Details for: MTHFD1P1

Gene ID: 4523

Symbol: MTHFD1P1

Ensembl ID: ENSG00000231831

Description: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.8108
    Cell Significance Index: 23.3200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.4708
    Cell Significance Index: 4.8100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.3936
    Cell Significance Index: 9.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1586
    Cell Significance Index: 8.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0832
    Cell Significance Index: 3.8800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0526
    Cell Significance Index: 0.7300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.0354
    Cell Significance Index: 0.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0232
    Cell Significance Index: 1.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0140
    Cell Significance Index: 2.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0117
    Cell Significance Index: 1.3400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.0107
    Cell Significance Index: 0.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0030
    Cell Significance Index: 0.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0002
    Cell Significance Index: 0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -2.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0031
    Cell Significance Index: -0.6200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0036
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0084
    Cell Significance Index: -3.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0159
    Cell Significance Index: -2.3100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0255
    Cell Significance Index: -0.3200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0267
    Cell Significance Index: -0.2600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0329
    Cell Significance Index: -0.3300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0395
    Cell Significance Index: -0.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0405
    Cell Significance Index: -4.2200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0506
    Cell Significance Index: -0.6500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0557
    Cell Significance Index: -1.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0557
    Cell Significance Index: -1.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0570
    Cell Significance Index: -1.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0572
    Cell Significance Index: -2.0000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0601
    Cell Significance Index: -1.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0605
    Cell Significance Index: -1.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0630
    Cell Significance Index: -2.0100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0637
    Cell Significance Index: -0.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0642
    Cell Significance Index: -1.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0771
    Cell Significance Index: -1.6400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0793
    Cell Significance Index: -0.8100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0793
    Cell Significance Index: -1.3700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0835
    Cell Significance Index: -1.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0845
    Cell Significance Index: -2.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0857
    Cell Significance Index: -3.0100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0922
    Cell Significance Index: -1.8400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0931
    Cell Significance Index: -1.0400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0943
    Cell Significance Index: -1.0900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0980
    Cell Significance Index: -1.2900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1032
    Cell Significance Index: -1.2200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1041
    Cell Significance Index: -1.3000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1056
    Cell Significance Index: -2.2000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1081
    Cell Significance Index: -1.0700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1191
    Cell Significance Index: -1.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1238
    Cell Significance Index: -2.7100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1252
    Cell Significance Index: -3.9600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1261
    Cell Significance Index: -1.3300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1270
    Cell Significance Index: -1.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1299
    Cell Significance Index: -3.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1312
    Cell Significance Index: -3.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1346
    Cell Significance Index: -1.6100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1371
    Cell Significance Index: -1.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1546
    Cell Significance Index: -3.9400
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1547
    Cell Significance Index: -1.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1620
    Cell Significance Index: -2.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1665
    Cell Significance Index: -1.6000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1672
    Cell Significance Index: -1.9900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1702
    Cell Significance Index: -1.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1722
    Cell Significance Index: -3.7300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1742
    Cell Significance Index: -2.9300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1762
    Cell Significance Index: -1.9200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1762
    Cell Significance Index: -1.5200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1884
    Cell Significance Index: -3.2000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1904
    Cell Significance Index: -2.4900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1942
    Cell Significance Index: -2.0100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1965
    Cell Significance Index: -2.1300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2025
    Cell Significance Index: -1.6400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2032
    Cell Significance Index: -2.2000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2051
    Cell Significance Index: -2.3600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2068
    Cell Significance Index: -2.3300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2221
    Cell Significance Index: -2.4700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2356
    Cell Significance Index: -2.4300
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.2374
    Cell Significance Index: -2.8700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2382
    Cell Significance Index: -1.9700
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2410
    Cell Significance Index: -2.5200
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.2418
    Cell Significance Index: -2.4700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2421
    Cell Significance Index: -3.1600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2424
    Cell Significance Index: -2.8500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2447
    Cell Significance Index: -3.3600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2458
    Cell Significance Index: -2.3300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2473
    Cell Significance Index: -2.9200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2602
    Cell Significance Index: -2.8200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2603
    Cell Significance Index: -2.6300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2617
    Cell Significance Index: -3.0400
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.2639
    Cell Significance Index: -3.1700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2692
    Cell Significance Index: -2.8100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2701
    Cell Significance Index: -3.2100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2721
    Cell Significance Index: -3.3100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2722
    Cell Significance Index: -3.3000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.2750
    Cell Significance Index: -2.6900
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.2774
    Cell Significance Index: -3.0800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2779
    Cell Significance Index: -2.6000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2801
    Cell Significance Index: -3.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MTHFD1P1 is a pseudogene, meaning that it is a non-functional copy of a gene that has been inactivated through mutations or other mechanisms. Despite its pseudogene status, MTHFD1P1 shares significant sequence homology with its functional counterpart, MTHFD1. This suggests that MTHFD1P1 may have evolved from MTHFD1 and could potentially be activated in the future. However, the gene's expression pattern and lack of functional evidence suggest that it is currently not playing a significant role in the organism. **Pathways and Functions** MTHFD1P1 is involved in the folate and one-carbon metabolism pathway, which is crucial for various cellular processes, including DNA synthesis, repair, and methylation. The gene is part of the methylene-tetrahydrofolate dehydrogenase enzyme complex, which is responsible for converting dihydrofolate to tetrahydrofolate. This step is essential for the transfer of one-carbon units to various biomolecules, including nucleotides, amino acids, and choline. The expression of MTHFD1P1 in specific cell types, such as retinal rod cells and astrocytes, suggests that it may play a role in the regulation of cell growth and differentiation in these tissues. The gene's expression in CD4-positive helper T cells may also be relevant in the context of immune responses. **Clinical Significance** The clinical significance of MTHFD1P1 is largely unknown, as it is a pseudogene and does not appear to be functional. However, the gene's expression pattern and involvement in folate and one-carbon metabolism suggest that alterations in its expression or function could have significant implications for human health. For example, disruptions in folate metabolism have been linked to various diseases, including anemia, megaloblastic anemia, and neural tube defects. MTHFD1P1's expression in specific cell types may also be relevant in the context of certain diseases, such as age-related macular degeneration, where retinal rod cells are affected. In conclusion, while MTHFD1P1 is a pseudogene, its expression pattern and involvement in folate and one-carbon metabolism suggest that it may have significant implications for human health. Further research is needed to fully understand the role of MTHFD1P1 and its potential clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.