Cell Significance Index: -0.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0006
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0006
    Cell Significance Index: -0.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0006
    Cell Significance Index: -0.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0007
    Cell Significance Index: -0.3800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0009
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0009
    Cell Significance Index: -0.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0012
    Cell Significance Index: -0.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0017
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0021
    Cell Significance Index: -0.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0054
    Cell Significance Index: -0.3600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0068
    Cell Significance Index: -0.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0068
    Cell Significance Index: -0.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0068
    Cell Significance Index: -0.3800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0070
    Cell Significance Index: -0.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0079
    Cell Significance Index: -0.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0083
    Cell Significance Index: -0.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0086
    Cell Significance Index: -0.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0092
    Cell Significance Index: -0.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0093
    Cell Significance Index: -0.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0098
    Cell Significance Index: -0.3200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0099
    Cell Significance Index: -0.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0100
    Cell Significance Index: -0.3200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0111
    Cell Significance Index: -0.2700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0113
    Cell Significance Index: -0.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0115
    Cell Significance Index: -0.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0116
    Cell Significance Index: -0.2900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0118
    Cell Significance Index: -0.2000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0122
    Cell Significance Index: -0.1300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0128
    Cell Significance Index: -0.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0130
    Cell Significance Index: -0.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0139
    Cell Significance Index: -0.3000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0145
    Cell Significance Index: -0.2200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0148
    Cell Significance Index: -0.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0151
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0152
    Cell Significance Index: -0.1600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0152
    Cell Significance Index: -0.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0159
    Cell Significance Index: -0.4300
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0161
    Cell Significance Index: -0.1800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0162
    Cell Significance Index: -0.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0163
    Cell Significance Index: -0.2400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0163
    Cell Significance Index: -0.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0164
    Cell Significance Index: -0.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0164
    Cell Significance Index: -0.4600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0167
    Cell Significance Index: -0.3300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0168
    Cell Significance Index: -0.3300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0171
    Cell Significance Index: -0.2300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0173
    Cell Significance Index: -0.2300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0174
    Cell Significance Index: -0.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0184
    Cell Significance Index: -0.9300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0186
    Cell Significance Index: -0.2100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0192
    Cell Significance Index: -0.4000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0193
    Cell Significance Index: -0.2300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0200
    Cell Significance Index: -0.2700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0201
    Cell Significance Index: -0.1800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0202
    Cell Significance Index: -0.3500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0203
    Cell Significance Index: -0.2600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0210
    Cell Significance Index: -0.2800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0211
    Cell Significance Index: -0.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0211
    Cell Significance Index: -0.2700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0213
    Cell Significance Index: -0.2500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0213
    Cell Significance Index: -0.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0213
    Cell Significance Index: -0.8700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0222
    Cell Significance Index: -0.2900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0223
    Cell Significance Index: -0.3200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0224
    Cell Significance Index: -0.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAGEB1 is a member of the MAGE gene family, which consists of six members (MAGEA1-6) that are known for their expression in melanoma and other cancer cells. The MAGEB1 gene is involved in the regulation of transcription, specifically in the negative regulation of transcription by RNA polymerase II. This function is crucial for maintaining gene expression in a controlled manner, ensuring that only specific genes are transcribed in response to environmental cues. The MAGEB1 gene is also characterized by its expression in various cell types, including: * Conventional dendritic cells * Erythrocytes * Granulocyte-monocyte progenitor cells * Male germ cells * Goblet cells * Early T lineage precursors * Absorptive cells * Intestinal crypt stem cells * Transit amplifying cells * Abnormal cells **Pathways and Functions:** The MAGEB1 gene is involved in several key pathways, including: * Negative regulation of transcription by RNA polymerase II: MAGEB1 acts as a transcriptional regulator, controlling the expression of specific genes by inhibiting transcription by RNA polymerase II. * Nucleus: MAGEB1 is localized to the nucleus, where it regulates gene expression and maintains the integrity of the genome. The functions of the MAGEB1 gene are multifaceted, including: * Maintenance of genome stability: By regulating gene expression, MAGEB1 helps maintain the integrity of the genome and prevents the aberrant expression of genes that could lead to cancer. * Regulation of cellular differentiation: MAGEB1 plays a role in regulating cellular differentiation, ensuring that cells undergo the necessary developmental processes to become functional. * Immune modulation: As a member of the MAGE gene family, MAGEB1 is involved in the regulation of immune responses, particularly in the context of cancer. **Clinical Significance:** The MAGEB1 gene has significant clinical implications, particularly in the context of cancer. The gene is overexpressed in numerous tumor types, including melanoma, making it a promising target for immunotherapy. The MAGEB1 gene is also involved in the regulation of transcription, which is critical for maintaining genome stability and preventing cancer. In conclusion, the MAGEB1 gene is a complex and multifaceted gene that plays a crucial role in regulating transcription and maintaining genome stability. Its overexpression in cancer cells makes it a promising target for immunotherapy, and its involvement in immune modulation and cellular differentiation highlights its importance in understanding the biology of cancer. **Implications for Future Research:** Further research is needed to fully understand the role of the MAGEB1 gene in cancer and its potential as a therapeutic target. Studies investigating the expression patterns of MAGEB1 in various cancer types, as well as its involvement in immune modulation and cellular differentiation, are essential for advancing our understanding of this gene. Additionally, the development of immunotherapies targeting the MAGEB1 gene, such as cancer vaccines and checkpoint inhibitors, holds promise for the treatment of cancer. By understanding the mechanisms by which MAGEB1 regulates transcription and maintains genome stability, researchers can design more effective therapies that target this gene and improve patient outcomes. In summary, the MAGEB1 gene is a complex and multifaceted gene that plays a critical role in regulating transcription and maintaining genome stability. Its overexpression in cancer cells makes it a promising target for immunotherapy, and its involvement in immune modulation and cellular differentiation highlights its importance in understanding the biology of cancer.

Genular Protein ID: 3076350179

Symbol: MAGB1_HUMAN

Name: Melanoma-associated antigen B1

UniProtKB Accession Codes:

P43366 B2RC79 O00601 O75862 Q6FHJ0 Q96CW8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 GO 2 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7761436

Title: Isolation and characterization of a MAGE gene family in the Xp21.3 region.

PubMed ID: 7761436

DOI: 10.1073/pnas.92.11.4987

PubMed ID: 8535061

Title: A family of rapidly evolving genes from the sex reversal critical region in Xp21.

PubMed ID: 8535061

DOI: 10.1007/bf00352360

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 347
  • Mass: 39037
  • Checksum: 538A65E02DC34155
  • Sequence:
    • MPRGQKSKLR AREKRRKARE ETQGLKVAHA TAAEKEECPS SSPVLGDTPT SSPAAGIPQK 
PQGAPPTTTA AAAVSCTESD EGAKCQGEEN ASFSQATTST ESSVKDPVAW EAGMLMHFIL 
RKYKMREPIM KADMLKVVDE KYKDHFTEIL NGASRRLELV FGLDLKEDNP SGHTYTLVSK 
LNLTNDGNLS NDWDFPRNGL LMPLLGVIFL KGNSATEEEI WKFMNVLGAY DGEEHLIYGE 
PRKFITQDLV QEKYLKYEQV PNSDPPRYQF LWGPRAYAET TKMKVLEFLA KMNGATPRDF 
PSHYEEALRD EEERAQVRSS VRARRRTTAT TFRARSRAPF SRSSHPM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.