Details for: POLG

Gene ID: 5428

Symbol: POLG

Ensembl ID: ENSG00000140521

Description: DNA polymerase gamma, catalytic subunit

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.16
    Marker Score: 2742
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71715
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47939
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.98
    Marker Score: 1719
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30395
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.94
    Marker Score: 1447
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 472
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 428
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2704
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13805
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4880
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.85
    Marker Score: 7283.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.84
    Marker Score: 7936
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.83
    Marker Score: 300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.82
    Marker Score: 50390
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.79
    Marker Score: 247
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.77
    Marker Score: 618
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.76
    Marker Score: 245
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.74
    Marker Score: 6916
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 555
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 288
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 367
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.7
    Marker Score: 1937.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2850
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.65
    Marker Score: 600.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.65
    Marker Score: 593
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 386
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.64
    Marker Score: 692
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.62
    Marker Score: 301
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.62
    Marker Score: 216
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.59
    Marker Score: 672
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.59
    Marker Score: 2272
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.58
    Marker Score: 5967.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 381
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.57
    Marker Score: 21151
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.57
    Marker Score: 3411
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.57
    Marker Score: 378
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.56
    Marker Score: 230
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.55
    Marker Score: 239
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.54
    Marker Score: 20609
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.54
    Marker Score: 265
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 422
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.52
    Marker Score: 128.5
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.52
    Marker Score: 113.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.52
    Marker Score: 380
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.52
    Marker Score: 115.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.52
    Marker Score: 439
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.52
    Marker Score: 113
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.51
    Marker Score: 1433
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.51
    Marker Score: 121.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.51
    Marker Score: 1737
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.5
    Marker Score: 578
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.5
    Marker Score: 113
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5
    Marker Score: 735
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.5
    Marker Score: 364
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.5
    Marker Score: 345
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.49
    Marker Score: 246
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 130
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.49
    Marker Score: 98.5
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.49
    Marker Score: 127.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.49
    Marker Score: 330
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.49
    Marker Score: 434
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 203
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.48
    Marker Score: 4909
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.48
    Marker Score: 168
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.48
    Marker Score: 167
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.48
    Marker Score: 2926
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.48
    Marker Score: 119.5
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.48
    Marker Score: 127
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.48
    Marker Score: 298
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.48
    Marker Score: 518
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.48
    Marker Score: 10163
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.47
    Marker Score: 177
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.47
    Marker Score: 613
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.47
    Marker Score: 272
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.47
    Marker Score: 7042
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.47
    Marker Score: 520
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.47
    Marker Score: 1950
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.47
    Marker Score: 122
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.47
    Marker Score: 100
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.47
    Marker Score: 92
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.47
    Marker Score: 352
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 452
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.47
    Marker Score: 297
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.47
    Marker Score: 9296
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.46
    Marker Score: 489
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.46
    Marker Score: 113.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.46
    Marker Score: 442
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.46
    Marker Score: 117
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.46
    Marker Score: 399
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.46
    Marker Score: 121
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.46
    Marker Score: 3521.5
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.46
    Marker Score: 119
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.46
    Marker Score: 461
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.46
    Marker Score: 126

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Other Information

**Key Characteristics:** The POLG gene is a crucial component of the mitochondrial DNA replication machinery. Its product, DNA polymerase gamma, possesses 3'-5' exonuclease activity, which allows for the proofreading and editing of mtDNA during replication. Additionally, POLG is involved in the repair of mtDNA damage through its 5'-deoxyribose-5-phosphate lyase activity. This enzyme helps to remove damaged bases from mtDNA, thereby maintaining genome stability. **Pathways and Functions:** The POLG gene is integral to several key pathways, including: 1. **Mitochondrial DNA Replication**: POLG is essential for the replication of mtDNA, which is necessary for the maintenance of energy production in cells. 2. **Base-Excision Repair**: POLG's 5'-deoxyribose-5-phosphate lyase activity is crucial for the removal of damaged bases from mtDNA, ensuring genome stability. 3. **DNA Metabolic Process**: POLG is involved in the biosynthetic process of mtDNA, where it facilitates the synthesis of new mtDNA strands. 4. **Chromatin Binding**: POLG interacts with chromatin, allowing for the regulation of mtDNA replication and expression. **Clinical Significance:** Mutations in the POLG gene have been identified as a cause of a range of mitochondrial disorders, including: 1. **Mitochondrial Myopathies**: Conditions such as MERRF (Myoclonic Epilepsy with Ragged Red Fibers) and MELAS (Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes) are associated with POLG mutations. 2. **Neuropathies**: POLG mutations have been linked to peripheral neuropathies, such as Charcot-Marie-Tooth disease. 3. **Cancer**: Some studies suggest that POLG mutations may contribute to the development of certain types of cancer, such as breast and ovarian cancer. In conclusion, the POLG gene plays a vital role in mitochondrial DNA replication and maintenance, and its dysfunction can lead to a range of clinical disorders. Further research is necessary to fully elucidate the mechanisms underlying POLG-related diseases and to develop effective therapeutic strategies for these conditions.

Genular Protein ID: 2206512358

Symbol: DPOG1_HUMAN

Name: DNA polymerase subunit gamma-1

UniProtKB Accession Codes:

P54098 Q8NFM2 Q92515

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 6 EMDB 2 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 15 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 14 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 8 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 10 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 Rhea 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8884268

Title: Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma.

PubMed ID: 8884268

DOI: 10.1006/geno.1996.0490

PubMed ID: 9034326

Title: Mitochondrial DNA polymerases from yeast to man: a new family of polymerases.

PubMed ID: 9034326

DOI: 10.1016/s0378-1119(96)00663-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18063578

Title: The layered structure of human mitochondrial DNA nucleoids.

PubMed ID: 18063578

DOI: 10.1074/jbc.m708444200

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26942291

Title: PRICKLE2 mutations might not be involved in epilepsy.

PubMed ID: 26942291

DOI: 10.1016/j.ajhg.2016.01.009

PubMed ID: 29290964

Title: Tetratricopeptide repeat domain 3 overexpression tends to form aggregates and inhibit ubiquitination and degradation of DNA polymerase gamma.

PubMed ID: 29290964

DOI: 10.18632/oncotarget.22476

PubMed ID: 33855352

Title: Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy.

PubMed ID: 33855352

DOI: 10.1093/brain/awab056

PubMed ID: 11431686

Title: Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions.

PubMed ID: 11431686

DOI: 10.1038/90034

PubMed ID: 12210792

Title: Mutations of mitochondrial DNA polymerase gammaA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia.

PubMed ID: 12210792

DOI: 10.1002/ana.10278

PubMed ID: 11897778

Title: Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis.

PubMed ID: 11897778

DOI: 10.1074/jbc.c200100200

PubMed ID: 12975295

Title: Clinical and genetic heterogeneity in progressive external ophthalmoplegia due to mutations in polymerase gamma.

PubMed ID: 12975295

DOI: 10.1001/archneur.60.9.1279

PubMed ID: 12825077

Title: Novel POLG mutations in progressive external ophthalmoplegia mimicking mitochondrial neurogastrointestinal encephalomyopathy.

PubMed ID: 12825077

DOI: 10.1038/sj.ejhg.5201002

PubMed ID: 12872260

Title: Digenic progressive external ophthalmoplegia in a sporadic patient: recessive mutations in POLG and C10orf2/Twinkle.

PubMed ID: 12872260

DOI: 10.1002/humu.10246

PubMed ID: 14635118

Title: POLG mutations in sporadic mitochondrial disorders with multiple mtDNA deletions.

PubMed ID: 14635118

DOI: 10.1002/humu.9203

PubMed ID: 12707443

Title: Mutations of ANT1, Twinkle, and POLG1 in sporadic progressive external ophthalmoplegia (PEO).

PubMed ID: 12707443

DOI: 10.1212/01.wnl.0000056088.09408.3c

PubMed ID: 14694057

Title: Patient homozygous for a recessive POLG mutation presents with features of MERRF.

PubMed ID: 14694057

DOI: 10.1212/01.wnl.0000098997.23471.65

PubMed ID: 12565911

Title: Recessive POLG mutations presenting with sensory and ataxic neuropathy in compound heterozygote patients with progressive external ophthalmoplegia.

PubMed ID: 12565911

DOI: 10.1016/s0960-8966(02)00216-x

PubMed ID: 15122711

Title: POLG mutations associated with Alpers' syndrome and mitochondrial DNA depletion.

PubMed ID: 15122711

DOI: 10.1002/ana.20079

PubMed ID: 15349879

Title: Sequence analysis of familial PEO shows additional mutations associated with the 752C-->T and 3527C-->T changes in the POLG1 gene.

PubMed ID: 15349879

DOI: 10.1002/ana.20219

PubMed ID: 15534189

Title: A novel polymerase gamma mutation in a family with ophthalmoplegia, neuropathy, and parkinsonism.

PubMed ID: 15534189

DOI: 10.1001/archneur.61.11.1777

PubMed ID: 15351195

Title: Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.

PubMed ID: 15351195

DOI: 10.1016/s0140-6736(04)16983-3

PubMed ID: 14745080

Title: POLG mutations causing ophthalmoplegia, sensorimotor polyneuropathy, ataxia, and deafness.

PubMed ID: 14745080

DOI: 10.1212/wnl.62.2.316

PubMed ID: 15477547

Title: POLG mutations in neurodegenerative disorders with ataxia but no muscle involvement.

PubMed ID: 15477547

DOI: 10.1212/01.wnl.0000140494.58732.83

PubMed ID: 16080118

Title: Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin.

PubMed ID: 16080118

DOI: 10.1086/444548

PubMed ID: 15929042

Title: POLG mutations and Alpers syndrome.

PubMed ID: 15929042

DOI: 10.1002/ana.20498

PubMed ID: 15689359

Title: Infantile hepatocerebral syndromes associated with mutations in the mitochondrial DNA polymerase-gammaA.

PubMed ID: 15689359

DOI: 10.1093/brain/awh410

PubMed ID: 15917273

Title: Functional defects due to spacer-region mutations of human mitochondrial DNA polymerase in a family with an ataxia-myopathy syndrome.

PubMed ID: 15917273

DOI: 10.1093/hmg/ddi196

PubMed ID: 15824347

Title: Autosomal recessive mitochondrial ataxic syndrome due to mitochondrial polymerase gamma mutations.

PubMed ID: 15824347

DOI: 10.1212/01.wnl.0000156516.77696.5a

PubMed ID: 16634032

Title: Early-onset familial parkinsonism due to POLG mutations.

PubMed ID: 16634032

DOI: 10.1002/ana.20831

PubMed ID: 16401742

Title: Association of novel POLG mutations and multiple mitochondrial DNA deletions with variable clinical phenotypes in a Spanish population.

PubMed ID: 16401742

DOI: 10.1001/archneur.63.1.107

PubMed ID: 16621917

Title: Phenotypic spectrum associated with mutations of the mitochondrial polymerase gamma gene.

PubMed ID: 16621917

DOI: 10.1093/brain/awl088

PubMed ID: 16639411

Title: Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.

PubMed ID: 16639411

DOI: 10.1038/sj.ejhg.5201627

PubMed ID: 16919951

Title: SANDO: two novel mutations in POLG1 gene.

PubMed ID: 16919951

DOI: 10.1016/j.nmd.2006.05.016

PubMed ID: 17420318

Title: Mutation of the linker region of the polymerase gamma-1 (POLG1) gene associated with progressive external ophthalmoplegia and Parkinsonism.

PubMed ID: 17420318

DOI: 10.1001/archneur.64.4.553

PubMed ID: 17846414

Title: Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease.

PubMed ID: 17846414

DOI: 10.1212/01.wnl.0000276955.23735.eb

PubMed ID: 18575922

Title: Novel Twinkle (PEO1) gene mutations in Mendelian progressive external ophthalmoplegia.

PubMed ID: 18575922

DOI: 10.1007/s00415-008-0926-3

PubMed ID: 18828154

Title: Analysis of mutant DNA polymerase gamma in patients with mitochondrial DNA depletion.

PubMed ID: 18828154

DOI: 10.1002/humu.20852

PubMed ID: 19307547

Title: Fatal congenital myopathy and gastrointestinal pseudo-obstruction due to POLG1 mutations.

PubMed ID: 19307547

DOI: 10.1212/01.wnl.0000345002.47396.e1

PubMed ID: 25129007

Title: Mitochondrial DNA depletion syndrome causing liver failure.

PubMed ID: 25129007

DOI: 10.1007/s13312-014-0475-z

Sequence Information:

  • Length: 1239
  • Mass: 139562
  • Checksum: 2D9ECCD75AD6E01E
  • Sequence:
    • MSRLLWRKVA GATVGPGPVP APGRWVSSSV PASDPSDGQR RRQQQQQQQQ QQQQQPQQPQ 
VLSSEGGQLR HNPLDIQMLS RGLHEQIFGQ GGEMPGEAAV RRSVEHLQKH GLWGQPAVPL 
PDVELRLPPL YGDNLDQHFR LLAQKQSLPY LEAANLLLQA QLPPKPPAWA WAEGWTRYGP 
EGEAVPVAIP EERALVFDVE VCLAEGTCPT LAVAISPSAW YSWCSQRLVE ERYSWTSQLS 
PADLIPLEVP TGASSPTQRD WQEQLVVGHN VSFDRAHIRE QYLIQGSRMR FLDTMSMHMA 
ISGLSSFQRS LWIAAKQGKH KVQPPTKQGQ KSQRKARRGP AISSWDWLDI SSVNSLAEVH 
RLYVGGPPLE KEPRELFVKG TMKDIRENFQ DLMQYCAQDV WATHEVFQQQ LPLFLERCPH 
PVTLAGMLEM GVSYLPVNQN WERYLAEAQG TYEELQREMK KSLMDLANDA CQLLSGERYK 
EDPWLWDLEW DLQEFKQKKA KKVKKEPATA SKLPIEGAGA PGDPMDQEDL GPCSEEEEFQ 
QDVMARACLQ KLKGTTELLP KRPQHLPGHP GWYRKLCPRL DDPAWTPGPS LLSLQMRVTP 
KLMALTWDGF PLHYSERHGW GYLVPGRRDN LAKLPTGTTL ESAGVVCPYR AIESLYRKHC 
LEQGKQQLMP QEAGLAEEFL LTDNSAIWQT VEELDYLEVE AEAKMENLRA AVPGQPLALT 
ARGGPKDTQP SYHHGNGPYN DVDIPGCWFF KLPHKDGNSC NVGSPFAKDF LPKMEDGTLQ 
AGPGGASGPR ALEINKMISF WRNAHKRISS QMVVWLPRSA LPRAVIRHPD YDEEGLYGAI 
LPQVVTAGTI TRRAVEPTWL TASNARPDRV GSELKAMVQA PPGYTLVGAD VDSQELWIAA 
VLGDAHFAGM HGCTAFGWMT LQGRKSRGTD LHSKTATTVG ISREHAKIFN YGRIYGAGQP 
FAERLLMQFN HRLTQQEAAE KAQQMYAATK GLRWYRLSDE GEWLVRELNL PVDRTEGGWI 
SLQDLRKVQR ETARKSQWKK WEVVAERAWK GGTESEMFNK LESIATSDIP RTPVLGCCIS 
RALEPSAVQE EFMTSRVNWV VQSSAVDYLH LMLVAMKWLF EEFAIDGRFC ISIHDEVRYL 
VREEDRYRAA LALQITNLLT RCMFAYKLGL NDLPQSVAFF SAVDIDRCLR KEVTMDCKTP 
SNPTGMERRY GIPQGEALDI YQIIELTKGS LEKRSQPGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.